DE01201911T1 - Methoden zur Hemmung der Knochenresorption - Google Patents

Methoden zur Hemmung der Knochenresorption Download PDF

Info

Publication number
DE01201911T1
DE01201911T1 DE01201911T DE01201911T DE01201911T1 DE 01201911 T1 DE01201911 T1 DE 01201911T1 DE 01201911 T DE01201911 T DE 01201911T DE 01201911 T DE01201911 T DE 01201911T DE 01201911 T1 DE01201911 T1 DE 01201911T1
Authority
DE
Germany
Prior art keywords
unit dose
bisphosphonate
week
mammal
twice
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
DE01201911T
Other languages
German (de)
English (en)
Other versions
DE20101911U1 (de
Inventor
Anastasia G. Daifotis
Arthur C. Santora Ii
John A. Yates
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck and Co Inc
Original Assignee
Merck and Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27451690&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DE01201911(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from GBGB9717590.5A external-priority patent/GB9717590D0/en
Priority claimed from GBGB9717850.3A external-priority patent/GB9717850D0/en
Application filed by Merck and Co Inc filed Critical Merck and Co Inc
Publication of DE01201911T1 publication Critical patent/DE01201911T1/de
Pending legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/662—Phosphorus acids or esters thereof having P—C bonds, e.g. foscarnet, trichlorfon
    • A61K31/663—Compounds having two or more phosphorus acid groups or esters thereof, e.g. clodronic acid, pamidronic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/675—Phosphorus compounds having nitrogen as a ring hetero atom, e.g. pyridoxal phosphate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
    • A61K9/0095—Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/08—Drugs for disorders of the urinary system of the prostate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
    • A61P3/14—Drugs for disorders of the metabolism for electrolyte homeostasis for calcium homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Rheumatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • Urology & Nephrology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Compounds Of Unknown Constitution (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicinal Preparation (AREA)
  • Hydrogenated Pyridines (AREA)
  • Saccharide Compounds (AREA)
  • Fittings On The Vehicle Exterior For Carrying Loads, And Devices For Holding Or Mounting Articles (AREA)
  • Pit Excavations, Shoring, Fill Or Stabilisation Of Slopes (AREA)
  • Aiming, Guidance, Guns With A Light Source, Armor, Camouflage, And Targets (AREA)
DE01201911T 1997-07-22 1998-07-17 Methoden zur Hemmung der Knochenresorption Pending DE01201911T1 (de)

Applications Claiming Priority (8)

Application Number Priority Date Filing Date Title
US5335197P 1997-07-22 1997-07-22
US53351P 1997-07-22
US5353597P 1997-07-23 1997-07-23
US53535P 1997-07-23
GB9717590 1997-08-20
GBGB9717590.5A GB9717590D0 (en) 1997-08-20 1997-08-20 Oral method for treating or preventing abnormal bone resorption
GBGB9717850.3A GB9717850D0 (en) 1997-08-22 1997-08-22 Oral method for treating or preventing abnormal bone resorption
GB9717850 1997-08-22

Publications (1)

Publication Number Publication Date
DE01201911T1 true DE01201911T1 (de) 2007-10-18

Family

ID=27451690

Family Applications (6)

Application Number Title Priority Date Filing Date
DE200712000063 Pending DE122007000063I1 (de) 1997-07-22 1998-07-17 Alendronate zur Behandlung von Osteoporose
DE69837450T Expired - Lifetime DE69837450T2 (de) 1997-07-22 1998-07-17 Alendronate zur Behandlung von Osteoporose
DE01201913T Pending DE01201913T1 (de) 1997-07-22 1998-07-17 Methoden zur Hemmung der Knochenresorption
DE01201911T Pending DE01201911T1 (de) 1997-07-22 1998-07-17 Methoden zur Hemmung der Knochenresorption
DE69803291T Revoked DE69803291T2 (de) 1997-07-22 1998-07-17 Methoden zur verhinderung von knochenresorption
DE1998603291 Pending DE122006000009I1 (de) 1997-07-22 1998-07-17 Methoden zur Verhinderung von Knochenresorption

Family Applications Before (3)

Application Number Title Priority Date Filing Date
DE200712000063 Pending DE122007000063I1 (de) 1997-07-22 1998-07-17 Alendronate zur Behandlung von Osteoporose
DE69837450T Expired - Lifetime DE69837450T2 (de) 1997-07-22 1998-07-17 Alendronate zur Behandlung von Osteoporose
DE01201913T Pending DE01201913T1 (de) 1997-07-22 1998-07-17 Methoden zur Hemmung der Knochenresorption

Family Applications After (2)

Application Number Title Priority Date Filing Date
DE69803291T Revoked DE69803291T2 (de) 1997-07-22 1998-07-17 Methoden zur verhinderung von knochenresorption
DE1998603291 Pending DE122006000009I1 (de) 1997-07-22 1998-07-17 Methoden zur Verhinderung von Knochenresorption

Country Status (31)

Country Link
EP (5) EP1132088A3 (cg-RX-API-DMAC7.html)
JP (2) JP3479780B2 (cg-RX-API-DMAC7.html)
KR (3) KR20030097610A (cg-RX-API-DMAC7.html)
CN (3) CN1299689C (cg-RX-API-DMAC7.html)
AT (2) ATE209037T1 (cg-RX-API-DMAC7.html)
AU (1) AU8493698A (cg-RX-API-DMAC7.html)
BG (1) BG66282B1 (cg-RX-API-DMAC7.html)
BR (1) BR9810779A (cg-RX-API-DMAC7.html)
CA (1) CA2294595C (cg-RX-API-DMAC7.html)
CY (2) CY1107535T1 (cg-RX-API-DMAC7.html)
DE (6) DE122007000063I1 (cg-RX-API-DMAC7.html)
DK (2) DK0998292T3 (cg-RX-API-DMAC7.html)
EA (1) EA004544B2 (cg-RX-API-DMAC7.html)
EE (1) EE05603B1 (cg-RX-API-DMAC7.html)
ES (3) ES2164447T3 (cg-RX-API-DMAC7.html)
HK (4) HK1042230A1 (cg-RX-API-DMAC7.html)
ID (1) ID24096A (cg-RX-API-DMAC7.html)
IL (1) IL133535A0 (cg-RX-API-DMAC7.html)
IS (3) IS5315A (cg-RX-API-DMAC7.html)
LU (2) LU91222I2 (cg-RX-API-DMAC7.html)
NL (2) NL300223I1 (cg-RX-API-DMAC7.html)
NO (1) NO20000323L (cg-RX-API-DMAC7.html)
NZ (1) NZ501807A (cg-RX-API-DMAC7.html)
PL (1) PL195272B1 (cg-RX-API-DMAC7.html)
PT (2) PT998292E (cg-RX-API-DMAC7.html)
SG (2) SG139556A1 (cg-RX-API-DMAC7.html)
SI (1) SI0998292T1 (cg-RX-API-DMAC7.html)
SK (1) SK932000A3 (cg-RX-API-DMAC7.html)
TR (1) TR200000145T2 (cg-RX-API-DMAC7.html)
UY (1) UY25950A1 (cg-RX-API-DMAC7.html)
WO (1) WO1999004773A2 (cg-RX-API-DMAC7.html)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1147773B1 (en) * 1998-12-25 2004-04-07 Yamanouchi Pharmaceutical Co. Ltd. Medicinal compositions for treating osseous lesion in multiple myeloma
PL351674A1 (en) * 1999-05-21 2003-05-19 Novartis Ag Use of bisphosphonic acids for treating angiogenesis
US6670343B1 (en) * 1999-07-19 2003-12-30 Toray Industries, Inc. Drugs for periodontal disease
AU2270101A (en) * 1999-12-20 2001-07-03 Merck & Co., Inc. Pharmaceutical kit
WO2001046040A1 (en) 1999-12-20 2001-06-28 Merck & Co., Inc. Blister package for pharmaceutical treatment card
CN1446093A (zh) * 2000-04-07 2003-10-01 得克萨斯系统大学董事会 两性离子型磷脂和双膦酸酯的独特组合物及其作为降低肠胃毒性的双膦酸酯释放系统的应用
DK1591122T3 (da) * 2000-06-20 2013-02-25 Novartis Ag Fremgangsmåde til indgivelse af bisphosphonater
NZ523086A (en) 2000-06-20 2007-07-27 Novartis Ag Method of administering bisphosphonates
US6638920B2 (en) * 2000-07-21 2003-10-28 Merck & Co., Inc. Compositions and methods of preventing or reducing the risk or incidence of skeletal injuries in horses
SE0101379D0 (sv) 2001-04-18 2001-04-18 Diabact Ab Komposition som hämmar utsöndring av magsyra
EP1392325B1 (en) * 2001-05-02 2006-06-21 Novartis AG Method of administration of bisphosphonates by inhalation in the treatment or prevention of bone resorption and osteoporosis
KR20150053811A (ko) * 2002-05-10 2015-05-18 에프. 호프만-라 로슈 아게 골다공증 치료 및 예방용 비스포스폰산
SE0203065D0 (sv) 2002-10-16 2002-10-16 Diabact Ab Gastric acid secretion inhibiting composition
CN1852719A (zh) * 2003-09-19 2006-10-25 辉瑞产品公司 包括2－亚烷基－19－去甲－维生素d衍生物和二膦酸盐的组合的药物组合物和方法
WO2005072747A1 (ja) * 2004-02-02 2005-08-11 Ono Pharmaceutical Co., Ltd. 骨吸収抑制剤
NZ567200A (en) * 2005-09-16 2010-08-27 Selamine Ltd Bisphosphonate formulation
CN103140220A (zh) * 2010-12-06 2013-06-05 给药技术公司 具有快速溶解特性的稳定的泡腾双磷酸盐制剂
CN106924257B (zh) * 2017-03-14 2019-11-19 湖南赛隆药业有限公司 质子泵抑制剂和抗骨质疏松药的复合物及其用途

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL84731A0 (en) * 1986-12-19 1988-05-31 Norwich Eaton Pharma Heterocycle-substituted diphosphonic acids and salts and esters and pharmaceutical compositions containing them
SE8704436D0 (sv) * 1987-11-13 1987-11-13 Pm Konsult Handelsbolag Anvendning av antisekretoriska substanser for nya indikationer
DK0521388T3 (da) * 1991-07-01 1995-09-11 Gergely Gerhard Fremgangsmåde til fremstilling af et farmaceutisk præparat med mindst to forskellige aktivstoffer samt anvendelsen af et sådant præparat
WO1993009785A1 (en) * 1991-11-22 1993-05-27 Procter & Gamble Pharmaceuticals, Inc. Risedronate delayed-release compositions
US5270365A (en) * 1991-12-17 1993-12-14 Merck & Co., Inc. Prevention and treatment of periodontal disease with alendronate
US5294433A (en) * 1992-04-15 1994-03-15 The Procter & Gamble Company Use of H-2 antagonists for treatment of gingivitis
DK0648120T3 (da) * 1992-06-30 1998-01-19 Procter & Gamble Pharma Anvendelse af phosphonater til behandling af osteoporose
US5431920A (en) * 1993-09-21 1995-07-11 Merck Frosst, Canada, Inc. Enteric coated oral compositions containing bisphosphonic acid antihypercalcemic agents
US5646134A (en) * 1994-04-21 1997-07-08 Merck & Co., Inc. Alendronate therapy to prevent loosening of, or pain associated with, orthopedic implant devices
JPH11506750A (ja) * 1995-06-06 1999-06-15 メルク エンド カンパニー インコーポレーテッド 慢性関節リウマチに係わる骨欠損に対するビスホスホネート療法
JP2000511178A (ja) * 1996-05-17 2000-08-29 メルク エンド カンパニー インコーポレーテッド 発泡性ビスホスホネート製剤

Also Published As

Publication number Publication date
HK1040495A1 (en) 2002-06-14
DK0998292T3 (da) 2002-05-13
TR200000145T2 (tr) 2000-05-22
DE69837450T2 (de) 2007-08-23
IL133535A0 (en) 2001-04-30
HK1024166A1 (en) 2000-10-05
SI0998292T1 (en) 2002-04-30
LU91222I2 (fr) 2006-04-18
PT1175904E (pt) 2007-04-30
KR100391732B1 (ko) 2003-07-16
ID24096A (id) 2000-07-06
DE01201913T1 (de) 2007-02-08
BR9810779A (pt) 2000-07-25
BG104093A (en) 2000-10-31
EP1151752A2 (en) 2001-11-07
WO1999004773A2 (en) 1999-02-04
HK1042230A1 (en) 2002-08-09
EP1175904B1 (en) 2007-03-28
UY25950A1 (es) 2000-09-29
NL300223I1 (nl) 2006-04-03
JP3479780B2 (ja) 2003-12-15
DE69803291T2 (de) 2002-08-08
IS5315A (is) 1999-12-21
BG66282B1 (bg) 2013-01-31
CN1602879A (zh) 2005-04-06
LU91364I2 (fr) 2007-11-12
HK1042232A1 (en) 2002-08-09
EP1175903A2 (en) 2002-01-30
NL300292I1 (nl) 2007-11-01
ES2269014T3 (es) 2007-05-01
CA2294595C (en) 2001-08-21
PL195272B1 (pl) 2007-08-31
KR20030097611A (ko) 2003-12-31
CN1265035A (zh) 2000-08-30
EP1132088A2 (en) 2001-09-12
SK932000A3 (en) 2000-09-12
EE200000040A (et) 2000-10-16
DK1175904T3 (da) 2007-05-07
WO1999004773A3 (en) 1999-04-15
NO20000323D0 (no) 2000-01-21
SG139556A1 (en) 2008-02-29
CN1166365C (zh) 2004-09-15
ES2269014T1 (es) 2007-04-01
WO1999004773A9 (en) 1999-10-28
ATE357921T1 (de) 2007-04-15
EP0998292B1 (en) 2001-11-21
CN1299689C (zh) 2007-02-14
CA2294595A1 (en) 1999-02-04
EP1132088A3 (en) 2002-04-24
EP1175903A3 (en) 2002-12-18
JP2005068010A (ja) 2005-03-17
NO20000323L (no) 2000-03-20
EA004544B1 (ru) 2004-06-24
IS7231A (is) 2004-04-21
EA004544B2 (ru) 2006-12-29
PT998292E (pt) 2002-04-29
AU8493698A (en) 1999-02-16
CY2007022I2 (el) 2012-01-25
KR20010022110A (ko) 2001-03-15
DE122007000063I1 (de) 2007-12-20
HK1040494A1 (en) 2002-06-14
EP1151752A3 (en) 2002-12-18
EP1175904A3 (en) 2002-12-18
DE69837450D1 (de) 2007-05-10
PL338635A1 (en) 2000-11-06
CN1602880A (zh) 2005-04-06
JP2002502433A (ja) 2002-01-22
ATE209037T1 (de) 2001-12-15
IS7230A (is) 2004-04-21
NZ501807A (en) 2003-02-28
EP1175904B8 (en) 2007-05-09
EP0998292A2 (en) 2000-05-10
DE122006000009I1 (de) 2006-06-14
CY2007022I1 (el) 2012-01-25
EE05603B1 (et) 2012-12-17
EA200000151A1 (ru) 2000-10-30
EP1175904A2 (en) 2002-01-30
ES2253136T1 (es) 2006-06-01
SG109478A1 (en) 2005-03-30
CY1107535T1 (el) 2012-01-25
KR20030097610A (ko) 2003-12-31
DE69803291D1 (de) 2002-02-21
ES2164447T3 (es) 2002-02-16

Similar Documents

Publication Publication Date Title
DE01201911T1 (de) Methoden zur Hemmung der Knochenresorption
EP1296689B1 (en) Method of administering bisphosphonates
Adachi et al. Effects of topical administration of a bisphosphonate (risedronate) on orthodontic tooth movements in rats
DE60317061T2 (de) Ibandronsäure zur behandlung und vorbeugung von osteoporose
DE60117362T2 (de) Parenteral anzuwendendes bisphosphonathaltiges arzneimittel
Martin et al. Bisphosphonates-mechanisms of action
IL104109A0 (en) Pharmaceutical compositions containing aldenorate for treating periodontal diseases
Fleisch Bisphosphonates: mechanisms of action and clinical use in osteoporosis-an update
JP2002529490A5 (cg-RX-API-DMAC7.html)
DE60019580T2 (de) Verwendung von biphosphonsäuren zur behandlung von angiogenese
CA2438848A1 (en) Compositions for delivering bisphosphonates
JPH08505142A (ja) 骨損失を治療及び予防するためのビスホスホネート／エストロゲン療法
ATE289199T1 (de) Formulierungen mit dem wasserfreien mononatriumsalz von alendronat und deren verwendung zur behandlung von knochenkrankheiten
RU2006110736A (ru) Комбинация, содержащая n-(3-метокси-5-метилпиразин-2-ил)-2-(1, 3, 4-оксадиазол-2-ил)пиридин-3-сульфонамид и lhrh- аналог и/или бифосфонат
Rossini et al. Intramuscular clodronate therapy in postmenopausal osteoporosis
KR970061249A (ko) 골다공증을 치료 또는 방지하기 위한 조성물
KR970705400A (ko) 골 활성 포스포네이트 및 부갑상선 호르몬을 사용한 골다공증의 치료방법(methods for the treatment of osteoporosis using bone active phosphonates and parathyroid hormone)
EP1591122B1 (en) Method of administering bisphosphonates
RU2004122433A (ru) Способ лечения костных нарушений
Fleisch Bisphosphonates
RU94046103A (ru) Содержащие четвертичный азот фосфонатные соединения для лечения аномального кальциевого и фосфатного метаболизма, фармацевтическая композиция, способ лечения
AU2012202489B2 (en) Bisphosphonic acid for the treatment and prevention of osteoporosis
HRP20000035A2 (en) Method for inhibiting bone resorption
JPH08277223A (ja) 高カルシウム血症治療のための薬剤