DE1643460A1 - Carbonsaeureester und -amide und Verfahren zur Herstellung derselben - Google Patents

Carbonsaeureester und -amide und Verfahren zur Herstellung derselben

Info

Publication number
DE1643460A1
DE1643460A1 DE19671643460 DE1643460A DE1643460A1 DE 1643460 A1 DE1643460 A1 DE 1643460A1 DE 19671643460 DE19671643460 DE 19671643460 DE 1643460 A DE1643460 A DE 1643460A DE 1643460 A1 DE1643460 A1 DE 1643460A1
Authority
DE
Germany
Prior art keywords
chlorophenyl
trifluoromethylphenoxy
acetic acid
radical
ether
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
DE19671643460
Other languages
German (de)
English (en)
Inventor
Bolhofer William Alfred
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck and Co Inc
Original Assignee
Merck and Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck and Co Inc filed Critical Merck and Co Inc
Publication of DE1643460A1 publication Critical patent/DE1643460A1/de
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C275/00—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
    • C07C275/46—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups containing any of the groups, X being a hetero atom, Y being any atom, e.g. acylureas
    • C07C275/48—Y being a hydrogen or a carbon atom
    • C07C275/50—Y being a hydrogen or an acyclic carbon atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C275/00—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
    • C07C275/04—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to acyclic carbon atoms
    • C07C275/06—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to acyclic carbon atoms of an acyclic and saturated carbon skeleton
    • C07C275/10—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to acyclic carbon atoms of an acyclic and saturated carbon skeleton being further substituted by singly-bound oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/08—Preparation of carboxylic acids or their salts, halides or anhydrides from nitriles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/40—Unsaturated compounds
    • C07C59/58—Unsaturated compounds containing ether groups, groups, groups, or groups
    • C07C59/64—Unsaturated compounds containing ether groups, groups, groups, or groups containing six-membered aromatic rings
    • C07C59/66—Unsaturated compounds containing ether groups, groups, groups, or groups containing six-membered aromatic rings the non-carboxylic part of the ether containing six-membered aromatic rings
    • C07C59/68—Unsaturated compounds containing ether groups, groups, groups, or groups containing six-membered aromatic rings the non-carboxylic part of the ether containing six-membered aromatic rings the oxygen atom of the ether group being bound to a non-condensed six-membered aromatic ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
DE19671643460 1966-10-03 1967-10-02 Carbonsaeureester und -amide und Verfahren zur Herstellung derselben Withdrawn DE1643460A1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US58393766A 1966-10-03 1966-10-03

Publications (1)

Publication Number Publication Date
DE1643460A1 true DE1643460A1 (de) 1971-01-28

Family

ID=24335223

Family Applications (1)

Application Number Title Priority Date Filing Date
DE19671643460 Withdrawn DE1643460A1 (de) 1966-10-03 1967-10-02 Carbonsaeureester und -amide und Verfahren zur Herstellung derselben

Country Status (19)

Country Link
US (1) US3517050A (OSRAM)
AT (2) AT279590B (OSRAM)
BE (1) BE704574A (OSRAM)
BR (1) BR6793319D0 (OSRAM)
CH (1) CH512422A (OSRAM)
CS (1) CS170496B2 (OSRAM)
CY (1) CY650A (OSRAM)
DE (1) DE1643460A1 (OSRAM)
DK (1) DK120955B (OSRAM)
ES (1) ES345582A1 (OSRAM)
FI (1) FI48064C (OSRAM)
FR (2) FR1573841A (OSRAM)
GB (1) GB1182007A (OSRAM)
GR (1) GR34667B (OSRAM)
MY (1) MY7300079A (OSRAM)
NL (1) NL149484B (OSRAM)
NO (1) NO121787B (OSRAM)
SE (1) SE332182B (OSRAM)
YU (1) YU32921B (OSRAM)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3923855A (en) * 1972-07-13 1975-12-02 Merck & Co Inc 2-sulfonyloxyethyl 3-trifluoromethylphenoxy-4{40 -chlorophenyl acetate
US4110351A (en) * 1973-04-02 1978-08-29 Richardson-Merrell Inc. Hypolipidemic agents RO- or RS- substituted furoic acids, esters and salts
DK115374A (OSRAM) 1974-03-04 1975-11-03 Byk Gulden Lomberg Chem Fab
IL48707A0 (en) * 1974-12-30 1976-02-29 Synthelabo Novel phenylacetic acid derivatives,their preparation and pharmaceutical compositions containing them
FR2424247A2 (fr) * 1978-04-27 1979-11-23 Science Union & Cie Nouveaux derives d'acides arylalcanoiques a action hypolipemiante et leurs procedes d'obtention
US4250191A (en) * 1978-11-30 1981-02-10 Edwards K David Preventing renal failure
US6624194B1 (en) 1999-06-04 2003-09-23 Metabolex, Inc. Use of (−) (3-trihalomethylphenoxy) (4-halophenyl) acetic acid derivatives for treatment of insulin resistance, type 2 diabetes, hyperlipidemia and hyperuricemia
US6262118B1 (en) * 1999-06-04 2001-07-17 Metabolex, Inc. Use of (-) (3-trihalomethylphenoxy) (4-halophenyl) acetic acid derivatives for treatment of insulin resistance, type 2 diabetes and hyperlipidemia
US7576131B2 (en) * 1999-06-04 2009-08-18 Metabolex, Inc. Use of (-) (3-trihalomethylphenoxy) (4-halophenyl) acetic acid derivatives for treatment of insulin resistance, type 2 diabetes, hyperlipidemia and hyperuricemia
US7091230B2 (en) * 2001-02-09 2006-08-15 Merck & Co., Inc. 2-aryloxy-2-arylalkanoic acids for diabetes and lipid disorders
MXPA05013981A (es) * 2003-06-20 2006-03-02 Metabolex Inc Resolucion de derivados de acido a- (fenoxi) fenilacetico.
US7199259B2 (en) * 2003-06-20 2007-04-03 Metabolex, Inc. Resolution of α-(phenoxy)phenylacetic acid derivatives
CN100525757C (zh) * 2003-06-20 2009-08-12 麦它波莱克斯股份有限公司 α-(苯氧基)苯乙酸衍生物的拆分
USD492579S1 (en) 2003-10-15 2004-07-06 The Gates Corporation Pulley
RU2006133284A (ru) 2004-02-18 2008-03-27 Метаболекс Альфа-(трифторметилзамещенные арилокси, ариламино, арилтио или арилметил)трифторметилзамещенные фенилуксусные кислоты и производные как противодиабетические средства
JP2008500358A (ja) * 2004-05-25 2008-01-10 メタボレックス インコーポレーティッド Ｐｐａｒのモジュレーターとしての、二環式の置換されたトリアゾール、およびこれらの調製方法
US7323480B2 (en) * 2004-05-25 2008-01-29 Metabolex, Inc. Substituted triazoles as modulators of PPAR and methods of their preparation
US20080194646A1 (en) 2005-03-21 2008-08-14 Sanders Martin E Methods For Avoiding Edema in the Treatment of Metabolic, Inflammatory, and Cardiovascular Disorders
US7432394B2 (en) * 2005-09-23 2008-10-07 Metabolex, Inc. Resolution of α-(phenoxy) phenylacetic acid derivatives with naphthyl-alkylamines
US7714131B2 (en) * 2005-09-23 2010-05-11 Metabolex, Inc. Process for the stereoselective preparation of (−)-halofenate and derivatives thereof
WO2009121940A1 (en) * 2008-04-03 2009-10-08 Janssen Pharmaceutica Nv Process for the preparation of (-)-(4-chloro-phenyl)-(3-trifluoromethyl-phenoxy)-acetic acid 2-acetylamino-ethyl ester
US9060987B2 (en) 2011-11-04 2015-06-23 Cymabay Therapeutics, Inc. Methods for treating gout flares
US9023856B2 (en) 2011-11-04 2015-05-05 Cymabay Therapeutics, Inc. Methods for treating hyperuricemia in patients with gout using halofenate or halogenic acid and a second urate-lowering agent
AU2013257717A1 (en) * 2012-05-10 2014-11-27 Cellixbio Private Limited Compositions and methods for the treatment of metabolic syndrome
HK1211020A1 (en) * 2013-01-18 2016-05-13 Cymabay Therapeutics, Inc. Dcc mediated coupling for halofenate manufacture

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES251290A1 (es) * 1958-08-21 1960-04-01 Parke Davis & Co Un procedimiento para la producciën de alcohilaminas arilsustituidas

Also Published As

Publication number Publication date
NL149484B (nl) 1976-05-17
GR34667B (el) 1968-06-05
AT282617B (de) 1970-07-10
CY650A (en) 1972-07-12
YU32921B (en) 1975-12-31
YU185167A (en) 1975-06-30
US3517050A (en) 1970-06-23
FR8372M (OSRAM) 1971-02-22
SE332182B (OSRAM) 1971-02-01
BE704574A (OSRAM) 1968-04-02
MY7300079A (en) 1973-12-31
AT279590B (de) 1970-03-10
FR1573841A (OSRAM) 1969-07-11
FI48064B (OSRAM) 1974-02-28
NL6712584A (OSRAM) 1968-04-04
GB1182007A (en) 1970-02-25
DK120955B (da) 1971-08-09
FI48064C (fi) 1974-06-10
BR6793319D0 (pt) 1973-05-24
NO121787B (OSRAM) 1971-04-13
CS170496B2 (OSRAM) 1976-08-27
ES345582A1 (es) 1970-02-01
CH512422A (de) 1971-09-15

Similar Documents

Publication Publication Date Title
DE1643460A1 (de) Carbonsaeureester und -amide und Verfahren zur Herstellung derselben
DE2446010A1 (de) 4-(monoalkylamino)benzoesaeurederivate und verfahren zu ihrer herstellung
DE2445584A1 (de) Aminosaeureester
DE2414680A1 (de) Substituierte furancarbonsaeuren und furancarbonsaeureester, verfahren zu ihrer herstellung und pharmazeutische zubereitungen, die diese verbindungen enthalten
DE2640920C3 (de) N-ß-(3',4'-Bis-acyloxy-phenäthyl) -glutamine und deren Äthylester sowie diese Verbindungen enthaltende Arzneimittel
DE2439859A1 (de) Verfahren zur herstellung von 3-(3,4dihydroxy-phenyl)-serin
DE3025238A1 (de) Basische cycloalkanonoximaether, verfahren zur herstellung derselben und diese enthaltende arzneimittel
DE2157272B2 (de) Verwendung von bis-(p-Chlorphenoxy)acetylharnstoff
DE2843811A1 (de) Retinsaeure- und 7,8-dehydro-retinsaeure-n-(carboxy)-phenylamide
DE2038628C3 (de) N,N'-Di(carboxyalkyI)-p-phenylendiamine, deren Salze und Diäthylester, Verfahren zu ihrer Herstellung und ihre Verwendung
DD297402A5 (de) Neue aminopropanol-derivate, diese verbindungen als wirkstoff enthaltende arzneimittelpraeparate sowie verfahren zur herstellung derselben
DE3013502C2 (de) [2''-(Trifluormethyl)-phenthiazin-10''-yl-(n-prop-3'''ylpiperazin-4''''-yläth-2'''''-yl)]-ester, Verfahren zur Herstellung derselben und diese enthaltende Arzneimittel
DE2412388A1 (de) Dibenzothiophenderivate, verfahren zu deren herstellung und sie enthaltende arzneimittel
DE2522218B2 (de) Zusammensetzung für die Human- oder Veterinärmedizin, Methylaminderivate und Verfahren zu deren Herstellung
DD142875A5 (de) Verfahren zur herstellung von 2-aminoaethanolderivaten
DE1801312A1 (de) Verfahren zur Herstellung einer neuen Aryloxyalkansaeure und ihrer Salze
DE2639935A1 (de) Benzoesaeuren und verfahren zu ihrer herstellung
DE1643460C (de) (3-Trifluormethylphenoxy)-(4-chlorphenyl)-essigsäureester, Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende Arzneimittel
DE1768553B1 (de) [3-(N-Alkyl-acylamino)-2,4,6-trijod-phenoxy]-alkoxy-alkansaeuren und diese enthaltende Roentgenkontrastmittel
DE2749213C2 (OSRAM)
AT250933B (de) Verfahren zur Herstellung von neuen Carbonsäuren
DE1793592C3 (de) Substituierte Phenylessigsäuren und deren Salze sowie diese Verbindungen enthaltende pharmazeutische Zusammensetzungen
DE2713506A1 (de) Ester der 2- eckige klammer auf 4-(4-chlorbenzoyl)-phenoxy eckige klammer zu -2-methylpropionsaeure mit bis-(hydroxyalkylthio)-alkanen und sie enthaltende arzneimittel
AT360541B (de) Verfahren zur herstellung von neuen nicotinamido- und nicotinamidoalkylbenzoesaeuren und deren derivaten
AT251565B (de) Verfahren zur Herstellung von neuen Carbonsäuren

Legal Events

Date Code Title Description
E77 Valid patent as to the heymanns-index 1977
EHJ Ceased/non-payment of the annual fee