DE2043350A1 - Armdderivate von 1 Piperaz.noessigsaure estern und Verfahren zu ihrer Herstellung - Google Patents
Armdderivate von 1 Piperaz.noessigsaure estern und Verfahren zu ihrer HerstellungInfo
- Publication number
- DE2043350A1 DE2043350A1 DE19702043350 DE2043350A DE2043350A1 DE 2043350 A1 DE2043350 A1 DE 2043350A1 DE 19702043350 DE19702043350 DE 19702043350 DE 2043350 A DE2043350 A DE 2043350A DE 2043350 A1 DE2043350 A1 DE 2043350A1
- Authority
- DE
- Germany
- Prior art keywords
- piperazine
- formula
- amide derivatives
- trimethoxyzinnamoyl
- addition salts
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 238000000034 method Methods 0.000 title claims description 6
- 239000002253 acid Substances 0.000 claims description 18
- 150000001408 amides Chemical class 0.000 claims description 18
- 150000003839 salts Chemical class 0.000 claims description 14
- 150000002148 esters Chemical class 0.000 claims description 6
- 125000004432 carbon atom Chemical group C* 0.000 claims description 5
- -1 methoxycarbonylmethyl Chemical group 0.000 claims description 4
- 125000005843 halogen group Chemical group 0.000 claims description 3
- 208000001953 Hypotension Diseases 0.000 claims description 2
- YTFVRYKNXDADBI-UHFFFAOYSA-N O-Methylsinapic acid Natural products COC1=CC(C=CC(O)=O)=CC(OC)=C1OC YTFVRYKNXDADBI-UHFFFAOYSA-N 0.000 claims description 2
- 150000007513 acids Chemical class 0.000 claims description 2
- 230000003276 anti-hypertensive effect Effects 0.000 claims description 2
- 208000021822 hypotensive Diseases 0.000 claims description 2
- 230000001077 hypotensive effect Effects 0.000 claims description 2
- GLUUGHFHXGJENI-UHFFFAOYSA-N Piperazine Chemical compound C1CNCCN1 GLUUGHFHXGJENI-UHFFFAOYSA-N 0.000 claims 8
- 239000003218 coronary vasodilator agent Substances 0.000 claims 2
- 241000251730 Chondrichthyes Species 0.000 claims 1
- 239000008186 active pharmaceutical agent Substances 0.000 claims 1
- 125000001931 aliphatic group Chemical group 0.000 claims 1
- 239000003795 chemical substances by application Substances 0.000 claims 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 1
- VZCYOOQTPOCHFL-UPHRSURJSA-N maleic acid Chemical compound OC(=O)\C=C/C(O)=O VZCYOOQTPOCHFL-UPHRSURJSA-N 0.000 description 14
- VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 description 14
- 239000004480 active ingredient Substances 0.000 description 4
- 150000001875 compounds Chemical class 0.000 description 4
- 238000001990 intravenous administration Methods 0.000 description 3
- 238000012360 testing method Methods 0.000 description 3
- 210000003462 vein Anatomy 0.000 description 3
- 230000004872 arterial blood pressure Effects 0.000 description 2
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 2
- 210000003748 coronary sinus Anatomy 0.000 description 2
- 210000004351 coronary vessel Anatomy 0.000 description 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 2
- 229910052760 oxygen Inorganic materials 0.000 description 2
- 239000001301 oxygen Substances 0.000 description 2
- 230000000144 pharmacologic effect Effects 0.000 description 2
- 230000001225 therapeutic effect Effects 0.000 description 2
- 206010065420 Coronary artery dilatation Diseases 0.000 description 1
- 206010052895 Coronary artery insufficiency Diseases 0.000 description 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 description 1
- 241001465754 Metazoa Species 0.000 description 1
- 125000000217 alkyl group Chemical group 0.000 description 1
- 238000010171 animal model Methods 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 230000017531 blood circulation Effects 0.000 description 1
- 230000036765 blood level Effects 0.000 description 1
- 229910052794 bromium Inorganic materials 0.000 description 1
- 229910052801 chlorine Inorganic materials 0.000 description 1
- 230000003111 delayed effect Effects 0.000 description 1
- 230000010339 dilation Effects 0.000 description 1
- IZEKFCXSFNUWAM-UHFFFAOYSA-N dipyridamole Chemical compound C=12N=C(N(CCO)CCO)N=C(N3CCCCC3)C2=NC(N(CCO)CCO)=NC=1N1CCCCC1 IZEKFCXSFNUWAM-UHFFFAOYSA-N 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000035475 disorder Diseases 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 238000000921 elemental analysis Methods 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 230000002349 favourable effect Effects 0.000 description 1
- 229910052731 fluorine Inorganic materials 0.000 description 1
- 229910052739 hydrogen Inorganic materials 0.000 description 1
- 239000001257 hydrogen Substances 0.000 description 1
- 238000002347 injection Methods 0.000 description 1
- 239000007924 injection Substances 0.000 description 1
- 231100000636 lethal dose Toxicity 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 208000010125 myocardial infarction Diseases 0.000 description 1
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 description 1
- 230000002265 prevention Effects 0.000 description 1
- 231100000419 toxicity Toxicity 0.000 description 1
- 230000001988 toxicity Effects 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
- C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
- C07D295/182—Radicals derived from carboxylic acids
- C07D295/185—Radicals derived from carboxylic acids from aliphatic carboxylic acids
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR6935562A FR2068407A6 (enrdf_load_stackoverflow) | 1969-10-17 | 1969-10-17 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DE2043350A1 true DE2043350A1 (de) | 1971-04-29 |
Family
ID=9041655
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE19702043350 Pending DE2043350A1 (de) | 1969-10-17 | 1970-09-01 | Armdderivate von 1 Piperaz.noessigsaure estern und Verfahren zu ihrer Herstellung |
Country Status (10)
| Country | Link |
|---|---|
| BE (1) | BE755569R (enrdf_load_stackoverflow) |
| CH (1) | CH524618A (enrdf_load_stackoverflow) |
| DE (1) | DE2043350A1 (enrdf_load_stackoverflow) |
| ES (1) | ES383268A2 (enrdf_load_stackoverflow) |
| FR (1) | FR2068407A6 (enrdf_load_stackoverflow) |
| GB (1) | GB1258726A (enrdf_load_stackoverflow) |
| IT (1) | IT1044725B (enrdf_load_stackoverflow) |
| LU (1) | LU61613A1 (enrdf_load_stackoverflow) |
| NL (1) | NL7012950A (enrdf_load_stackoverflow) |
| SE (1) | SE367629B (enrdf_load_stackoverflow) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2522325B1 (fr) * | 1982-02-26 | 1985-08-09 | Delalande Sa | Nouveaux derives aryliques de la piperazine, de l'homopiperazine et de n,n'-dialkyl diamino-1,2 ethane, leur procede de preparation et leur application en therapeutique |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1168108A (en) * | 1967-09-29 | 1969-10-22 | Delalande Sa | Amide Derivatives of 1-Piperazine Acetic Acid and Process for their Preparation |
-
1969
- 1969-10-17 FR FR6935562A patent/FR2068407A6/fr not_active Expired
-
1970
- 1970-08-22 IT IT6986770A patent/IT1044725B/it active
- 1970-08-28 GB GB4147570A patent/GB1258726A/en not_active Expired
- 1970-08-31 ES ES70383268A patent/ES383268A2/es not_active Expired
- 1970-09-01 NL NL7012950A patent/NL7012950A/xx unknown
- 1970-09-01 DE DE19702043350 patent/DE2043350A1/de active Pending
- 1970-09-01 BE BE755569D patent/BE755569R/xx active
- 1970-09-01 LU LU61613D patent/LU61613A1/xx unknown
- 1970-09-01 SE SE1186970A patent/SE367629B/xx unknown
- 1970-09-01 CH CH1305470A patent/CH524618A/fr not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| IT1044725B (it) | 1980-04-21 |
| NL7012950A (enrdf_load_stackoverflow) | 1971-04-20 |
| CH524618A (fr) | 1972-06-30 |
| LU61613A1 (enrdf_load_stackoverflow) | 1970-12-01 |
| ES383268A2 (es) | 1973-01-01 |
| SE367629B (enrdf_load_stackoverflow) | 1974-06-04 |
| BE755569R (fr) | 1971-03-01 |
| GB1258726A (enrdf_load_stackoverflow) | 1971-12-30 |
| FR2068407A6 (enrdf_load_stackoverflow) | 1971-08-27 |
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