EA004544B2 - Способ ингибирования резорбции костей - Google Patents

Способ ингибирования резорбции костей

Info

Publication number
EA004544B2
EA004544B2 EA200000151A EA200000151A EA004544B2 EA 004544 B2 EA004544 B2 EA 004544B2 EA 200000151 A EA200000151 A EA 200000151A EA 200000151 A EA200000151 A EA 200000151A EA 004544 B2 EA004544 B2 EA 004544B2
Authority
EA
Eurasian Patent Office
Prior art keywords
bone resorption
inhibiting bone
alendronic
dosing
etridronate
Prior art date
Application number
EA200000151A
Other languages
English (en)
Russian (ru)
Other versions
EA200000151A1 (ru
EA004544B1 (ru
Inventor
Анастасия Г. Дэйфотис
Артур К. II Сантора
А. Джон Йэйтс
Original Assignee
Мерк Энд Ко., Инк.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27451690&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=EA004544(B2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from GBGB9717590.5A external-priority patent/GB9717590D0/en
Priority claimed from GBGB9717850.3A external-priority patent/GB9717850D0/en
Application filed by Мерк Энд Ко., Инк. filed Critical Мерк Энд Ко., Инк.
Publication of EA200000151A1 publication Critical patent/EA200000151A1/ru
Publication of EA004544B1 publication Critical patent/EA004544B1/ru
Publication of EA004544B2 publication Critical patent/EA004544B2/ru

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/66Phosphorus compounds
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/66Phosphorus compounds
    • A61K31/662Phosphorus acids or esters thereof having P—C bonds, e.g. foscarnet, trichlorfon
    • A61K31/663Compounds having two or more phosphorus acid groups or esters thereof, e.g. clodronic acid, pamidronic acid
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/66Phosphorus compounds
    • A61K31/675Phosphorus compounds having nitrogen as a ring hetero atom, e.g. pyridoxal phosphate
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0087Galenical forms not covered by A61K9/02 - A61K9/7023
    • A61K9/0095Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/20Pills, tablets, discs, rods
    • A61K9/2004Excipients; Inactive ingredients
    • A61K9/2022Organic macromolecular compounds
    • A61K9/205Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2054Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00Drugs for disorders of the urinary system
    • A61P13/08Drugs for disorders of the urinary system of the prostate
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/08Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/08Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/12Drugs for disorders of the metabolism for electrolyte homeostasis
    • A61P3/14Drugs for disorders of the metabolism for electrolyte homeostasis for calcium homeostasis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Epidemiology (AREA)
  • Rheumatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Diabetes (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Endocrinology (AREA)
  • Urology & Nephrology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Compounds Of Unknown Constitution (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicinal Preparation (AREA)
  • Saccharide Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Pit Excavations, Shoring, Fill Or Stabilisation Of Slopes (AREA)
  • Aiming, Guidance, Guns With A Light Source, Armor, Camouflage, And Targets (AREA)
  • Fittings On The Vehicle Exterior For Carrying Loads, And Devices For Holding Or Mounting Articles (AREA)
EA200000151A 1997-07-22 1998-07-17 Способ ингибирования резорбции костей EA004544B2 (ru)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US5335197P 1997-07-22 1997-07-22
US5353597P 1997-07-23 1997-07-23
GBGB9717590.5A GB9717590D0 (en) 1997-08-20 1997-08-20 Oral method for treating or preventing abnormal bone resorption
GBGB9717850.3A GB9717850D0 (en) 1997-08-22 1997-08-22 Oral method for treating or preventing abnormal bone resorption
PCT/US1998/014796 WO1999004773A2 (en) 1997-07-22 1998-07-17 Method for inhibiting bone resorption

Publications (3)

Publication Number Publication Date
EA200000151A1 EA200000151A1 (ru) 2000-10-30
EA004544B1 EA004544B1 (ru) 2004-06-24
EA004544B2 true EA004544B2 (ru) 2006-12-29

Family

ID=27451690

Family Applications (1)

Application Number Title Priority Date Filing Date
EA200000151A EA004544B2 (ru) 1997-07-22 1998-07-17 Способ ингибирования резорбции костей

Country Status (31)

Country Link
EP (5) EP0998292B1 (cg-RX-API-DMAC7.html)
JP (2) JP3479780B2 (cg-RX-API-DMAC7.html)
KR (3) KR100391732B1 (cg-RX-API-DMAC7.html)
CN (3) CN1299689C (cg-RX-API-DMAC7.html)
AT (2) ATE357921T1 (cg-RX-API-DMAC7.html)
AU (1) AU8493698A (cg-RX-API-DMAC7.html)
BG (1) BG66282B1 (cg-RX-API-DMAC7.html)
BR (1) BR9810779A (cg-RX-API-DMAC7.html)
CA (1) CA2294595C (cg-RX-API-DMAC7.html)
CY (2) CY1107535T1 (cg-RX-API-DMAC7.html)
DE (6) DE01201911T1 (cg-RX-API-DMAC7.html)
DK (2) DK0998292T3 (cg-RX-API-DMAC7.html)
EA (1) EA004544B2 (cg-RX-API-DMAC7.html)
EE (1) EE05603B1 (cg-RX-API-DMAC7.html)
ES (3) ES2253136T1 (cg-RX-API-DMAC7.html)
HK (4) HK1042230A1 (cg-RX-API-DMAC7.html)
ID (1) ID24096A (cg-RX-API-DMAC7.html)
IL (1) IL133535A0 (cg-RX-API-DMAC7.html)
IS (3) IS5315A (cg-RX-API-DMAC7.html)
LU (2) LU91222I2 (cg-RX-API-DMAC7.html)
NL (2) NL300223I1 (cg-RX-API-DMAC7.html)
NO (1) NO20000323L (cg-RX-API-DMAC7.html)
NZ (1) NZ501807A (cg-RX-API-DMAC7.html)
PL (1) PL195272B1 (cg-RX-API-DMAC7.html)
PT (2) PT998292E (cg-RX-API-DMAC7.html)
SG (2) SG109478A1 (cg-RX-API-DMAC7.html)
SI (1) SI0998292T1 (cg-RX-API-DMAC7.html)
SK (1) SK932000A3 (cg-RX-API-DMAC7.html)
TR (1) TR200000145T2 (cg-RX-API-DMAC7.html)
UY (1) UY25950A1 (cg-RX-API-DMAC7.html)
WO (1) WO1999004773A2 (cg-RX-API-DMAC7.html)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2608724C2 (ru) * 2010-12-06 2017-01-23 Эффэрикс Фармасьютикалз Са Стабильные составы шипучего бисфосфоната со свойствами быстрой солюбилизации

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2356294C (en) 1998-12-25 2007-06-05 Yamanouchi Pharmaceutical Co., Ltd. Pharmaceutical compositions for treating bone lesions in multiple myeloma
IL146520A0 (en) * 1999-05-21 2002-07-25 Novartis Ag Use of bisphosphonic acids for treating angiogenesis
WO2001005403A1 (en) * 1999-07-19 2001-01-25 Toray Industries, Inc. Drugs for periodontal diseases
IL142515A0 (en) * 1999-12-20 2002-03-10 Merck & Co Inc Pharmaceutical kit
AU2580001A (en) 1999-12-20 2001-07-03 Merck & Co., Inc. Blister package for pharmaceutical treatment card
CA2405360A1 (en) * 2000-04-07 2001-10-18 The Board Of Regents Of The University Of Texas System Unique compositions of zwitterionic phospholipids and bisphosphonates and use of the compositions as bisphosphate delivery systems with reduced gi toxicity
RU2288722C2 (ru) * 2000-06-20 2006-12-10 Новартис Аг Способ введения бисфосфонатов
EP1296689B3 (en) 2000-06-20 2013-02-13 Novartis AG Method of administering bisphosphonates
US6638920B2 (en) * 2000-07-21 2003-10-28 Merck & Co., Inc. Compositions and methods of preventing or reducing the risk or incidence of skeletal injuries in horses
SE0101379D0 (sv) 2001-04-18 2001-04-18 Diabact Ab Komposition som hämmar utsöndring av magsyra
ES2268086T3 (es) * 2001-05-02 2007-03-16 Novartis Ag Metodo de administracion de bisfosfonatos por inhalacion en el tratamiento o prevencion de la resorcion osea y la osteoporosis.
PL371346A1 (en) 2002-05-10 2005-06-13 F.Hoffmann-La Roche Ag Bisphosphonic acid for the treatment and prevention of osteoporosis
SE0203065D0 (sv) 2002-10-16 2002-10-16 Diabact Ab Gastric acid secretion inhibiting composition
WO2005027921A1 (en) * 2003-09-19 2005-03-31 Pfizer Products Inc. Pharmaceutical compositions and methods comprising combinations of 2-alkylidene-19-nor-vitamin d derivatives and a bisphosphonate
WO2005072747A1 (ja) * 2004-02-02 2005-08-11 Ono Pharmaceutical Co., Ltd. 骨吸収抑制剤
BRPI0615770A2 (pt) * 2005-09-16 2011-05-24 Selamine Ltd formulação de bisfosfonato
CN106924257B (zh) * 2017-03-14 2019-11-19 湖南赛隆药业有限公司 质子泵抑制剂和抗骨质疏松药的复合物及其用途

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL84731A0 (en) * 1986-12-19 1988-05-31 Norwich Eaton Pharma Heterocycle-substituted diphosphonic acids and salts and esters and pharmaceutical compositions containing them
SE8704436D0 (sv) * 1987-11-13 1987-11-13 Pm Konsult Handelsbolag Anvendning av antisekretoriska substanser for nya indikationer
EP0521388B1 (de) * 1991-07-01 1995-05-10 Gerhard Dr. Gergely Verfahren zur Herstellung einer pharmazeutischen Zubereitung mit wenigstens zwei verschiedenen Wirkstoffen und Verwendung einer solchen Zubereitung
ES2149781T3 (es) * 1991-11-22 2000-11-16 Procter & Gamble Pharma Composiciones de risedronato de liberacion retardada.
US5270365A (en) * 1991-12-17 1993-12-14 Merck & Co., Inc. Prevention and treatment of periodontal disease with alendronate
US5294433A (en) * 1992-04-15 1994-03-15 The Procter & Gamble Company Use of H-2 antagonists for treatment of gingivitis
WO1994000129A1 (en) * 1992-06-30 1994-01-06 Procter & Gamble Pharmaceuticals, Inc. Use of phosphonates for the treatment of osteoporosis
US5431920A (en) * 1993-09-21 1995-07-11 Merck Frosst, Canada, Inc. Enteric coated oral compositions containing bisphosphonic acid antihypercalcemic agents
US5646134A (en) * 1994-04-21 1997-07-08 Merck & Co., Inc. Alendronate therapy to prevent loosening of, or pain associated with, orthopedic implant devices
CA2221416A1 (en) * 1995-06-06 1996-12-12 Merck & Co., Inc. Bisphosphonate therapy for bone loss associated with rheumatoid arthritis
CA2254060C (en) * 1996-05-17 2007-05-01 Merck & Co., Inc. Effervescent bisphosphonate formulation

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2608724C2 (ru) * 2010-12-06 2017-01-23 Эффэрикс Фармасьютикалз Са Стабильные составы шипучего бисфосфоната со свойствами быстрой солюбилизации

Also Published As

Publication number Publication date
EE200000040A (et) 2000-10-16
NZ501807A (en) 2003-02-28
IS7231A (is) 2004-04-21
DK1175904T3 (da) 2007-05-07
LU91364I2 (fr) 2007-11-12
DK0998292T3 (da) 2002-05-13
IL133535A0 (en) 2001-04-30
DE122007000063I1 (de) 2007-12-20
AU8493698A (en) 1999-02-16
HK1024166A1 (en) 2000-10-05
NO20000323L (no) 2000-03-20
PL338635A1 (en) 2000-11-06
CY2007022I1 (el) 2012-01-25
KR20010022110A (ko) 2001-03-15
HK1042230A1 (en) 2002-08-09
PT1175904E (pt) 2007-04-30
EP1175904A2 (en) 2002-01-30
EP1175903A2 (en) 2002-01-30
CN1602880A (zh) 2005-04-06
CY1107535T1 (el) 2012-01-25
EP1175903A3 (en) 2002-12-18
KR100391732B1 (ko) 2003-07-16
ATE209037T1 (de) 2001-12-15
NL300223I1 (nl) 2006-04-03
SG109478A1 (en) 2005-03-30
LU91222I2 (fr) 2006-04-18
EP1175904B1 (en) 2007-03-28
EP1175904A3 (en) 2002-12-18
EP0998292B1 (en) 2001-11-21
CA2294595A1 (en) 1999-02-04
CN1166365C (zh) 2004-09-15
JP2005068010A (ja) 2005-03-17
IS7230A (is) 2004-04-21
PT998292E (pt) 2002-04-29
SI0998292T1 (en) 2002-04-30
HK1040495A1 (en) 2002-06-14
DE69837450T2 (de) 2007-08-23
EP1132088A2 (en) 2001-09-12
ES2269014T3 (es) 2007-05-01
BR9810779A (pt) 2000-07-25
EA200000151A1 (ru) 2000-10-30
TR200000145T2 (tr) 2000-05-22
JP2002502433A (ja) 2002-01-22
DE122006000009I1 (de) 2006-06-14
EP1175904B8 (en) 2007-05-09
NL300292I1 (nl) 2007-11-01
ES2253136T1 (es) 2006-06-01
WO1999004773A2 (en) 1999-02-04
ES2269014T1 (es) 2007-04-01
EP1132088A3 (en) 2002-04-24
KR20030097610A (ko) 2003-12-31
EE05603B1 (et) 2012-12-17
PL195272B1 (pl) 2007-08-31
WO1999004773A9 (en) 1999-10-28
CN1602879A (zh) 2005-04-06
BG66282B1 (bg) 2013-01-31
NO20000323D0 (no) 2000-01-21
SG139556A1 (en) 2008-02-29
UY25950A1 (es) 2000-09-29
DE69803291T2 (de) 2002-08-08
CY2007022I2 (el) 2012-01-25
ES2164447T3 (es) 2002-02-16
CA2294595C (en) 2001-08-21
WO1999004773A3 (en) 1999-04-15
DE69837450D1 (de) 2007-05-10
BG104093A (en) 2000-10-31
JP3479780B2 (ja) 2003-12-15
DE01201911T1 (de) 2007-10-18
EA004544B1 (ru) 2004-06-24
HK1042232A1 (en) 2002-08-09
EP0998292A2 (en) 2000-05-10
DE69803291D1 (de) 2002-02-21
CN1265035A (zh) 2000-08-30
HK1040494A1 (en) 2002-06-14
SK932000A3 (en) 2000-09-12
EP1151752A2 (en) 2001-11-07
ATE357921T1 (de) 2007-04-15
DE01201913T1 (de) 2007-02-08
KR20030097611A (ko) 2003-12-31
IS5315A (is) 1999-12-21
EP1151752A3 (en) 2002-12-18
ID24096A (id) 2000-07-06
CN1299689C (zh) 2007-02-14

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Legal Events

Date Code Title Description
MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): AM AZ BY KZ KG MD TJ TM

NF4A Restoration of lapsed right to a eurasian patent

Designated state(s): AM AZ BY KZ KG MD TJ TM

DZ4A Eurasian patent assigned for amendment of claims
MF4A Revocation of a eurasian patent as invalid entirely
PD4A Registration of transfer of a eurasian patent in accordance with the succession in title
RL4A Court decisions rendered in respect of a eurasian patent
PD4A Registration of transfer of a eurasian patent in accordance with the succession in title
MK4A Patent expired

Designated state(s): AM BY KZ MD TJ RU