DE102008063234B4 - Biotechnologische Herstellung von Riboflavin mit hoher Ausbeute - Google Patents

Biotechnologische Herstellung von Riboflavin mit hoher Ausbeute Download PDF

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Publication number
DE102008063234B4
DE102008063234B4 DE102008063234A DE102008063234A DE102008063234B4 DE 102008063234 B4 DE102008063234 B4 DE 102008063234B4 DE 102008063234 A DE102008063234 A DE 102008063234A DE 102008063234 A DE102008063234 A DE 102008063234A DE 102008063234 B4 DE102008063234 B4 DE 102008063234B4
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DE
Germany
Prior art keywords
ccpc
nucleic acid
host cell
riboflavin
expression
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
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DE102008063234A
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German (de)
English (en)
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DE102008063234A1 (de
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DSM IP Assets BV
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Insilico Biotechnology AG
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Publication date
Priority to DE102008063234A priority Critical patent/DE102008063234B4/de
Application filed by Insilico Biotechnology AG filed Critical Insilico Biotechnology AG
Priority to PCT/EP2009/008987 priority patent/WO2010075960A2/de
Priority to KR1020117016203A priority patent/KR101739147B1/ko
Priority to JP2011539963A priority patent/JP5813512B2/ja
Priority to US13/139,896 priority patent/US8759024B2/en
Priority to EP09796959A priority patent/EP2358893A2/de
Priority to CN200980150515.7A priority patent/CN102245781B/zh
Publication of DE102008063234A1 publication Critical patent/DE102008063234A1/de
Application granted granted Critical
Publication of DE102008063234B4 publication Critical patent/DE102008063234B4/de
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P25/00—Preparation of compounds containing alloxazine or isoalloxazine nucleus, e.g. riboflavin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/32—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Bacillus (G)

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • Wood Science & Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Biotechnology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Microbiology (AREA)
  • Biophysics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
DE102008063234A 2008-12-15 2008-12-15 Biotechnologische Herstellung von Riboflavin mit hoher Ausbeute Expired - Fee Related DE102008063234B4 (de)

Priority Applications (7)

Application Number Priority Date Filing Date Title
DE102008063234A DE102008063234B4 (de) 2008-12-15 2008-12-15 Biotechnologische Herstellung von Riboflavin mit hoher Ausbeute
KR1020117016203A KR101739147B1 (ko) 2008-12-15 2009-12-15 리보플라빈의 제조 방법
JP2011539963A JP5813512B2 (ja) 2008-12-15 2009-12-15 リボフラビンの生産方法
US13/139,896 US8759024B2 (en) 2008-12-15 2009-12-15 Process for the production of riboflavin
PCT/EP2009/008987 WO2010075960A2 (de) 2008-12-15 2009-12-15 Verfahren zur herstellung von riboflavin
EP09796959A EP2358893A2 (de) 2008-12-15 2009-12-15 Verfahren zur herstellung von riboflavin
CN200980150515.7A CN102245781B (zh) 2008-12-15 2009-12-15 用于生产核黄素的方法

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE102008063234A DE102008063234B4 (de) 2008-12-15 2008-12-15 Biotechnologische Herstellung von Riboflavin mit hoher Ausbeute

Publications (2)

Publication Number Publication Date
DE102008063234A1 DE102008063234A1 (de) 2010-06-17
DE102008063234B4 true DE102008063234B4 (de) 2011-06-22

Family

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Family Applications (1)

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DE102008063234A Expired - Fee Related DE102008063234B4 (de) 2008-12-15 2008-12-15 Biotechnologische Herstellung von Riboflavin mit hoher Ausbeute

Country Status (7)

Country Link
US (1) US8759024B2 (https=)
EP (1) EP2358893A2 (https=)
JP (1) JP5813512B2 (https=)
KR (1) KR101739147B1 (https=)
CN (1) CN102245781B (https=)
DE (1) DE102008063234B4 (https=)
WO (1) WO2010075960A2 (https=)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102629304B (zh) * 2012-04-05 2015-02-04 天津大学 基于基因组尺度代谢网络模型的代谢工程设计预测方法
CN102816823B (zh) * 2012-09-18 2014-10-22 江南大学 利用多阶段转速调控策略提高Bacillus subtilis发酵生产核黄素产量的方法
CN107922464B (zh) * 2015-08-28 2022-03-15 帝斯曼知识产权资产管理有限公司 经改进的维生素生产
CN108588108B (zh) * 2018-05-04 2021-06-01 湖北大学 一种高效代谢甘油的芽胞杆菌的制备方法和应用
JP7497348B2 (ja) 2018-11-15 2024-06-10 ディーエスエム アイピー アセッツ ビー．ブイ． リボフラビンの改善された産生
KR102706898B1 (ko) * 2022-06-07 2024-09-19 씨제이제일제당 주식회사 리보플라빈 생산능이 향상된 코리네박테리움 속 미생물 및 이를 이용한 리보플라빈을 생산하는 방법

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006066925A2 (en) * 2004-12-22 2006-06-29 Dsm Ip Assets B.V. Novel genes involved in gluconeogenesis

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1066486C (zh) 1989-06-22 2001-05-30 霍夫曼-拉罗奇有限公司 高产核黄素的细菌菌株
JPH1084978A (ja) * 1996-07-24 1998-04-07 F Hoffmann La Roche Ag 改良されたリボフラビン生産
DE60336712D1 (de) * 2002-02-27 2011-05-26 Dsm Ip Assets Bv Fermentationsverfahren
JP4713469B2 (ja) 2003-06-18 2011-06-29 ディーエスエム アイピー アセッツ ビー．ブイ． 胞子形成できない微生物を用いたパントテネート（Ｐａｎｔｏｔｈｅｎａｔｅ）の製造
US8257944B2 (en) * 2005-11-02 2012-09-04 Dsm Ip Assets B.V. Modified transketolase and use thereof

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006066925A2 (en) * 2004-12-22 2006-06-29 Dsm Ip Assets B.V. Novel genes involved in gluconeogenesis

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
Datenbank PubMed bei NCBI, Adresse www.ncbi.nlm.nih.gov, Zusammenfassung zu: YING,M. & BAN,R.: [Knockout of the ccpA gene in Bacillus subtilis and influence on riboflavin production] [article in Chinese] Wei Sheng Wu Xue Bao (2006) 46 (1) 23-7 [recherchiert am 03.12.2009] *
JOURLIN-CASTELLI,C., u.a.: CcpC, a novel regulator of the LysR family required for glucose repression of the citB gene in Bacillus subtilis. J. Mol. Biol. (2000) 295 (4) 865-78 *
VITRESCHAK,A.G., u.a.: Regulation of riboflavin biosynthesis and transport genes in bacteria by transcriptional and translational attenuation. Nucleic Acids Res. (2002) 30 (14) 3141-51 *

Also Published As

Publication number Publication date
CN102245781B (zh) 2015-11-25
US20110312026A1 (en) 2011-12-22
WO2010075960A2 (de) 2010-07-08
JP2012511898A (ja) 2012-05-31
WO2010075960A8 (de) 2011-06-23
DE102008063234A1 (de) 2010-06-17
JP5813512B2 (ja) 2015-11-17
KR20110104955A (ko) 2011-09-23
US8759024B2 (en) 2014-06-24
EP2358893A2 (de) 2011-08-24
CN102245781A (zh) 2011-11-16
KR101739147B1 (ko) 2017-05-23
WO2010075960A3 (de) 2010-09-10

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