DE19820064A1 - Substituierte Sulfonylcyanamide, Verfahren zu ihrer Herstellung und ihre Verwendung als Medikament - Google Patents
Substituierte Sulfonylcyanamide, Verfahren zu ihrer Herstellung und ihre Verwendung als MedikamentInfo
- Publication number
- DE19820064A1 DE19820064A1 DE19820064A DE19820064A DE19820064A1 DE 19820064 A1 DE19820064 A1 DE 19820064A1 DE 19820064 A DE19820064 A DE 19820064A DE 19820064 A DE19820064 A DE 19820064A DE 19820064 A1 DE19820064 A1 DE 19820064A1
- Authority
- DE
- Germany
- Prior art keywords
- carbon atoms
- alkyl
- hydrogen
- substituted
- series
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
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Classifications
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- C—CHEMISTRY; METALLURGY
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- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/90—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
- C07C311/15—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings
- C07C311/16—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the sulfonamide groups bound to hydrogen atoms or to an acyclic carbon atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/68—Halogen atoms
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/70—One oxygen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/84—Sulfur atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/91—Nitro radicals
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- Medicinal Chemistry (AREA)
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- Heart & Thoracic Surgery (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Hospice & Palliative Care (AREA)
- Pulmonology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
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- Agricultural Chemicals And Associated Chemicals (AREA)
Priority Applications (30)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19820064A DE19820064A1 (de) | 1998-05-06 | 1998-05-06 | Substituierte Sulfonylcyanamide, Verfahren zu ihrer Herstellung und ihre Verwendung als Medikament |
| AU59479/99A AU756844B2 (en) | 1998-05-06 | 1999-04-30 | Substituted sulphonyl cyanamides, method for producing same and their use as medicament |
| BR9911009-1A BR9911009A (pt) | 1998-05-06 | 1999-04-30 | Sulfonilcianamidas substituìdas, processo para sua produção e seu uso como medicamento |
| DE19980787T DE19980787D2 (de) | 1998-05-06 | 1999-04-30 | Substituierte Sulfonylcyanamide, Verfahren zu ihrer Herstellung und ihre Verwendung als Medikament |
| IL13926499A IL139264A (en) | 1998-05-06 | 1999-04-30 | Substituted sulphonyl cyanamides, method for producing same and their use as medicaments |
| DK99948554T DK1076651T3 (da) | 1998-05-06 | 1999-04-30 | Substituerede sulfonylcyanamider, fremgangsmåde til fremstilling heraf og anvendelsen heraf som lægemidler |
| CA002331863A CA2331863A1 (en) | 1998-05-06 | 1999-04-30 | Substituted sulphonyl cyanamides, method for producing same and their use as medicament |
| CNB998073148A CN1177829C (zh) | 1998-05-06 | 1999-04-30 | 取代磺酰基氨基氰、其制备方法及其作为药物的应用 |
| HU0102459A HU225377B1 (en) | 1998-05-06 | 1999-04-30 | Substituted sulphonyl cyanamides, their use and pharmaceutical compositions containing them |
| SK1658-2000A SK16582000A3 (sk) | 1998-05-06 | 1999-04-30 | Substituované sulfonylkyánamidy a farmaceutický prostriedok, ktorý ich obsahuje |
| DE59911949T DE59911949D1 (de) | 1998-05-06 | 1999-04-30 | Substituierte sulfonylcyanamide, verfahren zu ihrer herstellung und ihre verwendung als medikament |
| TR2000/03248T TR200003248T2 (tr) | 1998-05-06 | 1999-04-30 | İkame edilmiş sülfonilsiyanamidler, üretimi için yöntem ve ilaç olarak kullanımları. |
| HR20000746A HRP20000746A2 (en) | 1998-05-06 | 1999-04-30 | Substituted sulphonyl cyanamides, method for producing same and their use as medicament |
| AT99948554T ATE293606T1 (de) | 1998-05-06 | 1999-04-30 | Substituierte sulfonylcyanamide, verfahren zu ihrer herstellung und ihre verwendung als medikament |
| PT99948554T PT1076651E (pt) | 1998-05-06 | 1999-04-30 | Sulfonilcianamidas substituidas, proceso para a sua preparacao e sua utilizacao como medicamento |
| JP2000547072A JP4546644B2 (ja) | 1998-05-06 | 1999-04-30 | 置換スルホニルシアナミド、その調製方法および医薬としての使用 |
| EP99948554A EP1076651B1 (de) | 1998-05-06 | 1999-04-30 | Substituierte sulfonylcyanamide, verfahren zu ihrer herstellung und ihre verwendung als medikament |
| IDW20002257A ID28020A (id) | 1998-05-06 | 1999-04-30 | Senyawa-senyawa sulfonilsianamida tersubstitusi, prose-proses pembuatannya dan penggunaannya sebagai obat |
| SI9930785T SI1076651T1 (enExample) | 1998-05-06 | 1999-04-30 | |
| PL99344041A PL344041A1 (en) | 1998-05-06 | 1999-04-30 | Substituted sulphonyl cyanamides, method for producing same and their use as medicament |
| NZ507964A NZ507964A (en) | 1998-05-06 | 1999-04-30 | Substituted sulphonyl cyanamides |
| PCT/EP1999/002940 WO1999057102A1 (de) | 1998-05-06 | 1999-04-30 | Substituierte sulfonylcyanamide, verfahren zu ihrer herstellung und ihre verwendung als medikament |
| KR1020007012268A KR20010043304A (ko) | 1998-05-06 | 1999-04-30 | 치환된 설포닐 시안아미드, 이의 제조방법 및 약물로서의이의 용도 |
| ES99948554T ES2241326T3 (es) | 1998-05-06 | 1999-04-30 | Sulfonilcianamidas sustituidas, procedimiento para su preparacion y su uso como medicamento. |
| HK01107942.3A HK1038008B (en) | 1998-05-06 | 1999-04-30 | Substituted sulphonyl cyanamides, method for producing same and their use as medicament |
| RU2000130719/04A RU2221789C2 (ru) | 1998-05-06 | 1999-04-30 | Замещенные сульфонилцианамиды и фармацевтическая препаративная форма |
| US09/674,606 US6573288B1 (en) | 1998-05-06 | 1999-04-30 | Substituted sulphonyl cyanamides, method for producing same and their use as medicament |
| ARP990102087A AR016255A1 (es) | 1998-05-06 | 1999-05-04 | Sulfonilcianamidas sustituidas, preparacion , y su utilizacion para la fabricacion de un lubricante. |
| ZA200006166A ZA200006166B (en) | 1998-05-06 | 2000-10-31 | Substituted sulphonyl cyanamides, method for producing same and their use as medicament. |
| NO20005549A NO317886B1 (no) | 1998-05-06 | 2000-11-03 | Substituerte sulfonylcyanamider og deres anvendelse samt preparater inneholdende forbindelsene |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19820064A DE19820064A1 (de) | 1998-05-06 | 1998-05-06 | Substituierte Sulfonylcyanamide, Verfahren zu ihrer Herstellung und ihre Verwendung als Medikament |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DE19820064A1 true DE19820064A1 (de) | 1999-11-11 |
Family
ID=7866747
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE19820064A Withdrawn DE19820064A1 (de) | 1998-05-06 | 1998-05-06 | Substituierte Sulfonylcyanamide, Verfahren zu ihrer Herstellung und ihre Verwendung als Medikament |
| DE19980787T Expired - Lifetime DE19980787D2 (de) | 1998-05-06 | 1999-04-30 | Substituierte Sulfonylcyanamide, Verfahren zu ihrer Herstellung und ihre Verwendung als Medikament |
| DE59911949T Expired - Lifetime DE59911949D1 (de) | 1998-05-06 | 1999-04-30 | Substituierte sulfonylcyanamide, verfahren zu ihrer herstellung und ihre verwendung als medikament |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE19980787T Expired - Lifetime DE19980787D2 (de) | 1998-05-06 | 1999-04-30 | Substituierte Sulfonylcyanamide, Verfahren zu ihrer Herstellung und ihre Verwendung als Medikament |
| DE59911949T Expired - Lifetime DE59911949D1 (de) | 1998-05-06 | 1999-04-30 | Substituierte sulfonylcyanamide, verfahren zu ihrer herstellung und ihre verwendung als medikament |
Country Status (26)
| Country | Link |
|---|---|
| US (1) | US6573288B1 (enExample) |
| EP (1) | EP1076651B1 (enExample) |
| JP (1) | JP4546644B2 (enExample) |
| KR (1) | KR20010043304A (enExample) |
| CN (1) | CN1177829C (enExample) |
| AR (1) | AR016255A1 (enExample) |
| AT (1) | ATE293606T1 (enExample) |
| AU (1) | AU756844B2 (enExample) |
| BR (1) | BR9911009A (enExample) |
| CA (1) | CA2331863A1 (enExample) |
| DE (3) | DE19820064A1 (enExample) |
| DK (1) | DK1076651T3 (enExample) |
| ES (1) | ES2241326T3 (enExample) |
| HR (1) | HRP20000746A2 (enExample) |
| HU (1) | HU225377B1 (enExample) |
| ID (1) | ID28020A (enExample) |
| IL (1) | IL139264A (enExample) |
| NO (1) | NO317886B1 (enExample) |
| NZ (1) | NZ507964A (enExample) |
| PL (1) | PL344041A1 (enExample) |
| PT (1) | PT1076651E (enExample) |
| RU (1) | RU2221789C2 (enExample) |
| SK (1) | SK16582000A3 (enExample) |
| TR (1) | TR200003248T2 (enExample) |
| WO (1) | WO1999057102A1 (enExample) |
| ZA (1) | ZA200006166B (enExample) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE10206354A1 (de) * | 2002-02-14 | 2003-08-28 | Aventis Pharma Gmbh | Verwendung von Inhibitoren des Natrium-abhängigen Chlorid-Bicarbonat-Austauschers zur Behandlung von thrombotischen und inflammatorischer Erkrankungen |
| US20030220383A1 (en) * | 2002-02-14 | 2003-11-27 | Aventis Pharma Deutschland Gmbh | Use of inhibitors of the sodium-dependent chloride/bicarbonate exchanger for the treatment of thrombotic and inflammatory disorders |
| ITTO20060575A1 (it) * | 2006-08-02 | 2008-02-03 | Univ Pisa | Inibitori di zinco proteinasi tioaril sostituiti e loro usi |
| WO2018002673A1 (en) | 2016-07-01 | 2018-01-04 | N4 Pharma Uk Limited | Novel formulations of angiotensin ii receptor antagonists |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA1334092C (en) * | 1986-07-11 | 1995-01-24 | David John Carini | Angiotensin ii receptor blocking imidazoles |
| PT97078B (pt) * | 1990-03-20 | 1997-07-31 | Sanofi Sa | Processo para a preparacao de derivados heterociclicos n-substituidos e de composicoes farmaceuticas que os contem |
| IL98319A (en) * | 1990-07-05 | 1997-04-15 | Roussel Uclaf | Sulphurous derivatives of imidazole, their preparation process, and pharmaceutical compositions containing them |
| US5126342A (en) * | 1990-10-01 | 1992-06-30 | Merck & Co., Inc. | Imidazole angiotensin ii antagonists incorporating acidic functional groups |
| CA2058198A1 (en) * | 1991-01-04 | 1992-07-05 | Adalbert Wagner | Azole derivatives, process for their preparation, and their use |
| TW215434B (enExample) * | 1992-03-07 | 1993-11-01 | Hoechst Ag | |
| US5310929A (en) * | 1992-08-06 | 1994-05-10 | E. I. Du Pont De Nemours And Company | Prodrugs of imidazole carboxylic acids as angiotensin II receptor antagonists |
| FR2711368B1 (fr) * | 1993-09-16 | 1996-01-05 | Roussel Uclaf | Nouveau procédé de préparation de dérivés soufrés de l'imidazole et les nouveaux intermédiaires obtenus. |
| FR2716883B1 (fr) * | 1994-03-04 | 1996-04-26 | Roussel Uclaf | Nouveaux dérivés tétrasubstitués de l'imidazole, leur préparation, nouveaux intermédiaires obtenus, leur application à titre de médicaments, compositions pharmaceutiques les renfermant. |
| DE19540995A1 (de) * | 1995-11-03 | 1997-05-07 | Hoechst Ag | Substituierte Sulfonimidamide, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament |
| EP0855392A3 (de) | 1997-01-22 | 2000-01-05 | Hoechst Aktiengesellschaft | Fünfgliedrige Heterocyclen mit Biphenylsulfonylsubstitution, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament |
| DE19741635A1 (de) * | 1997-09-22 | 1999-03-25 | Hoechst Marion Roussel De Gmbh | Biphenylsulfonylcyanamide, Verfahren zu ihrer Herstellung und ihre Verwendung als Medikament |
| DE19804251A1 (de) | 1998-02-04 | 1999-08-05 | Hoechst Marion Roussel De Gmbh | Biphenylsulfonylcyanamide, Verfahren zu ihrer Herstellung und ihre Verwendung als Medikament |
-
1998
- 1998-05-06 DE DE19820064A patent/DE19820064A1/de not_active Withdrawn
-
1999
- 1999-04-30 CA CA002331863A patent/CA2331863A1/en not_active Abandoned
- 1999-04-30 RU RU2000130719/04A patent/RU2221789C2/ru not_active IP Right Cessation
- 1999-04-30 HR HR20000746A patent/HRP20000746A2/hr not_active Application Discontinuation
- 1999-04-30 NZ NZ507964A patent/NZ507964A/xx unknown
- 1999-04-30 PL PL99344041A patent/PL344041A1/xx unknown
- 1999-04-30 ES ES99948554T patent/ES2241326T3/es not_active Expired - Lifetime
- 1999-04-30 ID IDW20002257A patent/ID28020A/id unknown
- 1999-04-30 KR KR1020007012268A patent/KR20010043304A/ko not_active Ceased
- 1999-04-30 CN CNB998073148A patent/CN1177829C/zh not_active Expired - Fee Related
- 1999-04-30 WO PCT/EP1999/002940 patent/WO1999057102A1/de not_active Ceased
- 1999-04-30 BR BR9911009-1A patent/BR9911009A/pt not_active IP Right Cessation
- 1999-04-30 US US09/674,606 patent/US6573288B1/en not_active Expired - Lifetime
- 1999-04-30 DK DK99948554T patent/DK1076651T3/da active
- 1999-04-30 PT PT99948554T patent/PT1076651E/pt unknown
- 1999-04-30 AT AT99948554T patent/ATE293606T1/de not_active IP Right Cessation
- 1999-04-30 IL IL13926499A patent/IL139264A/en not_active IP Right Cessation
- 1999-04-30 SK SK1658-2000A patent/SK16582000A3/sk unknown
- 1999-04-30 DE DE19980787T patent/DE19980787D2/de not_active Expired - Lifetime
- 1999-04-30 DE DE59911949T patent/DE59911949D1/de not_active Expired - Lifetime
- 1999-04-30 HU HU0102459A patent/HU225377B1/hu not_active IP Right Cessation
- 1999-04-30 JP JP2000547072A patent/JP4546644B2/ja not_active Expired - Fee Related
- 1999-04-30 TR TR2000/03248T patent/TR200003248T2/xx unknown
- 1999-04-30 AU AU59479/99A patent/AU756844B2/en not_active Ceased
- 1999-04-30 EP EP99948554A patent/EP1076651B1/de not_active Expired - Lifetime
- 1999-05-04 AR ARP990102087A patent/AR016255A1/es unknown
-
2000
- 2000-10-31 ZA ZA200006166A patent/ZA200006166B/xx unknown
- 2000-11-03 NO NO20005549A patent/NO317886B1/no unknown
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