DE2042324A1 - - Google Patents
Info
- Publication number
- DE2042324A1 DE2042324A1 DE19702042324 DE2042324A DE2042324A1 DE 2042324 A1 DE2042324 A1 DE 2042324A1 DE 19702042324 DE19702042324 DE 19702042324 DE 2042324 A DE2042324 A DE 2042324A DE 2042324 A1 DE2042324 A1 DE 2042324A1
- Authority
- DE
- Germany
- Prior art keywords
- water
- anhydrous
- soluble
- reaction
- amino acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- VZCYOOQTPOCHFL-OWOJBTEDSA-N Fumaric acid Chemical compound OC(=O)\C=C\C(O)=O VZCYOOQTPOCHFL-OWOJBTEDSA-N 0.000 claims description 23
- 238000000034 method Methods 0.000 claims description 20
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 claims description 13
- 150000001413 amino acids Chemical class 0.000 claims description 13
- VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 claims description 13
- 235000001014 amino acid Nutrition 0.000 claims description 12
- 150000003839 salts Chemical class 0.000 claims description 12
- 239000001530 fumaric acid Substances 0.000 claims description 11
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 claims description 10
- PMVSDNDAUGGCCE-TYYBGVCCSA-L Ferrous fumarate Chemical compound [Fe+2].[O-]C(=O)\C=C\C([O-])=O PMVSDNDAUGGCCE-TYYBGVCCSA-L 0.000 claims description 10
- 238000006243 chemical reaction Methods 0.000 claims description 10
- BAUYGSIQEAFULO-UHFFFAOYSA-L iron(2+) sulfate (anhydrous) Chemical compound [Fe+2].[O-]S([O-])(=O)=O BAUYGSIQEAFULO-UHFFFAOYSA-L 0.000 claims description 10
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 9
- XEEYBQQBJWHFJM-UHFFFAOYSA-N iron Substances [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 claims description 7
- 239000001744 Sodium fumarate Substances 0.000 claims description 5
- 229960005070 ascorbic acid Drugs 0.000 claims description 5
- 235000010323 ascorbic acid Nutrition 0.000 claims description 5
- 239000011668 ascorbic acid Substances 0.000 claims description 5
- MSJMDZAOKORVFC-SEPHDYHBSA-L disodium fumarate Chemical compound [Na+].[Na+].[O-]C(=O)\C=C\C([O-])=O MSJMDZAOKORVFC-SEPHDYHBSA-L 0.000 claims description 5
- 229940005573 sodium fumarate Drugs 0.000 claims description 5
- 235000019294 sodium fumarate Nutrition 0.000 claims description 5
- 238000009835 boiling Methods 0.000 claims description 4
- 239000011790 ferrous sulphate Substances 0.000 claims description 4
- 235000003891 ferrous sulphate Nutrition 0.000 claims description 4
- 229910052742 iron Inorganic materials 0.000 claims description 4
- 229910000359 iron(II) sulfate Inorganic materials 0.000 claims description 4
- 239000011541 reaction mixture Substances 0.000 claims description 4
- -1 alkali metal fumarate Chemical class 0.000 claims description 3
- 239000000839 emulsion Substances 0.000 claims description 3
- 238000004519 manufacturing process Methods 0.000 claims description 3
- 229920001296 polysiloxane Polymers 0.000 claims description 3
- 239000001729 Ammonium fumarate Substances 0.000 claims description 2
- QNAYBMKLOCPYGJ-REOHCLBHSA-N L-alanine Chemical compound C[C@H](N)C(O)=O QNAYBMKLOCPYGJ-REOHCLBHSA-N 0.000 claims description 2
- AYFVYJQAPQTCCC-GBXIJSLDSA-N L-threonine Chemical compound C[C@@H](O)[C@H](N)C(O)=O AYFVYJQAPQTCCC-GBXIJSLDSA-N 0.000 claims description 2
- AYFVYJQAPQTCCC-UHFFFAOYSA-N Threonine Natural products CC(O)C(N)C(O)=O AYFVYJQAPQTCCC-UHFFFAOYSA-N 0.000 claims description 2
- 239000004473 Threonine Substances 0.000 claims description 2
- 235000004279 alanine Nutrition 0.000 claims description 2
- 229910052783 alkali metal Inorganic materials 0.000 claims description 2
- 235000019297 ammonium fumarate Nutrition 0.000 claims description 2
- 150000001450 anions Chemical class 0.000 claims description 2
- 239000012736 aqueous medium Substances 0.000 claims description 2
- CKKXWJDFFQPBQL-SEPHDYHBSA-N azane;(e)-but-2-enedioic acid Chemical compound N.N.OC(=O)\C=C\C(O)=O CKKXWJDFFQPBQL-SEPHDYHBSA-N 0.000 claims description 2
- 230000015572 biosynthetic process Effects 0.000 claims description 2
- 239000002775 capsule Substances 0.000 claims description 2
- 150000001768 cations Chemical class 0.000 claims description 2
- 238000005187 foaming Methods 0.000 claims description 2
- 229940050411 fumarate Drugs 0.000 claims description 2
- 238000011065 in-situ storage Methods 0.000 claims description 2
- 239000003814 drug Substances 0.000 claims 2
- 101100072702 Drosophila melanogaster defl gene Proteins 0.000 claims 1
- 239000002253 acid Substances 0.000 claims 1
- 239000012876 carrier material Substances 0.000 claims 1
- DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 description 8
- 239000000047 product Substances 0.000 description 5
- 239000004471 Glycine Substances 0.000 description 4
- 239000007795 chemical reaction product Substances 0.000 description 4
- 238000003756 stirring Methods 0.000 description 4
- HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 description 2
- 239000000825 pharmaceutical preparation Substances 0.000 description 2
- 239000002244 precipitate Substances 0.000 description 2
- 239000002002 slurry Substances 0.000 description 2
- VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 description 1
- 239000001828 Gelatine Substances 0.000 description 1
- 239000001747 Potassium fumarate Substances 0.000 description 1
- 229920002472 Starch Polymers 0.000 description 1
- 239000011230 binding agent Substances 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 238000001035 drying Methods 0.000 description 1
- 239000000945 filler Substances 0.000 description 1
- 229920000159 gelatin Polymers 0.000 description 1
- 235000019322 gelatine Nutrition 0.000 description 1
- 230000003394 haemopoietic effect Effects 0.000 description 1
- 238000010438 heat treatment Methods 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 239000000314 lubricant Substances 0.000 description 1
- 235000019359 magnesium stearate Nutrition 0.000 description 1
- VRVKOZSIJXBAJG-TYYBGVCCSA-M monosodium fumarate Chemical compound [Na+].OC(=O)\C=C\C([O-])=O VRVKOZSIJXBAJG-TYYBGVCCSA-M 0.000 description 1
- 230000003647 oxidation Effects 0.000 description 1
- 238000007254 oxidation reaction Methods 0.000 description 1
- 239000008177 pharmaceutical agent Substances 0.000 description 1
- SHPKCSFVQGSAJU-SEPHDYHBSA-L potassium fumarate Chemical compound [K+].[K+].[O-]C(=O)\C=C\C([O-])=O SHPKCSFVQGSAJU-SEPHDYHBSA-L 0.000 description 1
- 235000019295 potassium fumarate Nutrition 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 239000008107 starch Substances 0.000 description 1
- 235000019698 starch Nutrition 0.000 description 1
- 238000003860 storage Methods 0.000 description 1
- 239000006228 supernatant Substances 0.000 description 1
- 239000000725 suspension Substances 0.000 description 1
- 239000000454 talc Substances 0.000 description 1
- 229910052623 talc Inorganic materials 0.000 description 1
- 235000012222 talc Nutrition 0.000 description 1
- 229910000859 α-Fe Inorganic materials 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
- C07C51/41—Preparation of salts of carboxylic acids
- C07C51/412—Preparation of salts of carboxylic acids by conversion of the acids, their salts, esters or anhydrides with the same carboxylic acid part
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB4288869 | 1969-08-28 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DE2042324A1 true DE2042324A1 (enrdf_load_stackoverflow) | 1971-03-04 |
Family
ID=10426402
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE19702042324 Pending DE2042324A1 (enrdf_load_stackoverflow) | 1969-08-28 | 1970-08-26 |
Country Status (7)
| Country | Link |
|---|---|
| BE (1) | BE755463A (enrdf_load_stackoverflow) |
| CH (1) | CH523922A (enrdf_load_stackoverflow) |
| DE (1) | DE2042324A1 (enrdf_load_stackoverflow) |
| FR (1) | FR2068526B1 (enrdf_load_stackoverflow) |
| GB (1) | GB1328494A (enrdf_load_stackoverflow) |
| NL (1) | NL7012586A (enrdf_load_stackoverflow) |
| ZA (1) | ZA705790B (enrdf_load_stackoverflow) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA885974A (en) * | 1968-04-02 | 1971-11-16 | R. Telfer William | Ferrous fumarate capsule and preparation |
| US7495117B2 (en) | 2006-08-04 | 2009-02-24 | Kemin Industries, Inc. | Metal carboxylate salts |
| CN111138271A (zh) * | 2020-01-20 | 2020-05-12 | 太原理工大学 | 一种有机金属盐添加剂的制备方法 |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BE569591A (enrdf_load_stackoverflow) * | 1956-05-18 |
-
0
- BE BE755463D patent/BE755463A/xx unknown
-
1969
- 1969-08-28 GB GB4288869A patent/GB1328494A/en not_active Expired
-
1970
- 1970-08-24 CH CH1260870A patent/CH523922A/fr not_active IP Right Cessation
- 1970-08-24 ZA ZA705790A patent/ZA705790B/xx unknown
- 1970-08-25 NL NL7012586A patent/NL7012586A/xx unknown
- 1970-08-26 DE DE19702042324 patent/DE2042324A1/de active Pending
- 1970-08-28 FR FR7031524A patent/FR2068526B1/fr not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| FR2068526B1 (enrdf_load_stackoverflow) | 1974-08-30 |
| NL7012586A (enrdf_load_stackoverflow) | 1971-03-02 |
| GB1328494A (en) | 1973-08-30 |
| ZA705790B (en) | 1972-04-26 |
| CH523922A (fr) | 1972-06-15 |
| BE755463A (fr) | 1971-03-01 |
| FR2068526A1 (enrdf_load_stackoverflow) | 1971-08-27 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| DE3238118A1 (de) | Verfahren zur herstellung von komplexverbindungen aus aminodicarbonsaeuren, zweiwertigen metallionen und halogenidionen | |
| EP0044050B1 (de) | Verfahren zur Herstellung von Eisen (III)-Hydroxid-Dextran-Komplexen und diese enthaltende pharmazeutische sterile Lösung | |
| DE2824191C2 (enrdf_load_stackoverflow) | ||
| DE2042324A1 (enrdf_load_stackoverflow) | ||
| DE1617463A1 (de) | Verfahren zur Herstellung von injizierbaren kolloidalen Eisenzubereitungen | |
| DE2006967C3 (de) | Verfahren zur Herstellung von Allantoin-Polygalacturonsäure-Verbindungen | |
| DE2226267B2 (de) | Komplexverbindung aus asparaginat-, cer(iii)- und zink-ionen, verfahren zu deren herstellung und diese enthaltende arzneimittel | |
| DE2924566C2 (de) | Eisen(III)-Chondroitinsulfat-Komplex, Verfahren zu seiner Herstellung und ihn enthaltende pharmazeutische Zusammensetzung | |
| US1644258A (en) | Thioglycollic acid compound | |
| DE922166C (de) | Verfahren zur Umwandlung olefinischer Aldehyde in Oxyaldehyde | |
| AT311332B (de) | Verfahren zur Herstellung eines neuen Esters von 3,3-Bis(p-hydroxyphenyl)-2-indolinon und dessen Salzen | |
| DE1543295C3 (de) | N-substituierte Anthranilsäuren, deren Salze, Verfahren zur Herstellung dieser Verbindungen und diese Verbindungen enthaltende Arzneimittel | |
| DE2200589C3 (de) | Nicotinoylglycin-ß-pyridylmethylester | |
| DE1924174C3 (de) | Magnesiumorotatglycinate | |
| DE2056758A1 (de) | Substituierte Metamlsauren | |
| US2228051A (en) | Compound of hydroxyquinoline-sulphonic acids and the production thereof | |
| DE752830C (de) | Verfahren zur Herstellung von Umsetzungsstoffen aus Sulfitcelluloseablauge | |
| DE604070C (de) | Verfahren zur Herstellung von neutralloeslichen Komplexsalzen des dreiwertigen Antimons | |
| DE182217C (enrdf_load_stackoverflow) | ||
| AT154021B (de) | Verfahren zur Darstellung von Formaldehydalkalisulfoxylaten von Arsenobenzolverbindungen. | |
| DE68908135T2 (de) | Verfahren zur Herstellung von einem Acexamsäurederivat. | |
| DE1238922B (de) | Verfahren zur Herstellung des Ferrosalzes der Ferriaethylendiamintetraessigsaeure | |
| DE893951C (de) | Verfahren zur Herstellung von therapeutischen Mitteln aus hoehermolekularen Aminosaeuren | |
| AT151657B (de) | Verfahren zur Darstellung von Formaldehydnatriumsulfoxylaten von Arsenobenzolverbindungen. | |
| DE482267C (de) | Verfahren zur Darstellung von Eisenverbindungen der Phosphorkerne der im Eigelb enthaltenen Proteide |