DE19921693A1 - Neuartige Arzneimittelkompositionen auf der Basis von anticholinergisch wirksamen Verbindungen und ß-Mimetika - Google Patents

Neuartige Arzneimittelkompositionen auf der Basis von anticholinergisch wirksamen Verbindungen und ß-Mimetika

Info

Publication number
DE19921693A1
DE19921693A1 DE19921693A DE19921693A DE19921693A1 DE 19921693 A1 DE19921693 A1 DE 19921693A1 DE 19921693 A DE19921693 A DE 19921693A DE 19921693 A DE19921693 A DE 19921693A DE 19921693 A1 DE19921693 A1 DE 19921693A1
Authority
DE
Germany
Prior art keywords
pharmaceutical composition
composition according
anticholinergic
radical
thienyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
DE19921693A
Other languages
German (de)
English (en)
Inventor
Michel Pairet
Richard Reichl
Alexander Walland
Karl-Heinz Bozung
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Boehringer Ingelheim Pharma GmbH and Co KG
Original Assignee
Boehringer Ingelheim Pharma GmbH and Co KG
Boehringer Ingelheim Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Ingelheim Pharma GmbH and Co KG, Boehringer Ingelheim Pharmaceuticals Inc filed Critical Boehringer Ingelheim Pharma GmbH and Co KG
Priority to DE19921693A priority Critical patent/DE19921693A1/de
Priority to UA2001128535A priority patent/UA74547C2/uk
Priority to SA00210064A priority patent/SA00210064B1/ar
Priority to EP10183392A priority patent/EP2266620A3/de
Priority to JP2000617928A priority patent/JP4612956B2/ja
Priority to CNA2006100045262A priority patent/CN1839833A/zh
Priority to EP10183369A priority patent/EP2269647A3/de
Priority to KR1020017014380A priority patent/KR100841909B1/ko
Priority to SG200307862-3A priority patent/SG158731A1/en
Priority to IL14611900A priority patent/IL146119A0/xx
Priority to YU71901A priority patent/RS50269B/sr
Priority to MEP-366/08A priority patent/MEP36608A/xx
Priority to EEP201000018A priority patent/EE201000018A/xx
Priority to EP00929478A priority patent/EP1178832B1/de
Priority to DK00929478T priority patent/DK1178832T3/da
Priority to NZ515596A priority patent/NZ515596A/en
Priority to CA002368583A priority patent/CA2368583C/en
Priority to EEP201000019A priority patent/EE05677B1/xx
Priority to DE50003116T priority patent/DE50003116D1/de
Priority to RSP-2009/0083A priority patent/RS20090083A/sr
Priority to PT00929478T priority patent/PT1178832E/pt
Priority to EA200101156A priority patent/EA004657B1/ru
Priority to MXPA01011400A priority patent/MXPA01011400A/es
Priority to SG2010027928A priority patent/SG175465A1/en
Priority to EEP200100594A priority patent/EE05193B1/xx
Priority to EEP201000020A priority patent/EE201000020A/xx
Priority to PCT/EP2000/003943 priority patent/WO2000069468A1/de
Priority to SK1637-2001A priority patent/SK287072B6/sk
Priority to HU0201103A priority patent/HUP0201103A3/hu
Priority to AU47545/00A priority patent/AU775588B2/en
Priority to SG2010018422A priority patent/SG178626A1/en
Priority to HK02104960.6A priority patent/HK1043064B/zh
Priority to AT00929478T priority patent/ATE245976T1/de
Priority to CZ20014055A priority patent/CZ302328B6/cs
Priority to TR2001/03233T priority patent/TR200103233T2/xx
Priority to TR2009/01979T priority patent/TR200901979T2/xx
Priority to CNB008073562A priority patent/CN1250290C/zh
Priority to EP05008960A priority patent/EP1570861A3/de
Priority to PL352131A priority patent/PL199442B1/pl
Priority to SG2010018414A priority patent/SG179293A1/en
Priority to EP10183425A priority patent/EP2269648A3/de
Priority to SI200030181T priority patent/SI1178832T1/xx
Priority to ES00929478T priority patent/ES2203470T3/es
Priority to KR1020077009915A priority patent/KR100962059B1/ko
Priority to PL383340A priority patent/PL206146B1/pl
Priority to EP03008310A priority patent/EP1327452A3/de
Priority to HR20010828A priority patent/HRP20010828A2/hr
Priority to BR0010498-1A priority patent/BR0010498A/pt
Priority to EP10180233A priority patent/EP2266621A3/de
Priority to TW093125578A priority patent/TW200505483A/zh
Priority to TW089108828A priority patent/TWI272106B/zh
Priority to US09/568,880 priority patent/US6455524B1/en
Priority to UY26139A priority patent/UY26139A1/es
Priority to PE2000000437A priority patent/PE20010133A1/es
Priority to MYPI20002026A priority patent/MY129512A/en
Priority to MYPI20045408A priority patent/MY134222A/en
Priority to CO00034118A priority patent/CO5140068A1/es
Priority to ARP000102288A priority patent/AR023972A1/es
Priority to US09/695,581 priority patent/US6433027B1/en
Publication of DE19921693A1 publication Critical patent/DE19921693A1/de
Priority to IL146119A priority patent/IL146119A/en
Priority to ZA200108942A priority patent/ZA200108942B/en
Priority to NO20015359A priority patent/NO328423B1/no
Priority to BG106095A priority patent/BG65189B1/bg
Priority to US10/075,687 priority patent/US6630466B2/en
Priority to US10/608,753 priority patent/US20040002548A1/en
Priority to IL172695A priority patent/IL172695A/en
Priority to JP2006102070A priority patent/JP2006188534A/ja
Priority to NO20093464A priority patent/NO20093464L/no
Priority to US12/757,127 priority patent/US20100197719A1/en
Priority to JP2010246159A priority patent/JP2011021037A/ja
Priority to JP2010246158A priority patent/JP2011021036A/ja
Priority to JP2010246160A priority patent/JP2011021038A/ja
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A61K31/138—Aryloxyalkylamines, e.g. propranolol, tamoxifen, phenoxybenzamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4748—Quinolines; Isoquinolines forming part of bridged ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A61K31/137—Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine or methadone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A61K31/167—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the nitrogen of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/275—Nitriles; Isonitriles
    • A61K31/277—Nitriles; Isonitriles having a ring, e.g. verapamil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4184—1,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/428—Thiazoles condensed with carbocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/439—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom the ring forming part of a bridged ring system, e.g. quinuclidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/46—8-Azabicyclo [3.2.1] octane; Derivatives thereof, e.g. atropine, cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/536—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines ortho- or peri-condensed with carbocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/16—Central respiratory analeptics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • A61K9/0075—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a dry powder inhaler [DPI], e.g. comprising micronized drug mixed with lactose carrier particles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • A61K9/0078—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a nebulizer such as a jet nebulizer, ultrasonic nebulizer, e.g. in the form of aqueous drug solutions or dispersions

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  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Emergency Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pyrrole Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
DE19921693A 1999-03-12 1999-05-12 Neuartige Arzneimittelkompositionen auf der Basis von anticholinergisch wirksamen Verbindungen und ß-Mimetika Ceased DE19921693A1 (de)

Priority Applications (72)

Application Number Priority Date Filing Date Title
DE19921693A DE19921693A1 (de) 1999-05-12 1999-05-12 Neuartige Arzneimittelkompositionen auf der Basis von anticholinergisch wirksamen Verbindungen und ß-Mimetika
UA2001128535A UA74547C2 (en) 1999-05-12 2000-03-05 Pharmaceutical composition based on anticholinergic compounds and beta-mimetics and method for its production
SA00210064A SA00210064B1 (ar) 1999-05-12 2000-05-02 تراكيب دوائية تحتوي علي مركبات فعال مضادة لافراز الكولينanticholinergically وسالمتيرول salmeterol
EP10183392A EP2266620A3 (de) 1999-05-12 2000-05-03 Arzneimittelkompositionen auf der Basis von anticholinergisch wirksamen Verbindungen und ß-Mimetika
JP2000617928A JP4612956B2 (ja) 1999-05-12 2000-05-03 抗コリン作用化合物及びβ−擬似剤に基づく新規医薬組成物
CNA2006100045262A CN1839833A (zh) 1999-05-12 2000-05-03 基于抗胆碱能有效的化合物及β－模拟物的新颖药物组合物
EP10183369A EP2269647A3 (de) 1999-05-12 2000-05-03 Arzneimittelkompositionen auf der Basis von anticholinergisch wirksamen Verbindungen und ß-Mimetika
KR1020017014380A KR100841909B1 (ko) 1999-05-12 2000-05-03 항콜린 유효 화합물과 β-유사체를 기본으로 하는 신규한 약제학적 조성물
SG200307862-3A SG158731A1 (en) 1999-05-12 2000-05-03 Novel medicament compositions, based on anticholinergically effective compounds and beta-mimetics
IL14611900A IL146119A0 (en) 1999-05-12 2000-05-03 Novel medicament compositions, based on anticholinergically effective compounds and beta-mimetics
YU71901A RS50269B (sr) 1999-05-12 2000-05-03 NOVE VRSTE LEKOVITIH KOMPOZICIJA NA BAZI JEDINJENJA KOJA DELUJU ANTIHOLINERGIJSKI I β-MIMETIKA
MEP-366/08A MEP36608A (en) 1999-05-12 2000-05-03 Novel medicament compositions, based on anticholinergically effective compounds and beta-mimetics
EEP201000018A EE201000018A (et) 1999-05-12 2000-05-03 Ravimkompositsioonid, mis p?hinevad antikolinergiliselt toimivatel henditel ja
EP00929478A EP1178832B1 (de) 1999-05-12 2000-05-03 Neuartige arzneimittelkompositionen auf der basis von tiotropiumbromid und salmeterol
DK00929478T DK1178832T3 (da) 1999-05-12 2000-05-03 Nye lægemiddelsammensætninger på basis af tiotropiumbromid og salmeterol
NZ515596A NZ515596A (en) 1999-05-12 2000-05-03 Medicament compositions, based on anticholinergically effective compounds and beta-mimetics
CA002368583A CA2368583C (en) 1999-05-12 2000-05-03 New medicament compositions based on anticholinergically-effective compounds and .beta.-mimetics
EEP201000019A EE05677B1 (et) 1999-05-12 2000-05-03 Ravimkompositsioonid, mis p?hinevad antikolinergikumina toimival glkoprrooniumbromiidil ja β-mimeetikumil
DE50003116T DE50003116D1 (de) 1999-05-12 2000-05-03 Neuartige arzneimittelkompositionen auf der basis von tiotropiumbromid und salmeterol
RSP-2009/0083A RS20090083A (sr) 1999-05-12 2000-05-03 Nove vrste kompozicija na bazi jedinjenja koja deluju antiholinergijski i beta-mimetika
PT00929478T PT1178832E (pt) 1999-05-12 2000-05-03 Novas composicoes de medicamentos a base de brometo de tiotropio e de salmeterol
EA200101156A EA004657B1 (ru) 1999-05-12 2000-05-03 Фармацевтическая композиция на основе обладающих антихолинергическим действием соединений , способ ее получения и применение
MXPA01011400A MXPA01011400A (es) 1999-05-12 2000-05-03 Nuevas composiciones de medicamentos a base de compuestos anitolinergicmanete activos y beta-mimeticos.
SG2010027928A SG175465A1 (en) 1999-05-12 2000-05-03 Novel medicament compositions, based on anticholinergically effective compounds and beta-mimetics
EEP200100594A EE05193B1 (et) 1999-05-12 2000-05-03 Ravimkompositsioonid, mis p?hinevad tiotroopiumbromiidil ja salmeteroolil
EEP201000020A EE201000020A (et) 1999-05-12 2000-05-03 Ravimkompositsioonid, mis p?hinevad antikolinergiliselt toimivatel henditel ja
PCT/EP2000/003943 WO2000069468A1 (de) 1999-05-12 2000-05-03 NEUARTIGE ARZNEIMITTELKOMPOSITIONEN AUF DER BASIS VON ANTICHOLINERGISCH WIRKSAMEN VERBINDUNGEN UND β-MIMETIKA
SK1637-2001A SK287072B6 (sk) 1999-05-12 2000-05-03 Farmaceutické prostriedky zahrnujúce tiotrópium a salmeterol a ich použitie
HU0201103A HUP0201103A3 (en) 1999-05-12 2000-05-03 Novel medicament compositions, based on anticholinergically effective compounds and beta-mimetics
AU47545/00A AU775588B2 (en) 1999-05-12 2000-05-03 Novel medicament compositions, based on anticholinergically effective compounds and beta-mimetics
SG2010018422A SG178626A1 (en) 1999-05-12 2000-05-03 Novel medicament compositions, based on anticholinergically effective compounds and beta-mimetics
HK02104960.6A HK1043064B (zh) 1999-05-12 2000-05-03 基於抗胆碱能有效的化合物及β-模拟物的新颖药物组合物
AT00929478T ATE245976T1 (de) 1999-05-12 2000-05-03 Neuartige arzneimittelkompositionen auf der basis von tiotropiumbromid und salmeterol
CZ20014055A CZ302328B6 (cs) 1999-05-12 2000-05-03 Farmaceutický prostredek
TR2001/03233T TR200103233T2 (tr) 1999-05-12 2000-05-03 Antikolinerjik etkili bileşik ve ß-mimetikler bazında yeni ilaç bileşimleri.
TR2009/01979T TR200901979T2 (tr) 1999-05-12 2000-05-03 Antikolinerjik etkili bileşik ve ?-mimetikler bazında yeni ilaç bileşimleri.
CNB008073562A CN1250290C (zh) 1999-05-12 2000-05-03 基于抗胆碱能有效的化合物及β－模拟物的新颖药物组合物
EP05008960A EP1570861A3 (de) 1999-05-12 2000-05-03 Neuartige Arzneimittelkompositionen auf der Basis von anticholinergisch wirksamen Verbindungen und B-Mimetika
PL352131A PL199442B1 (pl) 1999-05-12 2000-05-03 Kompozycja farmaceutyczna oparta na związkach antycholinergicznych i beta-mimetycznych oraz jej zastosowanie
SG2010018414A SG179293A1 (en) 1999-05-12 2000-05-03 Novel medicament compositions, based on anticholinergically effective compounds and beta-mimetics
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ZA200108942A ZA200108942B (en) 1999-05-12 2001-10-30 Novel medicament compositions, based on anticholinergically effective compounds and beta-mimetics.
NO20015359A NO328423B1 (no) 1999-05-12 2001-11-02 Medikamentblandinger basert pa anti-cholinergisk effektive forbindelser og β-mimetika samt anvendelse av slike for fremstilling av medikamenter for behandling av sykdommer.
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US10/075,687 US6630466B2 (en) 1999-05-12 2002-02-14 Medicament compositions containing anticholinergically-effective compounds and salmeterol
US10/608,753 US20040002548A1 (en) 1999-05-12 2003-06-27 Medicament compositions containing anticholinergically-effective compounds and betamimetics
IL172695A IL172695A (en) 1999-05-12 2005-12-20 Pharmaceutical composition comprising tiotropium bromide and salmetrol and use thereof for preparing a medicament for treating respiratory complaints
JP2006102070A JP2006188534A (ja) 1999-05-12 2006-04-03 抗コリン作用化合物及びβ−擬似剤に基づく新規医薬組成物
NO20093464A NO20093464L (no) 1999-05-12 2009-12-03 Nye medikamentblandinger basert pa anti-cholinergisk effektive forbindelser og beta-mimetika
US12/757,127 US20100197719A1 (en) 1999-05-12 2010-04-09 Medicament compositions containing anticholinergically-effective compounds and betamimetics
JP2010246159A JP2011021037A (ja) 1999-05-12 2010-11-02 抗コリン作用化合物及びβ−擬似剤に基づく新規医薬組成物
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