CN102245781B - 用于生产核黄素的方法 - Google Patents

用于生产核黄素的方法 Download PDF

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Publication number
CN102245781B
CN102245781B CN200980150515.7A CN200980150515A CN102245781B CN 102245781 B CN102245781 B CN 102245781B CN 200980150515 A CN200980150515 A CN 200980150515A CN 102245781 B CN102245781 B CN 102245781B
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CN
China
Prior art keywords
riboflavin
ccpc
gene
modified
nucleic acid
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Expired - Fee Related
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CN200980150515.7A
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English (en)
Chinese (zh)
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CN102245781A (zh
Inventor
弗洛瑞娜·柯克纳
克劳斯·穆彻
卓阿克姆·施密德
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DSM IP Assets BV
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DSM IP Assets BV
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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P25/00—Preparation of compounds containing alloxazine or isoalloxazine nucleus, e.g. riboflavin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/32—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Bacillus (G)

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • Wood Science & Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Biotechnology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Microbiology (AREA)
  • Biophysics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
CN200980150515.7A 2008-12-15 2009-12-15 用于生产核黄素的方法 Expired - Fee Related CN102245781B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE102008063234.1 2008-12-15
DE102008063234A DE102008063234B4 (de) 2008-12-15 2008-12-15 Biotechnologische Herstellung von Riboflavin mit hoher Ausbeute
PCT/EP2009/008987 WO2010075960A2 (de) 2008-12-15 2009-12-15 Verfahren zur herstellung von riboflavin

Publications (2)

Publication Number Publication Date
CN102245781A CN102245781A (zh) 2011-11-16
CN102245781B true CN102245781B (zh) 2015-11-25

Family

ID=42025765

Family Applications (1)

Application Number Title Priority Date Filing Date
CN200980150515.7A Expired - Fee Related CN102245781B (zh) 2008-12-15 2009-12-15 用于生产核黄素的方法

Country Status (7)

Country Link
US (1) US8759024B2 (https=)
EP (1) EP2358893A2 (https=)
JP (1) JP5813512B2 (https=)
KR (1) KR101739147B1 (https=)
CN (1) CN102245781B (https=)
DE (1) DE102008063234B4 (https=)
WO (1) WO2010075960A2 (https=)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102629304B (zh) * 2012-04-05 2015-02-04 天津大学 基于基因组尺度代谢网络模型的代谢工程设计预测方法
CN102816823B (zh) * 2012-09-18 2014-10-22 江南大学 利用多阶段转速调控策略提高Bacillus subtilis发酵生产核黄素产量的方法
CN107922464B (zh) * 2015-08-28 2022-03-15 帝斯曼知识产权资产管理有限公司 经改进的维生素生产
CN108588108B (zh) * 2018-05-04 2021-06-01 湖北大学 一种高效代谢甘油的芽胞杆菌的制备方法和应用
JP7497348B2 (ja) 2018-11-15 2024-06-10 ディーエスエム アイピー アセッツ ビー．ブイ． リボフラビンの改善された産生
KR102706898B1 (ko) * 2022-06-07 2024-09-19 씨제이제일제당 주식회사 리보플라빈 생산능이 향상된 코리네박테리움 속 미생물 및 이를 이용한 리보플라빈을 생산하는 방법

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0821063A2 (en) * 1996-07-24 1998-01-28 F. Hoffmann-La Roche Ag Improved riboflavin production
CN1639339A (zh) * 2002-02-27 2005-07-13 Dsmip资产有限公司 发酵方法
CN101124242A (zh) * 2004-12-22 2008-02-13 帝斯曼知识产权资产管理有限公司 与糖异生作用有关的新颖的基因

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1066486C (zh) 1989-06-22 2001-05-30 霍夫曼-拉罗奇有限公司 高产核黄素的细菌菌株
JP4713469B2 (ja) 2003-06-18 2011-06-29 ディーエスエム アイピー アセッツ ビー．ブイ． 胞子形成できない微生物を用いたパントテネート（Ｐａｎｔｏｔｈｅｎａｔｅ）の製造
US8257944B2 (en) * 2005-11-02 2012-09-04 Dsm Ip Assets B.V. Modified transketolase and use thereof

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0821063A2 (en) * 1996-07-24 1998-01-28 F. Hoffmann-La Roche Ag Improved riboflavin production
CN1639339A (zh) * 2002-02-27 2005-07-13 Dsmip资产有限公司 发酵方法
CN101124242A (zh) * 2004-12-22 2008-02-13 帝斯曼知识产权资产管理有限公司 与糖异生作用有关的新颖的基因

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
"CcpC, a novel regulator of the LysR family required for glucose repression of the citB gene in Bacillus subtilis";Cecile Jourlin-Castelli et al.,;《Journal of Molecular Biology》;20000128;第295卷(第4期);摘要部分，第868页左栏最后1段 *
"GenBank Accession No：AJ222587.1";Scanlan,E. and Devin,K.M.;《GenBank》;19971121;第7页及第17页 *
"Regulation of the Bacillus subtilis ccpC gene by CcpA and CcpC";Hyun-Jin Kim;《Molecular Microbiology》;20020131;第43卷(第2期);第399页左栏第1段；第401页左栏最后1段-第402页右栏第1段，第403页右栏最后1段-第404页左栏第1段，图5 *

Also Published As

Publication number Publication date
US20110312026A1 (en) 2011-12-22
WO2010075960A2 (de) 2010-07-08
JP2012511898A (ja) 2012-05-31
WO2010075960A8 (de) 2011-06-23
DE102008063234A1 (de) 2010-06-17
JP5813512B2 (ja) 2015-11-17
KR20110104955A (ko) 2011-09-23
US8759024B2 (en) 2014-06-24
EP2358893A2 (de) 2011-08-24
CN102245781A (zh) 2011-11-16
KR101739147B1 (ko) 2017-05-23
DE102008063234B4 (de) 2011-06-22
WO2010075960A3 (de) 2010-09-10

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Granted publication date: 20151125