DE2016729A1 - - Google Patents
Info
- Publication number
- DE2016729A1 DE2016729A1 DE19702016729 DE2016729A DE2016729A1 DE 2016729 A1 DE2016729 A1 DE 2016729A1 DE 19702016729 DE19702016729 DE 19702016729 DE 2016729 A DE2016729 A DE 2016729A DE 2016729 A1 DE2016729 A1 DE 2016729A1
- Authority
- DE
- Germany
- Prior art keywords
- enzyme
- polymer
- bound
- maleic anhydride
- poly
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 102000004190 Enzymes Human genes 0.000 claims description 156
- 108090000790 Enzymes Proteins 0.000 claims description 156
- 229940088598 enzyme Drugs 0.000 claims description 156
- 229920000642 polymer Polymers 0.000 claims description 67
- 238000000034 method Methods 0.000 claims description 52
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 claims description 40
- 239000003431 cross linking reagent Substances 0.000 claims description 30
- NAQMVNRVTILPCV-UHFFFAOYSA-N hexane-1,6-diamine Chemical compound NCCCCCCN NAQMVNRVTILPCV-UHFFFAOYSA-N 0.000 claims description 26
- 239000002244 precipitate Substances 0.000 claims description 25
- 108090000526 Papain Proteins 0.000 claims description 22
- 239000004365 Protease Substances 0.000 claims description 22
- 229940055729 papain Drugs 0.000 claims description 22
- 235000019834 papain Nutrition 0.000 claims description 22
- FPYJFEHAWHCUMM-UHFFFAOYSA-N maleic anhydride Chemical compound O=C1OC(=O)C=C1 FPYJFEHAWHCUMM-UHFFFAOYSA-N 0.000 claims description 21
- XJRBAMWJDBPFIM-UHFFFAOYSA-N methyl vinyl ether Chemical compound COC=C XJRBAMWJDBPFIM-UHFFFAOYSA-N 0.000 claims description 21
- 239000000463 material Substances 0.000 claims description 19
- 239000001993 wax Substances 0.000 claims description 19
- 229920001577 copolymer Polymers 0.000 claims description 18
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 18
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 16
- 238000004132 cross linking Methods 0.000 claims description 15
- LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 claims description 12
- 150000008064 anhydrides Chemical group 0.000 claims description 11
- 239000000203 mixture Substances 0.000 claims description 11
- 239000000872 buffer Substances 0.000 claims description 10
- 238000004519 manufacturing process Methods 0.000 claims description 10
- 239000003960 organic solvent Substances 0.000 claims description 10
- 239000008188 pellet Substances 0.000 claims description 10
- 229910019142 PO4 Inorganic materials 0.000 claims description 9
- 239000004372 Polyvinyl alcohol Substances 0.000 claims description 9
- 108010056079 Subtilisins Proteins 0.000 claims description 9
- 102000005158 Subtilisins Human genes 0.000 claims description 9
- XUJNEKJLAYXESH-UHFFFAOYSA-N cysteine Natural products SCC(N)C(O)=O XUJNEKJLAYXESH-UHFFFAOYSA-N 0.000 claims description 9
- 235000018417 cysteine Nutrition 0.000 claims description 9
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 claims description 9
- 239000010452 phosphate Substances 0.000 claims description 9
- 229920006254 polymer film Polymers 0.000 claims description 9
- 229920002451 polyvinyl alcohol Polymers 0.000 claims description 9
- 239000002904 solvent Substances 0.000 claims description 9
- 238000000576 coating method Methods 0.000 claims description 8
- 239000004744 fabric Substances 0.000 claims description 8
- 239000011521 glass Substances 0.000 claims description 8
- 235000011187 glycerol Nutrition 0.000 claims description 8
- 239000012188 paraffin wax Substances 0.000 claims description 8
- 239000012153 distilled water Substances 0.000 claims description 7
- 239000008363 phosphate buffer Substances 0.000 claims description 7
- 239000004382 Amylase Substances 0.000 claims description 6
- 108090000284 Pepsin A Proteins 0.000 claims description 6
- 102000057297 Pepsin A Human genes 0.000 claims description 6
- 102000035195 Peptidases Human genes 0.000 claims description 6
- 108091005804 Peptidases Proteins 0.000 claims description 6
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 claims description 6
- 238000006243 chemical reaction Methods 0.000 claims description 6
- 239000011248 coating agent Substances 0.000 claims description 6
- 238000010438 heat treatment Methods 0.000 claims description 6
- 229940111202 pepsin Drugs 0.000 claims description 6
- 239000000126 substance Substances 0.000 claims description 6
- NWZSZGALRFJKBT-KNIFDHDWSA-N (2s)-2,6-diaminohexanoic acid;(2s)-2-hydroxybutanedioic acid Chemical compound OC(=O)[C@@H](O)CC(O)=O.NCCCC[C@H](N)C(O)=O NWZSZGALRFJKBT-KNIFDHDWSA-N 0.000 claims description 5
- 239000004475 Arginine Substances 0.000 claims description 5
- 108010059712 Pronase Proteins 0.000 claims description 5
- 239000002253 acid Substances 0.000 claims description 5
- ODKSFYDXXFIFQN-UHFFFAOYSA-N arginine Natural products OC(=O)C(N)CCCNC(N)=N ODKSFYDXXFIFQN-UHFFFAOYSA-N 0.000 claims description 5
- 239000003054 catalyst Substances 0.000 claims description 5
- FJKIXWOMBXYWOQ-UHFFFAOYSA-N ethenoxyethane Chemical compound CCOC=C FJKIXWOMBXYWOQ-UHFFFAOYSA-N 0.000 claims description 5
- IKDUDTNKRLTJSI-UHFFFAOYSA-N hydrazine monohydrate Substances O.NN IKDUDTNKRLTJSI-UHFFFAOYSA-N 0.000 claims description 5
- 239000002861 polymer material Substances 0.000 claims description 5
- 229920000036 polyvinylpyrrolidone Polymers 0.000 claims description 5
- 239000001267 polyvinylpyrrolidone Substances 0.000 claims description 5
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 claims description 5
- 235000019833 protease Nutrition 0.000 claims description 5
- 102000015790 Asparaginase Human genes 0.000 claims description 4
- 108010024976 Asparaginase Proteins 0.000 claims description 4
- ZRALSGWEFCBTJO-UHFFFAOYSA-N Guanidine Chemical compound NC(N)=N ZRALSGWEFCBTJO-UHFFFAOYSA-N 0.000 claims description 4
- OAKJQQAXSVQMHS-UHFFFAOYSA-N Hydrazine Chemical compound NN OAKJQQAXSVQMHS-UHFFFAOYSA-N 0.000 claims description 4
- 108010019160 Pancreatin Proteins 0.000 claims description 4
- 239000002202 Polyethylene glycol Substances 0.000 claims description 4
- XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Chemical compound NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 claims description 4
- 229960003272 asparaginase Drugs 0.000 claims description 4
- DCXYFEDJOCDNAF-UHFFFAOYSA-M asparaginate Chemical compound [O-]C(=O)C(N)CC(N)=O DCXYFEDJOCDNAF-UHFFFAOYSA-M 0.000 claims description 4
- 108010047754 beta-Glucosidase Proteins 0.000 claims description 4
- 102000006995 beta-Glucosidase Human genes 0.000 claims description 4
- 125000003636 chemical group Chemical group 0.000 claims description 4
- 229940055695 pancreatin Drugs 0.000 claims description 4
- 229920001223 polyethylene glycol Polymers 0.000 claims description 4
- LWIHDJKSTIGBAC-UHFFFAOYSA-K tripotassium phosphate Chemical compound [K+].[K+].[K+].[O-]P([O-])([O-])=O LWIHDJKSTIGBAC-UHFFFAOYSA-K 0.000 claims description 4
- 238000005406 washing Methods 0.000 claims description 4
- FKJVYOFPTRGCSP-UHFFFAOYSA-N 2-[3-aminopropyl(2-hydroxyethyl)amino]ethanol Chemical compound NCCCN(CCO)CCO FKJVYOFPTRGCSP-UHFFFAOYSA-N 0.000 claims description 3
- LRFVTYWOQMYALW-UHFFFAOYSA-N 9H-xanthine Chemical class O=C1NC(=O)NC2=C1NC=N2 LRFVTYWOQMYALW-UHFFFAOYSA-N 0.000 claims description 3
- ATRRKUHOCOJYRX-UHFFFAOYSA-N Ammonium bicarbonate Chemical compound [NH4+].OC([O-])=O ATRRKUHOCOJYRX-UHFFFAOYSA-N 0.000 claims description 3
- 229910000013 Ammonium bicarbonate Inorganic materials 0.000 claims description 3
- 102000013142 Amylases Human genes 0.000 claims description 3
- 108010065511 Amylases Proteins 0.000 claims description 3
- 108010059892 Cellulase Proteins 0.000 claims description 3
- 108090000317 Chymotrypsin Proteins 0.000 claims description 3
- XUJNEKJLAYXESH-REOHCLBHSA-N L-Cysteine Chemical compound SC[C@H](N)C(O)=O XUJNEKJLAYXESH-REOHCLBHSA-N 0.000 claims description 3
- CTQNGGLPUBDAKN-UHFFFAOYSA-N O-Xylene Chemical compound CC1=CC=CC=C1C CTQNGGLPUBDAKN-UHFFFAOYSA-N 0.000 claims description 3
- 102000009609 Pyrophosphatases Human genes 0.000 claims description 3
- 108010009413 Pyrophosphatases Proteins 0.000 claims description 3
- 108090000631 Trypsin Proteins 0.000 claims description 3
- 102000004142 Trypsin Human genes 0.000 claims description 3
- 235000012538 ammonium bicarbonate Nutrition 0.000 claims description 3
- 239000001099 ammonium carbonate Substances 0.000 claims description 3
- 235000019418 amylase Nutrition 0.000 claims description 3
- 239000004202 carbamide Substances 0.000 claims description 3
- 229940106157 cellulase Drugs 0.000 claims description 3
- 229960002376 chymotrypsin Drugs 0.000 claims description 3
- 239000006185 dispersion Substances 0.000 claims description 3
- 239000003381 stabilizer Substances 0.000 claims description 3
- 239000012588 trypsin Substances 0.000 claims description 3
- 239000008096 xylene Substances 0.000 claims description 3
- RPNUMPOLZDHAAY-UHFFFAOYSA-N Diethylenetriamine Chemical compound NCCNCCN RPNUMPOLZDHAAY-UHFFFAOYSA-N 0.000 claims description 2
- 108010073178 Glucan 1,4-alpha-Glucosidase Proteins 0.000 claims description 2
- ODKSFYDXXFIFQN-BYPYZUCNSA-P L-argininium(2+) Chemical compound NC(=[NH2+])NCCC[C@H]([NH3+])C(O)=O ODKSFYDXXFIFQN-BYPYZUCNSA-P 0.000 claims description 2
- CHJJGSNFBQVOTG-UHFFFAOYSA-N N-methyl-guanidine Natural products CNC(N)=N CHJJGSNFBQVOTG-UHFFFAOYSA-N 0.000 claims description 2
- 230000002378 acidificating effect Effects 0.000 claims description 2
- 230000001580 bacterial effect Effects 0.000 claims description 2
- 238000009835 boiling Methods 0.000 claims description 2
- SWSQBOPZIKWTGO-UHFFFAOYSA-N dimethylaminoamidine Natural products CN(C)C(N)=N SWSQBOPZIKWTGO-UHFFFAOYSA-N 0.000 claims description 2
- 238000007598 dipping method Methods 0.000 claims description 2
- 229920001971 elastomer Polymers 0.000 claims description 2
- 229910052751 metal Inorganic materials 0.000 claims description 2
- 239000002184 metal Substances 0.000 claims description 2
- 238000006386 neutralization reaction Methods 0.000 claims description 2
- 239000000123 paper Substances 0.000 claims description 2
- 229920003023 plastic Polymers 0.000 claims description 2
- 239000004033 plastic Substances 0.000 claims description 2
- 235000019422 polyvinyl alcohol Nutrition 0.000 claims description 2
- 229910000160 potassium phosphate Inorganic materials 0.000 claims description 2
- 235000011009 potassium phosphates Nutrition 0.000 claims description 2
- 239000005060 rubber Substances 0.000 claims description 2
- 239000007787 solid Substances 0.000 claims description 2
- 239000002023 wood Substances 0.000 claims description 2
- YYXLGGIKSIZHSF-UHFFFAOYSA-N ethene;furan-2,5-dione Chemical compound C=C.O=C1OC(=O)C=C1 YYXLGGIKSIZHSF-UHFFFAOYSA-N 0.000 claims 3
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 claims 2
- 102000005548 Hexokinase Human genes 0.000 claims 2
- 108700040460 Hexokinases Proteins 0.000 claims 2
- VILCJCGEZXAXTO-UHFFFAOYSA-N 2,2,2-tetramine Chemical compound NCCNCCNCCN VILCJCGEZXAXTO-UHFFFAOYSA-N 0.000 claims 1
- QGZKDVFQNNGYKY-UHFFFAOYSA-O Ammonium Chemical compound [NH4+] QGZKDVFQNNGYKY-UHFFFAOYSA-O 0.000 claims 1
- 108010021511 Aspergillus oryzae carboxyl proteinase Proteins 0.000 claims 1
- 229920002134 Carboxymethyl cellulose Polymers 0.000 claims 1
- 102100035882 Catalase Human genes 0.000 claims 1
- 108010053835 Catalase Proteins 0.000 claims 1
- 244000089486 Phragmites australis subsp australis Species 0.000 claims 1
- OFOBLEOULBTSOW-UHFFFAOYSA-N Propanedioic acid Natural products OC(=O)CC(O)=O OFOBLEOULBTSOW-UHFFFAOYSA-N 0.000 claims 1
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 claims 1
- 102100033220 Xanthine oxidase Human genes 0.000 claims 1
- 108010093894 Xanthine oxidase Proteins 0.000 claims 1
- 235000013877 carbamide Nutrition 0.000 claims 1
- 239000001768 carboxy methyl cellulose Substances 0.000 claims 1
- 235000010948 carboxy methyl cellulose Nutrition 0.000 claims 1
- 239000008112 carboxymethyl-cellulose Substances 0.000 claims 1
- 238000010668 complexation reaction Methods 0.000 claims 1
- VZCYOOQTPOCHFL-UPHRSURJSA-N maleic acid Chemical compound OC(=O)\C=C/C(O)=O VZCYOOQTPOCHFL-UPHRSURJSA-N 0.000 claims 1
- 239000011976 maleic acid Substances 0.000 claims 1
- 239000000758 substrate Substances 0.000 claims 1
- 229940065721 systemic for obstructive airway disease xanthines Drugs 0.000 claims 1
- FAGUFWYHJQFNRV-UHFFFAOYSA-N tetraethylenepentamine Chemical compound NCCNCCNCCNCCN FAGUFWYHJQFNRV-UHFFFAOYSA-N 0.000 claims 1
- VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 claims 1
- 239000000243 solution Substances 0.000 description 33
- 239000010408 film Substances 0.000 description 29
- 230000000694 effects Effects 0.000 description 18
- 238000002360 preparation method Methods 0.000 description 7
- 239000011541 reaction mixture Substances 0.000 description 7
- 230000009257 reactivity Effects 0.000 description 5
- JUJWROOIHBZHMG-UHFFFAOYSA-N Pyridine Chemical compound C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 description 4
- 239000007864 aqueous solution Substances 0.000 description 4
- 230000007423 decrease Effects 0.000 description 4
- -1 i'rypsin Proteins 0.000 description 4
- 238000007654 immersion Methods 0.000 description 4
- 229920000573 polyethylene Polymers 0.000 description 4
- XAGFODPZIPBFFR-UHFFFAOYSA-N aluminium Chemical compound [Al] XAGFODPZIPBFFR-UHFFFAOYSA-N 0.000 description 3
- 239000012876 carrier material Substances 0.000 description 3
- 150000004985 diamines Chemical class 0.000 description 3
- 125000000118 dimethyl group Chemical group [H]C([H])([H])* 0.000 description 3
- 238000009826 distribution Methods 0.000 description 3
- 230000007062 hydrolysis Effects 0.000 description 3
- 238000006460 hydrolysis reaction Methods 0.000 description 3
- 239000000843 powder Substances 0.000 description 3
- 235000018102 proteins Nutrition 0.000 description 3
- 102000004169 proteins and genes Human genes 0.000 description 3
- 108090000623 proteins and genes Proteins 0.000 description 3
- 238000003860 storage Methods 0.000 description 3
- PAYRUJLWNCNPSJ-UHFFFAOYSA-N Aniline Chemical compound NC1=CC=CC=C1 PAYRUJLWNCNPSJ-UHFFFAOYSA-N 0.000 description 2
- ZHNUHDYFZUAESO-UHFFFAOYSA-N Formamide Chemical compound NC=O ZHNUHDYFZUAESO-UHFFFAOYSA-N 0.000 description 2
- 108010010803 Gelatin Proteins 0.000 description 2
- 102000004316 Oxidoreductases Human genes 0.000 description 2
- 108090000854 Oxidoreductases Proteins 0.000 description 2
- 239000004698 Polyethylene Substances 0.000 description 2
- 229910052782 aluminium Inorganic materials 0.000 description 2
- 230000015572 biosynthetic process Effects 0.000 description 2
- 239000001913 cellulose Substances 0.000 description 2
- 229920002678 cellulose Polymers 0.000 description 2
- 239000003153 chemical reaction reagent Substances 0.000 description 2
- 150000001875 compounds Chemical class 0.000 description 2
- 229940079919 digestives enzyme preparation Drugs 0.000 description 2
- 238000001914 filtration Methods 0.000 description 2
- 229920000159 gelatin Polymers 0.000 description 2
- 239000008273 gelatin Substances 0.000 description 2
- 235000019322 gelatine Nutrition 0.000 description 2
- 235000011852 gelatine desserts Nutrition 0.000 description 2
- 125000004836 hexamethylene group Chemical group [H]C([H])([*:2])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[*:1] 0.000 description 2
- 238000011534 incubation Methods 0.000 description 2
- 239000006223 plastic coating Substances 0.000 description 2
- 239000004800 polyvinyl chloride Substances 0.000 description 2
- 229920000915 polyvinyl chloride Polymers 0.000 description 2
- 238000001556 precipitation Methods 0.000 description 2
- UMJSCPRVCHMLSP-UHFFFAOYSA-N pyridine Natural products COC1=CC=CN=C1 UMJSCPRVCHMLSP-UHFFFAOYSA-N 0.000 description 2
- 239000007858 starting material Substances 0.000 description 2
- 238000003756 stirring Methods 0.000 description 2
- 239000000725 suspension Substances 0.000 description 2
- RYHBNJHYFVUHQT-UHFFFAOYSA-N 1,4-Dioxane Chemical compound C1COCCO1 RYHBNJHYFVUHQT-UHFFFAOYSA-N 0.000 description 1
- MGYAGUUKOYNYAT-UHFFFAOYSA-N 2-(oxan-2-yl)oxane Chemical compound O1CCCCC1C1OCCCC1 MGYAGUUKOYNYAT-UHFFFAOYSA-N 0.000 description 1
- 102100040430 Active breakpoint cluster region-related protein Human genes 0.000 description 1
- 229920000936 Agarose Polymers 0.000 description 1
- 229910017150 AlTi Inorganic materials 0.000 description 1
- AKGWUHIOEVNNPC-LURJTMIESA-N Arg-OEt Chemical compound CCOC(=O)[C@@H](N)CCCNC(N)=N AKGWUHIOEVNNPC-LURJTMIESA-N 0.000 description 1
- UXVMQQNJUSDDNG-UHFFFAOYSA-L Calcium chloride Chemical compound [Cl-].[Cl-].[Ca+2] UXVMQQNJUSDDNG-UHFFFAOYSA-L 0.000 description 1
- SQUHHTBVTRBESD-UHFFFAOYSA-N Hexa-Ac-myo-Inositol Natural products CC(=O)OC1C(OC(C)=O)C(OC(C)=O)C(OC(C)=O)C(OC(C)=O)C1OC(C)=O SQUHHTBVTRBESD-UHFFFAOYSA-N 0.000 description 1
- 101000964363 Homo sapiens Active breakpoint cluster region-related protein Proteins 0.000 description 1
- 241001442654 Percnon planissimum Species 0.000 description 1
- 108010013381 Porins Proteins 0.000 description 1
- HCHKCACWOHOZIP-UHFFFAOYSA-N Zinc Chemical compound [Zn] HCHKCACWOHOZIP-UHFFFAOYSA-N 0.000 description 1
- 150000007513 acids Chemical class 0.000 description 1
- 150000001336 alkenes Chemical class 0.000 description 1
- 125000003277 amino group Chemical group 0.000 description 1
- 239000012062 aqueous buffer Substances 0.000 description 1
- 239000003125 aqueous solvent Substances 0.000 description 1
- 230000001680 brushing effect Effects 0.000 description 1
- 239000011575 calcium Substances 0.000 description 1
- 239000001110 calcium chloride Substances 0.000 description 1
- 229910001628 calcium chloride Inorganic materials 0.000 description 1
- 238000005119 centrifugation Methods 0.000 description 1
- 238000001816 cooling Methods 0.000 description 1
- ZBCBWPMODOFKDW-UHFFFAOYSA-N diethanolamine Chemical compound OCCNCCO ZBCBWPMODOFKDW-UHFFFAOYSA-N 0.000 description 1
- 238000010790 dilution Methods 0.000 description 1
- 239000012895 dilution Substances 0.000 description 1
- 238000001035 drying Methods 0.000 description 1
- 238000006911 enzymatic reaction Methods 0.000 description 1
- UPBDXRPQPOWRKR-UHFFFAOYSA-N furan-2,5-dione;methoxyethene Chemical compound COC=C.O=C1OC(=O)C=C1 UPBDXRPQPOWRKR-UHFFFAOYSA-N 0.000 description 1
- 230000005021 gait Effects 0.000 description 1
- 150000002334 glycols Chemical class 0.000 description 1
- 230000000977 initiatory effect Effects 0.000 description 1
- CDAISMWEOUEBRE-GPIVLXJGSA-N inositol Chemical compound O[C@H]1[C@H](O)[C@@H](O)[C@H](O)[C@H](O)[C@@H]1O CDAISMWEOUEBRE-GPIVLXJGSA-N 0.000 description 1
- 229960000367 inositol Drugs 0.000 description 1
- 239000002198 insoluble material Substances 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 235000015097 nutrients Nutrition 0.000 description 1
- JRZJOMJEPLMPRA-UHFFFAOYSA-N olefin Natural products CCCCCCCC=C JRZJOMJEPLMPRA-UHFFFAOYSA-N 0.000 description 1
- 239000002245 particle Substances 0.000 description 1
- 239000000546 pharmaceutical excipient Substances 0.000 description 1
- 239000004014 plasticizer Substances 0.000 description 1
- 229920002959 polymer blend Polymers 0.000 description 1
- 102000007739 porin activity proteins Human genes 0.000 description 1
- 239000008057 potassium phosphate buffer Substances 0.000 description 1
- 239000000047 product Substances 0.000 description 1
- WGYKZJWCGVVSQN-UHFFFAOYSA-N propylamine Chemical group CCCN WGYKZJWCGVVSQN-UHFFFAOYSA-N 0.000 description 1
- 229940024999 proteolytic enzymes for treatment of wounds and ulcers Drugs 0.000 description 1
- HNJBEVLQSNELDL-UHFFFAOYSA-N pyrrolidin-2-one Chemical compound O=C1CCCN1 HNJBEVLQSNELDL-UHFFFAOYSA-N 0.000 description 1
- 239000002994 raw material Substances 0.000 description 1
- 229920005989 resin Polymers 0.000 description 1
- 239000011347 resin Substances 0.000 description 1
- 230000004043 responsiveness Effects 0.000 description 1
- CDAISMWEOUEBRE-UHFFFAOYSA-N scyllo-inosotol Natural products OC1C(O)C(O)C(O)C(O)C1O CDAISMWEOUEBRE-UHFFFAOYSA-N 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
- 229920005573 silicon-containing polymer Polymers 0.000 description 1
- 229920002379 silicone rubber Polymers 0.000 description 1
- 239000004945 silicone rubber Substances 0.000 description 1
- 229910001220 stainless steel Inorganic materials 0.000 description 1
- 239000010935 stainless steel Substances 0.000 description 1
- 239000010409 thin film Substances 0.000 description 1
- 229940075420 xanthine Drugs 0.000 description 1
- 229910052725 zinc Inorganic materials 0.000 description 1
- 239000011701 zinc Substances 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N11/00—Carrier-bound or immobilised enzymes; Carrier-bound or immobilised microbial cells; Preparation thereof
- C12N11/18—Multi-enzyme systems
-
- D—TEXTILES; PAPER
- D01—NATURAL OR MAN-MADE THREADS OR FIBRES; SPINNING
- D01H—SPINNING OR TWISTING
- D01H1/00—Spinning or twisting machines in which the product is wound-up continuously
- D01H1/14—Details
- D01H1/20—Driving or stopping arrangements
- D01H1/28—Driving or stopping arrangements for two or more machine elements possessing different characteristics but in operative association
- D01H1/30—Driving or stopping arrangements for two or more machine elements possessing different characteristics but in operative association with two or more speeds; with variable-speed arrangements
- D01H1/305—Speed control of the spindles in response to the displacements of the ring rail
Landscapes
- Engineering & Computer Science (AREA)
- Wood Science & Technology (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- Zoology (AREA)
- Genetics & Genomics (AREA)
- Textile Engineering (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- Mechanical Engineering (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Biomedical Technology (AREA)
- Winding Filamentary Materials (AREA)
- Enzymes And Modification Thereof (AREA)
- Spinning Or Twisting Of Yarns (AREA)
- Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP988369A JPS4836687B1 (enExample) | 1969-02-10 | 1969-02-10 | |
| GB08634/69A GB1276006A (en) | 1969-02-10 | 1969-04-11 | Enzymes |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DE2016729A1 true DE2016729A1 (enExample) | 1970-10-15 |
Family
ID=26253496
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE19702005362 Pending DE2005362B2 (de) | 1969-02-10 | 1970-02-06 | Verfahren zum trennen von einwandfreiem von nicht einwandfreiem, insbesondre von einwandfrei verstrecktem von nicht einwandfrei verstreckten gran, insbesondere an streckzwirnmaschinen |
| DE19702016729 Pending DE2016729A1 (enExample) | 1969-02-10 | 1970-04-08 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE19702005362 Pending DE2005362B2 (de) | 1969-02-10 | 1970-02-06 | Verfahren zum trennen von einwandfreiem von nicht einwandfreiem, insbesondre von einwandfrei verstrecktem von nicht einwandfrei verstreckten gran, insbesondere an streckzwirnmaschinen |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US3751898A (enExample) |
| DE (2) | DE2005362B2 (enExample) |
| FR (1) | FR2043161A5 (enExample) |
| GB (2) | GB1276006A (enExample) |
| NL (1) | NL7004923A (enExample) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0073611A1 (en) * | 1981-09-01 | 1983-03-09 | E.I. Du Pont De Nemours And Company | Covalently bonded high refractive index particle reagents and their use in light scattering immunoassays |
| EP0071704A3 (en) * | 1981-08-05 | 1983-05-04 | Rohm Gmbh | Multiple-surface systems for fixing substrates having nucleophilic groups |
| US5342646A (en) * | 1990-08-25 | 1994-08-30 | Rohm Gmbh | Method for making carrier systems for biologically active materials |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3925861A1 (de) * | 1989-08-04 | 1991-02-07 | Schlafhorst & Co W | Kopsvorbereitungseinrichtung zum aufwinden des fadenanfanges auf der huelsenspitze des kopses |
| DE4023291A1 (de) * | 1990-07-21 | 1992-05-14 | Schubert & Salzer Maschinen | Verfahren und vorrichtung zur bildung einer fadenendreservewicklung auf spulen an einer textilmaschine |
| US5393002A (en) * | 1990-07-21 | 1995-02-28 | Schubert & Salzer Maschinenfabrik Ag | Process and device for the constitution of a yarn end reserve winding on yarn packages of a textile machine |
| JP3042000B2 (ja) * | 1991-03-11 | 2000-05-15 | 豊和工業株式会社 | 粗紡機の適位置停止装置 |
| DE4415677C2 (de) * | 1993-05-12 | 2001-09-13 | Barmag Barmer Maschf | Verfahren zur Qualitätskennzeichnung einer Fadenspule und Spulvorrichtung |
| EP0631962B1 (en) * | 1993-05-28 | 1998-11-18 | SAVIO MACCHINE TESSILI S.p.A. | Improved bobbin winding method and winding machines for its implementation |
| DE19713959C2 (de) * | 1997-04-04 | 1999-05-12 | Zinser Textilmaschinen Gmbh | Verfahren zum Herstellen verschiedener Wicklungsarten, insbesondere einer Flyer- oder Verbundwicklung |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE187936C (enExample) * | ||||
| US1527751A (en) * | 1924-02-07 | 1925-02-24 | Firm Vogtlandische Maschinenfa | Device for fixing the free thread ends of the spools of embroidery machines |
| US2747359A (en) * | 1951-09-26 | 1956-05-29 | Du Pont | Process and apparatus for winding heavy denier yarn packages |
| GB1186281A (en) * | 1967-05-09 | 1970-04-02 | Teijin Ltd | Method of taking up Yarns of Synthetic Fibers |
-
1969
- 1969-04-11 GB GB08634/69A patent/GB1276006A/en not_active Expired
-
1970
- 1970-02-05 GB GB5663/70A patent/GB1276066A/en not_active Expired
- 1970-02-06 DE DE19702005362 patent/DE2005362B2/de active Pending
- 1970-04-06 NL NL7004923A patent/NL7004923A/xx unknown
- 1970-04-08 DE DE19702016729 patent/DE2016729A1/de active Pending
- 1970-04-10 FR FR7012966A patent/FR2043161A5/fr not_active Expired
-
1971
- 1971-09-15 US US00180615A patent/US3751898A/en not_active Expired - Lifetime
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0071704A3 (en) * | 1981-08-05 | 1983-05-04 | Rohm Gmbh | Multiple-surface systems for fixing substrates having nucleophilic groups |
| EP0073611A1 (en) * | 1981-09-01 | 1983-03-09 | E.I. Du Pont De Nemours And Company | Covalently bonded high refractive index particle reagents and their use in light scattering immunoassays |
| US5342646A (en) * | 1990-08-25 | 1994-08-30 | Rohm Gmbh | Method for making carrier systems for biologically active materials |
Also Published As
| Publication number | Publication date |
|---|---|
| NL7004923A (enExample) | 1970-10-13 |
| FR2043161A5 (enExample) | 1971-02-12 |
| GB1276066A (en) | 1972-06-01 |
| DE2005362A1 (de) | 1970-08-27 |
| DE2005362B2 (de) | 1972-09-28 |
| GB1276006A (en) | 1972-06-01 |
| US3751898A (en) | 1973-08-14 |
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