DE2047658C3 - 2-Styryl- und 2-Phenyläthinylbenzylaminderivate, Verfahren zu deren Herstellung und diese enthaltende Arzneimittel - Google Patents

2-Styryl- und 2-Phenyläthinylbenzylaminderivate, Verfahren zu deren Herstellung und diese enthaltende Arzneimittel

Info

Publication number
DE2047658C3
DE2047658C3 DE2047658A DE2047658A DE2047658C3 DE 2047658 C3 DE2047658 C3 DE 2047658C3 DE 2047658 A DE2047658 A DE 2047658A DE 2047658 A DE2047658 A DE 2047658A DE 2047658 C3 DE2047658 C3 DE 2047658C3
Authority
DE
Germany
Prior art keywords
acid
ether
benzylamine
trans
compound
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
DE2047658A
Other languages
German (de)
English (en)
Other versions
DE2047658B2 (de
DE2047658A1 (US20110158925A1-20110630-C00042.png
Inventor
D Remy
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck and Co Inc
Original Assignee
Merck and Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck and Co Inc filed Critical Merck and Co Inc
Publication of DE2047658A1 publication Critical patent/DE2047658A1/de
Publication of DE2047658B2 publication Critical patent/DE2047658B2/de
Application granted granted Critical
Publication of DE2047658C3 publication Critical patent/DE2047658C3/de
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C211/00—Compounds containing amino groups bound to a carbon skeleton
    • C07C211/01—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms
    • C07C211/26—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing at least one six-membered aromatic ring
    • C07C211/27—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing at least one six-membered aromatic ring having amino groups linked to the six-membered aromatic ring by saturated carbon chains
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C07C255/49—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C07C255/50—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton to carbon atoms of non-condensed six-membered aromatic rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Hydrogenated Pyridines (AREA)
DE2047658A 1969-09-29 1970-09-28 2-Styryl- und 2-Phenyläthinylbenzylaminderivate, Verfahren zu deren Herstellung und diese enthaltende Arzneimittel Expired DE2047658C3 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US86198769A 1969-09-29 1969-09-29

Publications (3)

Publication Number Publication Date
DE2047658A1 DE2047658A1 (US20110158925A1-20110630-C00042.png) 1971-04-08
DE2047658B2 DE2047658B2 (de) 1980-03-20
DE2047658C3 true DE2047658C3 (de) 1980-11-13

Family

ID=25337311

Family Applications (1)

Application Number Title Priority Date Filing Date
DE2047658A Expired DE2047658C3 (de) 1969-09-29 1970-09-28 2-Styryl- und 2-Phenyläthinylbenzylaminderivate, Verfahren zu deren Herstellung und diese enthaltende Arzneimittel

Country Status (8)

Country Link
US (1) US3719712A (US20110158925A1-20110630-C00042.png)
JP (1) JPS5010584B1 (US20110158925A1-20110630-C00042.png)
CH (1) CH554830A (US20110158925A1-20110630-C00042.png)
DE (1) DE2047658C3 (US20110158925A1-20110630-C00042.png)
FR (1) FR2070096B1 (US20110158925A1-20110630-C00042.png)
GB (1) GB1281289A (US20110158925A1-20110630-C00042.png)
NL (1) NL167412C (US20110158925A1-20110630-C00042.png)
SE (1) SE372256B (US20110158925A1-20110630-C00042.png)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3882130A (en) * 1969-09-29 1975-05-06 Merck & Co Inc 4-Phenylethynyl benzylamines
SE388603B (sv) * 1971-01-15 1976-10-11 Merck & Co Inc Forfarande for framstellning av en fenylalkylaralkylamin med antiarytmisk verkan
US4017543A (en) * 1973-12-19 1977-04-12 Merck & Co., Inc. α,α-Dialkyl-4-phenethyl-benzylamines and the salts thereof
US4042584A (en) * 1974-08-19 1977-08-16 Merck & Co., Inc. Ethynylaryl phenyl cyclopropyl thiazines and morpholines
US3903165A (en) * 1974-08-19 1975-09-02 Merck & Co Inc Ethynylaryl amines and processes for their preparation
JPS5339683U (US20110158925A1-20110630-C00042.png) * 1976-09-10 1978-04-06
JPS54109688U (US20110158925A1-20110630-C00042.png) * 1978-01-19 1979-08-02
US4898889A (en) * 1983-11-21 1990-02-06 Mcneilab, Inc. Methods for the treatment of hypertension
US4742084A (en) * 1983-11-21 1988-05-03 Mcneilab, Inc. Aralykyl (arylethynyl)aralkyl amines and their use as vasodilators and antihypertensives
US4661635A (en) * 1983-11-21 1987-04-28 Mcneilab, Inc. Aralykyl (arylethynyl)aralkyl amines and their use as vasodilators and antihypertensives
CA1292747C (en) * 1983-11-21 1991-12-03 John Robert Carson Aralykyl (arylethynyl) aralkyl amines and their use as vasodilators and antihypertensives
ES8604853A1 (es) * 1983-11-21 1986-03-01 Mcneilab Inc Un metodo para la preparacion de un derivado de acetileno.
US4960798A (en) * 1983-11-21 1990-10-02 Mcneilab, Inc. Methods for the treatment of angina
US4725602A (en) * 1984-02-06 1988-02-16 Mcneilab, Inc. Acetylene amines and their use as vasodilators and antihypertensives
CA1300632C (en) * 1984-02-06 1992-05-12 John Robert Carson Acetylene amines and their use as vasodilators and antihypertensives
ZA874448B (en) * 1986-06-20 1989-02-22 Mcneilab Inc Cis & trans stilbenes and their composition for the treatment of hypertension
US4772755A (en) * 1987-03-19 1988-09-20 Mcneilab, Inc. 1,2-1,4 addition reaction sequence leading to disubstituted acelylenes
JPH01112837U (US20110158925A1-20110630-C00042.png) * 1988-01-25 1989-07-28

Also Published As

Publication number Publication date
NL167412B (nl) 1981-07-16
CH554830A (de) 1974-10-15
US3719712A (en) 1973-03-06
FR2070096A1 (US20110158925A1-20110630-C00042.png) 1971-09-10
DE2047658B2 (de) 1980-03-20
FR2070096B1 (US20110158925A1-20110630-C00042.png) 1974-02-22
NL167412C (nl) 1981-12-16
GB1281289A (en) 1972-07-12
DE2047658A1 (US20110158925A1-20110630-C00042.png) 1971-04-08
NL7013565A (US20110158925A1-20110630-C00042.png) 1971-03-31
JPS5010584B1 (US20110158925A1-20110630-C00042.png) 1975-04-22
SE372256B (US20110158925A1-20110630-C00042.png) 1974-12-16

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Legal Events

Date Code Title Description
OD Request for examination
C3 Grant after two publication steps (3rd publication)
8339 Ceased/non-payment of the annual fee