EE05603B1 - Alendronaadi kasutamine ravimi valmistamiseks osteoporoosi raviks - Google Patents

Alendronaadi kasutamine ravimi valmistamiseks osteoporoosi raviks

Info

Publication number
EE05603B1
EE05603B1 EEP200000040A EEP200000040A EE05603B1 EE 05603 B1 EE05603 B1 EE 05603B1 EE P200000040 A EEP200000040 A EE P200000040A EE P200000040 A EEP200000040 A EE P200000040A EE 05603 B1 EE05603 B1 EE 05603B1
Authority
EE
Estonia
Prior art keywords
alendronate
disclosed
osteoporosis
medicament
manufacture
Prior art date
Application number
EEP200000040A
Other languages
English (en)
Estonian (et)
Inventor
G. Daifotis Anastasia
C. Ii Santora Arthur
John Yates A.
Original Assignee
Merck & Co., Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27451690&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=EE05603(B1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from GBGB9717590.5A external-priority patent/GB9717590D0/en
Priority claimed from GBGB9717850.3A external-priority patent/GB9717850D0/en
Application filed by Merck & Co., Inc. filed Critical Merck & Co., Inc.
Publication of EE200000040A publication Critical patent/EE200000040A/xx
Publication of EE05603B1 publication Critical patent/EE05603B1/xx

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/662—Phosphorus acids or esters thereof having P—C bonds, e.g. foscarnet, trichlorfon
    • A61K31/663—Compounds having two or more phosphorus acid groups or esters thereof, e.g. clodronic acid, pamidronic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/675—Phosphorus compounds having nitrogen as a ring hetero atom, e.g. pyridoxal phosphate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
    • A61K9/0095—Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/08—Drugs for disorders of the urinary system of the prostate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
    • A61P3/14—Drugs for disorders of the metabolism for electrolyte homeostasis for calcium homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Rheumatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Urology & Nephrology (AREA)
  • Endocrinology (AREA)
  • Obesity (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Compounds Of Unknown Constitution (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicinal Preparation (AREA)
  • Pit Excavations, Shoring, Fill Or Stabilisation Of Slopes (AREA)
  • Saccharide Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Fittings On The Vehicle Exterior For Carrying Loads, And Devices For Holding Or Mounting Articles (AREA)
  • Aiming, Guidance, Guns With A Light Source, Armor, Camouflage, And Targets (AREA)
EEP200000040A 1997-07-22 1998-07-17 Alendronaadi kasutamine ravimi valmistamiseks osteoporoosi raviks EE05603B1 (et)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US5335197P 1997-07-22 1997-07-22
US5353597P 1997-07-23 1997-07-23
GBGB9717590.5A GB9717590D0 (en) 1997-08-20 1997-08-20 Oral method for treating or preventing abnormal bone resorption
GBGB9717850.3A GB9717850D0 (en) 1997-08-22 1997-08-22 Oral method for treating or preventing abnormal bone resorption
PCT/US1998/014796 WO1999004773A2 (en) 1997-07-22 1998-07-17 Method for inhibiting bone resorption

Publications (2)

Publication Number Publication Date
EE200000040A EE200000040A (et) 2000-10-16
EE05603B1 true EE05603B1 (et) 2012-12-17

Family

ID=27451690

Family Applications (1)

Application Number Title Priority Date Filing Date
EEP200000040A EE05603B1 (et) 1997-07-22 1998-07-17 Alendronaadi kasutamine ravimi valmistamiseks osteoporoosi raviks

Country Status (31)

Country Link
EP (5) EP1132088A3 (xx)
JP (2) JP3479780B2 (xx)
KR (3) KR20030097610A (xx)
CN (3) CN1299689C (xx)
AT (2) ATE357921T1 (xx)
AU (1) AU8493698A (xx)
BG (1) BG66282B1 (xx)
BR (1) BR9810779A (xx)
CA (1) CA2294595C (xx)
CY (2) CY1107535T1 (xx)
DE (6) DE122006000009I1 (xx)
DK (2) DK1175904T3 (xx)
EA (1) EA004544B2 (xx)
EE (1) EE05603B1 (xx)
ES (3) ES2253136T1 (xx)
HK (5) HK1024166A1 (xx)
ID (1) ID24096A (xx)
IL (1) IL133535A0 (xx)
IS (3) IS5315A (xx)
LU (2) LU91222I2 (xx)
NL (2) NL300223I1 (xx)
NO (1) NO20000323L (xx)
NZ (1) NZ501807A (xx)
PL (1) PL195272B1 (xx)
PT (2) PT998292E (xx)
SG (2) SG139556A1 (xx)
SI (1) SI0998292T1 (xx)
SK (1) SK932000A3 (xx)
TR (1) TR200000145T2 (xx)
UY (1) UY25950A1 (xx)
WO (1) WO1999004773A2 (xx)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE263566T1 (de) 1998-12-25 2004-04-15 Yamanouchi Pharma Co Ltd Medizinische zusammensetzungen zur behandlung von knochenschäden im multiplen myelom
EP1178810B8 (en) * 1999-05-21 2005-07-27 Novartis AG Use of bisphosphonic acids for treating angiogenesis
DE60043648D1 (de) * 1999-07-19 2010-02-25 Toray Industries Medikamente zur behandlung von periodontalen erkrankungen
US6978894B2 (en) 1999-12-20 2005-12-27 Merck & Co., Inc. Blister package for pharmaceutical treatment card
AU2270101A (en) * 1999-12-20 2001-07-03 Merck & Co., Inc. Pharmaceutical kit
CA2405360A1 (en) * 2000-04-07 2001-10-18 The Board Of Regents Of The University Of Texas System Unique compositions of zwitterionic phospholipids and bisphosphonates and use of the compositions as bisphosphate delivery systems with reduced gi toxicity
US8052987B2 (en) 2000-06-20 2011-11-08 Novartis Pharmaceuticals Corporation Method of administering bisphosphonates
US6638920B2 (en) * 2000-07-21 2003-10-28 Merck & Co., Inc. Compositions and methods of preventing or reducing the risk or incidence of skeletal injuries in horses
SE0101379D0 (sv) 2001-04-18 2001-04-18 Diabact Ab Komposition som hämmar utsöndring av magsyra
JP2004528365A (ja) * 2001-05-02 2004-09-16 ノバルティス アクチエンゲゼルシャフト 骨再吸収症および骨粗しょう症の処置または予防におけるビスホスホネートの吸入投与方法
PT1506041E (pt) * 2002-05-10 2007-12-28 Hoffmann La Roche Ácido ibandrónico para o tratamento e a prevenção da osteoporose
SE0203065D0 (sv) * 2002-10-16 2002-10-16 Diabact Ab Gastric acid secretion inhibiting composition
JP2007505886A (ja) * 2003-09-19 2007-03-15 ファイザー・プロダクツ・インク ２−メチレン−１９−ノル−ビタミンｄ誘導体及びビスホスフォネートの組み合わせを含む医薬組成物及び方法
WO2005072747A1 (ja) * 2004-02-02 2005-08-11 Ono Pharmaceutical Co., Ltd. 骨吸収抑制剤
AU2006290519B2 (en) * 2005-09-16 2012-10-18 Selamine Ltd Bisphosphonate formulation
US9592195B2 (en) * 2010-12-06 2017-03-14 Effrx Pharmaceuticals Sa Stable effervescent bisphosphonate formulations with rapid solubilization characteristics
CN106924257B (zh) * 2017-03-14 2019-11-19 湖南赛隆药业有限公司 质子泵抑制剂和抗骨质疏松药的复合物及其用途

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL84731A0 (en) * 1986-12-19 1988-05-31 Norwich Eaton Pharma Heterocycle-substituted diphosphonic acids and salts and esters and pharmaceutical compositions containing them
SE8704436D0 (sv) * 1987-11-13 1987-11-13 Pm Konsult Handelsbolag Anvendning av antisekretoriska substanser for nya indikationer
DE59202126D1 (de) * 1991-07-01 1995-06-14 Gergely Gerhard Verfahren zur Herstellung einer pharmazeutischen Zubereitung mit wenigstens zwei verschiedenen Wirkstoffen und Verwendung einer solchen Zubereitung.
WO1993009785A1 (en) * 1991-11-22 1993-05-27 Procter & Gamble Pharmaceuticals, Inc. Risedronate delayed-release compositions
US5270365A (en) * 1991-12-17 1993-12-14 Merck & Co., Inc. Prevention and treatment of periodontal disease with alendronate
US5294433A (en) * 1992-04-15 1994-03-15 The Procter & Gamble Company Use of H-2 antagonists for treatment of gingivitis
ATE161423T1 (de) * 1992-06-30 1998-01-15 Procter & Gamble Pharma Verwendung von phosphinate zur behandlung der osteoporose
US5431920A (en) * 1993-09-21 1995-07-11 Merck Frosst, Canada, Inc. Enteric coated oral compositions containing bisphosphonic acid antihypercalcemic agents
US5646134A (en) * 1994-04-21 1997-07-08 Merck & Co., Inc. Alendronate therapy to prevent loosening of, or pain associated with, orthopedic implant devices
WO1996039150A1 (en) * 1995-06-06 1996-12-12 Merck & Co., Inc. Bisphosphonate therapy for bone loss associated with rheumatoid arthritis
JP2000511178A (ja) * 1996-05-17 2000-08-29 メルク エンド カンパニー インコーポレーテッド 発泡性ビスホスホネート製剤

Also Published As

Publication number Publication date
CN1166365C (zh) 2004-09-15
CA2294595A1 (en) 1999-02-04
DK1175904T3 (da) 2007-05-07
ID24096A (id) 2000-07-06
SK932000A3 (en) 2000-09-12
KR20030097610A (ko) 2003-12-31
LU91364I2 (fr) 2007-11-12
DK0998292T3 (da) 2002-05-13
WO1999004773A2 (en) 1999-02-04
DE122007000063I1 (de) 2007-12-20
NL300223I1 (nl) 2006-04-03
EE200000040A (et) 2000-10-16
WO1999004773A9 (en) 1999-10-28
HK1042230A1 (zh) 2002-08-09
WO1999004773A3 (en) 1999-04-15
EA004544B2 (ru) 2006-12-29
ES2269014T1 (es) 2007-04-01
ATE209037T1 (de) 2001-12-15
BR9810779A (pt) 2000-07-25
KR100391732B1 (ko) 2003-07-16
CN1299689C (zh) 2007-02-14
DE01201911T1 (de) 2007-10-18
NZ501807A (en) 2003-02-28
NL300292I1 (nl) 2007-11-01
CN1602880A (zh) 2005-04-06
ATE357921T1 (de) 2007-04-15
AU8493698A (en) 1999-02-16
IL133535A0 (en) 2001-04-30
PL338635A1 (en) 2000-11-06
PT1175904E (pt) 2007-04-30
DE69803291D1 (de) 2002-02-21
CN1602879A (zh) 2005-04-06
KR20030097611A (ko) 2003-12-31
PT998292E (pt) 2002-04-29
HK1024166A1 (en) 2000-10-05
EP1132088A2 (en) 2001-09-12
EP1175903A3 (en) 2002-12-18
JP2002502433A (ja) 2002-01-22
HK1042232A1 (zh) 2002-08-09
CY1107535T1 (el) 2012-01-25
SG139556A1 (en) 2008-02-29
CA2294595C (en) 2001-08-21
UY25950A1 (es) 2000-09-29
DE69837450T2 (de) 2007-08-23
CY2007022I2 (el) 2012-01-25
CY2007022I1 (el) 2012-01-25
EP1151752A2 (en) 2001-11-07
DE69837450D1 (de) 2007-05-10
ES2253136T1 (es) 2006-06-01
SI0998292T1 (en) 2002-04-30
CN1265035A (zh) 2000-08-30
EP1132088A3 (en) 2002-04-24
EP1175904A2 (en) 2002-01-30
NO20000323L (no) 2000-03-20
BG66282B1 (bg) 2013-01-31
HK1040494A1 (zh) 2002-06-14
EP0998292A2 (en) 2000-05-10
BG104093A (en) 2000-10-31
EP1151752A3 (en) 2002-12-18
IS5315A (is) 1999-12-21
EA200000151A1 (ru) 2000-10-30
IS7230A (is) 2004-04-21
EP1175904B8 (en) 2007-05-09
JP3479780B2 (ja) 2003-12-15
NO20000323D0 (no) 2000-01-21
ES2164447T3 (es) 2002-02-16
TR200000145T2 (tr) 2000-05-22
EP1175903A2 (en) 2002-01-30
EP1175904B1 (en) 2007-03-28
DE122006000009I1 (de) 2006-06-14
SG109478A1 (en) 2005-03-30
EA004544B1 (ru) 2004-06-24
HK1040495A1 (zh) 2002-06-14
DE69803291T2 (de) 2002-08-08
JP2005068010A (ja) 2005-03-17
DE01201913T1 (de) 2007-02-08
IS7231A (is) 2004-04-21
KR20010022110A (ko) 2001-03-15
ES2269014T3 (es) 2007-05-01
EP1175904A3 (en) 2002-12-18
PL195272B1 (pl) 2007-08-31
LU91222I2 (fr) 2006-04-18
EP0998292B1 (en) 2001-11-21

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Legal Events

Date Code Title Description
HC1A Change of owner name
GB1A Change in the ownership or in the address of the owner
HC1A Change of owner name