DE19775081I2 - Benzimidazolderivate Verfahren zu deren Herstellung und deren therapeutische Anwendung - Google Patents

Benzimidazolderivate Verfahren zu deren Herstellung und deren therapeutische Anwendung

Info

Publication number
DE19775081I2
DE19775081I2 DE1997175081 DE19775081C DE19775081I2 DE 19775081 I2 DE19775081 I2 DE 19775081I2 DE 1997175081 DE1997175081 DE 1997175081 DE 19775081 C DE19775081 C DE 19775081C DE 19775081 I2 DE19775081 I2 DE 19775081I2
Authority
DE
Germany
Prior art keywords
preparation
therapeutic use
benzimidazole derivatives
derivatives process
benzimidazole
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
DE1997175081
Other languages
German (de)
English (en)
Inventor
Philippe Manoury
Jean Binet
Gerard Defosse
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Synthelabo SA
Original Assignee
Synthelabo SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Synthelabo SA filed Critical Synthelabo SA
Application granted granted Critical
Publication of DE19775081I2 publication Critical patent/DE19775081I2/de
Active legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Pulmonology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
DE1997175081 1985-09-11 1986-09-02 Benzimidazolderivate Verfahren zu deren Herstellung und deren therapeutische Anwendung Active DE19775081I2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR8513453A FR2587029B1 (fr) 1985-09-11 1985-09-11 Derives de benzimidazole, leur preparation et leur application en therapeutique

Publications (1)

Publication Number Publication Date
DE19775081I2 true DE19775081I2 (de) 2002-08-29

Family

ID=9322797

Family Applications (2)

Application Number Title Priority Date Filing Date
DE1997175081 Active DE19775081I2 (de) 1985-09-11 1986-09-02 Benzimidazolderivate Verfahren zu deren Herstellung und deren therapeutische Anwendung
DE3689748T Expired - Lifetime DE3689748T2 (de) 1985-09-11 1986-09-02 Benzimidazolderivate, Verfahren zu deren Herstellung und deren therapeutische Anwendung.

Family Applications After (1)

Application Number Title Priority Date Filing Date
DE3689748T Expired - Lifetime DE3689748T2 (de) 1985-09-11 1986-09-02 Benzimidazolderivate, Verfahren zu deren Herstellung und deren therapeutische Anwendung.

Country Status (24)

Country Link
US (2) US4820710A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
EP (1) EP0217700B1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
JP (1) JPS6261979A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
KR (1) KR930001411B1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
AR (1) AR243187A1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
AT (1) ATE103603T1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
AU (1) AU582894B2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
CA (1) CA1272486A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
CS (1) CS357991A3 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
DE (2) DE19775081I2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
DK (1) DK170594B1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
ES (1) ES2001782A6 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
FI (1) FI87210C (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
FR (1) FR2587029B1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
GR (1) GR862318B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
HU (1) HU196597B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
IE (1) IE61607B1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
IL (1) IL79992A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
LU (1) LU90085I2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
NL (1) NL970029I2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
NO (2) NO167026C (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
NZ (1) NZ217537A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
PT (1) PT83355B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
ZA (1) ZA866901B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2618435B1 (fr) * 1987-07-23 1989-10-27 Synthelabo Derives de benzimidazole, leur preparation et leur application en therapeutique
FR2637595B1 (fr) * 1988-10-11 1990-11-30 Synthelabo Derives de benzimidazole, leur preparation et leur application en therapeutique
JPH02294758A (ja) * 1989-05-09 1990-12-05 Nec Corp 計算機使用時間管理方式
FR2658823B1 (fr) * 1990-02-27 1992-04-30 Adir Nouveaux derives d'aminomethylpiperidine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent .
FR2666582B1 (fr) * 1990-09-07 1994-09-02 Synthelabo Derives de benzimidazole, leur preparation et leur application en therapeutique.
FR2693194B1 (fr) * 1992-07-03 1994-09-23 Synthelabo Dérivés d'alcanecarboxamide, leur préparation et leur application thérapeutique.
FR2745500B1 (fr) * 1996-03-04 1998-04-03 Synthelabo Formulations pharmaceutiques a liberation prolongee contenant de la mizolastine
JPH10101564A (ja) * 1996-09-27 1998-04-21 Mitsubishi Chem Corp 鼻炎予防及び／又は治療剤
ATE238998T1 (de) 1997-02-25 2003-05-15 Us Gov Health & Human Serv Substituierte benzimidazole als nicht-nucleoside reverse transcriptase inhibitore
FR2762214B1 (fr) * 1997-04-17 2000-10-06 Synthelabo Utilisation de la mizolastine pour la preparation d'un medicament destine au traitement de l'inflammation
EP0958820A1 (en) * 1998-05-19 1999-11-24 Sanofi-Synthelabo Use of an imidazol derivative for the manufacture of a medicament for treating auto-immunodiseases
ES2208098B1 (es) * 2002-10-02 2005-10-16 Ragactives, S.L. Procedimiento e intermedios para la obtencion de derivados de 1-(1h-bencimidazol-2-il)-4-(2-aminopirimidin) piperidina.
CA2540704A1 (en) * 2003-09-30 2005-05-19 Janssen Pharmaceutica N.V. Benzoimidazole compounds
ES2245227B1 (es) * 2004-04-06 2007-03-01 Ragactives, S.L. Formas cristalinas de mizolastina, procedimientos para su obtencion y composiciones farmaceuticas que las contienen.
PT2445502T (pt) 2009-06-25 2017-09-22 Alkermes Pharma Ireland Ltd Compostos heterocíclicos para o tratamento de distúrbios neurológicos e psicológicos
WO2010151711A1 (en) * 2009-06-25 2010-12-29 Alkermes, Inc. Prodrugs of nh-acidic compounds
CN102140076A (zh) * 2010-02-03 2011-08-03 辽宁本源制药有限公司 咪唑斯汀中间体的制备
ES2715562T3 (es) 2011-12-15 2019-06-04 Alkermes Pharma Ireland Ltd Profármacos de compuestos de amina secundaria
US11273158B2 (en) 2018-03-05 2022-03-15 Alkermes Pharma Ireland Limited Aripiprazole dosing strategy
EP3952866B1 (en) * 2019-04-11 2025-07-23 Teijin Pharma Limited Benzimidazole derivatives and their uses
US12084453B2 (en) 2021-12-10 2024-09-10 Incyte Corporation Bicyclic amines as CDK12 inhibitors
CN116655596A (zh) * 2022-02-17 2023-08-29 济南同路医药科技发展有限公司 一种大粒径咪唑斯汀原料药制备方法

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4281005A (en) * 1979-03-05 1981-07-28 Merck & Co., Inc. Novel 2-pyridylimidazole compounds
US4556660A (en) * 1982-07-12 1985-12-03 Janssen Pharmaceutica N.V. N-(Bicyclic heterocyclyl)-4-piperidinamines
DE3484096D1 (de) * 1983-11-30 1991-03-14 Janssen Pharmaceutica Nv Bizyklisches heterozyklyl aufveisende n-(bizyklisches heterozyklyl-4-piperidinamine.
US4588722A (en) * 1984-01-09 1986-05-13 Janssen Pharmaceutica N.V. N-(4-piperidinyl) bicyclic condensed 2-imidazolamine derivatives
PH23995A (en) * 1984-01-09 1990-02-09 Janssen Pharmaceutica Nv 4((bicycle heterocyclyl)-methyl and hetero)piperidines

Also Published As

Publication number Publication date
EP0217700A1 (fr) 1987-04-08
IL79992A0 (en) 1986-12-31
FR2587029A1 (fr) 1987-03-13
NO167026C (no) 1991-09-25
LU90085I2 (fr) 1997-09-25
ES2001782A6 (es) 1988-06-16
US4912219A (en) 1990-03-27
HU196597B (en) 1988-12-28
NO167026B (no) 1991-06-17
FI87210B (fi) 1992-08-31
DE3689748D1 (de) 1994-05-05
PT83355A (fr) 1986-10-01
DK431586A (da) 1987-03-12
EP0217700B1 (fr) 1994-03-30
IL79992A (en) 1990-07-12
KR870003100A (ko) 1987-04-15
NL970029I2 (nl) 1998-04-01
AU6255286A (en) 1987-03-12
JPH0460596B2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) 1992-09-28
JPS6261979A (ja) 1987-03-18
HK1005592A1 (en) 1999-01-15
AR243187A1 (es) 1993-07-30
HUT41771A (en) 1987-05-28
PT83355B (pt) 1989-05-12
US4820710A (en) 1989-04-11
NO863608D0 (no) 1986-09-10
FI87210C (fi) 1992-12-10
IE862416L (en) 1987-03-11
ATE103603T1 (de) 1994-04-15
NO2001017I1 (no) 2001-11-05
DK170594B1 (da) 1995-11-06
GR862318B (en) 1987-01-19
CS357991A3 (en) 1992-06-17
AU582894B2 (en) 1989-04-13
NO863608L (no) 1987-03-12
FI863661A0 (fi) 1986-09-10
FR2587029B1 (fr) 1987-10-30
KR930001411B1 (ko) 1993-02-27
ZA866901B (en) 1987-04-29
NZ217537A (en) 1988-11-29
DK431586D0 (da) 1986-09-10
NL970029I1 (nl) 1997-10-01
CA1272486A (en) 1990-08-07
DE3689748T2 (de) 1994-08-11
IE61607B1 (en) 1994-11-16
FI863661L (fi) 1987-03-12

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8327 Change in the person/name/address of the patent owner

Owner name: SANOFI-SYNTHELABO, PARIS, FR