DE1770479A1 - Verfahren zur Gewinnung von gereinigtem,hypoallergenem Hetacillin - Google Patents
Verfahren zur Gewinnung von gereinigtem,hypoallergenem HetacillinInfo
- Publication number
- DE1770479A1 DE1770479A1 DE19681770479 DE1770479A DE1770479A1 DE 1770479 A1 DE1770479 A1 DE 1770479A1 DE 19681770479 DE19681770479 DE 19681770479 DE 1770479 A DE1770479 A DE 1770479A DE 1770479 A1 DE1770479 A1 DE 1770479A1
- Authority
- DE
- Germany
- Prior art keywords
- hetacillin
- molecular weight
- hypoallergenic
- purified
- differences
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- DXVUYOAEDJXBPY-NFFDBFGFSA-N hetacillin Chemical compound C1([C@@H]2C(=O)N(C(N2)(C)C)[C@H]2[C@H]3SC([C@@H](N3C2=O)C(O)=O)(C)C)=CC=CC=C1 DXVUYOAEDJXBPY-NFFDBFGFSA-N 0.000 title claims description 17
- 229960003884 hetacillin Drugs 0.000 title claims description 17
- 238000000034 method Methods 0.000 title claims description 14
- 230000000774 hypoallergenic effect Effects 0.000 title claims description 8
- 238000000502 dialysis Methods 0.000 claims description 9
- 239000000126 substance Substances 0.000 claims description 8
- 150000003839 salts Chemical class 0.000 claims description 7
- 230000000890 antigenic effect Effects 0.000 claims description 5
- 239000002253 acid Substances 0.000 claims description 4
- 238000000746 purification Methods 0.000 claims description 4
- 238000004140 cleaning Methods 0.000 claims description 3
- 238000002523 gelfiltration Methods 0.000 claims description 3
- 239000012528 membrane Substances 0.000 claims description 3
- 238000002360 preparation method Methods 0.000 claims description 3
- 238000004519 manufacturing process Methods 0.000 claims description 2
- 230000000144 pharmacologic effect Effects 0.000 claims description 2
- 239000002243 precursor Substances 0.000 claims description 2
- 238000000108 ultra-filtration Methods 0.000 claims description 2
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 12
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 8
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 description 6
- 150000001413 amino acids Chemical class 0.000 description 6
- 239000000047 product Substances 0.000 description 6
- 102000004169 proteins and genes Human genes 0.000 description 6
- 108090000623 proteins and genes Proteins 0.000 description 6
- 239000000243 solution Substances 0.000 description 6
- 206010020751 Hypersensitivity Diseases 0.000 description 4
- ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 description 4
- 229910052700 potassium Inorganic materials 0.000 description 4
- 239000011591 potassium Substances 0.000 description 4
- 230000003115 biocidal effect Effects 0.000 description 3
- 230000007062 hydrolysis Effects 0.000 description 3
- 238000006460 hydrolysis reaction Methods 0.000 description 3
- 239000000203 mixture Substances 0.000 description 3
- ZWEHNKRNPOVVGH-UHFFFAOYSA-N 2-Butanone Chemical compound CCC(C)=O ZWEHNKRNPOVVGH-UHFFFAOYSA-N 0.000 description 2
- 229930182555 Penicillin Natural products 0.000 description 2
- 208000030961 allergic reaction Diseases 0.000 description 2
- 229920002301 cellulose acetate Polymers 0.000 description 2
- 238000004108 freeze drying Methods 0.000 description 2
- 239000012535 impurity Substances 0.000 description 2
- 239000002808 molecular sieve Substances 0.000 description 2
- 150000002960 penicillins Chemical class 0.000 description 2
- URGAHOPLAPQHLN-UHFFFAOYSA-N sodium aluminosilicate Chemical compound [Na+].[Al+3].[O-][Si]([O-])=O.[O-][Si]([O-])=O URGAHOPLAPQHLN-UHFFFAOYSA-N 0.000 description 2
- VPSXHKGJZJCWLV-UHFFFAOYSA-N 2-[4-[2-(2,3-dihydro-1H-inden-2-ylamino)pyrimidin-5-yl]-3-(1-ethylpiperidin-4-yl)oxypyrazol-1-yl]-1-(2,4,6,7-tetrahydrotriazolo[4,5-c]pyridin-5-yl)ethanone Chemical compound C1C(CC2=CC=CC=C12)NC1=NC=C(C=N1)C=1C(=NN(C=1)CC(=O)N1CC2=C(CC1)NN=N2)OC1CCN(CC1)CC VPSXHKGJZJCWLV-UHFFFAOYSA-N 0.000 description 1
- NGHVIOIJCVXTGV-ALEPSDHESA-N 6-aminopenicillanic acid Chemical compound [O-]C(=O)[C@H]1C(C)(C)S[C@@H]2[C@H]([NH3+])C(=O)N21 NGHVIOIJCVXTGV-ALEPSDHESA-N 0.000 description 1
- NGHVIOIJCVXTGV-UHFFFAOYSA-N 6beta-amino-penicillanic acid Natural products OC(=O)C1C(C)(C)SC2C(N)C(=O)N21 NGHVIOIJCVXTGV-UHFFFAOYSA-N 0.000 description 1
- 206010002199 Anaphylactic shock Diseases 0.000 description 1
- 208000010201 Exanthema Diseases 0.000 description 1
- 241001465754 Metazoa Species 0.000 description 1
- VCUFZILGIRCDQQ-KRWDZBQOSA-N N-[[(5S)-2-oxo-3-(2-oxo-3H-1,3-benzoxazol-6-yl)-1,3-oxazolidin-5-yl]methyl]-2-[[3-(trifluoromethoxy)phenyl]methylamino]pyrimidine-5-carboxamide Chemical compound O=C1O[C@H](CN1C1=CC2=C(NC(O2)=O)C=C1)CNC(=O)C=1C=NC(=NC=1)NCC1=CC(=CC=C1)OC(F)(F)F VCUFZILGIRCDQQ-KRWDZBQOSA-N 0.000 description 1
- 229920005654 Sephadex Polymers 0.000 description 1
- 239000012507 Sephadex™ Substances 0.000 description 1
- AVKUERGKIZMTKX-NJBDSQKTSA-N ampicillin Chemical compound C1([C@@H](N)C(=O)N[C@H]2[C@H]3SC([C@@H](N3C2=O)C(O)=O)(C)C)=CC=CC=C1 AVKUERGKIZMTKX-NJBDSQKTSA-N 0.000 description 1
- 208000003455 anaphylaxis Diseases 0.000 description 1
- 239000003242 anti bacterial agent Substances 0.000 description 1
- 229940088710 antibiotic agent Drugs 0.000 description 1
- 239000007795 chemical reaction product Substances 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 230000006735 deficit Effects 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 238000010828 elution Methods 0.000 description 1
- ZINJLDJMHCUBIP-UHFFFAOYSA-N ethametsulfuron-methyl Chemical compound CCOC1=NC(NC)=NC(NC(=O)NS(=O)(=O)C=2C(=CC=CC=2)C(=O)OC)=N1 ZINJLDJMHCUBIP-UHFFFAOYSA-N 0.000 description 1
- 238000001704 evaporation Methods 0.000 description 1
- 230000008020 evaporation Effects 0.000 description 1
- 201000005884 exanthem Diseases 0.000 description 1
- 238000000855 fermentation Methods 0.000 description 1
- 230000004151 fermentation Effects 0.000 description 1
- 239000000706 filtrate Substances 0.000 description 1
- 125000000524 functional group Chemical group 0.000 description 1
- 239000007924 injection Substances 0.000 description 1
- 238000002347 injection Methods 0.000 description 1
- 238000005342 ion exchange Methods 0.000 description 1
- 238000002955 isolation Methods 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 231100000956 nontoxicity Toxicity 0.000 description 1
- 239000002674 ointment Substances 0.000 description 1
- 229920001184 polypeptide Polymers 0.000 description 1
- XAEFZNCEHLXOMS-UHFFFAOYSA-M potassium benzoate Chemical compound [K+].[O-]C(=O)C1=CC=CC=C1 XAEFZNCEHLXOMS-UHFFFAOYSA-M 0.000 description 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 description 1
- 102000004196 processed proteins & peptides Human genes 0.000 description 1
- 108090000765 processed proteins & peptides Proteins 0.000 description 1
- 206010037844 rash Diseases 0.000 description 1
- 239000012266 salt solution Substances 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
- 206010040400 serum sickness Diseases 0.000 description 1
- 239000007858 starting material Substances 0.000 description 1
- 229920002994 synthetic fiber Polymers 0.000 description 1
- 239000008399 tap water Substances 0.000 description 1
- 235000020679 tap water Nutrition 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB2529267 | 1967-06-01 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DE1770479A1 true DE1770479A1 (de) | 1971-11-11 |
Family
ID=10225347
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE19681770479 Pending DE1770479A1 (de) | 1967-06-01 | 1968-05-22 | Verfahren zur Gewinnung von gereinigtem,hypoallergenem Hetacillin |
Country Status (5)
| Country | Link |
|---|---|
| BE (1) | BE715996A (en:Method) |
| DE (1) | DE1770479A1 (en:Method) |
| ES (1) | ES354385A1 (en:Method) |
| FR (1) | FR8075M (en:Method) |
| NL (1) | NL6806965A (en:Method) |
-
1968
- 1968-05-16 NL NL6806965A patent/NL6806965A/xx unknown
- 1968-05-22 DE DE19681770479 patent/DE1770479A1/de active Pending
- 1968-05-28 ES ES354385A patent/ES354385A1/es not_active Expired
- 1968-05-31 BE BE715996D patent/BE715996A/xx unknown
- 1968-06-26 FR FR156593A patent/FR8075M/fr not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| BE715996A (en:Method) | 1968-12-02 |
| ES354385A1 (es) | 1969-11-01 |
| FR8075M (en:Method) | 1970-07-15 |
| NL6806965A (en:Method) | 1968-12-02 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| DE3886134T2 (de) | Polysaccharide, extrahiert aus Pflanzen und verwendet als Medizinen und Zusatzstoffe für Nahrungsmittel. | |
| EP0167575B1 (de) | Cardiodilatin, ein neues peptidhormon und verfahren zu seiner herstellung | |
| DE2519938A1 (de) | Extrakte von corynebakterien, verfahren zu ihrer herstellung und ihre verwendung in arzneimittelzubereitungen | |
| DE2512975A1 (de) | Polypeptid mit thymischer wirksamkeit | |
| DE2433209A1 (de) | Hitzestabile plasmaproteinloesungen, verfahren zu ihrer herstellung und arzneipraeparate | |
| DE69508890T2 (de) | Verwendung eines Dekapeptids mit benzodiazepinischer Wirkung zur Herstellung von Arzneimitteln und Diätzusätzen | |
| DE2137011A1 (de) | Aus Konjac-Mehl gewonnenes Konjac-Mannan sowie dessen Herstellung und Verwendung | |
| DE1076888B (de) | Verfahren zur Gewinnung atmungsfoerdernder Wirkstoffe fuer therapeutische Zwecke | |
| DE2357800A1 (de) | Verfahren zur herstellung von gammaglobulin | |
| DE1940130C2 (de) | Verfahren zur Reinigung von Insulin, nach diesem Verfahren gereinigtes Insulin und dessen Verwendung | |
| DE2428955C3 (de) | Verfahren zur Abtrennung der enzymatischen Komponente mit in vivo antikoagulierender und in vitro koagulierender Wirkung aus dem Gift der Schlange Ancistrodon rhodostoma und daraus hergestellte Mittel | |
| EP0395851B1 (de) | Glykoproteine aus Avena sativa, Verfahren zu ihrer Herstellung und ihre Verwendung als pharmazeutischer Wirkstoff | |
| DE2234832C2 (de) | Proteinfreies Hormonkonzentrat von Säugetier-Nebenschilddrüsen, dessen Herstellung und dieses Hormonkonzentrat enthaltende pharmazeutische Präparate | |
| DE1770479A1 (de) | Verfahren zur Gewinnung von gereinigtem,hypoallergenem Hetacillin | |
| DE2333884A1 (de) | Verfahren zur herstellung von gereinigtem albumin und das dabei erhaltene gereinigte albumin | |
| DE2720041A1 (de) | Herzstaerkendes mittel | |
| DE2713680A1 (de) | Verfahren zur herstellung eines mittels mit mitogenen und/oder adjuvans-eigenschaften und dieses mittel enthaltende arzneimittel | |
| DE1818054C2 (de) | Verfahren zur Gewinnung von cytobiotischen Globulinen | |
| DE951228C (de) | Verfahren zur Stabilisierung eines adrenocorticotropen Praeparates | |
| DE1767404A1 (de) | Verfahren zur Gewinnung von Lysozym | |
| DE3633797C2 (de) | Verfahren zur Gewinnung von biologisch aktiven Eiweissen (Peptiden) aus menschlichem und tierischem Blut (bzw. anderen Körperflüssigkeiten) | |
| AT224807B (de) | Verfahren zur Gewinnung eines neuen tumorhemmenden Polysaccharids | |
| DE743986C (de) | Verfahren zur Gewinnung von proteolytischen Abwehrfermenten | |
| DE1467773A1 (de) | Polypeptid und Verfahren zur Herstellung desselben | |
| DE1617566C (de) | Verfahren zur Herstellung eines physio logisch aktiven Polypeptide |