DD293112A5 - Heterocyclische verbindungen - Google Patents

Heterocyclische verbindungen Download PDF

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Publication number
DD293112A5
DD293112A5 DD90337728A DD33772890A DD293112A5 DD 293112 A5 DD293112 A5 DD 293112A5 DD 90337728 A DD90337728 A DD 90337728A DD 33772890 A DD33772890 A DD 33772890A DD 293112 A5 DD293112 A5 DD 293112A5
Authority
DD
German Democratic Republic
Prior art keywords
phenyl
dihydropyridazine
dihydro
formula
lower alkyl
Prior art date
Application number
DD90337728A
Other languages
German (de)
English (en)
Inventor
Heimo O Haikala
Erkki J Honkanen
Kari K Loennberg
Pentti T Nore
Jarmo J Pystynen
Anne M Luiro
Aino K Pippuri
Original Assignee
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Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by ����`��@���k�� filed Critical ����`��@���k��
Publication of DD293112A5 publication Critical patent/DD293112A5/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D285/00—Heterocyclic compounds containing rings having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by groups C07D275/00 - C07D283/00
    • C07D285/15—Six-membered rings
    • C07D285/16—Thiadiazines; Hydrogenated thiadiazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
    • C07D237/02—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings
    • C07D237/04—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having less than three double bonds between ring members or between ring members and non-ring members
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
    • C07D237/02—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings
    • C07D237/06—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D237/10—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D237/14—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
    • C07D237/26—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings condensed with carbocyclic rings or ring systems
    • C07D237/30—Phthalazines
    • C07D237/32—Phthalazines with oxygen atoms directly attached to carbon atoms of the nitrogen-containing ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D253/00—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00
    • C07D253/02—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00 not condensed with other rings
    • C07D253/06—1,2,4-Triazines
    • C07D253/065—1,2,4-Triazines having three double bonds between ring members or between ring members and non-ring members
    • C07D253/07—1,2,4-Triazines having three double bonds between ring members or between ring members and non-ring members with hetero atoms, or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D273/00—Heterocyclic compounds containing rings having nitrogen and oxygen atoms as the only ring hetero atoms, not provided for by groups C07D261/00 - C07D271/00
    • C07D273/02—Heterocyclic compounds containing rings having nitrogen and oxygen atoms as the only ring hetero atoms, not provided for by groups C07D261/00 - C07D271/00 having two nitrogen atoms and only one oxygen atom
    • C07D273/04—Six-membered rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cardiology (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Saccharide Compounds (AREA)
  • Cephalosporin Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Detergent Compositions (AREA)
  • Compounds Of Unknown Constitution (AREA)
DD90337728A 1989-02-11 1990-02-09 Heterocyclische verbindungen DD293112A5 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB898903130A GB8903130D0 (en) 1989-02-11 1989-02-11 Substituted pyridazinones

Publications (1)

Publication Number Publication Date
DD293112A5 true DD293112A5 (de) 1991-08-22

Family

ID=10651554

Family Applications (1)

Application Number Title Priority Date Filing Date
DD90337728A DD293112A5 (de) 1989-02-11 1990-02-09 Heterocyclische verbindungen

Country Status (24)

Country Link
US (2) US5019575A (no)
EP (1) EP0383449B1 (no)
JP (1) JP3011955B2 (no)
CN (1) CN1036265C (no)
AT (1) ATE127456T1 (no)
AU (1) AU619648B2 (no)
CA (1) CA2009678C (no)
CZ (1) CZ286036B6 (no)
DD (1) DD293112A5 (no)
DE (1) DE69022078T2 (no)
DK (1) DK0383449T3 (no)
ES (1) ES2078939T3 (no)
FI (1) FI96511C (no)
GB (2) GB8903130D0 (no)
GR (1) GR3017510T3 (no)
HU (2) HU206692B (no)
LT (1) LT3769B (no)
LU (1) LU90921I2 (no)
NO (2) NO178067C (no)
NZ (1) NZ232257A (no)
PT (1) PT93111B (no)
RU (3) RU2048467C1 (no)
SK (1) SK55790A3 (no)
ZA (1) ZA90681B (no)

Families Citing this family (38)

* Cited by examiner, † Cited by third party
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GB8824458D0 (en) * 1988-10-19 1988-11-23 Orion Yhtymae Oy Substituted pyridazinones
IE62890B1 (en) * 1988-12-06 1995-03-08 Hafslund Nycomed Pharma New piperazinylalkyl-3(2h)-pyridazinones process for the preparation thereof and the use thereof as agents lowering blood pressure
GB8903130D0 (en) * 1989-02-11 1989-03-30 Orion Yhtymae Oy Substituted pyridazinones
GB2251615B (en) * 1991-01-03 1995-02-08 Orion Yhtymae Oy (-)-[[4-(1,4,5,6-tetrahydro-4-methyl-6-oxo-3-pyridazinyl)phenyl]hydrazono]pro panedinitrile
GB2266841A (en) * 1992-05-06 1993-11-17 Orion Yhtymae Oy Compounds for use as anti-ischemic medicaments
DE4239540A1 (de) * 1992-11-25 1994-05-26 Asta Medica Ag Neue heterocyclische Verbindungen mit antiasthmatischer/antiallergischer, entzündungshemmender, positiv inotroper und blutdrucksenkender Wirkung
TW309520B (no) * 1994-04-26 1997-07-01 Mitsubishi Chem Corp
DE19514568A1 (de) 1995-04-20 1996-10-24 Merck Patent Gmbh Arylalkyl-pyridazinone
GB9606474D0 (en) * 1996-03-27 1996-06-05 Orion Yhytmo Oy Method for obtaining pure enantiomers of a pyridazinone derivative
GB9626472D0 (en) 1996-12-20 1997-02-05 Aperia Anita C New use of comt inhibitors
FI973804A (fi) * 1997-09-26 1999-03-27 Orion Yhtymae Oy Levosimendaanin oraalisia koostumuksia
FI980901A (fi) 1998-04-23 1999-10-24 Orion Yhtymae Oyj Levosimendaania säädellysti vapauttavia oraalisia koostumuksia
FI980902A (fi) 1998-04-23 1999-10-24 Orion Yhtymae Oyj Levosimendaanin stabiileja koostumuksia
FI105389B (fi) * 1998-04-23 2000-08-15 Orion Yhtymae Oyj Menetelmä levosimendaaniannon siedettävyyden seuraamiseksi
FI104718B (fi) * 1998-06-18 2000-03-31 Orion Yhtymae Oyj [[4-(2-atsido-3-metyyli-5-oksotetrahydrofuran-2-yyli)fenyyli]hydratsono]propaanidinitriili käytettäväksi referenssiaineena levosimendaanierien analyysissä
FI20000577A0 (fi) * 2000-03-13 2000-03-13 Orion Yhtymae Oy Pyridatsinyylifenyylihydratsoneja
FI20002525A (fi) 2000-11-17 2002-05-18 Orion Yhtymae Oyj Tulehduksenvastaisia aineita
WO2002072099A1 (fr) * 2001-03-14 2002-09-19 Mitsubishi Pharma Corporation Agent therapeutique et / ou prophylactique pour la cardiopathie ischemique diabetique
EP1612204A4 (en) * 2003-03-31 2007-04-11 Daiichi Seiyaku Co HYDRAZONE DERIVATIVE
DE102004011512B4 (de) 2004-03-08 2022-01-13 Boehringer Ingelheim Vetmedica Gmbh Pharmazeutische Zubereitung enthaltend Pimobendan
US8980894B2 (en) 2004-03-25 2015-03-17 Boehringer Ingelheim Vetmedica Gmbh Use of PDE III inhibitors for the treatment of asymptomatic (occult) heart failure
EP1579862A1 (en) 2004-03-25 2005-09-28 Boehringer Ingelheim Vetmedica Gmbh Use of PDE III inhibitors for the reduction of heart size in mammals suffering from heart failure
EP1758584A1 (en) * 2004-05-28 2007-03-07 Abbott Laboratories Methods for treating a mammal before, during and after cardiac arrest
WO2007054514A2 (en) 2005-11-14 2007-05-18 Boehringer Ingelheim Vetmedica Gmbh Use of pde iii inhibitors or calcium sensitizers for the treatment of asymptomatic (occult) heart failure
SI2069312T1 (sl) 2006-07-25 2013-03-29 Cephalon, Inc. Derivati piridizinona
EP1920785A1 (en) 2006-11-07 2008-05-14 Boehringer Ingelheim Vetmedica Gmbh Liquid preparation comprising a complex of pimobendan and cyclodextrin
FR2917975B1 (fr) 2007-06-26 2009-10-16 Ceva Sante Animale Sa Compositions et traitement de l'insuffisance cardiaque chez les animaux mammiferes non humains
CA2645772A1 (en) * 2007-12-05 2009-06-05 Tagawa Greenhouse Enterprises, Llc Collapsible support apparatus and methods
ES2436716T3 (es) 2008-11-25 2014-01-03 Boehringer Ingelheim Vetmedica Gmbh Pimobendan para uso en el tratamiento de la cardiomiopatía hipertrófica en gatos
ES2924478T3 (es) 2012-03-15 2022-10-07 Boehringer Ingelheim Vetmedica Gmbh Formulación de comprimidos farmacéuticos para el sector médico veterinario, método de producción y uso de los mismos
WO2014113620A2 (en) * 2013-01-18 2014-07-24 Bristol-Myers Squibb Company Phthalazinones and isoquinolinones as rock inhibitors
CN105377235A (zh) 2013-07-19 2016-03-02 勃林格殷格翰动物保健有限公司 含有防腐的醚化的环糊精衍生物的液体水性药物组合物
BR112016011111B1 (pt) 2013-12-04 2022-11-16 Boehringer Ingelheim Vetmedica Gmbh Composições farmacêuticas aprimoradas de pimobendan
US10537570B2 (en) 2016-04-06 2020-01-21 Boehringer Ingelheim Vetmedica Gmbh Use of pimobendan for the reduction of heart size and/or the delay of onset of clinical symptoms in patients with asymptomatic heart failure due to mitral valve disease
EP3424908A1 (en) 2017-07-07 2019-01-09 Melody Healthcare Pvt. Ltd. Process for preparation of levosimendan
KR102128509B1 (ko) * 2018-12-19 2020-07-01 한국과학기술연구원 말단 아민기에 아릴 또는 헤테로아릴기가 치환된 신규한 히드라존 유도체 및 이의 용도
CN111548310B (zh) * 2020-05-12 2021-07-02 成都欣捷高新技术开发股份有限公司 一种左西孟旦钠晶型及其制备方法
US11760730B2 (en) 2021-01-11 2023-09-19 Navinta, Llc Process for the preparation of high purity Levosimendan

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JPS58113180A (ja) * 1981-12-28 1983-07-05 Mitsui Toatsu Chem Inc ピリダジノン誘導体
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JPS61158969A (ja) * 1984-12-24 1986-07-18 ワーナー‐ランバート・コンパニー ４，５‐ジヒドロ‐４，４‐ジアルキル‐６‐（置換）フエニル‐３（２ｈ）‐ピリダジノン類
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DE3531658A1 (de) 1985-09-05 1987-03-12 Boehringer Mannheim Gmbh Heterocyclisch substituierte indole, zwischenprodukte, verfahren zu ihrer herstellung und arzneimittel
GB8603780D0 (en) * 1986-02-15 1986-03-19 Smith Kline French Lab Chemical compounds
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IT1208003B (it) * 1987-01-08 1989-06-01 Isf Spa Procedimento per preparare derivati alcossi alchiliden, idrazino, piridazinici.
DE3706427A1 (de) * 1987-02-27 1988-09-08 Boehringer Mannheim Gmbh Neue substituierte 3h-indole, zwischenprodukte, verfahren zu ihrer herstellung sowie arzneimittel
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JP2717687B2 (ja) * 1988-02-13 1998-02-18 日本曹達株式会社 ピリダジノン誘導体及びその製造方法
GB8903130D0 (en) * 1989-02-11 1989-03-30 Orion Yhtymae Oy Substituted pyridazinones

Also Published As

Publication number Publication date
GB2228004B (en) 1992-07-15
HUT53090A (en) 1990-09-28
FI900613A0 (fi) 1990-02-08
HU206692B (en) 1992-12-28
EP0383449A3 (en) 1991-07-03
HUT59384A (en) 1992-05-28
AU4929690A (en) 1990-08-16
PT93111B (pt) 1996-01-31
GB9001853D0 (en) 1990-03-28
GB2228004A (en) 1990-08-15
US5019575A (en) 1991-05-28
NO2001020I1 (no) 2001-12-03
NO900336L (no) 1990-08-13
DE69022078T2 (de) 1996-02-22
GR3017510T3 (en) 1995-12-31
HU913501D0 (en) 1992-02-28
ZA90681B (en) 1990-10-31
DK0383449T3 (da) 1996-01-02
JPH02288868A (ja) 1990-11-28
NO178067C (no) 1996-01-17
RU1836362C (ru) 1993-08-23
JP3011955B2 (ja) 2000-02-21
ES2078939T3 (es) 1996-01-01
PT93111A (pt) 1990-08-31
EP0383449B1 (en) 1995-09-06
RU2048467C1 (ru) 1995-11-20
HU204797B (en) 1992-02-28
NO900336D0 (no) 1990-01-24
CA2009678C (en) 1998-08-11
GB8903130D0 (en) 1989-03-30
CZ55790A3 (cs) 1999-10-13
FI96511C (fi) 1996-07-10
CN1036265C (zh) 1997-10-29
DE69022078D1 (de) 1995-10-12
LTIP1233A (en) 1995-04-25
SK280411B6 (sk) 2000-02-14
CA2009678A1 (en) 1990-08-11
AU619648B2 (en) 1992-01-30
LT3769B (en) 1996-03-25
EP0383449A2 (en) 1990-08-22
CN1044811A (zh) 1990-08-22
CZ286036B6 (cs) 1999-12-15
RU2068844C1 (ru) 1996-11-10
SK55790A3 (en) 2000-02-14
FI96511B (fi) 1996-03-29
US5122524A (en) 1992-06-16
ATE127456T1 (de) 1995-09-15
NO178067B (no) 1995-10-09
LU90921I2 (en) 2002-07-17
NZ232257A (en) 1991-03-26
HU900747D0 (en) 1990-04-28

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