DE2044530A1 - Verfahren zur Herstellung basisch substituierter 2,3 Dihydro 1,4 benzoxazm 3 one - Google Patents
Verfahren zur Herstellung basisch substituierter 2,3 Dihydro 1,4 benzoxazm 3 oneInfo
- Publication number
- DE2044530A1 DE2044530A1 DE19702044530 DE2044530A DE2044530A1 DE 2044530 A1 DE2044530 A1 DE 2044530A1 DE 19702044530 DE19702044530 DE 19702044530 DE 2044530 A DE2044530 A DE 2044530A DE 2044530 A1 DE2044530 A1 DE 2044530A1
- Authority
- DE
- Germany
- Prior art keywords
- general formula
- halogen
- meanings
- daö
- mean
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 238000000034 method Methods 0.000 title claims description 5
- 125000001931 aliphatic group Chemical group 0.000 claims description 2
- 238000009833 condensation Methods 0.000 claims description 2
- 230000005494 condensation Effects 0.000 claims description 2
- 229910052736 halogen Inorganic materials 0.000 claims 3
- 150000002367 halogens Chemical class 0.000 claims 3
- 125000004442 acylamino group Chemical group 0.000 claims 1
- 125000000217 alkyl group Chemical group 0.000 claims 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims 1
- 239000003795 chemical substances by application Substances 0.000 claims 1
- 150000002148 esters Chemical class 0.000 claims 1
- 239000003960 organic solvent Substances 0.000 claims 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 1
- 235000014347 soups Nutrition 0.000 claims 1
- 125000001424 substituent group Chemical group 0.000 claims 1
- 238000009835 boiling Methods 0.000 description 5
- 150000001875 compounds Chemical class 0.000 description 3
- 239000003921 oil Substances 0.000 description 3
- NLKNQRATVPKPDG-UHFFFAOYSA-M potassium iodide Chemical compound [K+].[I-] NLKNQRATVPKPDG-UHFFFAOYSA-M 0.000 description 3
- VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 description 2
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 2
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 2
- XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 description 2
- CTQNGGLPUBDAKN-UHFFFAOYSA-N O-Xylene Chemical compound CC1=CC=CC=C1C CTQNGGLPUBDAKN-UHFFFAOYSA-N 0.000 description 2
- 125000003118 aryl group Chemical group 0.000 description 2
- 229910052799 carbon Inorganic materials 0.000 description 2
- 238000004519 manufacturing process Methods 0.000 description 2
- 238000010992 reflux Methods 0.000 description 2
- 239000002904 solvent Substances 0.000 description 2
- 239000008096 xylene Substances 0.000 description 2
- 241000861718 Chloris <Aves> Species 0.000 description 1
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 1
- 241001465754 Metazoa Species 0.000 description 1
- 235000012093 Myrtus ugni Nutrition 0.000 description 1
- 244000061461 Tema Species 0.000 description 1
- ATJFFYVFTNAWJD-UHFFFAOYSA-N Tin Chemical compound [Sn] ATJFFYVFTNAWJD-UHFFFAOYSA-N 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 150000007513 acids Chemical class 0.000 description 1
- 150000001412 amines Chemical class 0.000 description 1
- 150000001414 amino alcohols Chemical class 0.000 description 1
- 230000001760 anti-analgesic effect Effects 0.000 description 1
- 230000003110 anti-inflammatory effect Effects 0.000 description 1
- 125000004432 carbon atom Chemical group C* 0.000 description 1
- 230000001055 chewing effect Effects 0.000 description 1
- 238000001816 cooling Methods 0.000 description 1
- 125000004122 cyclic group Chemical group 0.000 description 1
- 235000013601 eggs Nutrition 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 150000004820 halides Chemical class 0.000 description 1
- 125000005843 halogen group Chemical group 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-M hydroxide Chemical compound [OH-] XLYOFNOQVPJJNP-UHFFFAOYSA-M 0.000 description 1
- 229910052742 iron Inorganic materials 0.000 description 1
- -1 nitro, amino Chemical group 0.000 description 1
- 125000004433 nitrogen atom Chemical group N* 0.000 description 1
- 230000009090 positive inotropic effect Effects 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- 229910052708 sodium Inorganic materials 0.000 description 1
- 239000011734 sodium Substances 0.000 description 1
- QDRKDTQENPPHOJ-UHFFFAOYSA-N sodium ethoxide Chemical compound [Na+].CC[O-] QDRKDTQENPPHOJ-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
- C07D265/28—1,4-Oxazines; Hydrogenated 1,4-oxazines
- C07D265/30—1,4-Oxazines; Hydrogenated 1,4-oxazines not condensed with other rings
- C07D265/32—1,4-Oxazines; Hydrogenated 1,4-oxazines not condensed with other rings with oxygen atoms directly attached to ring carbon atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DD14527670 | 1970-02-04 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DE2044530A1 true DE2044530A1 (de) | 1971-08-19 |
Family
ID=5482088
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE19702044530 Pending DE2044530A1 (de) | 1970-02-04 | 1970-09-09 | Verfahren zur Herstellung basisch substituierter 2,3 Dihydro 1,4 benzoxazm 3 one |
Country Status (4)
| Country | Link |
|---|---|
| CH (1) | CH555356A (cg-RX-API-DMAC10.html) |
| DE (1) | DE2044530A1 (cg-RX-API-DMAC10.html) |
| FR (1) | FR2079223A1 (cg-RX-API-DMAC10.html) |
| SU (1) | SU430553A3 (cg-RX-API-DMAC10.html) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1999050257A1 (en) * | 1998-03-31 | 1999-10-07 | Warner-Lambert Company | Benzoxazinones/benzothiazinones as serine protease inhibitors |
-
1970
- 1970-09-09 DE DE19702044530 patent/DE2044530A1/de active Pending
- 1970-10-07 SU SU1482213A patent/SU430553A3/ru active
- 1970-11-09 FR FR7040233A patent/FR2079223A1/fr active Granted
- 1970-12-03 CH CH1790470A patent/CH555356A/xx not_active IP Right Cessation
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1999050257A1 (en) * | 1998-03-31 | 1999-10-07 | Warner-Lambert Company | Benzoxazinones/benzothiazinones as serine protease inhibitors |
| US6509335B1 (en) | 1998-03-31 | 2003-01-21 | Warner-Lambert Company | Benzoxazinoes/benzothiazinones as serine protease inhibitors |
Also Published As
| Publication number | Publication date |
|---|---|
| SU437300A3 (ru) | 1974-07-25 |
| FR2079223B1 (cg-RX-API-DMAC10.html) | 1974-08-30 |
| SU430553A3 (ru) | 1974-05-30 |
| CH555356A (de) | 1974-10-31 |
| FR2079223A1 (en) | 1971-11-12 |
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