DE1642660A1 - Verfahren zur Gewinnung von Urokinase - Google Patents

Verfahren zur Gewinnung von Urokinase

Info

Publication number
DE1642660A1
DE1642660A1 DE19651642660 DE1642660A DE1642660A1 DE 1642660 A1 DE1642660 A1 DE 1642660A1 DE 19651642660 DE19651642660 DE 19651642660 DE 1642660 A DE1642660 A DE 1642660A DE 1642660 A1 DE1642660 A1 DE 1642660A1
Authority
DE
Germany
Prior art keywords
urokinase
gel
solution
sodium phosphate
ethoxyacridine
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
DE19651642660
Other languages
German (de)
English (en)
Inventor
Alex Lesuk
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
STWB Inc
Original Assignee
Sterling Drug Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sterling Drug Inc filed Critical Sterling Drug Inc
Publication of DE1642660A1 publication Critical patent/DE1642660A1/de
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • C12N9/6456—Plasminogen activators
    • C12N9/6462—Plasminogen activators u-Plasminogen activator (3.4.21.73), i.e. urokinase
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/21—Serine endopeptidases (3.4.21)
    • C12Y304/21073—Serine endopeptidases (3.4.21) u-Plasminogen activator (3.4.21.73), i.e. urokinase

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Biomedical Technology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
DE19651642660 1964-10-15 1965-10-13 Verfahren zur Gewinnung von Urokinase Pending DE1642660A1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US404156A US3355361A (en) 1964-10-15 1964-10-15 Recovery and purification of urokinase

Publications (1)

Publication Number Publication Date
DE1642660A1 true DE1642660A1 (de) 1971-07-29

Family

ID=23598395

Family Applications (4)

Application Number Title Priority Date Filing Date
DE19651642660 Pending DE1642660A1 (de) 1964-10-15 1965-10-13 Verfahren zur Gewinnung von Urokinase
DE19651442162 Pending DE1442162A1 (de) 1964-10-15 1965-10-13 Verfahren zur Gewinnung von Urokinase
DE19651642662 Pending DE1642662A1 (de) 1964-10-15 1965-10-13 Verfahren zur Gewinnung von Urokinase
DE19651642661 Pending DE1642661A1 (de) 1964-10-15 1965-10-13 Verfahren zur Gewinnung von Urokinase

Family Applications After (3)

Application Number Title Priority Date Filing Date
DE19651442162 Pending DE1442162A1 (de) 1964-10-15 1965-10-13 Verfahren zur Gewinnung von Urokinase
DE19651642662 Pending DE1642662A1 (de) 1964-10-15 1965-10-13 Verfahren zur Gewinnung von Urokinase
DE19651642661 Pending DE1642661A1 (de) 1964-10-15 1965-10-13 Verfahren zur Gewinnung von Urokinase

Country Status (8)

Country Link
US (1) US3355361A (enExample)
JP (3) JPS5142195B1 (enExample)
AT (1) AT278239B (enExample)
CH (1) CH495384A (enExample)
DE (4) DE1642660A1 (enExample)
DK (4) DK117821B (enExample)
GB (1) GB1068817A (enExample)
SE (1) SE314045B (enExample)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH467075A (de) * 1964-07-01 1969-01-15 Pharmexbio S A Verfahren zur Gewinnung von Urokinase
US3477910A (en) * 1966-10-17 1969-11-11 Century Lab Inc Method of production of urokinase
US3542646A (en) * 1966-11-22 1970-11-24 Green Cross Corp Process for fractionally obtaining urokinase and blood coagulation accelerator in human urine
US3477913A (en) * 1967-10-31 1969-11-11 Century Lab Inc Method of production of urokinase
US3544427A (en) * 1968-04-18 1970-12-01 Century Lab Inc Method of production of urokinase
US3620924A (en) * 1969-04-01 1971-11-16 Baxter Laboratories Inc Production of acid-active lactase
FR2190412A1 (en) * 1972-06-30 1974-02-01 Choay Sa Stable,pyrogen-free urokinase prepns - from human urine
BE789189A (fr) * 1971-09-24 1973-03-22 Choay Sa Perfectionnements aux procedes de preparation, de depyrogenation et de stabilisation de l'urokinase et compositions obtenues
JPS5341485A (en) * 1976-09-25 1978-04-14 Wakamoto Pharma Co Ltd Removing method of pyrogenic substance containe in urokinase
US4066506A (en) * 1976-10-08 1978-01-03 The United States Of America As Represented By The Secretary Of Health, Education And Welfare Method of separating and purifying two active forms of urokinase using affinity chromatography
JPS53142592A (en) * 1977-05-13 1978-12-12 Green Cross Corp:The Stabilization of urokinase heating
JPS53142593A (en) * 1977-12-12 1978-12-12 Green Cross Corp:The Stabilization of urokinase by heating
JPS54155784U (enExample) * 1978-04-21 1979-10-30
AU6642281A (en) * 1979-11-13 1981-06-03 Husain, S.S. Isolation of plasminogen activators useful as therapeutic anddiagnostic agents
USRE32271E (en) * 1979-11-13 1986-10-28 Isolation of plasminogen activators useful as therapeutic and diagnostic agents
US4370417A (en) * 1980-04-03 1983-01-25 Abbott Laboratories Recombinant deoxyribonucleic acid which codes for plasminogen activator
US4558010A (en) * 1980-04-03 1985-12-10 Abbott Laboratories Recombinant deoxyribonucleic acid which codes for plasminogen activator and method of making plasminogen activator protein therefrom
JPS58189122A (ja) * 1982-04-30 1983-11-04 Kaken Pharmaceut Co Ltd 高脂血症予防治療剤
DE3439980A1 (de) * 1984-11-02 1986-05-07 Behringwerke Ag, 3550 Marburg Verfahren zur reinigung sowie pasteurisierung von urokinase
US4920051A (en) * 1988-02-03 1990-04-24 Damon Biotech, Inc. Recovery of urokinase compounds

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3281331A (en) * 1961-11-08 1966-10-25 Astra Ab Process of isolating and separating proteolytic enzymes

Also Published As

Publication number Publication date
DE1642662A1 (de) 1971-05-19
AT278239B (de) 1970-01-26
DK117821B (da) 1970-06-08
JPS5619229B1 (enExample) 1981-05-06
DE1642661A1 (de) 1971-07-29
DK112162B (da) 1968-11-18
DE1442162A1 (de) 1969-01-16
US3355361A (en) 1967-11-28
JPS5619228B1 (enExample) 1981-05-06
JPS5142195B1 (enExample) 1976-11-13
CH495384A (de) 1970-08-31
DK115536B (da) 1969-10-20
GB1068817A (en) 1967-05-17
SE314045B (enExample) 1969-09-01
DK112232B (da) 1968-11-25

Similar Documents

Publication Publication Date Title
DE1642660A1 (de) Verfahren zur Gewinnung von Urokinase
DE3010801C2 (de) Verfahren zur Herstellung von Immunglobulin zur intravenösen Verabreichung
DE1054405B (de) Verfahren zur Gewinnung von Urokinasekonzentraten
CH652030A5 (de) Verfahren zur herstellung eines faktor-viii-hochkonzentrates aus blutplasma.
DE3229132A1 (de) Reinigung von rinder-thrombin
CH628246A5 (de) Verfahren zur herstellung eines schuetzenden pertussis-antigens.
DE2551966C3 (de) Verfahren zum Reinigen von Urokinase
DE3419581A1 (de) Verfahren zur gewinnung einer faktor xiii-praeparation sowie ihre verwendung
ES382048A1 (es) Procedimiento para obtener acido fenilacetico por carboni- lacion de cloruro de bencilo.
GB1472429A (en) Nitrohumic acid-based adsorbent
DE484464T1 (de) Methode der reinigung von proteinen.
DE2823353A1 (de) Verfahren zum reinigen von urokinase
DE2632212C3 (de) Verfahren zur Gewinnung von Urokinase
DE2428955A1 (de) Verfahren zur extraktion von bestandteilen mit in vivo antikoagulierender wirkung aus schlangengiften und daraus erhaltene produkte
JPS5547143A (en) Manufacture of ammonia deodorizer
DE2812609A1 (de) Verfahren zur reinigung roher urokinase
DE2635894A1 (de) Verfahren zur herstellung eines antihaemophiles globulin a enthaltenden konzentrats
GB1415453A (en) Composition and process for producing aquarium water having improved properties
AT264709B (de) Verfahren zur Herstellung von Urokinase für Injektionszwecke
DE1942900B2 (de) Verfahren zur abtrennung von l-asparaginase aus bakterienkulturen, danach hergestellte l-asparaginase und diese enthaltendes therapeutisches mittel
GB1069045A (en) A process for the preparation of cytochrome c
CH645406A5 (de) Plasminogenaktivierende substanz, deren herstellung und verwendung.
BG31214A3 (en) Method for obtaining of human albumine
ES383879A1 (es) Procedimiento para conservar piedra.
DE2057401C3 (de) Verfahren zur Isolierung von nativem, hochgereinigtem Plasminogen