DE2044621C3 - 33-Diphenyl-3-i]nidazol-l-yl-propine, Verfahren zu ihrer Herstellung sowie ihre Verwendung als Arzneimittel - Google Patents

33-Diphenyl-3-i]nidazol-l-yl-propine, Verfahren zu ihrer Herstellung sowie ihre Verwendung als Arzneimittel

Info

Publication number
DE2044621C3
DE2044621C3 DE2044621A DE2044621A DE2044621C3 DE 2044621 C3 DE2044621 C3 DE 2044621C3 DE 2044621 A DE2044621 A DE 2044621A DE 2044621 A DE2044621 A DE 2044621A DE 2044621 C3 DE2044621 C3 DE 2044621C3
Authority
DE
Germany
Prior art keywords
diphenyl
compounds
acetonitrile
general formula
propine
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
DE2044621A
Other languages
German (de)
English (en)
Other versions
DE2044621A1 (de
DE2044621B2 (de
Inventor
Karl-Heinz Dr. Buechel
Gerhard Dr. Jaeger
Manfred Dr. Plempel
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bayer AG
Original Assignee
Bayer AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer AG filed Critical Bayer AG
Priority to DE2044621A priority Critical patent/DE2044621C3/de
Priority to AU32946/71A priority patent/AU456701B2/en
Priority to CH928474A priority patent/CH556334A/xx
Priority to CH1305171A priority patent/CH555332A/xx
Priority to IL7137660A priority patent/IL37660A/xx
Priority to SU1696682A priority patent/SU430551A1/ru
Priority to SU1861749A priority patent/SU447887A3/ru
Priority to AT776871A priority patent/AT307413B/de
Priority to HUBA002641 priority patent/HU163659B/hu
Priority to PL15040271A priority patent/PL85326B1/pl
Priority to GB4188171A priority patent/GB1332393A/en
Priority to SE7111381A priority patent/SE395143B/xx
Priority to ZA716019A priority patent/ZA716019B/xx
Priority to CA122,319A priority patent/CA960213A/en
Priority to ES394928A priority patent/ES394928A1/es
Priority to JP6931371A priority patent/JPS5613714B1/ja
Priority to CS6452A priority patent/CS177816B2/cs
Priority to NLAANVRAGE7112441,A priority patent/NL174461C/xx
Priority to BE772402A priority patent/BE772402A/xx
Priority to FR7132614A priority patent/FR2106408B1/fr
Priority to DD157889A priority patent/DD95002A5/xx
Publication of DE2044621A1 publication Critical patent/DE2044621A1/de
Priority to US348581A priority patent/US3870726A/en
Priority to ES422340A priority patent/ES422340A1/es
Publication of DE2044621B2 publication Critical patent/DE2044621B2/de
Application granted granted Critical
Publication of DE2044621C3 publication Critical patent/DE2044621C3/de
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
    • C07D295/084—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/092—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings with aromatic radicals attached to the chain
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C29/00—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring
    • C07C29/36—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring increasing the number of carbon atoms by reactions with formation of hydroxy groups, which may occur via intermediates being derivatives of hydroxy, e.g. O-metal
    • C07C29/38—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring increasing the number of carbon atoms by reactions with formation of hydroxy groups, which may occur via intermediates being derivatives of hydroxy, e.g. O-metal by reaction with aldehydes or ketones
    • C07C29/42—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring increasing the number of carbon atoms by reactions with formation of hydroxy groups, which may occur via intermediates being derivatives of hydroxy, e.g. O-metal by reaction with aldehydes or ketones with compounds containing triple carbon-to-carbon bonds, e.g. with metal-alkynes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • H02J2101/24—
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02E—REDUCTION OF GREENHOUSE GAS [GHG] EMISSIONS, RELATED TO ENERGY GENERATION, TRANSMISSION OR DISTRIBUTION
    • Y02E10/00—Energy generation through renewable energy sources
    • Y02E10/50—Photovoltaic [PV] energy
    • Y02E10/56—Power conversion systems, e.g. maximum power point trackers

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
DE2044621A 1970-09-09 1970-09-09 33-Diphenyl-3-i]nidazol-l-yl-propine, Verfahren zu ihrer Herstellung sowie ihre Verwendung als Arzneimittel Expired DE2044621C3 (de)

Priority Applications (23)

Application Number Priority Date Filing Date Title
DE2044621A DE2044621C3 (de) 1970-09-09 1970-09-09 33-Diphenyl-3-i]nidazol-l-yl-propine, Verfahren zu ihrer Herstellung sowie ihre Verwendung als Arzneimittel
AU32946/71A AU456701B2 (en) 1970-09-09 1971-09-01 New substituted propynes, their production, and their pharmaceutical and veterinary use
CH928474A CH556334A (de) 1970-09-09 1971-09-06 Verfahren zur herstellung neuer 1,3,3-trisubstituierter 3azolylpropine.
CH1305171A CH555332A (de) 1970-09-09 1971-09-06 Verfahren zur herstellung von neuen 1,3,3-trisubstituierten 3-azolylpropinen.
IL7137660A IL37660A (en) 1970-09-09 1971-09-06 Substituted 3-(1-imidazolyl)-3-phenyl-propynes,their production and pharmaceutical and veterinary compositions containing them
SU1861749A SU447887A3 (ru) 1970-09-09 1971-09-07 Способ получения 1,3,3-тризамещенных 3-азолилпропинов
AT776871A AT307413B (de) 1970-09-09 1971-09-07 Verfahren zur Herstellung von neuen heterocyclischen Verbindungen und ihren Salzen
HUBA002641 HU163659B (enExample) 1970-09-09 1971-09-07
SU1696682A SU430551A1 (ru) 1971-09-07 Способ получения 1,3,3-трехзаме1ценных 3-азолилпропинов
CA122,319A CA960213A (en) 1970-09-09 1971-09-08 Process for the preparation of 3-azolylpropynes and compounds thereby produced
SE7111381A SE395143B (sv) 1970-09-09 1971-09-08 Sett for framstellning av 1,3,3-trisubstituerade 3-azolylpropiner med antimykotisk verkan
ZA716019A ZA716019B (en) 1970-09-09 1971-09-08 New substituted propynes,their production,and their pharmaceutical and veterinary use
PL15040271A PL85326B1 (enExample) 1970-09-09 1971-09-08
GB4188171A GB1332393A (en) 1970-09-09 1971-09-08 Substituted propynes their production and their pharmaceutical and veterinary use
NLAANVRAGE7112441,A NL174461C (nl) 1970-09-09 1971-09-09 Werkwijze ter bereiding van preparaten met antimycotische werking, die als werkzame bestanddelen 1,3,3-trigesubstitueerde 3-imidazolylalkynen bevatten.
JP6931371A JPS5613714B1 (enExample) 1970-09-09 1971-09-09
CS6452A CS177816B2 (enExample) 1970-09-09 1971-09-09
ES394928A ES394928A1 (es) 1970-09-09 1971-09-09 Procedimiento para la obtencion de 3-azolilpropinas 1,3,3- trisustituidas.
BE772402A BE772402A (fr) 1970-09-09 1971-09-09 Nouveaux propynes substitues a usage pharmaceutique et veterinaire et leur procede de preparation
FR7132614A FR2106408B1 (enExample) 1970-09-09 1971-09-09
DD157889A DD95002A5 (enExample) 1970-09-09 1971-09-22
US348581A US3870726A (en) 1970-09-09 1973-04-06 Derivatives of 3-azolylpropyne and processes for their preparation and use
ES422340A ES422340A1 (es) 1970-09-09 1974-01-16 Procedimiento para la obtencion de 3-azolipropinas-1,3,3- trisustituidas.

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE2044621A DE2044621C3 (de) 1970-09-09 1970-09-09 33-Diphenyl-3-i]nidazol-l-yl-propine, Verfahren zu ihrer Herstellung sowie ihre Verwendung als Arzneimittel
DD157889A DD95002A5 (enExample) 1970-09-09 1971-09-22

Publications (3)

Publication Number Publication Date
DE2044621A1 DE2044621A1 (de) 1972-03-16
DE2044621B2 DE2044621B2 (de) 1978-11-09
DE2044621C3 true DE2044621C3 (de) 1979-07-05

Family

ID=25747422

Family Applications (1)

Application Number Title Priority Date Filing Date
DE2044621A Expired DE2044621C3 (de) 1970-09-09 1970-09-09 33-Diphenyl-3-i]nidazol-l-yl-propine, Verfahren zu ihrer Herstellung sowie ihre Verwendung als Arzneimittel

Country Status (13)

Country Link
AT (1) AT307413B (enExample)
AU (1) AU456701B2 (enExample)
BE (1) BE772402A (enExample)
CA (1) CA960213A (enExample)
CH (2) CH556334A (enExample)
CS (1) CS177816B2 (enExample)
DD (1) DD95002A5 (enExample)
DE (1) DE2044621C3 (enExample)
FR (1) FR2106408B1 (enExample)
GB (1) GB1332393A (enExample)
NL (1) NL174461C (enExample)
SE (1) SE395143B (enExample)
ZA (1) ZA716019B (enExample)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2932691A1 (de) * 1979-08-11 1981-04-09 Bayer Ag, 5090 Leverkusen Antimykotische mittel mit hoeherer freisetzung der wirkstoffe
EP0080051B1 (en) * 1981-10-07 1986-02-05 Meiji Seika Kaisha Ltd. Heterocyclic compounds and antibacterial and antifungal compositions containing the same as active ingredients
DE3217018A1 (de) * 1982-05-06 1983-11-10 Bayer Ag, 5090 Leverkusen Azolyl-butine, verfahren zu ihrer herstellung sowie ihre verwendung als fungizide und pflanzenwachstumsregulatoren

Also Published As

Publication number Publication date
SE395143B (sv) 1977-08-01
AU456701B2 (en) 1975-01-09
AU3294671A (en) 1973-03-15
DD95002A5 (enExample) 1973-01-12
CA960213A (en) 1974-12-31
CH555332A (de) 1974-10-31
ZA716019B (en) 1972-04-26
NL174461C (nl) 1984-06-18
NL174461B (nl) 1984-01-16
CS177816B2 (enExample) 1977-08-31
FR2106408B1 (enExample) 1975-08-01
DE2044621A1 (de) 1972-03-16
FR2106408A1 (enExample) 1972-05-05
GB1332393A (en) 1973-10-03
DE2044621B2 (de) 1978-11-09
CH556334A (de) 1974-11-29
NL7112441A (enExample) 1972-03-13
BE772402A (fr) 1972-03-09
AT307413B (de) 1973-05-25

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Legal Events

Date Code Title Description
C3 Grant after two publication steps (3rd publication)
8339 Ceased/non-payment of the annual fee