DE102005047561A1 - Feste, oral applizierbare pharmazeutische Darreichungsformen mit schneller Wirkstofffreisetzung - Google Patents
Feste, oral applizierbare pharmazeutische Darreichungsformen mit schneller Wirkstofffreisetzung Download PDFInfo
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- DE102005047561A1 DE102005047561A1 DE102005047561A DE102005047561A DE102005047561A1 DE 102005047561 A1 DE102005047561 A1 DE 102005047561A1 DE 102005047561 A DE102005047561 A DE 102005047561A DE 102005047561 A DE102005047561 A DE 102005047561A DE 102005047561 A1 DE102005047561 A1 DE 102005047561A1
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- OYACROKNLOSFPA-UHFFFAOYSA-N calcium;dioxido(oxo)silane Chemical compound [Ca+2].[O-][Si]([O-])=O OYACROKNLOSFPA-UHFFFAOYSA-N 0.000 description 1
- 235000011089 carbon dioxide Nutrition 0.000 description 1
- 239000001768 carboxy methyl cellulose Substances 0.000 description 1
- 235000010948 carboxy methyl cellulose Nutrition 0.000 description 1
- 239000008112 carboxymethyl-cellulose Substances 0.000 description 1
- 229920003086 cellulose ether Polymers 0.000 description 1
- 238000012512 characterization method Methods 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 238000005352 clarification Methods 0.000 description 1
- 239000008120 corn starch Substances 0.000 description 1
- 229960000913 crospovidone Drugs 0.000 description 1
- 238000000354 decomposition reaction Methods 0.000 description 1
- 239000008121 dextrose Substances 0.000 description 1
- NEFBYIFKOOEVPA-UHFFFAOYSA-K dicalcium phosphate Chemical compound [Ca+2].[Ca+2].[O-]P([O-])([O-])=O NEFBYIFKOOEVPA-UHFFFAOYSA-K 0.000 description 1
- 229940038472 dicalcium phosphate Drugs 0.000 description 1
- 229910000390 dicalcium phosphate Inorganic materials 0.000 description 1
- FSBVERYRVPGNGG-UHFFFAOYSA-N dimagnesium dioxido-bis[[oxido(oxo)silyl]oxy]silane hydrate Chemical compound O.[Mg+2].[Mg+2].[O-][Si](=O)O[Si]([O-])([O-])O[Si]([O-])=O FSBVERYRVPGNGG-UHFFFAOYSA-N 0.000 description 1
- 239000007884 disintegrant Substances 0.000 description 1
- 239000002706 dry binder Substances 0.000 description 1
- 235000019414 erythritol Nutrition 0.000 description 1
- UNXHWFMMPAWVPI-ZXZARUISSA-N erythritol Chemical compound OC[C@H](O)[C@H](O)CO UNXHWFMMPAWVPI-ZXZARUISSA-N 0.000 description 1
- 229940009714 erythritol Drugs 0.000 description 1
- MVPICKVDHDWCJQ-UHFFFAOYSA-N ethyl 3-pyrrolidin-1-ylpropanoate Chemical compound CCOC(=O)CCN1CCCC1 MVPICKVDHDWCJQ-UHFFFAOYSA-N 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 239000007948 fast release tablet Substances 0.000 description 1
- 150000002191 fatty alcohols Chemical class 0.000 description 1
- 238000012395 formulation development Methods 0.000 description 1
- 229960002737 fructose Drugs 0.000 description 1
- 239000001530 fumaric acid Substances 0.000 description 1
- 210000004051 gastric juice Anatomy 0.000 description 1
- 239000012362 glacial acetic acid Substances 0.000 description 1
- 239000008103 glucose Substances 0.000 description 1
- 238000005469 granulation Methods 0.000 description 1
- 230000003179 granulation Effects 0.000 description 1
- 229920001477 hydrophilic polymer Polymers 0.000 description 1
- 238000001727 in vivo Methods 0.000 description 1
- 239000003112 inhibitor Substances 0.000 description 1
- VBMVTYDPPZVILR-UHFFFAOYSA-N iron(2+);oxygen(2-) Chemical class [O-2].[Fe+2] VBMVTYDPPZVILR-UHFFFAOYSA-N 0.000 description 1
- 239000004922 lacquer Substances 0.000 description 1
- ZLNQQNXFFQJAID-UHFFFAOYSA-L magnesium carbonate Chemical compound [Mg+2].[O-]C([O-])=O ZLNQQNXFFQJAID-UHFFFAOYSA-L 0.000 description 1
- 239000001095 magnesium carbonate Substances 0.000 description 1
- 229910000021 magnesium carbonate Inorganic materials 0.000 description 1
- 239000000395 magnesium oxide Substances 0.000 description 1
- CPLXHLVBOLITMK-UHFFFAOYSA-N magnesium oxide Inorganic materials [Mg]=O CPLXHLVBOLITMK-UHFFFAOYSA-N 0.000 description 1
- 239000000391 magnesium silicate Substances 0.000 description 1
- 229940099273 magnesium trisilicate Drugs 0.000 description 1
- 235000019793 magnesium trisilicate Nutrition 0.000 description 1
- 229910000386 magnesium trisilicate Inorganic materials 0.000 description 1
- AXZKOIWUVFPNLO-UHFFFAOYSA-N magnesium;oxygen(2-) Chemical compound [O-2].[Mg+2] AXZKOIWUVFPNLO-UHFFFAOYSA-N 0.000 description 1
- 229960002160 maltose Drugs 0.000 description 1
- 229920003117 medium viscosity grade hydroxypropyl cellulose Polymers 0.000 description 1
- QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 description 1
- OQCDKBAXFALNLD-UHFFFAOYSA-N octadecanoic acid Natural products CCCCCCCC(C)CCCCCCCCC(O)=O OQCDKBAXFALNLD-UHFFFAOYSA-N 0.000 description 1
- 239000003960 organic solvent Substances 0.000 description 1
- 238000011170 pharmaceutical development Methods 0.000 description 1
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- 229920001451 polypropylene glycol Polymers 0.000 description 1
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- 235000013809 polyvinylpolypyrrolidone Nutrition 0.000 description 1
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- 235000009566 rice Nutrition 0.000 description 1
- 229940100486 rice starch Drugs 0.000 description 1
- 239000011734 sodium Substances 0.000 description 1
- 229910052708 sodium Inorganic materials 0.000 description 1
- 235000017281 sodium acetate Nutrition 0.000 description 1
- 229940087562 sodium acetate trihydrate Drugs 0.000 description 1
- 229940023144 sodium glycolate Drugs 0.000 description 1
- 235000019333 sodium laurylsulphate Nutrition 0.000 description 1
- 229940045902 sodium stearyl fumarate Drugs 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
- 239000008117 stearic acid Substances 0.000 description 1
- 239000005720 sucrose Substances 0.000 description 1
- 229960004793 sucrose Drugs 0.000 description 1
- 230000000475 sunscreen effect Effects 0.000 description 1
- 239000000516 sunscreening agent Substances 0.000 description 1
- 239000000454 talc Substances 0.000 description 1
- 229910052623 talc Inorganic materials 0.000 description 1
- VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 description 1
- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 description 1
- 235000019731 tricalcium phosphate Nutrition 0.000 description 1
- 229940078499 tricalcium phosphate Drugs 0.000 description 1
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- JEJAMASKDTUEBZ-UHFFFAOYSA-N tris(1,1,3-tribromo-2,2-dimethylpropyl) phosphate Chemical compound BrCC(C)(C)C(Br)(Br)OP(=O)(OC(Br)(Br)C(C)(C)CBr)OC(Br)(Br)C(C)(C)CBr JEJAMASKDTUEBZ-UHFFFAOYSA-N 0.000 description 1
- 208000004043 venous thromboembolism Diseases 0.000 description 1
- 239000000080 wetting agent Substances 0.000 description 1
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
- A61K9/2077—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1682—Processes
- A61K9/1694—Processes resulting in granules or microspheres of the matrix type containing more than 5% of excipient
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Vascular Medicine (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Priority Applications (28)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE102005047561A DE102005047561A1 (de) | 2005-10-04 | 2005-10-04 | Feste, oral applizierbare pharmazeutische Darreichungsformen mit schneller Wirkstofffreisetzung |
| AU2006299192A AU2006299192B2 (en) | 2005-10-04 | 2006-09-21 | Solid orally administerable pharmaceutical dosage forms with rapid active principle release |
| EP06792199A EP1957048A2 (de) | 2005-10-04 | 2006-09-21 | Feste, oral applizierbare pharmazeutische darreichungsformen mit schneller wirkstofffreisetzung |
| KR1020087010702A KR101445398B1 (ko) | 2005-10-04 | 2006-09-21 | 활성 성분을 신속 방출하는 고형 경구 투여용 제약 투여형태 |
| PCT/EP2006/009178 WO2007039122A2 (de) | 2005-10-04 | 2006-09-21 | Feste, oral applizierbare pharmazeutische darreichungsformen mit schneller wirkstofffreisetzung |
| NZ567094A NZ567094A (en) | 2005-10-04 | 2006-09-21 | Solid orally administerable pharmaceutical dosage forms with rapid active principle release |
| HK09105035.7A HK1127284B (en) | 2005-10-04 | 2006-09-21 | Solid orally administerable pharmaceutical dosage forms with rapid active principle release |
| US12/089,148 US8586082B2 (en) | 2005-10-04 | 2006-09-21 | Solid orally administerable pharmaceutical dosage forms with rapid active principle release |
| CA2624306A CA2624306C (en) | 2005-10-04 | 2006-09-21 | Solid pharmaceutical dosage forms which can be adminstered orally and have rapid release of active ingredient |
| UAA200805665A UA90545C2 (ru) | 2005-10-04 | 2006-09-21 | Твердая фармацевтическая лекарственная форма для перорального введения с быстрым высвобождением ингибитора фактора ха свертывания крови |
| RU2008116831/15A RU2440119C2 (ru) | 2005-10-04 | 2006-09-21 | Твердые применяемые орально фармацевтические формы применения с быстрым высвобождением активного вещества |
| CN2006800455481A CN101321517B (zh) | 2005-10-04 | 2006-09-21 | 能够口服和活性成分快速释放的固体药物剂型 |
| MYPI20080998A MY143351A (en) | 2005-10-04 | 2006-09-21 | Solid orally administerable pharmaceutical dosage forms with rapid active principle release |
| BRPI0616874-4A BRPI0616874A2 (pt) | 2005-10-04 | 2006-09-21 | formas sólidas de apresentação farmacêutica de administração oral com liberação rápida de substáncia ativa |
| JP2008533890A JP5147703B2 (ja) | 2005-10-04 | 2006-09-21 | 経口投与でき、かつ活性成分の迅速な放出を有する固形医薬投与形態 |
| DO2006000209A DOP2006000209A (es) | 2005-10-04 | 2006-10-02 | Forma de presentacion farmaceutica solidas de administracion oral con liberacion rapida del principio activo |
| PE2006001198A PE20070588A1 (es) | 2005-10-04 | 2006-10-03 | Formas de presentacion farmaceuticas solidas de administracion oral con liberacion rapida del principio activo |
| TW095136623A TWI389691B (zh) | 2005-10-04 | 2006-10-03 | 可口服且具有活性成分快速釋出之固態醫藥劑型 |
| UY29835A UY29835A1 (es) | 2005-10-04 | 2006-10-03 | Formas de dosificación farmacéutica sólidas que comprenden 5-cloro-n-(((5s)-2-oxo-3-(4-(3-oxo-4-morfolinil)fenil)-1,3-oxazolidin-5-il)metil)-2-tiofenocarboxamida |
| GT200600445A GT200600445A (es) | 2005-10-04 | 2006-10-04 | Formas de presentación farmaceuticas solidas de administración oral con liberacion rapida del principio activo. |
| ARP060104365A AR056564A1 (es) | 2005-10-04 | 2006-10-04 | Formas de presentacion farmaceuticas solidas de administracion oral con liberacion rapida del principio activo |
| ZA200802873A ZA200802873B (en) | 2005-10-04 | 2008-04-02 | Solid orally administerable pharmaceutical dosage forms with rapid active principle release |
| SV2008002857A SV2009002857A (es) | 2005-10-04 | 2008-04-02 | Formas de presentacion farmaceutica solidas de administracion oral con liberacion rapida de principio activo |
| EC2008008339A ECSP088339A (es) | 2005-10-04 | 2008-04-02 | Formas de presentación farmacéutica sólidas de administración oral con liberación rápida de principio activo |
| IL190618A IL190618A0 (en) | 2005-10-04 | 2008-04-03 | Solid orally administerable pharmaceutical dosage forms with rapid active principle release |
| CR9864A CR9864A (es) | 2005-10-04 | 2008-04-03 | Formas de presentacion farmaceutica solidas de administracion oral con liberacion rapida de principio activo |
| CU20080052A CU23808B7 (es) | 2005-10-04 | 2008-04-04 | Formas de presentación farmacéutica sólidas de administración oral con liberación rápida de principio activo |
| NO20081982A NO20081982L (no) | 2005-10-04 | 2008-04-25 | Faste, oralt administrerbare farmasoytiske doseringsformer med rask frigivelse av aktiv forbindelse |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE102005047561A DE102005047561A1 (de) | 2005-10-04 | 2005-10-04 | Feste, oral applizierbare pharmazeutische Darreichungsformen mit schneller Wirkstofffreisetzung |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DE102005047561A1 true DE102005047561A1 (de) | 2007-04-05 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE102005047561A Withdrawn DE102005047561A1 (de) | 2005-10-04 | 2005-10-04 | Feste, oral applizierbare pharmazeutische Darreichungsformen mit schneller Wirkstofffreisetzung |
Country Status (26)
| Country | Link |
|---|---|
| US (1) | US8586082B2 (https=) |
| EP (1) | EP1957048A2 (https=) |
| JP (1) | JP5147703B2 (https=) |
| KR (1) | KR101445398B1 (https=) |
| CN (1) | CN101321517B (https=) |
| AR (1) | AR056564A1 (https=) |
| AU (1) | AU2006299192B2 (https=) |
| BR (1) | BRPI0616874A2 (https=) |
| CA (1) | CA2624306C (https=) |
| CR (1) | CR9864A (https=) |
| CU (1) | CU23808B7 (https=) |
| DE (1) | DE102005047561A1 (https=) |
| DO (1) | DOP2006000209A (https=) |
| EC (1) | ECSP088339A (https=) |
| GT (1) | GT200600445A (https=) |
| IL (1) | IL190618A0 (https=) |
| MY (1) | MY143351A (https=) |
| NZ (1) | NZ567094A (https=) |
| PE (1) | PE20070588A1 (https=) |
| RU (1) | RU2440119C2 (https=) |
| SV (1) | SV2009002857A (https=) |
| TW (1) | TWI389691B (https=) |
| UA (1) | UA90545C2 (https=) |
| UY (1) | UY29835A1 (https=) |
| WO (1) | WO2007039122A2 (https=) |
| ZA (1) | ZA200802873B (https=) |
Families Citing this family (38)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE19962924A1 (de) | 1999-12-24 | 2001-07-05 | Bayer Ag | Substituierte Oxazolidinone und ihre Verwendung |
| DE10129725A1 (de) * | 2001-06-20 | 2003-01-02 | Bayer Ag | Kombinationstherapie substituierter Oxazolidinone |
| DE10300111A1 (de) | 2003-01-07 | 2004-07-15 | Bayer Healthcare Ag | Verfahren zur Herstellung von 5-Chlor-N-({(5S)-2-oxo-3-[4-(3-oxo-4-morpholinyl)-phenyl]-1,3-oxazolidin-5-yl}-methyl)-2-thiophencarboxamid |
| DE10355461A1 (de) | 2003-11-27 | 2005-06-23 | Bayer Healthcare Ag | Verfahren zur Herstellung einer festen, oral applizierbaren pharmazeutischen Zusammensetzung |
| DE102004062475A1 (de) * | 2004-12-24 | 2006-07-06 | Bayer Healthcare Ag | Feste, oral applizierbare pharmazeutische Darreichungsformen mit modifizierter Freisetzung |
| EP1685841A1 (en) | 2005-01-31 | 2006-08-02 | Bayer Health Care Aktiengesellschaft | Prevention and treatment of thromboembolic disorders |
| DE102005045518A1 (de) | 2005-09-23 | 2007-03-29 | Bayer Healthcare Ag | 2-Aminoethoxyessigsäure-Derivate und ihre Verwendung |
| US8188270B2 (en) | 2005-10-04 | 2012-05-29 | Bayer Schering Pharma Aktiengesellschaft | Polymorphous form of 5-chloro-N-({(5S)-2-oxo-3[4-(3-oxo-4-morpholinyl)-phenyl]-1,3-oxazolidine-5-yl}-methyl)-2-thiophene carboxamide |
| DE102005047561A1 (de) | 2005-10-04 | 2007-04-05 | Bayer Healthcare Ag | Feste, oral applizierbare pharmazeutische Darreichungsformen mit schneller Wirkstofffreisetzung |
| MX2011000277A (es) | 2008-07-08 | 2011-06-22 | Ratiopharm Gmbh | Composiciones farmaceuticas que comprenden 5-cloro-n-({(5s)-2-oxo- 3-[4-(3-oxo-4-morfolinil)-fenil]-1,3-oxazolidin-5-il}-metil)-2-ti ofencarboxamida. |
| EP2317980A2 (en) * | 2008-08-11 | 2011-05-11 | Ratiopharm GmbH | Pharmaceutical compositions of rivaroxaban with modified release properties |
| US7816355B1 (en) | 2009-04-28 | 2010-10-19 | Apotex Pharmachem Inc | Processes for the preparation of rivaroxaban and intermediates thereof |
| GB0909680D0 (en) * | 2009-06-05 | 2009-07-22 | Euro Celtique Sa | Dosage form |
| EP2266541A1 (en) | 2009-06-18 | 2010-12-29 | Krka Tovarna Zdravil, D.D., Novo Mesto | Solid pharmaceutical composition comprising rivaroxaban |
| EA035562B1 (ru) * | 2009-06-18 | 2020-07-08 | Крка, Товарна Здравил, Д. Д., Ново Место | Способ получения твердой фармацевтической композиции, содержащей ривароксабан |
| US20120231076A1 (en) | 2009-10-06 | 2012-09-13 | Ratiopharm Gmbh | Pharmaceutical compositions comprising rivaroxaban |
| EP2308472A1 (en) | 2009-10-06 | 2011-04-13 | ratiopharm GmbH | Pharmaceutical compositions comprising rivaroxaban |
| AU2011252039B2 (en) | 2010-05-10 | 2014-06-12 | Euro-Celtique S.A. | Pharmaceutical compositions comprising hydromorphone and naloxone |
| CN103002881B (zh) | 2010-05-10 | 2015-09-02 | 欧洲凯尔特公司 | 载有活性剂的颗粒与额外活性剂的组合 |
| CA2798884C (en) | 2010-05-10 | 2016-09-13 | Euro-Celtique S.A. | Manufacturing of active-free granules and tablets comprising the same |
| EP2387993B1 (en) * | 2010-05-21 | 2012-11-07 | Sanovel Ilaç Sanayi Ve Ticaret Anonim Sirketi | Orally disintegrating tablets of zolmitriptan and process for preparing the same |
| EP2404920A1 (en) | 2010-07-06 | 2012-01-11 | Sandoz AG | Crystalline form of Rivaroxaban dihydrate |
| DE102010063127A1 (de) | 2010-12-15 | 2012-06-21 | Bayer Schering Pharma Aktiengesellschaft | Flüssige, oral applizierbare pharmazeutische Zusammensetzungen enthaltend 5-Chlor-N-({(5S)-2-oxo-3-[4-(3-oxo-4-morpholinyl)-phenyl]-1,3-oxazolidin-5-yl}-methyl)-2-thiophencarboxamid |
| WO2013022924A1 (en) | 2011-08-08 | 2013-02-14 | Teva Pharmaceutical Industries Ltd. | Pharmaceutical formulations |
| EP2808011A1 (en) * | 2013-05-29 | 2014-12-03 | Sandoz Ag | Process for the preparation of a pharmaceutical composition comprising Rivaroxaban |
| CN103550166A (zh) * | 2013-10-31 | 2014-02-05 | 江苏阿尔法药业有限公司 | 一种利伐沙班口服微球制剂 |
| WO2015071380A1 (en) | 2013-11-13 | 2015-05-21 | Euro-Celtique S.A. | Hydromorphone and naloxone for treatment of pain and opioid bowel dysfunction syndrome |
| WO2015124995A1 (en) | 2014-02-19 | 2015-08-27 | Aurobindo Pharma Ltd | Solid dosage forms of rivaroxaban |
| KR101499867B1 (ko) * | 2014-04-22 | 2015-03-06 | 에스케이케미칼주식회사 | 활성 성분 (i) 함유 조성물 및 이의 제조 방법 |
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-
2005
- 2005-10-04 DE DE102005047561A patent/DE102005047561A1/de not_active Withdrawn
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2006
- 2006-09-21 KR KR1020087010702A patent/KR101445398B1/ko not_active Expired - Fee Related
- 2006-09-21 JP JP2008533890A patent/JP5147703B2/ja not_active Expired - Fee Related
- 2006-09-21 RU RU2008116831/15A patent/RU2440119C2/ru active
- 2006-09-21 CN CN2006800455481A patent/CN101321517B/zh not_active Expired - Fee Related
- 2006-09-21 WO PCT/EP2006/009178 patent/WO2007039122A2/de not_active Ceased
- 2006-09-21 NZ NZ567094A patent/NZ567094A/en not_active IP Right Cessation
- 2006-09-21 UA UAA200805665A patent/UA90545C2/ru unknown
- 2006-09-21 AU AU2006299192A patent/AU2006299192B2/en active Active
- 2006-09-21 BR BRPI0616874-4A patent/BRPI0616874A2/pt not_active Application Discontinuation
- 2006-09-21 MY MYPI20080998A patent/MY143351A/en unknown
- 2006-09-21 CA CA2624306A patent/CA2624306C/en active Active
- 2006-09-21 EP EP06792199A patent/EP1957048A2/de not_active Withdrawn
- 2006-09-21 US US12/089,148 patent/US8586082B2/en active Active
- 2006-10-02 DO DO2006000209A patent/DOP2006000209A/es unknown
- 2006-10-03 TW TW095136623A patent/TWI389691B/zh not_active IP Right Cessation
- 2006-10-03 PE PE2006001198A patent/PE20070588A1/es not_active Application Discontinuation
- 2006-10-03 UY UY29835A patent/UY29835A1/es not_active Application Discontinuation
- 2006-10-04 AR ARP060104365A patent/AR056564A1/es unknown
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2008
- 2008-04-02 SV SV2008002857A patent/SV2009002857A/es active IP Right Grant
- 2008-04-02 ZA ZA200802873A patent/ZA200802873B/xx unknown
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- 2008-04-03 IL IL190618A patent/IL190618A0/en unknown
- 2008-04-03 CR CR9864A patent/CR9864A/es not_active Application Discontinuation
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