DE1236239B - Reagens zur Bestimmung gonadotroper Hormone - Google Patents
Reagens zur Bestimmung gonadotroper HormoneInfo
- Publication number
- DE1236239B DE1236239B DE1962N0022478 DEN0022478A DE1236239B DE 1236239 B DE1236239 B DE 1236239B DE 1962N0022478 DE1962N0022478 DE 1962N0022478 DE N0022478 A DEN0022478 A DE N0022478A DE 1236239 B DE1236239 B DE 1236239B
- Authority
- DE
- Germany
- Prior art keywords
- acid
- added
- antiserum
- erythrocytes
- solution
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000003153 chemical reaction reagent Substances 0.000 title claims description 11
- 239000005556 hormone Substances 0.000 title claims description 5
- 229940088597 hormone Drugs 0.000 title claims description 5
- 230000001456 gonadotroph Effects 0.000 title claims description 4
- 210000002700 urine Anatomy 0.000 claims description 16
- 239000002738 chelating agent Substances 0.000 claims description 12
- 239000002622 gonadotropin Substances 0.000 claims description 12
- 102000006771 Gonadotropins Human genes 0.000 claims description 11
- 108010086677 Gonadotropins Proteins 0.000 claims description 11
- 210000003743 erythrocyte Anatomy 0.000 claims description 11
- BHPQYMZQTOCNFJ-UHFFFAOYSA-N Calcium cation Chemical compound [Ca+2] BHPQYMZQTOCNFJ-UHFFFAOYSA-N 0.000 claims description 9
- 229910001424 calcium ion Inorganic materials 0.000 claims description 9
- 102000011022 Chorionic Gonadotropin Human genes 0.000 claims description 7
- 108010062540 Chorionic Gonadotropin Proteins 0.000 claims description 7
- 229940015047 chorionic gonadotropin Drugs 0.000 claims description 5
- 238000000034 method Methods 0.000 claims description 5
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 claims description 4
- 239000011575 calcium Substances 0.000 claims description 4
- 229910052791 calcium Inorganic materials 0.000 claims description 4
- 229940094892 gonadotropins Drugs 0.000 claims description 4
- 239000007788 liquid Substances 0.000 claims description 4
- 230000035935 pregnancy Effects 0.000 claims description 4
- 210000002966 serum Anatomy 0.000 claims description 4
- 230000000052 comparative effect Effects 0.000 claims description 2
- 229940084986 human chorionic gonadotropin Drugs 0.000 claims description 2
- 239000011541 reaction mixture Substances 0.000 claims description 2
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 claims 9
- 239000000243 solution Substances 0.000 claims 7
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 claims 6
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 claims 6
- 239000000725 suspension Substances 0.000 claims 5
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 5
- KCXVZYZYPLLWCC-UHFFFAOYSA-N EDTA Chemical compound OC(=O)CN(CC(O)=O)CCN(CC(O)=O)CC(O)=O KCXVZYZYPLLWCC-UHFFFAOYSA-N 0.000 claims 4
- 239000002253 acid Substances 0.000 claims 4
- 239000000203 mixture Substances 0.000 claims 4
- LWIHDJKSTIGBAC-UHFFFAOYSA-K tripotassium phosphate Chemical compound [K+].[K+].[K+].[O-]P([O-])([O-])=O LWIHDJKSTIGBAC-UHFFFAOYSA-K 0.000 claims 4
- KWYUFKZDYYNOTN-UHFFFAOYSA-M Potassium hydroxide Chemical compound [OH-].[K+] KWYUFKZDYYNOTN-UHFFFAOYSA-M 0.000 claims 3
- 239000012153 distilled water Substances 0.000 claims 3
- 150000003839 salts Chemical class 0.000 claims 3
- 239000011780 sodium chloride Substances 0.000 claims 3
- 229910019142 PO4 Inorganic materials 0.000 claims 2
- 238000007792 addition Methods 0.000 claims 2
- 239000003513 alkali Substances 0.000 claims 2
- 150000001447 alkali salts Chemical class 0.000 claims 2
- 150000003863 ammonium salts Chemical class 0.000 claims 2
- 239000000872 buffer Substances 0.000 claims 2
- 239000007853 buffer solution Substances 0.000 claims 2
- 239000007979 citrate buffer Substances 0.000 claims 2
- 150000001875 compounds Chemical class 0.000 claims 2
- 229940079593 drug Drugs 0.000 claims 2
- 239000003814 drug Substances 0.000 claims 2
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 claims 2
- 239000010452 phosphate Substances 0.000 claims 2
- 239000008363 phosphate buffer Substances 0.000 claims 2
- 229910000160 potassium phosphate Inorganic materials 0.000 claims 2
- 235000011009 potassium phosphates Nutrition 0.000 claims 2
- CMHJKGDUDQZWBN-UHFFFAOYSA-N 2-(methylamino)-3-oxobutanoic acid Chemical compound CNC(C(C)=O)C(O)=O CMHJKGDUDQZWBN-UHFFFAOYSA-N 0.000 claims 1
- QGZKDVFQNNGYKY-UHFFFAOYSA-O Ammonium Chemical compound [NH4+] QGZKDVFQNNGYKY-UHFFFAOYSA-O 0.000 claims 1
- FEWJPZIEWOKRBE-JCYAYHJZSA-N Dextrotartaric acid Chemical compound OC(=O)[C@H](O)[C@@H](O)C(O)=O FEWJPZIEWOKRBE-JCYAYHJZSA-N 0.000 claims 1
- PIICEJLVQHRZGT-UHFFFAOYSA-N Ethylenediamine Chemical compound NCCN PIICEJLVQHRZGT-UHFFFAOYSA-N 0.000 claims 1
- IAJILQKETJEXLJ-UHFFFAOYSA-N Galacturonsaeure Natural products O=CC(O)C(O)C(O)C(O)C(O)=O IAJILQKETJEXLJ-UHFFFAOYSA-N 0.000 claims 1
- 206010020751 Hypersensitivity Diseases 0.000 claims 1
- FEWJPZIEWOKRBE-UHFFFAOYSA-N Tartaric acid Natural products [H+].[H+].[O-]C(=O)C(O)C(O)C([O-])=O FEWJPZIEWOKRBE-UHFFFAOYSA-N 0.000 claims 1
- HCHKCACWOHOZIP-UHFFFAOYSA-N Zinc Chemical compound [Zn] HCHKCACWOHOZIP-UHFFFAOYSA-N 0.000 claims 1
- 150000007513 acids Chemical class 0.000 claims 1
- IAJILQKETJEXLJ-QTBDOELSSA-N aldehydo-D-glucuronic acid Chemical compound O=C[C@H](O)[C@@H](O)[C@H](O)[C@H](O)C(O)=O IAJILQKETJEXLJ-QTBDOELSSA-N 0.000 claims 1
- 208000026935 allergic disease Diseases 0.000 claims 1
- 230000007815 allergy Effects 0.000 claims 1
- 239000007864 aqueous solution Substances 0.000 claims 1
- HJMZMZRCABDKKV-UHFFFAOYSA-N carbonocyanidic acid Chemical compound OC(=O)C#N HJMZMZRCABDKKV-UHFFFAOYSA-N 0.000 claims 1
- 239000013522 chelant Substances 0.000 claims 1
- 239000003795 chemical substances by application Substances 0.000 claims 1
- BNIILDVGGAEEIG-UHFFFAOYSA-L disodium hydrogen phosphate Chemical compound [Na+].[Na+].OP([O-])([O-])=O BNIILDVGGAEEIG-UHFFFAOYSA-L 0.000 claims 1
- 238000004821 distillation Methods 0.000 claims 1
- -1 e.g. Chemical class 0.000 claims 1
- 229940097043 glucuronic acid Drugs 0.000 claims 1
- 238000011835 investigation Methods 0.000 claims 1
- 239000000463 material Substances 0.000 claims 1
- 230000007170 pathology Effects 0.000 claims 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 1
- 229920001223 polyethylene glycol Polymers 0.000 claims 1
- 159000000000 sodium salts Chemical class 0.000 claims 1
- 239000011975 tartaric acid Substances 0.000 claims 1
- 235000002906 tartaric acid Nutrition 0.000 claims 1
- UEUXEKPTXMALOB-UHFFFAOYSA-J tetrasodium;2-[2-[bis(carboxylatomethyl)amino]ethyl-(carboxylatomethyl)amino]acetate Chemical compound [Na+].[Na+].[Na+].[Na+].[O-]C(=O)CN(CC([O-])=O)CCN(CC([O-])=O)CC([O-])=O UEUXEKPTXMALOB-UHFFFAOYSA-J 0.000 claims 1
- 239000011701 zinc Substances 0.000 claims 1
- 229910052725 zinc Inorganic materials 0.000 claims 1
- 238000006243 chemical reaction Methods 0.000 description 3
- 239000000427 antigen Substances 0.000 description 2
- 102000036639 antigens Human genes 0.000 description 2
- 108091007433 antigens Proteins 0.000 description 2
- 230000001817 pituitary effect Effects 0.000 description 2
- 102000007474 Multiprotein Complexes Human genes 0.000 description 1
- 108010085220 Multiprotein Complexes Proteins 0.000 description 1
- 230000004520 agglutination Effects 0.000 description 1
- 230000015556 catabolic process Effects 0.000 description 1
- 230000002124 endocrine Effects 0.000 description 1
- 239000000284 extract Substances 0.000 description 1
- 150000002500 ions Chemical class 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 230000001575 pathological effect Effects 0.000 description 1
- 238000001556 precipitation Methods 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 239000002994 raw material Substances 0.000 description 1
- 230000002269 spontaneous effect Effects 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/74—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving hormones or other non-cytokine intercellular protein regulatory factors such as growth factors, including receptors to hormones and growth factors
- G01N33/76—Human chorionic gonadotropin including luteinising hormone, follicle stimulating hormone, thyroid stimulating hormone or their receptors
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Molecular Biology (AREA)
- Engineering & Computer Science (AREA)
- Urology & Nephrology (AREA)
- Chemical & Material Sciences (AREA)
- Biomedical Technology (AREA)
- Endocrinology (AREA)
- Immunology (AREA)
- Hematology (AREA)
- Physics & Mathematics (AREA)
- General Physics & Mathematics (AREA)
- Biotechnology (AREA)
- Reproductive Health (AREA)
- Food Science & Technology (AREA)
- Medicinal Chemistry (AREA)
- Biochemistry (AREA)
- Analytical Chemistry (AREA)
- Microbiology (AREA)
- General Health & Medical Sciences (AREA)
- Cell Biology (AREA)
- Pathology (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| NL272588 | 1961-12-15 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DE1236239B true DE1236239B (de) | 1967-03-09 |
Family
ID=19753480
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE1962N0022478 Pending DE1236239B (de) | 1961-12-15 | 1962-12-14 | Reagens zur Bestimmung gonadotroper Hormone |
Country Status (9)
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4816857A (en) * | 1987-05-07 | 1989-03-28 | Arnold & Richter Cine Technik Gmbh & Co. Betriebs Kg | Interchangeable lens for movie camera with a sound dampening system |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4071314A (en) | 1973-01-08 | 1978-01-31 | Laboratoire Theranol | Processes, reagents and means for early diagnosis of pregnancy |
| US3957435A (en) | 1974-12-12 | 1976-05-18 | Miles Laboratories, Inc. | Passive hemagglutination test method and composition for use therein |
| CN111295094A (zh) | 2017-10-09 | 2020-06-16 | 泰尔茂比司特生物技术有限公司 | 冻干容器及使用冻干容器的方法 |
| WO2020185909A2 (en) | 2019-03-14 | 2020-09-17 | Terumo Bct Biotechnologies, Llc | Lyophilization loading tray assembly and system |
-
0
- NL NL105810D patent/NL105810C/xx active
- BE BE626138D patent/BE626138A/xx unknown
-
1962
- 1962-12-07 GB GB4629162A patent/GB979759A/en not_active Expired
- 1962-12-12 ES ES283302A patent/ES283302A1/es not_active Expired
- 1962-12-12 CH CH1462362A patent/CH445157A/de unknown
- 1962-12-12 FI FI223762A patent/FI44719C/fi active
- 1962-12-13 SE SE13450/62A patent/SE328370B/xx unknown
- 1962-12-13 AT AT973862A patent/AT238884B/de active
- 1962-12-14 DE DE1962N0022478 patent/DE1236239B/de active Pending
Non-Patent Citations (1)
| Title |
|---|
| None * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4816857A (en) * | 1987-05-07 | 1989-03-28 | Arnold & Richter Cine Technik Gmbh & Co. Betriebs Kg | Interchangeable lens for movie camera with a sound dampening system |
Also Published As
| Publication number | Publication date |
|---|---|
| FI44719C (fi) | 1974-06-03 |
| BE626138A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | |
| AT238884B (de) | 1965-03-10 |
| CH445157A (de) | 1967-10-15 |
| FI44719B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | 1971-08-31 |
| NL105810C (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | |
| ES283302A1 (es) | 1963-05-16 |
| SE328370B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | 1970-09-14 |
| GB979759A (en) | 1965-01-06 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| E77 | Valid patent as to the heymanns-index 1977 |