RU2221789C2 - Замещенные сульфонилцианамиды и фармацевтическая препаративная форма - Google Patents

Замещенные сульфонилцианамиды и фармацевтическая препаративная форма Download PDF

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RU2221789C2
RU2221789C2 RU2000130719/04A RU2000130719A RU2221789C2 RU 2221789 C2 RU2221789 C2 RU 2221789C2 RU 2000130719/04 A RU2000130719/04 A RU 2000130719/04A RU 2000130719 A RU2000130719 A RU 2000130719A RU 2221789 C2 RU2221789 C2 RU 2221789C2
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RU
Russia
Prior art keywords
hydrogen
alkyl
independently
carbon atoms
sulfonylcyanamides
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RU2000130719/04A
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English (en)
Russian (ru)
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RU2000130719A (ru
Inventor
Андреас ВАЙХЕРТ (DE)
Андреас Вайхерт
Ханс Йохен ЛАНГ (DE)
Ханс Йохен Ланг
Штефан ПЕТРИ (DE)
Штефан Петри
Ян-Роберт ШВАРК (DE)
Ян-Роберт Шварк
Хайнц-Вернер КЛЕЕМАНН (DE)
Хайнц-Вернер КЛЕЕМАНН
Сабине ФАБЕР (DE)
Сабине Фабер
Ханс-Вилли ЯНСЕН (DE)
Ханс-Вилли ЯНСЕН
Original Assignee
Авентис Фарма Дойчланд Гмбх
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Publication of RU2000130719A publication Critical patent/RU2000130719A/ru
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/90—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/15—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings
    • C07C311/16—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the sulfonamide groups bound to hydrogen atoms or to an acyclic carbon atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/68—Halogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/70—One oxygen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/84—Sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/91—Nitro radicals

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  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Hospice & Palliative Care (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
RU2000130719/04A 1998-05-06 1999-04-30 Замещенные сульфонилцианамиды и фармацевтическая препаративная форма RU2221789C2 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19820064.1 1998-05-06
DE19820064A DE19820064A1 (de) 1998-05-06 1998-05-06 Substituierte Sulfonylcyanamide, Verfahren zu ihrer Herstellung und ihre Verwendung als Medikament

Publications (2)

Publication Number Publication Date
RU2000130719A RU2000130719A (ru) 2003-01-27
RU2221789C2 true RU2221789C2 (ru) 2004-01-20

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RU2000130719/04A RU2221789C2 (ru) 1998-05-06 1999-04-30 Замещенные сульфонилцианамиды и фармацевтическая препаративная форма

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US (1) US6573288B1 (enExample)
EP (1) EP1076651B1 (enExample)
JP (1) JP4546644B2 (enExample)
KR (1) KR20010043304A (enExample)
CN (1) CN1177829C (enExample)
AR (1) AR016255A1 (enExample)
AT (1) ATE293606T1 (enExample)
AU (1) AU756844B2 (enExample)
BR (1) BR9911009A (enExample)
CA (1) CA2331863A1 (enExample)
DE (3) DE19820064A1 (enExample)
DK (1) DK1076651T3 (enExample)
ES (1) ES2241326T3 (enExample)
HR (1) HRP20000746A2 (enExample)
HU (1) HU225377B1 (enExample)
ID (1) ID28020A (enExample)
IL (1) IL139264A (enExample)
NO (1) NO317886B1 (enExample)
NZ (1) NZ507964A (enExample)
PL (1) PL344041A1 (enExample)
PT (1) PT1076651E (enExample)
RU (1) RU2221789C2 (enExample)
SK (1) SK16582000A3 (enExample)
TR (1) TR200003248T2 (enExample)
WO (1) WO1999057102A1 (enExample)
ZA (1) ZA200006166B (enExample)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10206354A1 (de) * 2002-02-14 2003-08-28 Aventis Pharma Gmbh Verwendung von Inhibitoren des Natrium-abhängigen Chlorid-Bicarbonat-Austauschers zur Behandlung von thrombotischen und inflammatorischer Erkrankungen
US20030220383A1 (en) * 2002-02-14 2003-11-27 Aventis Pharma Deutschland Gmbh Use of inhibitors of the sodium-dependent chloride/bicarbonate exchanger for the treatment of thrombotic and inflammatory disorders
ITTO20060575A1 (it) * 2006-08-02 2008-02-03 Univ Pisa Inibitori di zinco proteinasi tioaril sostituiti e loro usi
WO2018002673A1 (en) 2016-07-01 2018-01-04 N4 Pharma Uk Limited Novel formulations of angiotensin ii receptor antagonists

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SU1694062A3 (ru) * 1986-07-11 1991-11-23 Е.И.Дюпон Де Немур Энд Компани (Фирма) Способ получени производных имидазола или их фармацевтически приемлемых солей
WO1995023791A1 (fr) * 1994-03-04 1995-09-08 Roussel Uclaf Nouveaux derives tetrasubstitues de l'imidazole, leur procede de preparation, les nouveaux intermediaires obtenus, leur application a titre de medicaments et les compositions pharmaceutiques les renfermant
US5482957A (en) * 1991-01-04 1996-01-09 Hoechst Aktiengesellschaft Azole derivatives, process for their preparation and their use
US5604251A (en) * 1992-03-07 1997-02-18 Hoechst Aktiengesellschaft Imidazole derivatives with a biphenylsulfonylurea or biphenylsulfonylurethane side chain and their use as angitensin II receptors
RU2099331C1 (ru) * 1990-03-20 1997-12-20 Санофи N-замещенные гетероциклические производные или их соли, промежуточные производные пиримидина и имидазолина и фармацевтическая композиция на основе замещенных гетероциклических производных

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL98319A (en) * 1990-07-05 1997-04-15 Roussel Uclaf Sulphurous derivatives of imidazole, their preparation process, and pharmaceutical compositions containing them
US5126342A (en) * 1990-10-01 1992-06-30 Merck & Co., Inc. Imidazole angiotensin ii antagonists incorporating acidic functional groups
US5310929A (en) * 1992-08-06 1994-05-10 E. I. Du Pont De Nemours And Company Prodrugs of imidazole carboxylic acids as angiotensin II receptor antagonists
FR2711368B1 (fr) * 1993-09-16 1996-01-05 Roussel Uclaf Nouveau procédé de préparation de dérivés soufrés de l'imidazole et les nouveaux intermédiaires obtenus.
DE19540995A1 (de) * 1995-11-03 1997-05-07 Hoechst Ag Substituierte Sulfonimidamide, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament
EP0855392A3 (de) 1997-01-22 2000-01-05 Hoechst Aktiengesellschaft Fünfgliedrige Heterocyclen mit Biphenylsulfonylsubstitution, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament
DE19741635A1 (de) * 1997-09-22 1999-03-25 Hoechst Marion Roussel De Gmbh Biphenylsulfonylcyanamide, Verfahren zu ihrer Herstellung und ihre Verwendung als Medikament
DE19804251A1 (de) 1998-02-04 1999-08-05 Hoechst Marion Roussel De Gmbh Biphenylsulfonylcyanamide, Verfahren zu ihrer Herstellung und ihre Verwendung als Medikament

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SU1694062A3 (ru) * 1986-07-11 1991-11-23 Е.И.Дюпон Де Немур Энд Компани (Фирма) Способ получени производных имидазола или их фармацевтически приемлемых солей
RU2099331C1 (ru) * 1990-03-20 1997-12-20 Санофи N-замещенные гетероциклические производные или их соли, промежуточные производные пиримидина и имидазолина и фармацевтическая композиция на основе замещенных гетероциклических производных
US5482957A (en) * 1991-01-04 1996-01-09 Hoechst Aktiengesellschaft Azole derivatives, process for their preparation and their use
US5604251A (en) * 1992-03-07 1997-02-18 Hoechst Aktiengesellschaft Imidazole derivatives with a biphenylsulfonylurea or biphenylsulfonylurethane side chain and their use as angitensin II receptors
WO1995023791A1 (fr) * 1994-03-04 1995-09-08 Roussel Uclaf Nouveaux derives tetrasubstitues de l'imidazole, leur procede de preparation, les nouveaux intermediaires obtenus, leur application a titre de medicaments et les compositions pharmaceutiques les renfermant

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ATE293606T1 (de) 2005-05-15
HRP20000746A2 (en) 2001-06-30
NZ507964A (en) 2003-06-30
SK16582000A3 (sk) 2001-06-11
DK1076651T3 (da) 2005-08-15
IL139264A0 (en) 2001-11-25
IL139264A (en) 2004-07-25
NO317886B1 (no) 2004-12-27
CA2331863A1 (en) 1999-11-11
AU5947999A (en) 1999-11-23
CN1305463A (zh) 2001-07-25
NO20005549L (no) 2001-01-05
US6573288B1 (en) 2003-06-03
AR016255A1 (es) 2001-06-20
ES2241326T3 (es) 2005-10-16
ZA200006166B (en) 2001-09-26
AU756844B2 (en) 2003-01-23
ID28020A (id) 2001-05-03
EP1076651A1 (de) 2001-02-21
TR200003248T2 (tr) 2001-03-21
HK1038008A1 (en) 2002-03-01
CN1177829C (zh) 2004-12-01
PT1076651E (pt) 2005-08-31
WO1999057102A1 (de) 1999-11-11
EP1076651B1 (de) 2005-04-20
DE19820064A1 (de) 1999-11-11
DE59911949D1 (de) 2005-05-25
JP2002513785A (ja) 2002-05-14
HU225377B1 (en) 2006-10-28
KR20010043304A (ko) 2001-05-25
NO20005549D0 (no) 2000-11-03
HUP0102459A2 (hu) 2002-03-28
JP4546644B2 (ja) 2010-09-15
PL344041A1 (en) 2001-09-24
DE19980787D2 (de) 2001-03-22
BR9911009A (pt) 2001-02-13
HUP0102459A3 (en) 2002-12-28

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Effective date: 20070501