DE1568807C3 - Verfahren zur Herstellung von aktiven Calciumsuccinaten in eis-Form - Google Patents
Verfahren zur Herstellung von aktiven Calciumsuccinaten in eis-FormInfo
- Publication number
- DE1568807C3 DE1568807C3 DE1568807A DE1568807A DE1568807C3 DE 1568807 C3 DE1568807 C3 DE 1568807C3 DE 1568807 A DE1568807 A DE 1568807A DE 1568807 A DE1568807 A DE 1568807A DE 1568807 C3 DE1568807 C3 DE 1568807C3
- Authority
- DE
- Germany
- Prior art keywords
- calcium
- succinates
- succinic acid
- production
- active calcium
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- PBUBJNYXWIDFMU-UHFFFAOYSA-L calcium;butanedioate Chemical class [Ca+2].[O-]C(=O)CCC([O-])=O PBUBJNYXWIDFMU-UHFFFAOYSA-L 0.000 title claims description 19
- 238000000034 method Methods 0.000 title claims description 8
- 238000004519 manufacturing process Methods 0.000 title claims description 4
- KDYFGRWQOYBRFD-UHFFFAOYSA-N succinic acid Chemical compound OC(=O)CCC(O)=O KDYFGRWQOYBRFD-UHFFFAOYSA-N 0.000 claims description 29
- 239000001384 succinic acid Substances 0.000 claims description 15
- 159000000007 calcium salts Chemical class 0.000 claims description 3
- 239000002253 acid Substances 0.000 claims description 2
- 150000003839 salts Chemical class 0.000 claims 1
- 239000011575 calcium Substances 0.000 description 16
- 241000699670 Mus sp. Species 0.000 description 8
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 8
- 239000007864 aqueous solution Substances 0.000 description 7
- ZVQOOHYFBIDMTQ-UHFFFAOYSA-N [methyl(oxido){1-[6-(trifluoromethyl)pyridin-3-yl]ethyl}-lambda(6)-sulfanylidene]cyanamide Chemical compound N#CN=S(C)(=O)C(C)C1=CC=C(C(F)(F)F)N=C1 ZVQOOHYFBIDMTQ-UHFFFAOYSA-N 0.000 description 6
- 230000009102 absorption Effects 0.000 description 6
- 238000010521 absorption reaction Methods 0.000 description 6
- 229910052791 calcium Inorganic materials 0.000 description 6
- 150000003890 succinate salts Chemical class 0.000 description 6
- 230000003217 anti-cancerogenic effect Effects 0.000 description 5
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 4
- VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical compound [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 description 4
- 230000004083 survival effect Effects 0.000 description 4
- WSFSSNUMVMOOMR-UHFFFAOYSA-N Formaldehyde Chemical compound O=C WSFSSNUMVMOOMR-UHFFFAOYSA-N 0.000 description 3
- 206010028980 Neoplasm Diseases 0.000 description 3
- 238000000862 absorption spectrum Methods 0.000 description 3
- 201000011510 cancer Diseases 0.000 description 3
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 description 3
- 238000006243 chemical reaction Methods 0.000 description 3
- 239000003795 chemical substances by application Substances 0.000 description 3
- 239000000706 filtrate Substances 0.000 description 3
- 229910052739 hydrogen Inorganic materials 0.000 description 3
- 239000001257 hydrogen Substances 0.000 description 3
- 238000002360 preparation method Methods 0.000 description 3
- 239000000243 solution Substances 0.000 description 3
- 241000251468 Actinopterygii Species 0.000 description 2
- 241001465754 Metazoa Species 0.000 description 2
- 210000001015 abdomen Anatomy 0.000 description 2
- 230000037396 body weight Effects 0.000 description 2
- 229910000019 calcium carbonate Inorganic materials 0.000 description 2
- 239000013078 crystal Substances 0.000 description 2
- 239000012153 distilled water Substances 0.000 description 2
- OGNXNCLSLZOOPG-UHFFFAOYSA-F C(CCC(=O)[O-])(=O)[O-].[Ca+2].[Ca+2].[Ca+2].[Ca+2].C(CCC(=O)[O-])(=O)[O-].C(CCC(=O)[O-])(=O)[O-].C(CCC(=O)[O-])(=O)[O-] Chemical compound C(CCC(=O)[O-])(=O)[O-].[Ca+2].[Ca+2].[Ca+2].[Ca+2].C(CCC(=O)[O-])(=O)[O-].C(CCC(=O)[O-])(=O)[O-].C(CCC(=O)[O-])(=O)[O-] OGNXNCLSLZOOPG-UHFFFAOYSA-F 0.000 description 1
- -1 Calcium pentasuccinate Chemical compound 0.000 description 1
- 241000283153 Cetacea Species 0.000 description 1
- 208000000059 Dyspnea Diseases 0.000 description 1
- 206010013975 Dyspnoeas Diseases 0.000 description 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 1
- 239000005662 Paraffin oil Substances 0.000 description 1
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 1
- YCQNYYQBPIRAEO-UHFFFAOYSA-H [Ca++].[Ca++].[Ca++].[O-]C(=O)CCC([O-])=O.[O-]C(=O)CCC([O-])=O.[O-]C(=O)CCC([O-])=O Chemical compound [Ca++].[Ca++].[Ca++].[O-]C(=O)CCC([O-])=O.[O-]C(=O)CCC([O-])=O.[O-]C(=O)CCC([O-])=O YCQNYYQBPIRAEO-UHFFFAOYSA-H 0.000 description 1
- 230000003187 abdominal effect Effects 0.000 description 1
- 125000001931 aliphatic group Chemical group 0.000 description 1
- 230000003266 anti-allergic effect Effects 0.000 description 1
- 239000003005 anticarcinogenic agent Substances 0.000 description 1
- 239000002220 antihypertensive agent Substances 0.000 description 1
- 229940030600 antihypertensive agent Drugs 0.000 description 1
- 239000003443 antiviral agent Substances 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- KDYFGRWQOYBRFD-NUQCWPJISA-N butanedioic acid Chemical class O[14C](=O)CC[14C](O)=O KDYFGRWQOYBRFD-NUQCWPJISA-N 0.000 description 1
- AXCZMVOFGPJBDE-UHFFFAOYSA-L calcium dihydroxide Chemical compound [OH-].[OH-].[Ca+2] AXCZMVOFGPJBDE-UHFFFAOYSA-L 0.000 description 1
- 239000000920 calcium hydroxide Substances 0.000 description 1
- 229910001861 calcium hydroxide Inorganic materials 0.000 description 1
- 230000000747 cardiac effect Effects 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 239000002781 deodorant agent Substances 0.000 description 1
- 230000001877 deodorizing effect Effects 0.000 description 1
- RTEZGDQCOFKPKO-UHFFFAOYSA-J dicalcium butanedioate Chemical compound [Ca+2].[Ca+2].[O-]C(=O)CCC([O-])=O.[O-]C(=O)CCC([O-])=O RTEZGDQCOFKPKO-UHFFFAOYSA-J 0.000 description 1
- 239000002934 diuretic Substances 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 230000008020 evaporation Effects 0.000 description 1
- 238000001704 evaporation Methods 0.000 description 1
- 238000010438 heat treatment Methods 0.000 description 1
- 238000002329 infrared spectrum Methods 0.000 description 1
- 230000007721 medicinal effect Effects 0.000 description 1
- 230000008018 melting Effects 0.000 description 1
- 238000002844 melting Methods 0.000 description 1
- 230000004060 metabolic process Effects 0.000 description 1
- WSFSSNUMVMOOMR-NJFSPNSNSA-N methanone Chemical compound O=[14CH2] WSFSSNUMVMOOMR-NJFSPNSNSA-N 0.000 description 1
- 239000002504 physiological saline solution Substances 0.000 description 1
- XAEFZNCEHLXOMS-UHFFFAOYSA-M potassium benzoate Chemical compound [K+].[O-]C(=O)C1=CC=CC=C1 XAEFZNCEHLXOMS-UHFFFAOYSA-M 0.000 description 1
- 239000000047 product Substances 0.000 description 1
- 230000001105 regulatory effect Effects 0.000 description 1
- 208000013220 shortness of breath Diseases 0.000 description 1
- 239000011780 sodium chloride Substances 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
- 238000000859 sublimation Methods 0.000 description 1
- 230000008022 sublimation Effects 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- KDYFGRWQOYBRFD-UHFFFAOYSA-L succinate(2-) Chemical compound [O-]C(=O)CCC([O-])=O KDYFGRWQOYBRFD-UHFFFAOYSA-L 0.000 description 1
- 230000001256 tonic effect Effects 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
- 238000005303 weighing Methods 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C55/00—Saturated compounds having more than one carboxyl group bound to acyclic carbon atoms
- C07C55/02—Dicarboxylic acids
- C07C55/10—Succinic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/16—Central respiratory analeptics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/26—Psychostimulants, e.g. nicotine, cocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/10—Antioedematous agents; Diuretics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Cardiology (AREA)
- Pulmonology (AREA)
- Oncology (AREA)
- Heart & Thoracic Surgery (AREA)
- Obesity (AREA)
- Communicable Diseases (AREA)
- Biomedical Technology (AREA)
- Virology (AREA)
- Endocrinology (AREA)
- Hospice & Palliative Care (AREA)
- Emergency Medicine (AREA)
- Psychiatry (AREA)
- Immunology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Disinfection, Sterilisation Or Deodorisation Of Air (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP40077042A JPS498849B1 (cg-RX-API-DMAC7.html) | 1965-12-16 | 1965-12-16 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| DE1568807A1 DE1568807A1 (de) | 1970-04-02 |
| DE1568807B2 DE1568807B2 (cg-RX-API-DMAC7.html) | 1974-06-12 |
| DE1568807C3 true DE1568807C3 (de) | 1975-02-20 |
Family
ID=13622700
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE1568807A Expired DE1568807C3 (de) | 1965-12-16 | 1966-12-14 | Verfahren zur Herstellung von aktiven Calciumsuccinaten in eis-Form |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US3527798A (cg-RX-API-DMAC7.html) |
| JP (1) | JPS498849B1 (cg-RX-API-DMAC7.html) |
| CH (1) | CH480284A (cg-RX-API-DMAC7.html) |
| DE (1) | DE1568807C3 (cg-RX-API-DMAC7.html) |
| FR (1) | FR1505788A (cg-RX-API-DMAC7.html) |
| GB (1) | GB1173615A (cg-RX-API-DMAC7.html) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2019261A1 (en) * | 1969-03-19 | 1970-07-03 | Melon Jean Marie | Treatment of oxalic lithiase with succinic - acid and its derivs |
| RU2174508C1 (ru) * | 2000-02-29 | 2001-10-10 | Казанская государственная академия ветеринарной медицины им. Н.Э. Баумана | Способ получения сукцинатов d-элементов |
| RU2228183C2 (ru) * | 2002-07-18 | 2004-05-10 | ЗАО "НПО ПЦ Биофизика" | Средство для трансмембранной доставки катионов двухвалентных металлов, обеспечивающее их включение во внутриклеточный синтез |
| RU2290395C8 (ru) * | 2005-06-01 | 2007-06-27 | Пятигорская государственная фармацевтическая академия | Способ получения сукцината кальция |
| RU2315032C1 (ru) * | 2006-04-27 | 2008-01-20 | Федеральное государственное образовательное учреждение высшего профессионального образования "Московская государственная академия ветеринарной медицины и биотехнологии имени К.И. Скрябина | Способ получения сукцината марганца (ii) тетрагидрата |
| RU2638157C1 (ru) * | 2016-09-19 | 2017-12-12 | Евгений Ильич Маевский | Способ получения комплексных кислых солей двухвалентных металлов дикарбоновых кислот |
-
1965
- 1965-12-16 JP JP40077042A patent/JPS498849B1/ja active Pending
-
1966
- 1966-12-12 US US600949A patent/US3527798A/en not_active Expired - Lifetime
- 1966-12-14 DE DE1568807A patent/DE1568807C3/de not_active Expired
- 1966-12-15 CH CH1790166A patent/CH480284A/fr not_active IP Right Cessation
- 1966-12-15 GB GB56323/66A patent/GB1173615A/en not_active Expired
- 1966-12-16 FR FR87824A patent/FR1505788A/fr not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| JPS498849B1 (cg-RX-API-DMAC7.html) | 1974-02-28 |
| GB1173615A (en) | 1969-12-10 |
| US3527798A (en) | 1970-09-08 |
| DE1568807A1 (de) | 1970-04-02 |
| CH480284A (fr) | 1969-10-31 |
| FR1505788A (fr) | 1967-12-15 |
| DE1568807B2 (cg-RX-API-DMAC7.html) | 1974-06-12 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C3 | Grant after two publication steps (3rd publication) | ||
| E77 | Valid patent as to the heymanns-index 1977 |