DE1241443B - Verfahren zur Herstellung alicyclischer Diamine mit den Blutcholesterinspiegel senkender Wirkung - Google Patents

Verfahren zur Herstellung alicyclischer Diamine mit den Blutcholesterinspiegel senkender Wirkung

Info

Publication number
DE1241443B
DE1241443B DEA44861A DEA0044861A DE1241443B DE 1241443 B DE1241443 B DE 1241443B DE A44861 A DEA44861 A DE A44861A DE A0044861 A DEA0044861 A DE A0044861A DE 1241443 B DE1241443 B DE 1241443B
Authority
DE
Germany
Prior art keywords
radical
bis
yield
found
calculated
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
DEA44861A
Other languages
German (de)
English (en)
Other versions
DE1241443C2 (enExample
Inventor
Leslie George Humber
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Mckenna & Harrison Ltd
Wyeth Canada Inc
Original Assignee
Mckenna & Harrison Ltd
Ayerst Mckenna and Harrison Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US256270A external-priority patent/US3202712A/en
Priority claimed from US285204A external-priority patent/US3202703A/en
Priority claimed from US298590A external-priority patent/US3154582A/en
Priority claimed from US328521A external-priority patent/US3244750A/en
Application filed by Mckenna & Harrison Ltd, Ayerst Mckenna and Harrison Inc filed Critical Mckenna & Harrison Ltd
Publication of DE1241443B publication Critical patent/DE1241443B/de
Application granted granted Critical
Publication of DE1241443C2 publication Critical patent/DE1241443C2/de
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C209/00—Preparation of compounds containing amino groups bound to a carbon skeleton
    • C07C209/24—Preparation of compounds containing amino groups bound to a carbon skeleton by reductive alkylation of ammonia, amines or compounds having groups reducible to amino groups, with carbonyl compounds
    • C07C209/28—Preparation of compounds containing amino groups bound to a carbon skeleton by reductive alkylation of ammonia, amines or compounds having groups reducible to amino groups, with carbonyl compounds by reduction with other reducing agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14—The ring being saturated
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2603/00—Systems containing at least three condensed rings
    • C07C2603/02—Ortho- or ortho- and peri-condensed systems
    • C07C2603/04—Ortho- or ortho- and peri-condensed systems containing three rings
    • C07C2603/06—Ortho- or ortho- and peri-condensed systems containing three rings containing at least one ring with less than six ring members
    • C07C2603/10—Ortho- or ortho- and peri-condensed systems containing three rings containing at least one ring with less than six ring members containing five-membered rings
    • C07C2603/12—Ortho- or ortho- and peri-condensed systems containing three rings containing at least one ring with less than six ring members containing five-membered rings only one five-membered ring
    • C07C2603/18—Fluorenes; Hydrogenated fluorenes

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
DEA44861A 1962-12-21 1963-12-20 Verfahren zur Herstellung alicyclischer Diamine mit den Blutcholesterinspiegel senkender Wirkung Granted DE1241443B (de)

Applications Claiming Priority (10)

Application Number Priority Date Filing Date Title
CA865190 1962-12-21
US256270A US3202712A (en) 1963-02-05 1963-02-05 1-cyclohexene-4-bis (omicron-chlorobenzylaminomethyl) and derivatives
CA865191 1963-02-12
CA868682 1963-02-12
US285204A US3202703A (en) 1963-06-04 1963-06-04 1, 4-bis (omicron-chlorobenzylamino)-cyclohexane and salt thereof
US298590A US3154582A (en) 1963-07-30 1963-07-30 Aminoindane derivatives and their preparation
CA881631 1963-08-02
CA881632 1963-08-02
CA881630 1963-08-02
US328521A US3244750A (en) 1963-12-06 1963-12-06 Nu, nu'-disubstituted-aliphatic-bis-aminomethyl-cyclohexane derivatives

Publications (2)

Publication Number Publication Date
DE1241443B true DE1241443B (de) 1967-06-01
DE1241443C2 DE1241443C2 (enExample) 1967-11-30

Family

ID=37123746

Family Applications (1)

Application Number Title Priority Date Filing Date
DEA44861A Granted DE1241443B (de) 1962-12-21 1963-12-20 Verfahren zur Herstellung alicyclischer Diamine mit den Blutcholesterinspiegel senkender Wirkung

Country Status (6)

Country Link
CH (1) CH452508A (enExample)
DE (1) DE1241443B (enExample)
DK (1) DK125172B (enExample)
FR (1) FR3559M (enExample)
GB (1) GB1074578A (enExample)
SE (1) SE322769B (enExample)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5145874A (en) * 1985-10-18 1992-09-08 The Upjohn Company Cyclic hydrocarbons with an aminoalkyl sidechain
EP0243449A1 (en) * 1985-10-18 1987-11-04 The Upjohn Company Cyclic hydrocarbons with an aminoalkyl sidechain

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
None *

Also Published As

Publication number Publication date
SE322769B (enExample) 1970-04-20
CH452508A (fr) 1968-03-15
DK125172B (da) 1973-01-08
FR3559M (fr) 1965-09-20
DE1241443C2 (enExample) 1967-11-30
GB1074578A (en) 1967-07-05

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