DE2057544C3 - Impfstoff gegen ein neonatales Kälberdiarrhoevirus, Verfahren zu seiner Herstellung und seine Verwendung - Google Patents
Impfstoff gegen ein neonatales Kälberdiarrhoevirus, Verfahren zu seiner Herstellung und seine VerwendungInfo
- Publication number
- DE2057544C3 DE2057544C3 DE2057544A DE2057544A DE2057544C3 DE 2057544 C3 DE2057544 C3 DE 2057544C3 DE 2057544 A DE2057544 A DE 2057544A DE 2057544 A DE2057544 A DE 2057544A DE 2057544 C3 DE2057544 C3 DE 2057544C3
- Authority
- DE
- Germany
- Prior art keywords
- virus
- vaccine
- calves
- passages
- calf
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 229960005486 vaccine Drugs 0.000 title claims description 48
- 238000000034 method Methods 0.000 title claims description 11
- 241000711443 Bovine coronavirus Species 0.000 title claims 2
- 238000002360 preparation method Methods 0.000 title description 2
- 241000700605 Viruses Species 0.000 claims description 115
- 244000309466 calf Species 0.000 claims description 115
- 238000004113 cell culture Methods 0.000 claims description 45
- 206010012735 Diarrhoea Diseases 0.000 claims description 33
- 210000003608 fece Anatomy 0.000 claims description 20
- 239000002671 adjuvant Substances 0.000 claims description 15
- 210000003292 kidney cell Anatomy 0.000 claims description 11
- 238000010166 immunofluorescence Methods 0.000 claims description 9
- 210000003734 kidney Anatomy 0.000 claims description 9
- 238000011534 incubation Methods 0.000 claims description 4
- 230000001717 pathogenic effect Effects 0.000 claims description 2
- 238000004108 freeze drying Methods 0.000 claims 1
- 238000003306 harvesting Methods 0.000 claims 1
- 230000036039 immunity Effects 0.000 claims 1
- 230000002163 immunogen Effects 0.000 claims 1
- 230000000415 inactivating effect Effects 0.000 claims 1
- 230000001537 neural effect Effects 0.000 claims 1
- 238000012545 processing Methods 0.000 claims 1
- 230000003313 weakening effect Effects 0.000 claims 1
- 241000283690 Bos taurus Species 0.000 description 45
- 210000004027 cell Anatomy 0.000 description 17
- 239000002609 medium Substances 0.000 description 15
- 239000000203 mixture Substances 0.000 description 11
- 235000015097 nutrients Nutrition 0.000 description 11
- 239000000706 filtrate Substances 0.000 description 8
- 239000007788 liquid Substances 0.000 description 8
- 210000003022 colostrum Anatomy 0.000 description 7
- 235000021277 colostrum Nutrition 0.000 description 7
- 238000002255 vaccination Methods 0.000 description 7
- 239000012930 cell culture fluid Substances 0.000 description 6
- 210000001198 duodenum Anatomy 0.000 description 6
- 238000011081 inoculation Methods 0.000 description 6
- UCSJYZPVAKXKNQ-HZYVHMACSA-N streptomycin Chemical compound CN[C@H]1[C@H](O)[C@@H](O)[C@H](CO)O[C@H]1O[C@@H]1[C@](C=O)(O)[C@H](C)O[C@H]1O[C@@H]1[C@@H](NC(N)=N)[C@H](O)[C@@H](NC(N)=N)[C@H](O)[C@H]1O UCSJYZPVAKXKNQ-HZYVHMACSA-N 0.000 description 6
- 238000012360 testing method Methods 0.000 description 6
- 230000002550 fecal effect Effects 0.000 description 5
- 208000015181 infectious disease Diseases 0.000 description 5
- 210000000056 organ Anatomy 0.000 description 5
- 238000011160 research Methods 0.000 description 5
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 4
- 241000588724 Escherichia coli Species 0.000 description 4
- 102000004407 Lactalbumin Human genes 0.000 description 4
- 108090000942 Lactalbumin Proteins 0.000 description 4
- 201000010099 disease Diseases 0.000 description 4
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 4
- 238000004519 manufacturing process Methods 0.000 description 4
- 229930182555 Penicillin Natural products 0.000 description 3
- JGSARLDLIJGVTE-MBNYWOFBSA-N Penicillin G Chemical compound N([C@H]1[C@H]2SC([C@@H](N2C1=O)C(O)=O)(C)C)C(=O)CC1=CC=CC=C1 JGSARLDLIJGVTE-MBNYWOFBSA-N 0.000 description 3
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 3
- STDBAQMTJLUMFW-UHFFFAOYSA-N butobarbital Chemical compound CCCCC1(CC)C(=O)NC(=O)NC1=O STDBAQMTJLUMFW-UHFFFAOYSA-N 0.000 description 3
- 239000012531 culture fluid Substances 0.000 description 3
- 230000000120 cytopathologic effect Effects 0.000 description 3
- 230000000741 diarrhetic effect Effects 0.000 description 3
- 230000002183 duodenal effect Effects 0.000 description 3
- 238000002474 experimental method Methods 0.000 description 3
- 230000001605 fetal effect Effects 0.000 description 3
- 210000004072 lung Anatomy 0.000 description 3
- 229940049954 penicillin Drugs 0.000 description 3
- 239000000523 sample Substances 0.000 description 3
- 238000001179 sorption measurement Methods 0.000 description 3
- 229960005322 streptomycin Drugs 0.000 description 3
- 239000000725 suspension Substances 0.000 description 3
- 230000003612 virological effect Effects 0.000 description 3
- 208000010711 Cattle disease Diseases 0.000 description 2
- HEDRZPFGACZZDS-UHFFFAOYSA-N Chloroform Chemical compound ClC(Cl)Cl HEDRZPFGACZZDS-UHFFFAOYSA-N 0.000 description 2
- WSFSSNUMVMOOMR-UHFFFAOYSA-N Formaldehyde Chemical compound O=C WSFSSNUMVMOOMR-UHFFFAOYSA-N 0.000 description 2
- 241001465754 Metazoa Species 0.000 description 2
- 229910019142 PO4 Inorganic materials 0.000 description 2
- 235000019485 Safflower oil Nutrition 0.000 description 2
- 241000282887 Suidae Species 0.000 description 2
- 230000002238 attenuated effect Effects 0.000 description 2
- 230000001580 bacterial effect Effects 0.000 description 2
- 239000012267 brine Substances 0.000 description 2
- 229940041514 candida albicans extract Drugs 0.000 description 2
- 238000001493 electron microscopy Methods 0.000 description 2
- 210000002257 embryonic structure Anatomy 0.000 description 2
- 210000002919 epithelial cell Anatomy 0.000 description 2
- 238000010820 immunofluorescence microscopy Methods 0.000 description 2
- 239000000463 material Substances 0.000 description 2
- 239000003921 oil Substances 0.000 description 2
- 235000019198 oils Nutrition 0.000 description 2
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 2
- 239000010452 phosphate Substances 0.000 description 2
- 239000002504 physiological saline solution Substances 0.000 description 2
- 235000005713 safflower oil Nutrition 0.000 description 2
- 239000003813 safflower oil Substances 0.000 description 2
- 210000000813 small intestine Anatomy 0.000 description 2
- HPALAKNZSZLMCH-UHFFFAOYSA-M sodium;chloride;hydrate Chemical compound O.[Na+].[Cl-] HPALAKNZSZLMCH-UHFFFAOYSA-M 0.000 description 2
- 239000006228 supernatant Substances 0.000 description 2
- 239000012138 yeast extract Substances 0.000 description 2
- FHVDTGUDJYJELY-UHFFFAOYSA-N 6-{[2-carboxy-4,5-dihydroxy-6-(phosphanyloxy)oxan-3-yl]oxy}-4,5-dihydroxy-3-phosphanyloxane-2-carboxylic acid Chemical compound O1C(C(O)=O)C(P)C(O)C(O)C1OC1C(C(O)=O)OC(OP)C(O)C1O FHVDTGUDJYJELY-UHFFFAOYSA-N 0.000 description 1
- 208000031295 Animal disease Diseases 0.000 description 1
- 241000282693 Cercopithecidae Species 0.000 description 1
- 241000699800 Cricetinae Species 0.000 description 1
- 208000004232 Enteritis Diseases 0.000 description 1
- 241000282326 Felis catus Species 0.000 description 1
- 241001446459 Heia Species 0.000 description 1
- 235000019687 Lamb Nutrition 0.000 description 1
- 208000020241 Neonatal disease Diseases 0.000 description 1
- 208000037129 Newborn Diseases Infant Diseases 0.000 description 1
- 241000282376 Panthera tigris Species 0.000 description 1
- 241000778355 Tetilla <angiosperm> Species 0.000 description 1
- 102000004142 Trypsin Human genes 0.000 description 1
- 108090000631 Trypsin Proteins 0.000 description 1
- 239000000654 additive Substances 0.000 description 1
- 230000000996 additive effect Effects 0.000 description 1
- 229940072056 alginate Drugs 0.000 description 1
- 235000010443 alginic acid Nutrition 0.000 description 1
- 229920000615 alginic acid Polymers 0.000 description 1
- WNROFYMDJYEPJX-UHFFFAOYSA-K aluminium hydroxide Chemical compound [OH-].[OH-].[OH-].[Al+3] WNROFYMDJYEPJX-UHFFFAOYSA-K 0.000 description 1
- 239000000427 antigen Substances 0.000 description 1
- 102000036639 antigens Human genes 0.000 description 1
- 108091007433 antigens Proteins 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 230000001364 causal effect Effects 0.000 description 1
- 230000001413 cellular effect Effects 0.000 description 1
- 238000012512 characterization method Methods 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 210000002987 choroid plexus Anatomy 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 230000037029 cross reaction Effects 0.000 description 1
- 235000013365 dairy product Nutrition 0.000 description 1
- 230000003247 decreasing effect Effects 0.000 description 1
- 231100000676 disease causative agent Toxicity 0.000 description 1
- 241001493065 dsRNA viruses Species 0.000 description 1
- 208000001848 dysentery Diseases 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 210000000981 epithelium Anatomy 0.000 description 1
- 230000003203 everyday effect Effects 0.000 description 1
- 238000000605 extraction Methods 0.000 description 1
- 210000003754 fetus Anatomy 0.000 description 1
- 239000012530 fluid Substances 0.000 description 1
- 230000008014 freezing Effects 0.000 description 1
- 238000007710 freezing Methods 0.000 description 1
- 244000144980 herd Species 0.000 description 1
- 238000009802 hysterectomy Methods 0.000 description 1
- 238000002649 immunization Methods 0.000 description 1
- 230000003053 immunization Effects 0.000 description 1
- 230000002458 infectious effect Effects 0.000 description 1
- 239000002054 inoculum Substances 0.000 description 1
- 230000000968 intestinal effect Effects 0.000 description 1
- 210000000936 intestine Anatomy 0.000 description 1
- 238000002955 isolation Methods 0.000 description 1
- 150000002632 lipids Chemical class 0.000 description 1
- 210000005265 lung cell Anatomy 0.000 description 1
- 210000001165 lymph node Anatomy 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 239000012528 membrane Substances 0.000 description 1
- 235000013336 milk Nutrition 0.000 description 1
- 239000008267 milk Substances 0.000 description 1
- 210000004080 milk Anatomy 0.000 description 1
- 238000002156 mixing Methods 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 231100000989 no adverse effect Toxicity 0.000 description 1
- 229960005030 other vaccine in atc Drugs 0.000 description 1
- 244000052769 pathogen Species 0.000 description 1
- 230000007170 pathology Effects 0.000 description 1
- 239000011148 porous material Substances 0.000 description 1
- 210000000664 rectum Anatomy 0.000 description 1
- 239000012266 salt solution Substances 0.000 description 1
- 238000004062 sedimentation Methods 0.000 description 1
- 210000002966 serum Anatomy 0.000 description 1
- 239000012679 serum free medium Substances 0.000 description 1
- 210000000952 spleen Anatomy 0.000 description 1
- 230000006641 stabilisation Effects 0.000 description 1
- 238000011105 stabilization Methods 0.000 description 1
- 238000010561 standard procedure Methods 0.000 description 1
- 239000008223 sterile water Substances 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 210000001550 testis Anatomy 0.000 description 1
- 238000010257 thawing Methods 0.000 description 1
- 210000001685 thyroid gland Anatomy 0.000 description 1
- 210000003437 trachea Anatomy 0.000 description 1
- 239000012588 trypsin Substances 0.000 description 1
- 230000001018 virulence Effects 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
- A61K39/15—Reoviridae, e.g. calf diarrhea virus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/525—Virus
- A61K2039/5254—Virus avirulent or attenuated
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2720/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsRNA viruses
- C12N2720/00011—Details
- C12N2720/12011—Reoviridae
- C12N2720/12034—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Medicinal Chemistry (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Virology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US88095669A | 1969-11-28 | 1969-11-28 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| DE2057544A1 DE2057544A1 (de) | 1971-06-09 |
| DE2057544B2 DE2057544B2 (de) | 1978-06-29 |
| DE2057544C3 true DE2057544C3 (de) | 1979-02-22 |
Family
ID=25377480
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE2057544A Expired DE2057544C3 (de) | 1969-11-28 | 1970-11-23 | Impfstoff gegen ein neonatales Kälberdiarrhoevirus, Verfahren zu seiner Herstellung und seine Verwendung |
Country Status (10)
| Country | Link |
|---|---|
| JP (1) | JPS55105622A (cg-RX-API-DMAC7.html) |
| BE (1) | BE759425A (cg-RX-API-DMAC7.html) |
| CA (1) | CA943063A (cg-RX-API-DMAC7.html) |
| DE (1) | DE2057544C3 (cg-RX-API-DMAC7.html) |
| DK (1) | DK132447C (cg-RX-API-DMAC7.html) |
| FI (1) | FI46520C (cg-RX-API-DMAC7.html) |
| FR (1) | FR2073429B1 (cg-RX-API-DMAC7.html) |
| GB (1) | GB1276218A (cg-RX-API-DMAC7.html) |
| NL (1) | NL7017377A (cg-RX-API-DMAC7.html) |
| ZA (1) | ZA707947B (cg-RX-API-DMAC7.html) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SE419500B (sv) * | 1972-10-30 | 1981-08-10 | Univ Nebraska | Forfarande for attenuering av ett koronavirusliknande kalvdiarrevirus for framstellning av kalvdiarrevaccin |
| US4636385A (en) * | 1985-02-15 | 1987-01-13 | The Wistar Institute Of Anatomy & Biology | Vaccine, method for its preparation, and use thereof in vaccinating humans against rotavirus infection |
| US5626851A (en) * | 1987-11-30 | 1997-05-06 | The Wistar Institute Of Anatomy And Biology | Rotavirus reassortant vaccine |
| US5610049A (en) * | 1991-05-01 | 1997-03-11 | The Wistar Institute Of Anatomy And Biology | Human rotavirus HCR3A and method of growing said rotavirus |
| JP2006501237A (ja) * | 2002-08-26 | 2006-01-12 | ファイザー・プロダクツ・インク | 家畜の呼吸系と生殖系の感染症に対するワクチン |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3293129A (en) * | 1962-02-01 | 1966-12-20 | Cornell Res Foundation Inc | Immunization of cattle against virus diarrhea virus |
-
0
- BE BE759425D patent/BE759425A/xx not_active IP Right Cessation
-
1970
- 1970-11-23 DE DE2057544A patent/DE2057544C3/de not_active Expired
- 1970-11-24 ZA ZA707947A patent/ZA707947B/xx unknown
- 1970-11-24 CA CA098,958A patent/CA943063A/en not_active Expired
- 1970-11-24 FR FR7042105A patent/FR2073429B1/fr not_active Expired
- 1970-11-25 DK DK600770A patent/DK132447C/da not_active IP Right Cessation
- 1970-11-26 GB GB56205/70A patent/GB1276218A/en not_active Expired
- 1970-11-27 NL NL7017377A patent/NL7017377A/xx unknown
- 1970-11-27 FI FI703207A patent/FI46520C/fi active
-
1973
- 1973-09-06 JP JP10073673A patent/JPS55105622A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| FI46520B (fi) | 1973-01-02 |
| DE2057544B2 (de) | 1978-06-29 |
| FR2073429A1 (cg-RX-API-DMAC7.html) | 1971-10-01 |
| BE759425A (fr) | 1971-05-25 |
| FR2073429B1 (cg-RX-API-DMAC7.html) | 1974-03-22 |
| DK132447C (da) | 1976-05-10 |
| DE2057544A1 (de) | 1971-06-09 |
| FI46520C (fi) | 1973-04-10 |
| GB1276218A (en) | 1972-06-01 |
| JPS55105622A (en) | 1980-08-13 |
| DK132447B (da) | 1975-12-08 |
| ZA707947B (en) | 1971-10-27 |
| NL7017377A (cg-RX-API-DMAC7.html) | 1971-06-02 |
| CA943063A (en) | 1974-03-05 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C3 | Grant after two publication steps (3rd publication) |