DD280322A5 - Verfahren zur herstellung urethangeschuetzter aminosaeure-n-carboxyanhydride oder n-thiocarboxyanhydride - Google Patents

Verfahren zur herstellung urethangeschuetzter aminosaeure-n-carboxyanhydride oder n-thiocarboxyanhydride Download PDF

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Publication number
DD280322A5
DD280322A5 DD89326451A DD32645189A DD280322A5 DD 280322 A5 DD280322 A5 DD 280322A5 DD 89326451 A DD89326451 A DD 89326451A DD 32645189 A DD32645189 A DD 32645189A DD 280322 A5 DD280322 A5 DD 280322A5
Authority
DD
German Democratic Republic
Prior art keywords
side chain
amino acid
protected
substituted
suitably protected
Prior art date
Application number
DD89326451A
Other languages
German (de)
English (en)
Inventor
William D Fuller
Michael Ph Cohen
Fred R Naider
Murray Goodman
Original Assignee
Kkk
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kkk filed Critical Kkk
Publication of DD280322A5 publication Critical patent/DD280322A5/de

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
    • C07D263/08—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D263/16—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D263/18—Oxygen atoms
    • C07D263/20—Oxygen atoms attached in position 2
    • C07D263/26—Oxygen atoms attached in position 2 with hetero atoms or acyl radicals directly attached to the ring nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
    • C07D263/30—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D263/34—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D263/44—Two oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/34—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/36—Sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/02—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length in solution
    • C07K1/023—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length in solution using racemisation inhibiting agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/04—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length on carriers

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Analytical Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Peptides Or Proteins (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Hydrogenated Pyridines (AREA)
  • Polyethers (AREA)
  • Saccharide Compounds (AREA)
  • Solid-Sorbent Or Filter-Aiding Compositions (AREA)
DD89326451A 1988-03-11 1989-03-10 Verfahren zur herstellung urethangeschuetzter aminosaeure-n-carboxyanhydride oder n-thiocarboxyanhydride DD280322A5 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/168,087 US4946942A (en) 1988-03-11 1988-03-11 Urethane-protected amino acid-N-carboxyanhydrides

Publications (1)

Publication Number Publication Date
DD280322A5 true DD280322A5 (de) 1990-07-04

Family

ID=22610066

Family Applications (1)

Application Number Title Priority Date Filing Date
DD89326451A DD280322A5 (de) 1988-03-11 1989-03-10 Verfahren zur herstellung urethangeschuetzter aminosaeure-n-carboxyanhydride oder n-thiocarboxyanhydride

Country Status (21)

Country Link
US (1) US4946942A (no)
EP (1) EP0357750B1 (no)
JP (1) JP2875834B2 (no)
KR (1) KR970002229B1 (no)
CN (1) CN1022412C (no)
AT (1) ATE108438T1 (no)
AU (1) AU616054B2 (no)
CA (1) CA1321280C (no)
CZ (1) CZ148989A3 (no)
DD (1) DD280322A5 (no)
DE (1) DE68916722T2 (no)
FI (1) FI102379B (no)
HK (1) HK1007744A1 (no)
HU (1) HU205091B (no)
IE (1) IE65149B1 (no)
IL (1) IL89541A0 (no)
NO (1) NO306304B1 (no)
NZ (1) NZ228282A (no)
PT (1) PT89961B (no)
RU (1) RU2007396C1 (no)
WO (1) WO1989008643A1 (no)

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Publication number Priority date Publication date Assignee Title
US5006661A (en) * 1987-06-16 1991-04-09 University Of Cincinnati Selective stereospecific biologically active beta-lactams
DE3839379A1 (de) * 1988-11-22 1990-05-23 Hoechst Ag Verfahren zur herstellung von tripeptiden
US5800992A (en) 1989-06-07 1998-09-01 Fodor; Stephen P.A. Method of detecting nucleic acids
US6406844B1 (en) 1989-06-07 2002-06-18 Affymetrix, Inc. Very large scale immobilized polymer synthesis
US6551784B2 (en) 1989-06-07 2003-04-22 Affymetrix Inc Method of comparing nucleic acid sequences
US5547839A (en) 1989-06-07 1996-08-20 Affymax Technologies N.V. Sequencing of surface immobilized polymers utilizing microflourescence detection
US5424186A (en) 1989-06-07 1995-06-13 Affymax Technologies N.V. Very large scale immobilized polymer synthesis
US5744101A (en) * 1989-06-07 1998-04-28 Affymax Technologies N.V. Photolabile nucleoside protecting groups
US6379895B1 (en) 1989-06-07 2002-04-30 Affymetrix, Inc. Photolithographic and other means for manufacturing arrays
US6309822B1 (en) 1989-06-07 2001-10-30 Affymetrix, Inc. Method for comparing copy number of nucleic acid sequences
US6346413B1 (en) 1989-06-07 2002-02-12 Affymetrix, Inc. Polymer arrays
US5143854A (en) 1989-06-07 1992-09-01 Affymax Technologies N.V. Large scale photolithographic solid phase synthesis of polypeptides and receptor binding screening thereof
US6506558B1 (en) 1990-03-07 2003-01-14 Affymetrix Inc. Very large scale immobilized polymer synthesis
AU1248292A (en) 1990-12-06 1992-07-08 Affymax Technologies N.V. Sequencing by hybridization of a target nucleic acid to a matrix of defined oligonucleotides
US6468740B1 (en) 1992-11-05 2002-10-22 Affymetrix, Inc. Cyclic and substituted immobilized molecular synthesis
TW306932B (no) * 1993-08-27 1997-06-01 Holland Sweetener Co
US7625697B2 (en) * 1994-06-17 2009-12-01 The Board Of Trustees Of The Leland Stanford Junior University Methods for constructing subarrays and subarrays made thereby
US7378236B1 (en) 1994-06-17 2008-05-27 The Board Of Trustees Of The Leland Stanford Junior University Method for analyzing gene expression patterns
US7323298B1 (en) * 1994-06-17 2008-01-29 The Board Of Trustees Of The Leland Stanford Junior University Microarray for determining the relative abundances of polynuceotide sequences
IN184759B (no) * 1997-07-22 2000-09-23 Kaneka Corp
SI20211A (sl) * 1998-07-21 2000-10-31 Kaneka Corporation Postopek za kristaliziranje maleatne soli N-(1(S)-etoksikarbonil-3-fenilpropil)-L-alanil-L-prolina
US6545264B1 (en) 1998-10-30 2003-04-08 Affymetrix, Inc. Systems and methods for high performance scanning
SE0000382D0 (sv) 2000-02-07 2000-02-07 Astrazeneca Ab New process
WO2002002538A1 (fr) * 2000-07-04 2002-01-10 Mitsui Chemicals, Inc. Anhydrides d'acide-amino-n-carboxy presentant un substituant a la position de l'azote
DE10333368B4 (de) * 2003-07-23 2008-08-28 Universität Leipzig Oberflächenfunktionalisiertes Trägermaterial, Verfahren zu dessen Herstellung und dessen Verwendungen
FR2858976B1 (fr) * 2003-08-22 2006-02-10 Isochem Sa Procede d'obtention de n-carboxyanhydrides d'alpha-aminoacides a protection urethane
CN100575348C (zh) * 2004-10-26 2009-12-30 西格玛-奥尔德利希公司 氨基酸n-羧酸酐的合成
EP1973587B1 (en) * 2005-12-12 2019-02-06 AllAccem, Inc. Methods and systems for preparing antimicrobial films and coatings
ES2522908T3 (es) 2007-02-21 2014-11-19 Allaccem, Inc. Composiciones a base de compuestos policíclicos con puente para la inhibición y el alivio de enfermedades
WO2009017775A2 (en) * 2007-08-02 2009-02-05 Scinopharm Taiwan Ltd. Process for the preparation of a polypeptide
US8188068B2 (en) * 2007-08-10 2012-05-29 Allaccem, Inc. Bridged polycyclic compound based compositions for coating oral surfaces in pets
US8153617B2 (en) * 2007-08-10 2012-04-10 Allaccem, Inc. Bridged polycyclic compound based compositions for coating oral surfaces in humans
US8153618B2 (en) * 2007-08-10 2012-04-10 Allaccem, Inc. Bridged polycyclic compound based compositions for topical applications for pets
US20090074833A1 (en) * 2007-08-17 2009-03-19 Whiteford Jeffery A Bridged polycyclic compound based compositions for controlling bone resorption
FR2928372B1 (fr) * 2008-03-10 2010-12-31 Solvay Procede de synthese peptidique
US20100004218A1 (en) * 2008-06-20 2010-01-07 Whiteford Jeffery A Bridged polycyclic compound based compositions for renal therapy
US20100016270A1 (en) * 2008-06-20 2010-01-21 Whiteford Jeffery A Bridged polycyclic compound based compositions for controlling cholesterol levels
AU2012234640B2 (en) * 2011-03-25 2015-11-05 Nippon Soda Co., Ltd. Glutamic acid benzyl ester N-carboxylic anhydride
CN107750247A (zh) * 2015-03-17 2018-03-02 里珍纳龙药品有限公司 氨基酸酰化试剂及其使用方法
JP6766432B2 (ja) * 2016-04-28 2020-10-14 Jsr株式会社 ポリアミノ酸の製造方法
US11214592B2 (en) * 2017-03-02 2022-01-04 Glytech, Inc. Production method for amino-acid polymer
CN112778236A (zh) * 2019-11-08 2021-05-11 华东理工大学 β、γ-氨基酸N-羧基硫代羰基环内酸酐单体的合成、聚合反应、聚合物制备及其应用

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1173562A (en) * 1966-04-25 1969-12-10 Pierrel Spa Chloramphenicol Ester Salts, the Preparation therof and Compositions Containing them
US4267344A (en) * 1972-09-22 1981-05-12 Proteinkemisk Institut. Tilknyttet Akademiet For De Tekniske Videnskaber N-Substituted N-carboxyanhydrides of α-amino acids and their application in the preparation of peptides
US4038411A (en) * 1973-09-25 1977-07-26 Merck & Co., Inc. Antihypertensive amino acid esters
US4038282A (en) * 1975-11-26 1977-07-26 Merck & Co., Inc. Pyridyl-4-methyl-succinimidocarbonate and process for its preparation
US4367234A (en) * 1980-07-28 1983-01-04 Pfizer Inc. Hypoglycemic 5-substituted oxazolidine-2,4-diones

Also Published As

Publication number Publication date
FI895382A0 (fi) 1989-11-10
PT89961B (pt) 1994-04-29
HU205091B (en) 1992-03-30
EP0357750A1 (en) 1990-03-14
NZ228282A (en) 1990-10-26
CN1040793A (zh) 1990-03-28
RU2007396C1 (ru) 1994-02-15
NO894503D0 (no) 1989-11-10
IL89541A0 (en) 1989-09-10
CA1321280C (en) 1993-08-10
KR900700469A (ko) 1990-08-13
CN1022412C (zh) 1993-10-13
JPH02503923A (ja) 1990-11-15
FI102379B1 (fi) 1998-11-30
HK1007744A1 (en) 1999-04-23
DE68916722T2 (de) 1994-11-03
HUT52488A (en) 1990-07-28
PT89961A (pt) 1989-11-10
EP0357750A4 (en) 1991-01-30
HU891841D0 (en) 1990-04-28
US4946942A (en) 1990-08-07
NO306304B1 (no) 1999-10-18
NO894503L (no) 1989-11-10
AU4188789A (en) 1989-10-05
AU616054B2 (en) 1991-10-17
ATE108438T1 (de) 1994-07-15
JP2875834B2 (ja) 1999-03-31
IE890778L (en) 1989-09-11
KR970002229B1 (ko) 1997-02-26
EP0357750B1 (en) 1994-07-13
IE65149B1 (en) 1995-10-04
CZ148989A3 (en) 1997-11-12
FI102379B (fi) 1998-11-30
WO1989008643A1 (en) 1989-09-21
DE68916722D1 (de) 1994-08-18

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Date Code Title Description
IF04 In force in the year 2004

Expiry date: 20090311