RU2006110736A - Комбинация, содержащая n-(3-метокси-5-метилпиразин-2-ил)-2-(1, 3, 4-оксадиазол-2-ил)пиридин-3-сульфонамид и lhrh- аналог и/или бифосфонат - Google Patents
Комбинация, содержащая n-(3-метокси-5-метилпиразин-2-ил)-2-(1, 3, 4-оксадиазол-2-ил)пиридин-3-сульфонамид и lhrh- аналог и/или бифосфонат Download PDFInfo
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- RU2006110736A RU2006110736A RU2006110736/15A RU2006110736A RU2006110736A RU 2006110736 A RU2006110736 A RU 2006110736A RU 2006110736/15 A RU2006110736/15 A RU 2006110736/15A RU 2006110736 A RU2006110736 A RU 2006110736A RU 2006110736 A RU2006110736 A RU 2006110736A
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- NKFLEFWUYAUDJV-UHFFFAOYSA-N pyridine-3-sulfonamide Chemical compound NS(=O)(=O)C1=CC=CN=C1 NKFLEFWUYAUDJV-UHFFFAOYSA-N 0.000 title 1
- 239000002253 acid Substances 0.000 claims 24
- 229960002286 clodronic acid Drugs 0.000 claims 12
- ACSIXWWBWUQEHA-UHFFFAOYSA-N clodronic acid Chemical compound OP(O)(=O)C(Cl)(Cl)P(O)(O)=O ACSIXWWBWUQEHA-UHFFFAOYSA-N 0.000 claims 12
- XLXSAKCOAKORKW-UHFFFAOYSA-N gonadorelin Chemical class C1CCC(C(=O)NCC(N)=O)N1C(=O)C(CCCN=C(N)N)NC(=O)C(CC(C)C)NC(=O)CNC(=O)C(NC(=O)C(CO)NC(=O)C(CC=1C2=CC=CC=C2NC=1)NC(=O)C(CC=1NC=NC=1)NC(=O)C1NC(=O)CC1)CC1=CC=C(O)C=C1 XLXSAKCOAKORKW-UHFFFAOYSA-N 0.000 claims 10
- 229940122361 Bisphosphonate Drugs 0.000 claims 8
- 150000004663 bisphosphonates Chemical class 0.000 claims 8
- OGSPWJRAVKPPFI-UHFFFAOYSA-N Alendronic Acid Chemical compound NCCCC(O)(P(O)(O)=O)P(O)(O)=O OGSPWJRAVKPPFI-UHFFFAOYSA-N 0.000 claims 6
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 claims 6
- MPBVHIBUJCELCL-UHFFFAOYSA-N Ibandronate Chemical compound CCCCCN(C)CCC(O)(P(O)(O)=O)P(O)(O)=O MPBVHIBUJCELCL-UHFFFAOYSA-N 0.000 claims 6
- IIDJRNMFWXDHID-UHFFFAOYSA-N Risedronic acid Chemical compound OP(=O)(O)C(P(O)(O)=O)(O)CC1=CC=CN=C1 IIDJRNMFWXDHID-UHFFFAOYSA-N 0.000 claims 6
- DKJJVAGXPKPDRL-UHFFFAOYSA-N Tiludronic acid Chemical compound OP(O)(=O)C(P(O)(O)=O)SC1=CC=C(Cl)C=C1 DKJJVAGXPKPDRL-UHFFFAOYSA-N 0.000 claims 6
- 229960004343 alendronic acid Drugs 0.000 claims 6
- 229910052791 calcium Inorganic materials 0.000 claims 6
- 239000011575 calcium Substances 0.000 claims 6
- ASMGFLAYDQSOPU-UHFFFAOYSA-N hydroxy-[1-hydroxy-3-[methyl(3-phenoxypropyl)azaniumyl]-1-phosphonopropyl]phosphinate Chemical compound OP(=O)(O)C(O)(P(O)(O)=O)CCN(C)CCCOC1=CC=CC=C1 ASMGFLAYDQSOPU-UHFFFAOYSA-N 0.000 claims 6
- 229960005236 ibandronic acid Drugs 0.000 claims 6
- 229950006971 incadronic acid Drugs 0.000 claims 6
- LWRDQHOZTAOILO-UHFFFAOYSA-N incadronic acid Chemical compound OP(O)(=O)C(P(O)(O)=O)NC1CCCCCC1 LWRDQHOZTAOILO-UHFFFAOYSA-N 0.000 claims 6
- 229950011129 minodronic acid Drugs 0.000 claims 6
- VMMKGHQPQIEGSQ-UHFFFAOYSA-N minodronic acid Chemical compound C1=CC=CN2C(CC(O)(P(O)(O)=O)P(O)(O)=O)=CN=C21 VMMKGHQPQIEGSQ-UHFFFAOYSA-N 0.000 claims 6
- WRUUGTRCQOWXEG-UHFFFAOYSA-N pamidronate Chemical compound NCCC(O)(P(O)(O)=O)P(O)(O)=O WRUUGTRCQOWXEG-UHFFFAOYSA-N 0.000 claims 6
- 229960003978 pamidronic acid Drugs 0.000 claims 6
- 229960000759 risedronic acid Drugs 0.000 claims 6
- 229960005324 tiludronic acid Drugs 0.000 claims 6
- 229960004276 zoledronic acid Drugs 0.000 claims 6
- XRASPMIURGNCCH-UHFFFAOYSA-N zoledronic acid Chemical compound OP(=O)(O)C(P(O)(O)=O)(O)CN1C=CN=C1 XRASPMIURGNCCH-UHFFFAOYSA-N 0.000 claims 6
- 229940124041 Luteinizing hormone releasing hormone (LHRH) antagonist Drugs 0.000 claims 5
- 239000002474 gonadorelin antagonist Substances 0.000 claims 5
- 101000904173 Homo sapiens Progonadoliberin-1 Proteins 0.000 claims 4
- 102100024028 Progonadoliberin-1 Human genes 0.000 claims 4
- 101000996723 Sus scrofa Gonadotropin-releasing hormone receptor Proteins 0.000 claims 4
- 239000000556 agonist Substances 0.000 claims 4
- -1 3-methoxy-5-methylpyrazin-2-yl Chemical group 0.000 claims 3
- 206010028980 Neoplasm Diseases 0.000 claims 3
- 201000011510 cancer Diseases 0.000 claims 3
- 150000003839 salts Chemical class 0.000 claims 3
- 108010000817 Leuprolide Proteins 0.000 claims 2
- 239000003085 diluting agent Substances 0.000 claims 2
- 239000003814 drug Substances 0.000 claims 2
- GFIJNRVAKGFPGQ-LIJARHBVSA-N leuprolide Chemical compound CCNC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](CO)NC(=O)[C@H](CC=1C2=CC=CC=C2NC=1)NC(=O)[C@H](CC=1N=CNC=1)NC(=O)[C@H]1NC(=O)CC1)CC1=CC=C(O)C=C1 GFIJNRVAKGFPGQ-LIJARHBVSA-N 0.000 claims 2
- 229960004338 leuprorelin Drugs 0.000 claims 2
- 239000008194 pharmaceutical composition Substances 0.000 claims 2
- NOENHWMKHNSHGX-IZOOSHNJSA-N (2s)-1-[(2s)-2-[[(2s)-2-[[(2r)-2-[[(2r)-2-[[(2s)-2-[[(2r)-2-[[(2s)-2-[[(2r)-2-acetamido-3-naphthalen-2-ylpropanoyl]amino]-3-(4-chlorophenyl)propanoyl]amino]-3-pyridin-3-ylpropanoyl]amino]-3-hydroxypropanoyl]amino]-3-(4-hydroxyphenyl)propanoyl]amino]-6-(ca Chemical compound C([C@H](C(=O)N[C@H](CCCCNC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCNC(C)C)C(=O)N1[C@@H](CCC1)C(=O)N[C@H](C)C(N)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](CC=1C=NC=CC=1)NC(=O)[C@H](CC=1C=CC(Cl)=CC=1)NC(=O)[C@@H](CC=1C=C2C=CC=CC2=CC=1)NC(C)=O)C1=CC=C(O)C=C1 NOENHWMKHNSHGX-IZOOSHNJSA-N 0.000 claims 1
- 108010023617 abarelix Proteins 0.000 claims 1
- AIWRTTMUVOZGPW-HSPKUQOVSA-N abarelix Chemical compound C([C@@H](C(=O)N[C@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCNC(C)C)C(=O)N1[C@@H](CCC1)C(=O)N[C@H](C)C(N)=O)N(C)C(=O)[C@H](CO)NC(=O)[C@@H](CC=1C=NC=CC=1)NC(=O)[C@@H](CC=1C=CC(Cl)=CC=1)NC(=O)[C@@H](CC=1C=C2C=CC=CC2=CC=1)NC(C)=O)C1=CC=C(O)C=C1 AIWRTTMUVOZGPW-HSPKUQOVSA-N 0.000 claims 1
- 229960002184 abarelix Drugs 0.000 claims 1
- 108010070670 antarelix Proteins 0.000 claims 1
- 108700032141 ganirelix Proteins 0.000 claims 1
- GJNXBNATEDXMAK-PFLSVRRQSA-N ganirelix Chemical compound C([C@@H](C(=O)N[C@H](CCCCN=C(NCC)NCC)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN=C(NCC)NCC)C(=O)N1[C@@H](CCC1)C(=O)N[C@H](C)C(N)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](CC=1C=NC=CC=1)NC(=O)[C@@H](CC=1C=CC(Cl)=CC=1)NC(=O)[C@@H](CC=1C=C2C=CC=CC2=CC=1)NC(C)=O)C1=CC=C(O)C=C1 GJNXBNATEDXMAK-PFLSVRRQSA-N 0.000 claims 1
- 229960003794 ganirelix Drugs 0.000 claims 1
- 239000002434 gonadorelin derivative Substances 0.000 claims 1
- QRYFGTULTGLGHU-NBERXCRTSA-N iturelix Chemical compound C([C@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCNC(C)C)C(=O)N1[C@@H](CCC1)C(=O)N[C@H](C)C(N)=O)NC(=O)[C@H](CCCCNC(=O)C=1C=NC=CC=1)NC(=O)[C@H](CO)NC(=O)[C@@H](CC=1C=NC=CC=1)NC(=O)[C@@H](CC=1C=CC(Cl)=CC=1)NC(=O)[C@@H](CC=1C=C2C=CC=CC2=CC=1)NC(C)=O)CCCNC(=O)C1=CC=CN=C1 QRYFGTULTGLGHU-NBERXCRTSA-N 0.000 claims 1
- 108010083551 iturelix Proteins 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 238000000034 method Methods 0.000 claims 1
- 239000000203 mixture Substances 0.000 claims 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/4965—Non-condensed pyrazines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/4965—Non-condensed pyrazines
- A61K31/497—Non-condensed pyrazines containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
- A61K31/662—Phosphorus acids or esters thereof having P—C bonds, e.g. foscarnet, trichlorfon
- A61K31/663—Compounds having two or more phosphorus acid groups or esters thereof, e.g. clodronic acid, pamidronic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
- A61K31/675—Phosphorus compounds having nitrogen as a ring hetero atom, e.g. pyridoxal phosphate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/08—Peptides having 5 to 11 amino acids
- A61K38/09—Luteinising hormone-releasing hormone [LHRH], i.e. Gonadotropin-releasing hormone [GnRH]; Related peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/08—Drugs for disorders of the urinary system of the prostate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/02—Drugs for disorders of the endocrine system of the hypothalamic hormones, e.g. TRH, GnRH, CRH, GRH, somatostatin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/02—Drugs for disorders of the endocrine system of the hypothalamic hormones, e.g. TRH, GnRH, CRH, GRH, somatostatin
- A61P5/04—Drugs for disorders of the endocrine system of the hypothalamic hormones, e.g. TRH, GnRH, CRH, GRH, somatostatin for decreasing, blocking or antagonising the activity of the hypothalamic hormones
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Endocrinology (AREA)
- Diabetes (AREA)
- Reproductive Health (AREA)
- Gastroenterology & Hepatology (AREA)
- Immunology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Urology & Nephrology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Plural Heterocyclic Compounds (AREA)
Claims (23)
1. Комбинация, включающая N-(3-метокси-5-метилпиразин-2-ил)-2-(4-[1,3,4-оксадиазол-2-ил]фенил)пиридин-2-сульфонамид или его фармацевтически приемлемую соль и аналог LHRH.
2. Комбинация, включающая N-(3-метокси-5-метилпиразин-2-ил)-2-(4-[1,3,4-оксадиазол-2-ил]фенил)пиридин-2-сульфонамид или его фармацевтически приемлемую соль и бисфосфонат.
3. Комбинация, включающая N-(3-метокси-5-метилпиразин-2-ил)-2-(4-[1,3,4-оксадиазол-2-ил]фенил)пиридин-2-сульфонамид или его фармацевтически приемлемую соль, аналог LHRH и бисфосфонат.
4. Комбинация по п.1, где аналог LHRH является антагонистом LHRH.
5. Комбинация по п.3, где аналог LHRH является антагонистом LHRH.
6. Комбинация по п.4 или 5, где агонист LHRH выбирают из группы, включающей лейпрорелин, буселерин, триптор и госелерин.
7. Комбинация по п.5, где агонист LHRH выбирают из группы, включающей лейпрорелин, буселерин, триптор и госелерин.
8. Комбинация по п.4 или 5, где агонист LHRH означает госелерин.
9. Комбинация по п.5, где агонист LHRH означает госелерин.
10. Комбинация по п.1, где аналог LHRH является антагонистом LHRH.
11. Комбинация по п.3, где аналог LHRH является антагонистом LHRH.
12. Комбинация по п.10, где антагонист LHRH выбирают из группы, включающей антид, абареликс, антареликс, ценореликс, азалин и ганиреликс.
13. Комбинация по п.2, где бисфосфонат выбирают из группы, включающей тилудроновую кислоту, ибандроновую кислоту, инкадроновую кислоту, риседроновую кислоту, золедроновую кислоту, клодроновую кислоту, неридроновую кислоту, памидроновую кислоту, алендроновую кислоту, минодроновую кислоту, олпадроновую кислоту, TRK 530, CGP 47072, клодронат кальция и ЕВ 1053.
14. Комбинация по п.3, где бисфосфонат выбирают из группы, включающей тилудроновую кислоту, ибандроновую кислоту, инкадроновую кислоту, риседроновую кислоту, золедроновую кислоту, клодроновую кислоту, неридроновую кислоту, памидроновую кислоту, алендроновую кислоту, минодроновую кислоту, олпадроновую кислоту, TRK 530, CGP 47072, клодронат кальция и ЕВ 1053.
15. Комбинация по п.5, где бисфосфонат выбирают из группы, включающей тилудроновую кислоту, ибандроновую кислоту, инкадроновую кислоту, риседроновую кислоту, золедроновую кислоту, клодроновую кислоту, неридроновую кислоту, памидроновую кислоту, алендроновую кислоту, минодроновую кислоту, олпадроновую кислоту, TRK 530, CGP 47072, клодронат кальция и ЕВ 1053.
16. Комбинация по п.7, где бисфосфонат выбирают из группы, включающей тилудроновую кислоту, ибандроновую кислоту, инкадроновую кислоту, риседроновую кислоту, золедроновую кислоту, клодроновую кислоту, неридроновую кислоту, памидроновую кислоту, алендроновую кислоту, минодроновую кислоту, олпадроновую кислоту, TRK 530, CGP 47072, клодронат кальция и ЕВ 1053.
17. Комбинация по п.9, где бисфосфонат выбирают из группы, включающей тилудроновую кислоту, ибандроновую кислоту, инкадроновую кислоту, риседроновую кислоту, золедроновую кислоту, клодроновую кислоту, неридроновую кислоту, памидроновую кислоту, алендроновую кислоту, минодроновую кислоту, олпадроновую кислоту, TRK 530, CGP 47072, клодронат кальция и ЕВ 1053.
18. Комбинация по п.11, где бисфосфонат выбирают из группы, включающей тилудроновую кислоту, ибандроновую кислоту, инкадроновую кислоту, риседроновую кислоту, золедроновую кислоту, клодроновую кислоту, неридроновую кислоту, памидроновую кислоту, алендроновую кислоту, минодроновую кислоту, олпадроновую кислоту, TRK 530, CGP 47072, клодронат кальция и ЕВ 1053.
19. Комбинация по любому из пп.1-18 для применения в качестве лекарственного средства.
20. Фармацевтическая композиция по любому из пп.1-18 в смеси с фармацевтически приемлемым разбавителем или носителем.
21. Способ лечения рака у теплокровного животного, такого, как человек, нуждающегося в таком лечении, который включает введение указанному животному эффективного количества комбинации по любому из пп.1-18.
22. Фармацевтическая композиция, включающая комбинацию по любому из пп.1-18 в смеси с фармацевтически приемлемым разбавителем или носителем для применения при лечении рака.
23. Применение комбинации по любому из пп.1-18 для получения лекарственного средства, предназначенного для лечения рака у теплокровного животного, такого, как человек.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB0320806.3A GB0320806D0 (en) | 2003-09-05 | 2003-09-05 | Therapeutic treatment |
| GB0320806.3 | 2003-09-05 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| RU2006110736A true RU2006110736A (ru) | 2007-10-10 |
| RU2398588C2 RU2398588C2 (ru) | 2010-09-10 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2006110736/15A RU2398588C2 (ru) | 2003-09-05 | 2004-09-02 | Комбинация, содержащая n-(3-метокси-5-метилпиразин-2-ил)-2-(4-[1,3,4-оксадиазол-2-ил]фенил)пиридин-3-сульфонамид и lhrh-аналог и/или бифосфонат |
Country Status (30)
| Country | Link |
|---|---|
| US (2) | US20060287241A1 (ru) |
| EP (2) | EP1663236B1 (ru) |
| JP (1) | JP2007504265A (ru) |
| KR (1) | KR20060069857A (ru) |
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| GB0219660D0 (en) | 2002-08-23 | 2002-10-02 | Astrazeneca Ab | Therapeutic use |
| GB0403744D0 (en) | 2004-02-20 | 2004-03-24 | Astrazeneca Ab | Chemical process |
| CA2701385A1 (en) | 2007-10-12 | 2009-04-16 | Astrazeneca Ab | Composition 064 |
| JP5616233B2 (ja) | 2008-01-24 | 2014-10-29 | エスペランス ファーマシューティカルズＥｓｐｅｒａｎｃｅ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ | 溶解ドメイン融合コンストラクト及びその生成及び使用方法 |
| AU2013337926B2 (en) | 2012-10-30 | 2017-12-21 | Esperance Pharmaceuticals, Inc. | Antibody/drug conjugates and methods of use |
| US9393265B2 (en) | 2013-03-13 | 2016-07-19 | Transdermal Biotechnology, Inc. | Wound healing using topical systems and methods |
| US9295647B2 (en) | 2013-03-13 | 2016-03-29 | Transdermal Biotechnology, Inc. | Systems and methods for delivery of peptides |
| US20140271937A1 (en) | 2013-03-13 | 2014-09-18 | Transdermal Biotechnology, Inc. | Brain and neural treatments comprising peptides and other compositions |
| US9320706B2 (en) | 2013-03-13 | 2016-04-26 | Transdermal Biotechnology, Inc. | Immune modulation using peptides and other compositions |
| US20140271731A1 (en) | 2013-03-13 | 2014-09-18 | Transdermal Biotechnology, Inc. | Cardiovascular disease treatment and prevention |
| US9724419B2 (en) | 2013-03-13 | 2017-08-08 | Transdermal Biotechnology, Inc. | Peptide systems and methods for metabolic conditions |
| US9295637B2 (en) | 2013-03-13 | 2016-03-29 | Transdermal Biotechnology, Inc. | Compositions and methods for affecting mood states |
| US9314423B2 (en) | 2013-03-13 | 2016-04-19 | Transdermal Biotechnology, Inc. | Hair treatment systems and methods using peptides and other compositions |
| US20140271938A1 (en) | 2013-03-13 | 2014-09-18 | Transdermal Biotechnology, Inc. | Systems and methods for delivery of peptides |
| US9241899B2 (en) | 2013-03-13 | 2016-01-26 | Transdermal Biotechnology, Inc. | Topical systems and methods for treating sexual dysfunction |
| US9339457B2 (en) | 2013-03-13 | 2016-05-17 | Transdermal Biotechnology, Inc. | Cardiovascular disease treatment and prevention |
| US9314417B2 (en) | 2013-03-13 | 2016-04-19 | Transdermal Biotechnology, Inc. | Treatment of skin, including aging skin, to improve appearance |
| US9314422B2 (en) | 2013-03-13 | 2016-04-19 | Transdermal Biotechnology, Inc. | Peptide systems and methods for metabolic conditions |
| US9387159B2 (en) | 2013-03-13 | 2016-07-12 | Transdermal Biotechnology, Inc. | Treatment of skin, including aging skin, to improve appearance |
| US9393264B2 (en) | 2013-03-13 | 2016-07-19 | Transdermal Biotechnology, Inc. | Immune modulation using peptides and other compositions |
| US9314433B2 (en) | 2013-03-13 | 2016-04-19 | Transdermal Biotechnology, Inc. | Methods and systems for treating or preventing cancer |
| US9750787B2 (en) | 2013-03-13 | 2017-09-05 | Transdermal Biotechnology, Inc. | Memory or learning improvement using peptide and other compositions |
| US9687520B2 (en) | 2013-03-13 | 2017-06-27 | Transdermal Biotechnology, Inc. | Memory or learning improvement using peptide and other compositions |
| US9849160B2 (en) | 2013-03-13 | 2017-12-26 | Transdermal Biotechnology, Inc. | Methods and systems for treating or preventing cancer |
| US9320758B2 (en) | 2013-03-13 | 2016-04-26 | Transdermal Biotechnology, Inc. | Brain and neural treatments comprising peptides and other compositions |
| US9295636B2 (en) | 2013-03-13 | 2016-03-29 | Transdermal Biotechnology, Inc. | Wound healing using topical systems and methods |
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| SE0100567D0 (sv) | 2001-02-20 | 2001-02-20 | Astrazeneca Ab | Compounds |
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| HUP0400096A2 (hu) * | 2001-05-02 | 2004-04-28 | Novartis Ag. | Biszfoszfonátok gyógyászati alkalmazása |
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| GB0223367D0 (en) * | 2002-10-09 | 2002-11-13 | Astrazeneca Ab | Therapeutic treatment |
| GB0223854D0 (en) * | 2002-10-12 | 2002-11-20 | Astrazeneca Ab | Therapeutic treatment |
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