DE19818964A1 - Neue Hydroxyindole, deren Verwendung als Inhibitoren der Phospodiesterase 4 und Verfahren zu deren Herstellung - Google Patents

Neue Hydroxyindole, deren Verwendung als Inhibitoren der Phospodiesterase 4 und Verfahren zu deren Herstellung

Info

Publication number
DE19818964A1
DE19818964A1 DE19818964A DE19818964A DE19818964A1 DE 19818964 A1 DE19818964 A1 DE 19818964A1 DE 19818964 A DE19818964 A DE 19818964A DE 19818964 A DE19818964 A DE 19818964A DE 19818964 A1 DE19818964 A1 DE 19818964A1
Authority
DE
Germany
Prior art keywords
alkyl
aryl
mono
compounds
polyunsaturated
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
DE19818964A
Other languages
German (de)
English (en)
Inventor
Norbert Hoefgen
Ute Egerland
Hildegard Poppe
Degenhard Marx
Stefan Szelenyi
Thomas Kronbach
Emmanuel Polymeropoulos
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Elbion GmbH
Original Assignee
Arzneimittelwerk Dresden GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Arzneimittelwerk Dresden GmbH filed Critical Arzneimittelwerk Dresden GmbH
Priority to DE19818964A priority Critical patent/DE19818964A1/de
Priority to SI9930670T priority patent/SI1076657T1/xx
Priority to JP2000545856A priority patent/JP3842043B2/ja
Priority to AT04018391T priority patent/ATE330955T1/de
Priority to TR2000/03130T priority patent/TR200003130T2/xx
Priority to KR10-2000-7011992A priority patent/KR100448748B1/ko
Priority to IL13884799A priority patent/IL138847A0/xx
Priority to ES99920779T priority patent/ES2222706T3/es
Priority to UA2000116726A priority patent/UA59443C2/uk
Priority to CNB2005100746573A priority patent/CN1321981C/zh
Priority to AT99920779T priority patent/ATE272631T1/de
Priority to CNB998079766A priority patent/CN1234705C/zh
Priority to DK99920779T priority patent/DK1076657T3/da
Priority to DE59913617T priority patent/DE59913617D1/de
Priority to DK04018391T priority patent/DK1475377T3/da
Priority to PL343569A priority patent/PL198983B1/pl
Priority to PT04018391T priority patent/PT1475377E/pt
Priority to BR9910029-0A priority patent/BR9910029A/pt
Priority to ES04018391T priority patent/ES2262072T3/es
Priority to HU0101625A priority patent/HUP0101625A3/hu
Priority to PT99920779T priority patent/PT1076657E/pt
Priority to PCT/EP1999/002792 priority patent/WO1999055696A1/fr
Priority to AU38229/99A priority patent/AU748403B2/en
Priority to SI9930922T priority patent/SI1475377T1/sl
Priority to SK1575-2000A priority patent/SK286192B6/sk
Priority to DE59910142T priority patent/DE59910142D1/de
Priority to EP99920779A priority patent/EP1076657B1/fr
Priority to EP04018391A priority patent/EP1475377B1/fr
Priority to NZ507406A priority patent/NZ507406A/xx
Priority to RU2000129678/04A priority patent/RU2217422C2/ru
Priority to CZ20003985A priority patent/CZ20003985A3/cs
Priority to TW088106886A priority patent/TW530048B/zh
Priority to CA002270301A priority patent/CA2270301C/fr
Priority to ARP990101965A priority patent/AR016236A1/es
Priority to US09/300,973 priority patent/US6251923B1/en
Publication of DE19818964A1 publication Critical patent/DE19818964A1/de
Priority to IL138847A priority patent/IL138847A/en
Priority to ZA200005540A priority patent/ZA200005540B/xx
Priority to BG104842A priority patent/BG65023B1/bg
Priority to NO20005454A priority patent/NO321867B1/no
Priority to HK01105669A priority patent/HK1035183A1/xx
Priority to US10/081,395 priority patent/US6545158B2/en
Priority to US10/081,642 priority patent/US7161009B2/en
Priority to US10/080,821 priority patent/US6545025B2/en
Priority to US10/081,807 priority patent/US6602890B2/en
Priority to US10/176,435 priority patent/USRE38624E1/en
Priority to US10/347,659 priority patent/US6613794B2/en
Priority to US10/856,034 priority patent/US20040220183A1/en
Priority to HK04109841A priority patent/HK1066804A1/xx
Priority to JP2006086619A priority patent/JP2006249091A/ja
Priority to CY20061100948T priority patent/CY1105075T1/el
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D209/24—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with an alkyl or cycloalkyl radical attached to the ring nitrogen atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D209/22—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with an aralkyl radical attached to the ring nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Pulmonology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
DE19818964A 1998-04-28 1998-04-28 Neue Hydroxyindole, deren Verwendung als Inhibitoren der Phospodiesterase 4 und Verfahren zu deren Herstellung Ceased DE19818964A1 (de)

Priority Applications (50)

Application Number Priority Date Filing Date Title
DE19818964A DE19818964A1 (de) 1998-04-28 1998-04-28 Neue Hydroxyindole, deren Verwendung als Inhibitoren der Phospodiesterase 4 und Verfahren zu deren Herstellung
SI9930670T SI1076657T1 (en) 1998-04-28 1999-04-24 New hydroxyindoles, their use as phosphodiesterase 4 inhibitors and method for producing same
JP2000545856A JP3842043B2 (ja) 1998-04-28 1999-04-24 新規ヒドロキシインドール、ホスホジエステラーゼ４のインヒビタとしてのその使用及びその製法
AT04018391T ATE330955T1 (de) 1998-04-28 1999-04-24 Indolderivate und deren verwendung als inhibitoren der phosphodiesterase 4.
TR2000/03130T TR200003130T2 (tr) 1998-04-28 1999-04-24 Yeni hidroksiindoller, bunların fosfodiesteraz 4 inhibitörleri olarak kullanımları ve hazırlanmaları için işlemler
KR10-2000-7011992A KR100448748B1 (ko) 1998-04-28 1999-04-24 하이드록시인돌, 이를 함유하는 약제 및 이의 제조방법
IL13884799A IL138847A0 (en) 1998-04-28 1999-04-24 New hydroxyindoles, their use as phosphodiesterase 4 inhibitors and method for producing same
ES99920779T ES2222706T3 (es) 1998-04-28 1999-04-24 Nuevos hidroxiindoles, su utilizacion como inhibidores de la fosfodiesterasa 4, y procedimiento para su preparacion.
UA2000116726A UA59443C2 (uk) 1998-04-28 1999-04-24 Гідроксііндол, спосіб його одержання, лікарська форма на його основі та спосіб її одержання
CNB2005100746573A CN1321981C (zh) 1998-04-28 1999-04-24 羟基吲哚、其作为磷酸二酯酶4抑制剂的应用及其制备方法
AT99920779T ATE272631T1 (de) 1998-04-28 1999-04-24 Neue hydroxyindole, deren verwendung als inhibitoren der phosphodiesterase 4 und verfahren zu deren herstellung
CNB998079766A CN1234705C (zh) 1998-04-28 1999-04-24 新的羟基吲哚、其作为磷酸二酯酶4抑制剂的应用及其制备方法
DK99920779T DK1076657T3 (da) 1998-04-28 1999-04-24 Hidtil ukendte hydroxyindoler, deres anvendelse som inhibitorer for phosphodiesterase 4 og fremgangsmåde til deres fremstilling
DE59913617T DE59913617D1 (de) 1998-04-28 1999-04-24 Indolderivate und deren Verwendung als Inhibitoren der Phosphodiesterase 4.
DK04018391T DK1475377T3 (da) 1998-04-28 1999-04-24 Indol-derivater og deres anvendelse som inhibitorer for phosphodiesterase 4
PL343569A PL198983B1 (pl) 1998-04-28 1999-04-24 Nowe hydroksyindole, ich zastosowanie jako inhibitorów fosfodiesterazy 4 oraz sposoby ich wytwarzania
PT04018391T PT1475377E (pt) 1998-04-28 1999-04-24 Derivados de indole e sua utilização como inibidores da fosfodiesterase 4
BR9910029-0A BR9910029A (pt) 1998-04-28 1999-04-24 Hidróxi indóis, sua aplicação como inibidores da fosfodiesterase 4 e processo para sua preparação
ES04018391T ES2262072T3 (es) 1998-04-28 1999-04-24 Derivados de indol y su utilizacion como inhibidores de la fosfodiesterasa 4.
HU0101625A HUP0101625A3 (en) 1998-04-28 1999-04-24 New hydroxyindoles, their use as phosphodiesterase 4 inhibitors and method for producing same
PT99920779T PT1076657E (pt) 1998-04-28 1999-04-24 Novos hidroxi-indoles, sua utilizacao como inibidores da fosfodiesterase 4 e processo para a sua producao
PCT/EP1999/002792 WO1999055696A1 (fr) 1998-04-28 1999-04-24 Nouveaux hydroxyindoles, leur utilisation comme inhibiteurs de la phosphodiesterase 4 et leur procede de preparation
AU38229/99A AU748403B2 (en) 1998-04-28 1999-04-24 New hydroxyindoles, their use as phosphodiesterase 4 inhibitors and method for producing same
SI9930922T SI1475377T1 (sl) 1998-04-28 1999-04-24 Indolni derivati in njihova uporaba kot inhibitorji fosfodiesteraze 4
SK1575-2000A SK286192B6 (sk) 1998-04-28 1999-04-24 Hydroxyindol, spôsob jeho prípravy a jeho použitie ako inhibítora fosfodiesterázy 4
DE59910142T DE59910142D1 (de) 1998-04-28 1999-04-24 Neue hydroxyindole, deren verwendung als inhibitoren der phosphodiesterase 4 und verfahren zu deren herstellung
EP99920779A EP1076657B1 (fr) 1998-04-28 1999-04-24 Nouveaux hydroxyindoles, leur utilisation comme inhibiteurs de la phosphodiesterase 4 et leur procede de preparation
EP04018391A EP1475377B1 (fr) 1998-04-28 1999-04-24 Dérivés d'indole et leur utilisation en tant qu'inhibiteurs de la phosphodiestérase 4.
NZ507406A NZ507406A (en) 1998-04-28 1999-04-24 New hydroxyindoles, their use as phosphodiesterase 4 (PDE4) inhibitors and a method of preparation
RU2000129678/04A RU2217422C2 (ru) 1998-04-28 1999-04-24 Гидроксииндолы, их применение в качестве ингибиторов фосфодиэстеразы 4 и способ их получения
CZ20003985A CZ20003985A3 (cs) 1998-04-28 1999-04-24 Nový hydroxyindol, způsob jeho přípravy a jeho použití jako inhibitoru fosfodiesterázy 4
TW088106886A TW530048B (en) 1998-04-28 1999-04-28 New hydroxyindoles, their use as inhibitors of phosphodiesterase 4 and processes for their preparation
CA002270301A CA2270301C (fr) 1998-04-28 1999-04-28 Hydroxyindoles, leur utilisation en tant qu'inhibiteurs de phos phodiesterase 4, et procedes de preparation de ceux-ci
ARP990101965A AR016236A1 (es) 1998-04-28 1999-04-28 Compuestos de hidroxiindol, utiles como inhibidores de la 4- fosfodiestearasas, procedimiento para prepararlos, utilizacion de dichos compuestos, medicamentos que contienen dichos compuestos, procedimiento para prepararlos
US09/300,973 US6251923B1 (en) 1998-04-28 1999-04-28 Hydroxyindoles, their use as inhibitors of phosphodiesterase 4 and process for their preparation
IL138847A IL138847A (en) 1998-04-28 2000-10-04 The hydroxyindoles, methods for their production and their use in the manufacture of drugs for the treatment of disorders in which there is a medical advantage in inhibiting phosphodiesterase 4
ZA200005540A ZA200005540B (en) 1998-04-28 2000-10-10 New hydroxyindoles, their use as phosphodiestrase 4 inhibitors and method for producing same.
BG104842A BG65023B1 (bg) 1998-04-28 2000-10-11 Нови хидроксииндоли, тяхното приложение като инхибитори на фосфодиестераза 4 и метод за тяхното получаване
NO20005454A NO321867B1 (no) 1998-04-28 2000-10-27 Nye hydroksyindoler, disse for bruk som medikament, fremgangsmate for fremstilling derav, anvendelse av disse for fremstilling av legemidler, legemiddel inneholdende disse samt en fremgangsmate for fremstilling av legemidlene
HK01105669A HK1035183A1 (en) 1998-04-28 2001-08-14 New hydroxyindoles, their use as phosphodiesterase4 inhibitors and method for producing same.
US10/081,395 US6545158B2 (en) 1998-04-28 2002-02-21 Hydroxyindoles, their use as inhibitors of phosphodiesterase 4 and processes for their preparation
US10/081,642 US7161009B2 (en) 1998-04-28 2002-02-21 Hydroxyindoles, their use as inhibitors of phosphodiesterase 4 and processes for their preparation
US10/080,821 US6545025B2 (en) 1998-04-28 2002-02-21 Hydroxyindoles, their use as inhibitors of phosphodiesterase 4 and processes for their preparation
US10/081,807 US6602890B2 (en) 1998-04-28 2002-02-21 Hydroxyindoles, their use as inhibitors of phosphodiesterase 4 and processes for their preparation
US10/176,435 USRE38624E1 (en) 1998-04-28 2002-09-19 Hydroxyindoles, their use as inhibitors of phosphodiesterase 4 and process for their preparation
US10/347,659 US6613794B2 (en) 1998-04-28 2003-01-20 Hydroxyindoles, their use as inhibitors of phosphodiesterase 4 and processes for their preparation
US10/856,034 US20040220183A1 (en) 1998-04-28 2004-05-27 Hydroxyindoles, their use as inhibitors of phosphodiesterase 4 and processes for their preparation
HK04109841A HK1066804A1 (en) 1998-04-28 2004-12-13 Derivatives of indole and their use as phosphodiesterase 4 inhibitors
JP2006086619A JP2006249091A (ja) 1998-04-28 2006-03-27 新規ヒドロキシインドール、ホスホジエステラーゼ４のインヒビタとしてのその使用及びその製法
CY20061100948T CY1105075T1 (el) 1998-04-28 2006-07-07 Παραγωγα ινδολων και η χρησιμοποιηση τους σαν αναστολεις της φωσφοδιεστepασης 4

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19818964A DE19818964A1 (de) 1998-04-28 1998-04-28 Neue Hydroxyindole, deren Verwendung als Inhibitoren der Phospodiesterase 4 und Verfahren zu deren Herstellung

Publications (1)

Publication Number Publication Date
DE19818964A1 true DE19818964A1 (de) 1999-11-04

Family

ID=7866051

Family Applications (1)

Application Number Title Priority Date Filing Date
DE19818964A Ceased DE19818964A1 (de) 1998-04-28 1998-04-28 Neue Hydroxyindole, deren Verwendung als Inhibitoren der Phospodiesterase 4 und Verfahren zu deren Herstellung

Country Status (6)

Country Link
CN (1) CN1321981C (fr)
CA (1) CA2270301C (fr)
DE (1) DE19818964A1 (fr)
HK (1) HK1066804A1 (fr)
RU (1) RU2217422C2 (fr)
ZA (1) ZA200005540B (fr)

Cited By (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19962300A1 (de) * 1999-12-23 2001-06-28 Asta Medica Ag Substituierte N-Benzyl-Indol-3-yl-glyoxylsäure-Derivate mit Antitumorwirkung
WO2004013127A1 (fr) * 2002-08-01 2004-02-12 Elbion Ag Procede de preparation d'amides d'acide hydroxy-indolylglyoxyle de grande purete
WO2004022041A2 (fr) * 2002-09-06 2004-03-18 Elbion Ag Traitement de la rhinite non allergique au moyen d'inhibiteurs selectifs de phosphodiesterase-4
WO2004045607A1 (fr) * 2002-11-15 2004-06-03 Elbion Ag Nouveaux hydroxyindoles, leur utilisation comme inhibiteurs de la phosphodiesterase 4 et procedes de production desdits composes
WO2004094406A1 (fr) * 2003-04-24 2004-11-04 Elbion Ag 5-hydroxy-indoles comportant des groupes n-oxyde et leur utilisation comme inhibiteurs de la phosphodiesterase 4
WO2004094416A1 (fr) * 2003-04-24 2004-11-04 Elbion Ag 7-azaindoles et leur utilisation comme produits therapeutiques
US6903104B2 (en) 2001-12-06 2005-06-07 National Health Research Institutes Indol-3-YL-2-oxoacetamide compounds and methods of use thereof
WO2007000289A1 (fr) * 2005-06-27 2007-01-04 Elbion Ag Hydroxyindoles nitro-substitues, leur utilisation en tant qu'inhibiteurs de la phosphodiesterase 4, et procedes de preparation de ces derniers
US7645752B2 (en) 2006-01-13 2010-01-12 Wyeth Llc Sulfonyl substituted 1H-indoles as ligands for the 5-hydroxytryptamine receptors

Citations (10)

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Publication number Priority date Publication date Assignee Title
WO1994012461A1 (fr) * 1992-12-02 1994-06-09 Pfizer Inc. Diethers de pyrocatechine utilises comme inhibiteurs selectifs de la pde¿iv?
WO1995014667A1 (fr) * 1993-11-26 1995-06-01 Pfizer Inc. Indoles substitues en tant qu'inhibiteurs de la phosphodiesterase de type iv
US5424329A (en) * 1993-08-18 1995-06-13 Warner-Lambert Company Indole-2-carboxamides as inhibitors of cell adhesion
WO1995024408A1 (fr) * 1994-03-07 1995-09-14 Warner-Lambert Company Thiazepinones de benzothiophene, de benzofurane et d'indole, oxazepinones et diazepinones utilisees comme inhibiteurs d'adherence cellulaire et du vih
DE19511916A1 (de) * 1994-08-03 1996-02-08 Asta Medica Ag Neue N-Benzylindol- und Benzopyrazol-Derivate mit antiasthmatischer, antiallergischer, entzündungshemmender und immunmodulierender Wirkung
EP0773024A2 (fr) * 1995-10-27 1997-05-14 Pfizer Inc. Utilisation des composés nicotinamidiques N-substituées pour le traitement des maladies inflammatoires aigues et chroniques
WO1997048697A1 (fr) * 1996-06-19 1997-12-24 Rhone-Poulenc Rorer Limited Composes azabicycliques substitues et leur utilisation en tant qu'inhibiteurs de la production de tnf et de la photodiesterase cyclique d'amp
WO1998002151A2 (fr) * 1996-07-12 1998-01-22 Leukosite, Inc. Antagonistes des recepteurs de la chemokine et procedes d'utilisation de ces derniers
WO1998008818A1 (fr) * 1996-08-26 1998-03-05 Genetics Institute, Inc. Inhibiteurs des enzymes phospholipases
DE19636150A1 (de) * 1996-09-06 1998-03-12 Asta Medica Ag N-substituierte Indol-3-glyoxylamide mit antiasthmatischer, antiallergischer und immunsuppressiver/immunmodulierender Wirkung

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US5192770A (en) * 1990-12-07 1993-03-09 Syntex (U.S.A.) Inc. Serotonergic alpha-oxoacetamides
US5728844A (en) * 1995-08-29 1998-03-17 Celgene Corporation Immunotherapeutic agents

Patent Citations (10)

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Publication number Priority date Publication date Assignee Title
WO1994012461A1 (fr) * 1992-12-02 1994-06-09 Pfizer Inc. Diethers de pyrocatechine utilises comme inhibiteurs selectifs de la pde¿iv?
US5424329A (en) * 1993-08-18 1995-06-13 Warner-Lambert Company Indole-2-carboxamides as inhibitors of cell adhesion
WO1995014667A1 (fr) * 1993-11-26 1995-06-01 Pfizer Inc. Indoles substitues en tant qu'inhibiteurs de la phosphodiesterase de type iv
WO1995024408A1 (fr) * 1994-03-07 1995-09-14 Warner-Lambert Company Thiazepinones de benzothiophene, de benzofurane et d'indole, oxazepinones et diazepinones utilisees comme inhibiteurs d'adherence cellulaire et du vih
DE19511916A1 (de) * 1994-08-03 1996-02-08 Asta Medica Ag Neue N-Benzylindol- und Benzopyrazol-Derivate mit antiasthmatischer, antiallergischer, entzündungshemmender und immunmodulierender Wirkung
EP0773024A2 (fr) * 1995-10-27 1997-05-14 Pfizer Inc. Utilisation des composés nicotinamidiques N-substituées pour le traitement des maladies inflammatoires aigues et chroniques
WO1997048697A1 (fr) * 1996-06-19 1997-12-24 Rhone-Poulenc Rorer Limited Composes azabicycliques substitues et leur utilisation en tant qu'inhibiteurs de la production de tnf et de la photodiesterase cyclique d'amp
WO1998002151A2 (fr) * 1996-07-12 1998-01-22 Leukosite, Inc. Antagonistes des recepteurs de la chemokine et procedes d'utilisation de ces derniers
WO1998008818A1 (fr) * 1996-08-26 1998-03-05 Genetics Institute, Inc. Inhibiteurs des enzymes phospholipases
DE19636150A1 (de) * 1996-09-06 1998-03-12 Asta Medica Ag N-substituierte Indol-3-glyoxylamide mit antiasthmatischer, antiallergischer und immunsuppressiver/immunmodulierender Wirkung

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Title
Chemical Abstracts: Vol.114, 1991, Ref. 240174a *
The Merck Index, MERCK & Co., Inc., Rahway, N.J., U.S.A., 1989, S.786 *
Vol.117, 1992, Ref. 225926r *
Vol.121, 1994, Ref. 2861x *
Vol.121, 1994, Ref. 81303t *
Vol.127, 1997, Ref. 108841e *
Vol.127, 1997, Ref. 219990x *

Cited By (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19962300A1 (de) * 1999-12-23 2001-06-28 Asta Medica Ag Substituierte N-Benzyl-Indol-3-yl-glyoxylsäure-Derivate mit Antitumorwirkung
US7662834B2 (en) 2001-12-06 2010-02-16 National Health Research Institutes Methods of 1H-indol-3-yl-2-oxoacetamide compounds
US7396838B2 (en) 2001-12-06 2008-07-08 National Health Research Institutes Use of 1H-indol-3-yl-2-oxoacetamide compounds
US6903104B2 (en) 2001-12-06 2005-06-07 National Health Research Institutes Indol-3-YL-2-oxoacetamide compounds and methods of use thereof
WO2004013127A1 (fr) * 2002-08-01 2004-02-12 Elbion Ag Procede de preparation d'amides d'acide hydroxy-indolylglyoxyle de grande purete
US7122674B2 (en) 2002-08-01 2006-10-17 Elbion Ag Process for preparing high-purity hydroxyindolylglyoxylamides
WO2004022041A2 (fr) * 2002-09-06 2004-03-18 Elbion Ag Traitement de la rhinite non allergique au moyen d'inhibiteurs selectifs de phosphodiesterase-4
WO2004022041A3 (fr) * 2002-09-06 2004-05-06 Elbion Ag Traitement de la rhinite non allergique au moyen d'inhibiteurs selectifs de phosphodiesterase-4
DE10253426B4 (de) * 2002-11-15 2005-09-22 Elbion Ag Neue Hydroxyindole, deren Verwendung als Inhibitoren der Phosphodiesterase 4 und Verfahren zu deren Herstellung
US7166637B2 (en) 2002-11-15 2007-01-23 Elbion Ag Hydroxyindoles, their use as inhibitors of phosphodiesterase 4, and processes for preparing them
WO2004045607A1 (fr) * 2002-11-15 2004-06-03 Elbion Ag Nouveaux hydroxyindoles, leur utilisation comme inhibiteurs de la phosphodiesterase 4 et procedes de production desdits composes
WO2004094416A1 (fr) * 2003-04-24 2004-11-04 Elbion Ag 7-azaindoles et leur utilisation comme produits therapeutiques
US7211583B2 (en) 2003-04-24 2007-05-01 Elbion Ag 7-azaindoles and the use thereof as therapeutic agents
WO2004094406A1 (fr) * 2003-04-24 2004-11-04 Elbion Ag 5-hydroxy-indoles comportant des groupes n-oxyde et leur utilisation comme inhibiteurs de la phosphodiesterase 4
US7947705B2 (en) * 2003-04-24 2011-05-24 Biotie Therapies Gmbh 7-azaindoles and the use thereof as therapeutic agents
WO2007000289A1 (fr) * 2005-06-27 2007-01-04 Elbion Ag Hydroxyindoles nitro-substitues, leur utilisation en tant qu'inhibiteurs de la phosphodiesterase 4, et procedes de preparation de ces derniers
US7645752B2 (en) 2006-01-13 2010-01-12 Wyeth Llc Sulfonyl substituted 1H-indoles as ligands for the 5-hydroxytryptamine receptors

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RU2217422C2 (ru) 2003-11-27
HK1066804A1 (en) 2005-04-01
CN1699342A (zh) 2005-11-23
ZA200005540B (en) 2001-03-27
CA2270301A1 (fr) 1999-10-28
CN1321981C (zh) 2007-06-20

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