DE1598048B2 - Diagnostisches mittel zum nachweis von inhaltsstoffen des vollblutes - Google Patents
Diagnostisches mittel zum nachweis von inhaltsstoffen des vollblutesInfo
- Publication number
- DE1598048B2 DE1598048B2 DE1965B0082023 DEB0082023A DE1598048B2 DE 1598048 B2 DE1598048 B2 DE 1598048B2 DE 1965B0082023 DE1965B0082023 DE 1965B0082023 DE B0082023 A DEB0082023 A DE B0082023A DE 1598048 B2 DE1598048 B2 DE 1598048B2
- Authority
- DE
- Germany
- Prior art keywords
- whole blood
- blood
- diagnostic agent
- paper
- ingredients
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 210000004369 blood Anatomy 0.000 title claims description 19
- 239000008280 blood Substances 0.000 title claims description 19
- 229940039227 diagnostic agent Drugs 0.000 title claims description 6
- 239000000032 diagnostic agent Substances 0.000 title claims description 6
- 239000004615 ingredient Substances 0.000 title description 3
- 239000002250 absorbent Substances 0.000 claims description 6
- 230000002745 absorbent Effects 0.000 claims description 6
- 238000001514 detection method Methods 0.000 claims description 6
- 230000002209 hydrophobic effect Effects 0.000 claims description 5
- 229920001296 polysiloxane Polymers 0.000 claims description 3
- 239000000470 constituent Substances 0.000 claims description 2
- 239000000203 mixture Substances 0.000 claims description 2
- 239000003925 fat Substances 0.000 claims 1
- 239000000553 indicators and reagents Substances 0.000 claims 1
- 239000003921 oil Substances 0.000 claims 1
- 239000001993 wax Substances 0.000 claims 1
- 238000012360 testing method Methods 0.000 description 15
- YMWUJEATGCHHMB-UHFFFAOYSA-N Dichloromethane Chemical compound ClCCl YMWUJEATGCHHMB-UHFFFAOYSA-N 0.000 description 12
- 238000006243 chemical reaction Methods 0.000 description 8
- 238000005470 impregnation Methods 0.000 description 7
- COLNVLDHVKWLRT-QMMMGPOBSA-N L-phenylalanine Chemical compound OC(=O)[C@@H](N)CC1=CC=CC=C1 COLNVLDHVKWLRT-QMMMGPOBSA-N 0.000 description 6
- 229930182830 galactose Natural products 0.000 description 5
- 238000004519 manufacturing process Methods 0.000 description 5
- 229960005190 phenylalanine Drugs 0.000 description 5
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 5
- NUIURNJTPRWVAP-UHFFFAOYSA-N 3,3'-Dimethylbenzidine Chemical compound C1=C(N)C(C)=CC(C=2C=C(C)C(N)=CC=2)=C1 NUIURNJTPRWVAP-UHFFFAOYSA-N 0.000 description 4
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 4
- 210000003743 erythrocyte Anatomy 0.000 description 4
- 239000008103 glucose Substances 0.000 description 4
- COLNVLDHVKWLRT-UHFFFAOYSA-N phenylalanine Natural products OC(=O)C(N)CC1=CC=CC=C1 COLNVLDHVKWLRT-UHFFFAOYSA-N 0.000 description 4
- LWIHDJKSTIGBAC-UHFFFAOYSA-K tripotassium phosphate Chemical compound [K+].[K+].[K+].[O-]P([O-])([O-])=O LWIHDJKSTIGBAC-UHFFFAOYSA-K 0.000 description 4
- 102000003992 Peroxidases Human genes 0.000 description 3
- 238000000034 method Methods 0.000 description 3
- 239000012188 paraffin wax Substances 0.000 description 3
- 108040007629 peroxidase activity proteins Proteins 0.000 description 3
- 210000002966 serum Anatomy 0.000 description 3
- XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Chemical compound NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 description 2
- WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 description 2
- 239000004202 carbamide Substances 0.000 description 2
- 239000003795 chemical substances by application Substances 0.000 description 2
- 239000012153 distilled water Substances 0.000 description 2
- 229910000160 potassium phosphate Inorganic materials 0.000 description 2
- 235000011009 potassium phosphates Nutrition 0.000 description 2
- 239000001488 sodium phosphate Substances 0.000 description 2
- 229910000162 sodium phosphate Inorganic materials 0.000 description 2
- RYFMWSXOAZQYPI-UHFFFAOYSA-K trisodium phosphate Chemical compound [Na+].[Na+].[Na+].[O-]P([O-])([O-])=O RYFMWSXOAZQYPI-UHFFFAOYSA-K 0.000 description 2
- 229940045136 urea Drugs 0.000 description 2
- 102000003914 Cholinesterases Human genes 0.000 description 1
- 108090000322 Cholinesterases Proteins 0.000 description 1
- 229920000742 Cotton Polymers 0.000 description 1
- 108020005199 Dehydrogenases Proteins 0.000 description 1
- 108010015133 Galactose oxidase Proteins 0.000 description 1
- 108010015776 Glucose oxidase Proteins 0.000 description 1
- 239000004366 Glucose oxidase Substances 0.000 description 1
- 102000001554 Hemoglobins Human genes 0.000 description 1
- 108010054147 Hemoglobins Proteins 0.000 description 1
- 108010008292 L-Amino Acid Oxidase Proteins 0.000 description 1
- 102000007070 L-amino-acid oxidase Human genes 0.000 description 1
- 102000045595 Phosphoprotein Phosphatases Human genes 0.000 description 1
- 108700019535 Phosphoprotein Phosphatases Proteins 0.000 description 1
- 208000007536 Thrombosis Diseases 0.000 description 1
- 102000003929 Transaminases Human genes 0.000 description 1
- 108090000340 Transaminases Proteins 0.000 description 1
- 102000004142 Trypsin Human genes 0.000 description 1
- 108090000631 Trypsin Proteins 0.000 description 1
- LEHOTFFKMJEONL-UHFFFAOYSA-N Uric Acid Chemical compound N1C(=O)NC(=O)C2=C1NC(=O)N2 LEHOTFFKMJEONL-UHFFFAOYSA-N 0.000 description 1
- TVWHNULVHGKJHS-UHFFFAOYSA-N Uric acid Natural products N1C(=O)NC(=O)C2NC(=O)NC21 TVWHNULVHGKJHS-UHFFFAOYSA-N 0.000 description 1
- WQZGKKKJIJFFOK-PHYPRBDBSA-N alpha-D-galactose Chemical compound OC[C@H]1O[C@H](O)[C@H](O)[C@@H](O)[C@H]1O WQZGKKKJIJFFOK-PHYPRBDBSA-N 0.000 description 1
- 239000010425 asbestos Substances 0.000 description 1
- 238000009534 blood test Methods 0.000 description 1
- 239000000969 carrier Substances 0.000 description 1
- 239000001913 cellulose Substances 0.000 description 1
- 229920002678 cellulose Polymers 0.000 description 1
- 239000003153 chemical reaction reagent Substances 0.000 description 1
- 229940048961 cholinesterase Drugs 0.000 description 1
- 238000000576 coating method Methods 0.000 description 1
- 238000004040 coloring Methods 0.000 description 1
- 230000001419 dependent effect Effects 0.000 description 1
- 210000000624 ear auricle Anatomy 0.000 description 1
- 239000012530 fluid Substances 0.000 description 1
- 229940116332 glucose oxidase Drugs 0.000 description 1
- 235000019420 glucose oxidase Nutrition 0.000 description 1
- HNDVDQJCIGZPNO-UHFFFAOYSA-N histidine Natural products OC(=O)C(N)CC1=CN=CN1 HNDVDQJCIGZPNO-UHFFFAOYSA-N 0.000 description 1
- 230000000149 penetrating effect Effects 0.000 description 1
- 239000008363 phosphate buffer Substances 0.000 description 1
- 239000011148 porous material Substances 0.000 description 1
- 230000002940 repellent Effects 0.000 description 1
- 239000005871 repellent Substances 0.000 description 1
- 229910052895 riebeckite Inorganic materials 0.000 description 1
- 238000012216 screening Methods 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 239000012588 trypsin Substances 0.000 description 1
- 229940116269 uric acid Drugs 0.000 description 1
- 239000002023 wood Substances 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/54—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving glucose or galactose
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N1/00—Sampling; Preparing specimens for investigation
- G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/52—Use of compounds or compositions for colorimetric, spectrophotometric or fluorometric investigation, e.g. use of reagent paper and including single- and multilayer analytical elements
- G01N33/521—Single-layer analytical elements
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S435/00—Chemistry: molecular biology and microbiology
- Y10S435/805—Test papers
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T436/00—Chemistry: analytical and immunological testing
- Y10T436/14—Heterocyclic carbon compound [i.e., O, S, N, Se, Te, as only ring hetero atom]
- Y10T436/142222—Hetero-O [e.g., ascorbic acid, etc.]
- Y10T436/143333—Saccharide [e.g., DNA, etc.]
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T436/00—Chemistry: analytical and immunological testing
- Y10T436/14—Heterocyclic carbon compound [i.e., O, S, N, Se, Te, as only ring hetero atom]
- Y10T436/142222—Hetero-O [e.g., ascorbic acid, etc.]
- Y10T436/143333—Saccharide [e.g., DNA, etc.]
- Y10T436/144444—Glucose
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Molecular Biology (AREA)
- Hematology (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Organic Chemistry (AREA)
- Wood Science & Technology (AREA)
- General Physics & Mathematics (AREA)
- Biotechnology (AREA)
- Zoology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Microbiology (AREA)
- Urology & Nephrology (AREA)
- Biomedical Technology (AREA)
- Pathology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Genetics & Genomics (AREA)
- Emergency Medicine (AREA)
- Biophysics (AREA)
- Cell Biology (AREA)
- General Engineering & Computer Science (AREA)
- Food Science & Technology (AREA)
- Medicinal Chemistry (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Priority Applications (14)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| NL129843D NL129843C (enrdf_load_stackoverflow) | 1965-05-20 | ||
| DE1965B0082023 DE1598048B2 (de) | 1965-05-20 | 1965-05-20 | Diagnostisches mittel zum nachweis von inhaltsstoffen des vollblutes |
| US535010A US3418083A (en) | 1965-05-20 | 1966-03-17 | Hydrophobic test strip for analyzing whole blood |
| SE06543/66A SE326318B (enrdf_load_stackoverflow) | 1965-05-20 | 1966-05-12 | |
| FI661290A FI41879C (fi) | 1965-05-20 | 1966-05-16 | Diagnostinen aine kokoveren sisältämien aineosien määräämiseksi |
| ES0326843A ES326843A1 (es) | 1965-05-20 | 1966-05-17 | Procedimiento de fabricacion de un medio de diagnosis para el reconocimiento de constituyentes de sangre pura. |
| CH714966A CH458793A (de) | 1965-05-20 | 1966-05-17 | Diagnostisches Mittel zum Nachweis von Inhaltsstoffen des Vollblutes |
| FR62067A FR1484845A (fr) | 1965-05-20 | 1966-05-18 | Agent de diagnostic pour la détection de susbstances contenues dans le sang entier |
| NL6606814A NL6606814A (enrdf_load_stackoverflow) | 1965-05-20 | 1966-05-18 | |
| AT474366A AT262511B (de) | 1965-05-20 | 1966-05-18 | Diagnostisches Mittel zum Nachweis von Inhaltsstoffen des Vollblutes |
| LU51140A LU51140A1 (enrdf_load_stackoverflow) | 1965-05-20 | 1966-05-18 | |
| NO163069A NO116823B (enrdf_load_stackoverflow) | 1965-05-20 | 1966-05-18 | |
| GB22112/66A GB1083683A (en) | 1965-05-20 | 1966-05-18 | Diagnostic agents |
| BE681364D BE681364A (enrdf_load_stackoverflow) | 1965-05-20 | 1966-05-20 |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE1965B0082023 DE1598048B2 (de) | 1965-05-20 | 1965-05-20 | Diagnostisches mittel zum nachweis von inhaltsstoffen des vollblutes |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE1598048A1 DE1598048A1 (de) | 1969-06-12 |
| DE1598048B2 true DE1598048B2 (de) | 1977-06-16 |
Family
ID=6981343
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE1965B0082023 Granted DE1598048B2 (de) | 1965-05-20 | 1965-05-20 | Diagnostisches mittel zum nachweis von inhaltsstoffen des vollblutes |
Country Status (13)
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3237233A1 (de) * | 1982-08-02 | 1984-02-02 | Eiken Kagaku K.K., Tokyo | Teststueck fuer die quantitative analyse von substanzen in koerperfluessigkeiten |
| EP0207360A3 (en) * | 1985-06-28 | 1988-01-07 | Miles Laboratories, Inc. | Diagnostic test device |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3607093A (en) * | 1968-02-15 | 1971-09-21 | Schering Corp | Devices for testing biological liquids |
| GB1364980A (en) * | 1972-02-25 | 1974-08-29 | Omnium Tech Administrat | Models of macro structures |
| US3917453A (en) * | 1974-08-16 | 1975-11-04 | Polaroid Corp | Method and device for determining the concentration of a substance in a fluid |
| CS175782B1 (enrdf_load_stackoverflow) * | 1974-10-16 | 1977-05-31 | ||
| AT347600B (de) * | 1974-11-11 | 1979-01-10 | Wellcome Found | Testeinrichtungen |
| DE2460903C3 (de) * | 1974-12-21 | 1981-12-24 | Boehringer Mannheim Gmbh, 6800 Mannheim | Neue 3,3',5,5'-Tetraalkylbenzidine |
| US4160008A (en) * | 1978-01-26 | 1979-07-03 | Miles Laboratories, Inc. | Multilayered test device for determining the presence of a liquid sample component, and method of use |
| US4336330A (en) * | 1980-12-15 | 1982-06-22 | Miles Laboratories, Inc. | Device for detecting glucose concentration |
| US4557900A (en) * | 1982-09-28 | 1985-12-10 | Cardiovascular Devices, Inc. | Optical sensor with beads |
| DE3343636A1 (de) * | 1982-12-07 | 1984-06-07 | AVL AG, 8201 Schaffhausen | Sensorelement fuer fluoreszenzoptische messung sowie verfahren zu seiner herstellung |
| US4522786A (en) * | 1983-08-10 | 1985-06-11 | E. I. Du Pont De Nemours And Company | Multilayered test device for detecting analytes in liquid test samples |
| US4689309A (en) * | 1985-09-30 | 1987-08-25 | Miles Laboratories, Inc. | Test device, method of manufacturing same and method of determining a component in a sample |
| DE3800661A1 (de) * | 1988-01-13 | 1989-07-27 | Zuckerindustrie Verein | Teststreifen aus einem saugfaehigen werkstoff oder mit einer saugfaehigen beschichtung aus diesem werkstoff sowie verfahren zu seiner herstellung |
| US5312759A (en) * | 1989-12-20 | 1994-05-17 | Iatron Laboratories, Inc. | Method for measurement of fructosamines using 1,2-quinones |
| US5962215A (en) * | 1996-04-05 | 1999-10-05 | Mercury Diagnostics, Inc. | Methods for testing the concentration of an analyte in a body fluid |
| GB9614851D0 (en) * | 1996-07-17 | 1996-09-04 | Cunningham Robert W | New test device for mass screening |
| US20030211006A1 (en) * | 2002-05-10 | 2003-11-13 | Suyue Qian | Multilayer reagent test strips that include at least one fluid flow control layer and methods for using the same |
| WO2006000999A1 (en) * | 2004-06-24 | 2006-01-05 | University College Cork - National University Of Ireland, Cork | Support for biological or chemical arrays having increased spot quality |
| CA2849804C (en) | 2011-09-28 | 2019-07-16 | Power Fit S.R.L. | Measurement of lactic acid in biological fluids |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3092465A (en) * | 1960-03-25 | 1963-06-04 | Miles Lab | Diagnostic test device for blood sugar |
| US3298789A (en) * | 1964-12-14 | 1967-01-17 | Miles Lab | Test article for the detection of glucose |
-
0
- NL NL129843D patent/NL129843C/xx active
-
1965
- 1965-05-20 DE DE1965B0082023 patent/DE1598048B2/de active Granted
-
1966
- 1966-03-17 US US535010A patent/US3418083A/en not_active Expired - Lifetime
- 1966-05-12 SE SE06543/66A patent/SE326318B/xx unknown
- 1966-05-16 FI FI661290A patent/FI41879C/fi active
- 1966-05-17 CH CH714966A patent/CH458793A/de unknown
- 1966-05-17 ES ES0326843A patent/ES326843A1/es not_active Expired
- 1966-05-18 NL NL6606814A patent/NL6606814A/xx unknown
- 1966-05-18 LU LU51140A patent/LU51140A1/xx unknown
- 1966-05-18 FR FR62067A patent/FR1484845A/fr not_active Expired
- 1966-05-18 GB GB22112/66A patent/GB1083683A/en not_active Expired
- 1966-05-18 NO NO163069A patent/NO116823B/no unknown
- 1966-05-18 AT AT474366A patent/AT262511B/de active
- 1966-05-20 BE BE681364D patent/BE681364A/xx unknown
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3237233A1 (de) * | 1982-08-02 | 1984-02-02 | Eiken Kagaku K.K., Tokyo | Teststueck fuer die quantitative analyse von substanzen in koerperfluessigkeiten |
| EP0207360A3 (en) * | 1985-06-28 | 1988-01-07 | Miles Laboratories, Inc. | Diagnostic test device |
Also Published As
| Publication number | Publication date |
|---|---|
| GB1083683A (en) | 1967-09-20 |
| CH458793A (de) | 1968-06-30 |
| FR1484845A (fr) | 1967-06-16 |
| FI41879B (enrdf_load_stackoverflow) | 1969-12-01 |
| AT262511B (de) | 1968-06-10 |
| SE326318B (enrdf_load_stackoverflow) | 1970-07-20 |
| US3418083A (en) | 1968-12-24 |
| BE681364A (enrdf_load_stackoverflow) | 1966-11-21 |
| NL129843C (enrdf_load_stackoverflow) | |
| FI41879C (fi) | 1970-03-10 |
| LU51140A1 (enrdf_load_stackoverflow) | 1966-07-18 |
| DE1598048A1 (de) | 1969-06-12 |
| NL6606814A (enrdf_load_stackoverflow) | 1966-11-21 |
| NO116823B (enrdf_load_stackoverflow) | 1969-05-27 |
| ES326843A1 (es) | 1967-03-16 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C3 | Grant after two publication steps (3rd publication) | ||
| EHJ | Ceased/non-payment of the annual fee |