JPS53142593A - Stabilization of urokinase by heating - Google Patents

Stabilization of urokinase by heating

Info

Publication number
JPS53142593A
JPS53142593A JP14976377A JP14976377A JPS53142593A JP S53142593 A JPS53142593 A JP S53142593A JP 14976377 A JP14976377 A JP 14976377A JP 14976377 A JP14976377 A JP 14976377A JP S53142593 A JPS53142593 A JP S53142593A
Authority
JP
Japan
Prior art keywords
urokinase
heating
stabilization
solution
followed
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP14976377A
Other languages
Japanese (ja)
Other versions
JPS6140392B2 (en
Inventor
Ryoichi Naito
Takehiko Kawano
Masayuki Nishida
Masakazu Tajima
Kazuo Morimoto
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Mitsubishi Tanabe Pharma Corp
Original Assignee
Green Cross Corp Japan
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Green Cross Corp Japan filed Critical Green Cross Corp Japan
Priority to JP14976377A priority Critical patent/JPS53142593A/en
Publication of JPS53142593A publication Critical patent/JPS53142593A/en
Publication of JPS6140392B2 publication Critical patent/JPS6140392B2/ja
Granted legal-status Critical Current

Links

Abstract

PURPOSE: To inactivate viruses in a urokinase-containing solution, by adjusting the pH of the solution to 6-8 by adding a buffer solution, followed by heating thereof.
COPYRIGHT: (C)1978,JPO&Japio
JP14976377A 1977-12-12 1977-12-12 Stabilization of urokinase by heating Granted JPS53142593A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP14976377A JPS53142593A (en) 1977-12-12 1977-12-12 Stabilization of urokinase by heating

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP14976377A JPS53142593A (en) 1977-12-12 1977-12-12 Stabilization of urokinase by heating

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
JP5589477A Division JPS53142592A (en) 1977-05-13 1977-05-13 Stabilization of urokinase heating

Publications (2)

Publication Number Publication Date
JPS53142593A true JPS53142593A (en) 1978-12-12
JPS6140392B2 JPS6140392B2 (en) 1986-09-09

Family

ID=15482199

Family Applications (1)

Application Number Title Priority Date Filing Date
JP14976377A Granted JPS53142593A (en) 1977-12-12 1977-12-12 Stabilization of urokinase by heating

Country Status (1)

Country Link
JP (1) JPS53142593A (en)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2444465A1 (en) * 1978-12-22 1980-07-18 Green Cross Corp Antithrombotic agent contg. urokinase - produced by maintaining pH neutral or weakly alkaline during each processing step for urokinase prodn.
JPS649937A (en) * 1987-05-22 1989-01-13 Armour Pharma Stabilization of biological and pharmacological product of virus and bacteria infected matter in thermal inactivation
US5932468A (en) * 1995-11-03 1999-08-03 Grupo Grifols, S.A. Method of inactivating viruses in proteins

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3355361A (en) * 1964-10-15 1967-11-28 Sterling Drug Inc Recovery and purification of urokinase

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3355361A (en) * 1964-10-15 1967-11-28 Sterling Drug Inc Recovery and purification of urokinase

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2444465A1 (en) * 1978-12-22 1980-07-18 Green Cross Corp Antithrombotic agent contg. urokinase - produced by maintaining pH neutral or weakly alkaline during each processing step for urokinase prodn.
JPS649937A (en) * 1987-05-22 1989-01-13 Armour Pharma Stabilization of biological and pharmacological product of virus and bacteria infected matter in thermal inactivation
US5932468A (en) * 1995-11-03 1999-08-03 Grupo Grifols, S.A. Method of inactivating viruses in proteins

Also Published As

Publication number Publication date
JPS6140392B2 (en) 1986-09-09

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