DE10353205A1 - Ortho-substituierte Pentafluorsulfuranyl-Benzole, Verfahren zu ihrer Herstellung sowie ihre Verwendung als wertvolle Synthese-Zwischenstufen - Google Patents

Ortho-substituierte Pentafluorsulfuranyl-Benzole, Verfahren zu ihrer Herstellung sowie ihre Verwendung als wertvolle Synthese-Zwischenstufen Download PDF

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Publication number
DE10353205A1
DE10353205A1 DE10353205A DE10353205A DE10353205A1 DE 10353205 A1 DE10353205 A1 DE 10353205A1 DE 10353205 A DE10353205 A DE 10353205A DE 10353205 A DE10353205 A DE 10353205A DE 10353205 A1 DE10353205 A1 DE 10353205A1
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DE
Germany
Prior art keywords
atoms
zero
alkyl
hydrogen
independently
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
DE10353205A
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German (de)
English (en)
Inventor
Heinz-Werner Dr. Kleemann
Remo Weck
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sanofi Aventis Deutschland GmbH
Original Assignee
Aventis Pharma Deutschland GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aventis Pharma Deutschland GmbH filed Critical Aventis Pharma Deutschland GmbH
Priority to DE10353205A priority Critical patent/DE10353205A1/de
Priority to CN200480033240A priority patent/CN100579960C/zh
Priority to PT04818381T priority patent/PT1685098E/pt
Priority to AT04818381T priority patent/ATE464288T1/de
Priority to RU2006120474/04A priority patent/RU2372332C2/ru
Priority to JP2006538731A priority patent/JP4516968B2/ja
Priority to BRPI0416031-2A priority patent/BRPI0416031A/pt
Priority to HK07102567.2A priority patent/HK1095583B/xx
Priority to CA2545452A priority patent/CA2545452C/en
Priority to DK04818381.8T priority patent/DK1685098T3/da
Priority to KR1020067009185A priority patent/KR101165583B1/ko
Priority to NZ547171A priority patent/NZ547171A/en
Priority to AU2004288759A priority patent/AU2004288759B2/en
Priority to EP04818381A priority patent/EP1685098B1/de
Priority to ES04818381T priority patent/ES2344296T3/es
Priority to DE502004011054T priority patent/DE502004011054D1/de
Priority to PCT/EP2004/012394 priority patent/WO2005047240A1/de
Priority to TW093134388A priority patent/TWI334412B/zh
Priority to ARP040104155A priority patent/AR046619A1/es
Priority to PE2004001109A priority patent/PE20050493A1/es
Priority to MYPI20044736A priority patent/MY143530A/en
Priority to UY28615A priority patent/UY28615A1/es
Priority to US10/989,027 priority patent/US7317124B2/en
Publication of DE10353205A1 publication Critical patent/DE10353205A1/de
Priority to ZA200602578A priority patent/ZA200602578B/en
Priority to IL175239A priority patent/IL175239A/en
Priority to CO06045608A priority patent/CO5690545A2/es
Priority to NO20062701A priority patent/NO20062701L/no
Priority to US11/955,501 priority patent/US7932416B2/en
Withdrawn legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D209/00Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/44Iso-indoles; Hydrogenated iso-indoles
    • C07D209/48Iso-indoles; Hydrogenated iso-indoles with oxygen atoms in positions 1 and 3, e.g. phthalimide
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C381/00Compounds containing carbon and sulfur and having functional groups not covered by groups C07C301/00 - C07C337/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D209/00Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04Indoles; Hydrogenated indoles
    • C07D209/10Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/14Radicals substituted by nitrogen atoms, not forming part of a nitro radical

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Indole Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Saccharide Compounds (AREA)
DE10353205A 2003-11-13 2003-11-13 Ortho-substituierte Pentafluorsulfuranyl-Benzole, Verfahren zu ihrer Herstellung sowie ihre Verwendung als wertvolle Synthese-Zwischenstufen Withdrawn DE10353205A1 (de)

Priority Applications (28)

Application Number Priority Date Filing Date Title
DE10353205A DE10353205A1 (de) 2003-11-13 2003-11-13 Ortho-substituierte Pentafluorsulfuranyl-Benzole, Verfahren zu ihrer Herstellung sowie ihre Verwendung als wertvolle Synthese-Zwischenstufen
EP04818381A EP1685098B1 (de) 2003-11-13 2004-11-03 Ortho-substituierte pentafluorsulfanyl-benzole, verfahren zu ihrer herstellung sowie ihre verwendung ais wertvolle synthese-zwischenstufen
DE502004011054T DE502004011054D1 (de) 2003-11-13 2004-11-03 Ortho-substituierte pentafluorsulfanyl-benzole, verfahren zu ihrer herstellung sowie ihre verwendung ais wertvolle synthese-zwischenstufen
AT04818381T ATE464288T1 (de) 2003-11-13 2004-11-03 Ortho-substituierte pentafluorsulfanyl-benzole, verfahren zu ihrer herstellung sowie ihre verwendung ais wertvolle synthese-zwischenstufen
RU2006120474/04A RU2372332C2 (ru) 2003-11-13 2004-11-03 Орто-замещенные пентафторсульфанилбензолы, способ их получения, а также их применение в качестве ценных промежуточных продуктов синтеза
JP2006538731A JP4516968B2 (ja) 2003-11-13 2004-11-03 オルト−置換ペンタフルオリドスルファニル−ベンゼン、その製造法及び有用な合成中間体段階の形態でのその使用
BRPI0416031-2A BRPI0416031A (pt) 2003-11-13 2004-11-03 pentaflúorsulfanila-benzenos orto-substituìdos, processos para produção dos mesmos, bem como seu uso como intermediários de sìntese valiosos
HK07102567.2A HK1095583B (en) 2003-11-13 2004-11-03 Ortho-substituted pentafluoride sulfanyl-benzenes, method for the production thereof and the use thereof in the form of valuable synthesis intermediate stages
CA2545452A CA2545452C (en) 2003-11-13 2004-11-03 Ortho-substituted pentafluoride sulfanyl-benzenes, method for the production thereof and the use thereof in the form of valuable synthesis intermediate stages
DK04818381.8T DK1685098T3 (da) 2003-11-13 2004-11-03 Ortho-substituerede pentafluorsulfanyl-benzoler, fremgangsmåde til deres fremstilling samt deres anvendelse som værdifulde syntese-mellemtrin
PT04818381T PT1685098E (pt) 2003-11-13 2004-11-03 Pentafluorossulfanil-benzenos ortossubstituídos, processo para a sua preparação, bem como sua utilização como intermediários de síntese valiosos
NZ547171A NZ547171A (en) 2003-11-13 2004-11-03 Ortho-substituted pentafluoride sulfanyl-benzenes, method for the production thereof and the use thereof in the form of valuable synthesis intermediate stages
AU2004288759A AU2004288759B2 (en) 2003-11-13 2004-11-03 Ortho-substituted pentafluoride sulfanyl-benzenes, method for the production thereof and the use thereof in the form of valuable synthesis intermediate stages
CN200480033240A CN100579960C (zh) 2003-11-13 2004-11-03 邻位取代的五氟化硫基苯、其制备方法和其作为有价值的合成中间体阶段形式的用途
ES04818381T ES2344296T3 (es) 2003-11-13 2004-11-03 Pentafluorosulfanil-bencenos orto-sustituidos, procedimiento para su preparacion asi como su uso como valiosas etapas intermedias de la sintesis.
PCT/EP2004/012394 WO2005047240A1 (de) 2003-11-13 2004-11-03 Ortho-substituierte pentafluorsulfanyl-benzole, verfahren zu ihrer herstellung sowie ihre verwendung ais wertvolle synthese-zwischenstufen
KR1020067009185A KR101165583B1 (ko) 2003-11-13 2004-11-03 오르토-치환된 펜타플루오라이드 설파닐-벤젠, 이의제조방법 및 유용한 합성 중간체 단계 형태의 이의 용도
TW093134388A TWI334412B (en) 2003-11-13 2004-11-11 Ortho-substituted pentafluorosulfanylbenzenes, process for their preparation and their use as valuable synthetic intermediates
ARP040104155A AR046619A1 (es) 2003-11-13 2004-11-11 Pentafluorosulfanilbencenos orto-sustituidos, procedimiento para su preparacion y uso como productos intermediarios de sintesis
MYPI20044736A MY143530A (en) 2003-11-13 2004-11-12 Ortho-substituted pentafluorosulfanylbenzenes, process for their preparation and their use as valuable synthetic intermediates
PE2004001109A PE20050493A1 (es) 2003-11-13 2004-11-12 Pentafluorosulfanilbencenos orto-sustituidos como valiosos productos intermedios de sintesis y procedimiento para su preparacion
UY28615A UY28615A1 (es) 2003-11-13 2004-11-12 Pentafluorosulfanilbencenos orto-sustituidos, procedimiento para su preparación y su uso como valiosos productos intermedios de síntesis
US10/989,027 US7317124B2 (en) 2003-11-13 2004-11-15 Ortho-substituted pentafluorosulfanylbenzenes, process for their preparation and their use as valuable synthetic intermediates
ZA200602578A ZA200602578B (en) 2003-11-13 2006-03-29 Ortho-substituted pentaflouride sulfanyl-benzenes, method for the production thereof and the use thereof in the form of valuable synthesis in intermediate stage
IL175239A IL175239A (en) 2003-11-13 2006-04-26 Ortho-substituted pentafluoride sulfanyl-benzenes, method for the production thereof and the use thereof as valuable synthesis intermediates
CO06045608A CO5690545A2 (es) 2003-11-13 2006-05-12 Pentafluoruro-sulfanilbencenos orto-sustituidos y metodo para su produccion
NO20062701A NO20062701L (no) 2003-11-13 2006-06-12 Orto-substituerte pentafluoridsulfanylbenzener, fremgangsmate for fremstilling og anvendelse derav i form av verdifulle syntesemellomtrinn
US11/955,501 US7932416B2 (en) 2003-11-13 2007-12-13 Ortho-substituted pentafluorosulfanylbenzenes, process for their preparation and their use as valuable synthetic intermediates

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE10353205A DE10353205A1 (de) 2003-11-13 2003-11-13 Ortho-substituierte Pentafluorsulfuranyl-Benzole, Verfahren zu ihrer Herstellung sowie ihre Verwendung als wertvolle Synthese-Zwischenstufen

Publications (1)

Publication Number Publication Date
DE10353205A1 true DE10353205A1 (de) 2005-06-16

Family

ID=34585096

Family Applications (2)

Application Number Title Priority Date Filing Date
DE10353205A Withdrawn DE10353205A1 (de) 2003-11-13 2003-11-13 Ortho-substituierte Pentafluorsulfuranyl-Benzole, Verfahren zu ihrer Herstellung sowie ihre Verwendung als wertvolle Synthese-Zwischenstufen
DE502004011054T Expired - Lifetime DE502004011054D1 (de) 2003-11-13 2004-11-03 Ortho-substituierte pentafluorsulfanyl-benzole, verfahren zu ihrer herstellung sowie ihre verwendung ais wertvolle synthese-zwischenstufen

Family Applications After (1)

Application Number Title Priority Date Filing Date
DE502004011054T Expired - Lifetime DE502004011054D1 (de) 2003-11-13 2004-11-03 Ortho-substituierte pentafluorsulfanyl-benzole, verfahren zu ihrer herstellung sowie ihre verwendung ais wertvolle synthese-zwischenstufen

Country Status (24)

Country Link
EP (1) EP1685098B1 (enExample)
JP (1) JP4516968B2 (enExample)
KR (1) KR101165583B1 (enExample)
CN (1) CN100579960C (enExample)
AR (1) AR046619A1 (enExample)
AT (1) ATE464288T1 (enExample)
AU (1) AU2004288759B2 (enExample)
BR (1) BRPI0416031A (enExample)
CA (1) CA2545452C (enExample)
CO (1) CO5690545A2 (enExample)
DE (2) DE10353205A1 (enExample)
DK (1) DK1685098T3 (enExample)
ES (1) ES2344296T3 (enExample)
IL (1) IL175239A (enExample)
MY (1) MY143530A (enExample)
NO (1) NO20062701L (enExample)
NZ (1) NZ547171A (enExample)
PE (1) PE20050493A1 (enExample)
PT (1) PT1685098E (enExample)
RU (1) RU2372332C2 (enExample)
TW (1) TWI334412B (enExample)
UY (1) UY28615A1 (enExample)
WO (1) WO2005047240A1 (enExample)
ZA (1) ZA200602578B (enExample)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE102006036023A1 (de) 2006-08-02 2008-02-07 Sanofi-Aventis Imino-imidazo-pyridinderivate mit antithrombotischer Aktivität
AU2008212594C1 (en) * 2007-02-09 2013-04-11 Zoetis Uk Limited Antiparasitic agents
WO2009097972A1 (de) 2008-02-05 2009-08-13 Sanofi-Aventis Sf5-derivate als par1-inhibitoren, ihre herstellung und verwendung als arzneimittel
US8030512B2 (en) 2008-10-20 2011-10-04 Ube Industries, Ltd. Polycyclic pentafluorosulfanylbenzene compound and process for producing the compound
US9868701B2 (en) 2014-12-25 2018-01-16 Ube Industries, Ltd. Method for producing nitrogen-containing pentafluorosulfanylbenzene compound
CN111454186B (zh) * 2019-01-18 2022-11-08 山东省联合农药工业有限公司 一种含五氟硫基的芳基甲酰苯胺类化合物及其制备方法与用途

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1994021606A1 (en) * 1993-03-25 1994-09-29 Zeneca Limited Pentafluorosulphanylphenyl and pentafluorosulphanylpyridil substituted heteroaromatic compounds with insecticidal or acaricidal activity
WO1994022817A1 (en) * 1993-04-07 1994-10-13 Zeneca Limited Process for the preparation of aryl- and heteroarylsulphurpentafluorides
WO1995016676A1 (en) * 1993-12-17 1995-06-22 E.I. Du Pont De Nemours And Company Arthropodicidal pentafluorothio substituted anilides
WO1997005106A1 (en) * 1995-07-29 1997-02-13 British Nuclear Fuels Plc The preparation of fluorinated organic compounds
WO2003093228A1 (en) * 2002-05-02 2003-11-13 Bayer Cropscience Ag Phthalamide derivative, agricultural or horticultural insecticide, and method of use thereof
DE10222192A1 (de) * 2002-05-18 2003-11-27 Aventis Pharma Gmbh Pentafluorsulfuranyl-benzoylguanidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5045554A (en) * 1988-11-29 1991-09-03 Monsanto Company Substituted thiazoles and their use as fungicides
US5220070A (en) * 1991-09-05 1993-06-15 The United States Of America As Represented By The Administrator National Aeronautics And Space Administration 1,3-diamino-5-pentafluorosulfanylbenzene
GB9120641D0 (en) * 1991-09-27 1991-11-06 Ici Plc Heterocyclic compounds
GB9306183D0 (en) * 1993-03-25 1993-05-19 Zeneca Ltd Novel compounds
GB9606015D0 (en) * 1996-03-22 1996-05-22 Rhone Poulenc Agriculture New herbicides
DE19748109B4 (de) * 1997-10-31 2006-09-07 Merck Patent Gmbh Schwefelpentafluorid-Derivate und flüssigkristallines Medium
KR20010034302A (ko) * 1998-01-22 2001-04-25 한스 루돌프 하우스 유기 니트릴 유도체 및 살충제로서의 이의 용도
EP1110454A3 (en) * 1999-12-16 2002-06-05 Rohm And Haas Company 5-Carboxanilido-haloalkylthiazoles as antimicrobial and marine antifouling agents
JP4389243B2 (ja) * 2002-05-02 2009-12-24 日本農薬株式会社 フタルアミド誘導体及び農園芸用殺虫剤並びにその使用方法
JP2004059452A (ja) * 2002-07-25 2004-02-26 Asahi Glass Co Ltd ペンタフルオロサルファー置換ベンズイミダゾール化合物およびその製造方法
JP2004067524A (ja) * 2002-08-01 2004-03-04 Asahi Glass Co Ltd ペンタフルオロサルファー置換インドール化合物の製造方法、ペンタフルオロサルファー置換インドール化合物およびその中間体
JP2004067525A (ja) * 2002-08-01 2004-03-04 Asahi Glass Co Ltd ペンタフルオロサルファー置換アントラニル酸誘導体の製造方法およびペンタフルオロサルファー置換アントラニル酸誘導体

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1994021606A1 (en) * 1993-03-25 1994-09-29 Zeneca Limited Pentafluorosulphanylphenyl and pentafluorosulphanylpyridil substituted heteroaromatic compounds with insecticidal or acaricidal activity
WO1994022817A1 (en) * 1993-04-07 1994-10-13 Zeneca Limited Process for the preparation of aryl- and heteroarylsulphurpentafluorides
WO1995016676A1 (en) * 1993-12-17 1995-06-22 E.I. Du Pont De Nemours And Company Arthropodicidal pentafluorothio substituted anilides
WO1997005106A1 (en) * 1995-07-29 1997-02-13 British Nuclear Fuels Plc The preparation of fluorinated organic compounds
WO2003093228A1 (en) * 2002-05-02 2003-11-13 Bayer Cropscience Ag Phthalamide derivative, agricultural or horticultural insecticide, and method of use thereof
DE10222192A1 (de) * 2002-05-18 2003-11-27 Aventis Pharma Gmbh Pentafluorsulfuranyl-benzoylguanidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament

Also Published As

Publication number Publication date
AR046619A1 (es) 2005-12-14
RU2006120474A (ru) 2007-12-27
KR20060111507A (ko) 2006-10-27
CO5690545A2 (es) 2006-10-31
CN1878753A (zh) 2006-12-13
AU2004288759B2 (en) 2011-04-07
PE20050493A1 (es) 2005-10-07
EP1685098B1 (de) 2010-04-14
WO2005047240A1 (de) 2005-05-26
EP1685098A1 (de) 2006-08-02
KR101165583B1 (ko) 2012-07-23
IL175239A0 (en) 2006-09-05
IL175239A (en) 2011-07-31
NZ547171A (en) 2009-12-24
CN100579960C (zh) 2010-01-13
CA2545452A1 (en) 2005-05-26
PT1685098E (pt) 2010-06-22
TW200530168A (en) 2005-09-16
AU2004288759A1 (en) 2005-05-26
DE502004011054D1 (de) 2010-05-27
CA2545452C (en) 2013-01-08
UY28615A1 (es) 2005-06-30
JP2007512246A (ja) 2007-05-17
MY143530A (en) 2011-05-31
HK1095583A1 (zh) 2007-05-11
BRPI0416031A (pt) 2007-01-02
NO20062701L (no) 2006-08-10
TWI334412B (en) 2010-12-11
ATE464288T1 (de) 2010-04-15
DK1685098T3 (da) 2011-01-10
RU2372332C2 (ru) 2009-11-10
ZA200602578B (en) 2007-06-27
JP4516968B2 (ja) 2010-08-04
ES2344296T3 (es) 2010-08-24

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OM8 Search report available as to paragraph 43 lit. 1 sentence 1 patent law
8127 New person/name/address of the applicant

Owner name: SANOFI-AVENTIS DEUTSCHLAND GMBH, 65929 FRANKFURT,

8141 Disposal/no request for examination