DD218359A5 - Verfahren zur herstellung von 3-(5-aminopenthyl)-amino-1-benzazepin-2-on-1-alkansaeuren - Google Patents

Verfahren zur herstellung von 3-(5-aminopenthyl)-amino-1-benzazepin-2-on-1-alkansaeuren Download PDF

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Publication number
DD218359A5
DD218359A5 DD84259979A DD25997984A DD218359A5 DD 218359 A5 DD218359 A5 DD 218359A5 DD 84259979 A DD84259979 A DD 84259979A DD 25997984 A DD25997984 A DD 25997984A DD 218359 A5 DD218359 A5 DD 218359A5
Authority
DD
German Democratic Republic
Prior art keywords
formula
compound
cor
hydroxy
groups
Prior art date
Application number
DD84259979A
Other languages
German (de)
English (en)
Inventor
Jeffry W H Watthey
Stephen K Boyer
Joseph Bach
Gottfried Sedelmeier
Original Assignee
Ciba Geigy Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ciba Geigy Ag filed Critical Ciba Geigy Ag
Publication of DD218359A5 publication Critical patent/DD218359A5/de

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
    • C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D223/16—Benzazepines; Hydrogenated benzazepines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/022—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -X-C(=O)-(C)n-N-C-C(=O)-Y-; X and Y being heteroatoms; n being 1 or 2
    • C07K5/0222—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -X-C(=O)-(C)n-N-C-C(=O)-Y-; X and Y being heteroatoms; n being 1 or 2 with the first amino acid being heterocyclic, e.g. Pro, Trp
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
    • C07K5/06026—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atom, i.e. Gly or Ala
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06086—Dipeptides with the first amino acid being basic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Cardiology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Peptides Or Proteins (AREA)
DD84259979A 1983-02-10 1984-02-09 Verfahren zur herstellung von 3-(5-aminopenthyl)-amino-1-benzazepin-2-on-1-alkansaeuren DD218359A5 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/465,695 US4473575A (en) 1982-07-19 1983-02-10 3-Amino-(1)-benzazepin-2-one-1-alkanoic acids

Publications (1)

Publication Number Publication Date
DD218359A5 true DD218359A5 (de) 1985-02-06

Family

ID=23848805

Family Applications (1)

Application Number Title Priority Date Filing Date
DD84259979A DD218359A5 (de) 1983-02-10 1984-02-09 Verfahren zur herstellung von 3-(5-aminopenthyl)-amino-1-benzazepin-2-on-1-alkansaeuren

Country Status (24)

Country Link
US (1) US4473575A (xx)
EP (2) EP0119954B1 (xx)
JP (2) JPS59172473A (xx)
KR (1) KR900009023B1 (xx)
AR (8) AR242564A1 (xx)
AT (2) ATE48598T1 (xx)
AU (1) AU574061B2 (xx)
CA (2) CA1218993A (xx)
CY (1) CY1674A (xx)
DD (1) DD218359A5 (xx)
DE (2) DE3480705D1 (xx)
DK (2) DK171257B1 (xx)
ES (10) ES8707216A1 (xx)
FI (1) FI77857C (xx)
GR (1) GR79809B (xx)
HK (1) HK97592A (xx)
HU (1) HU192394B (xx)
IE (1) IE56858B1 (xx)
IL (1) IL70881A (xx)
NO (1) NO166232C (xx)
NZ (1) NZ207091A (xx)
PT (1) PT78075B (xx)
SG (1) SG94992G (xx)
ZA (1) ZA84958B (xx)

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US4473575A (en) * 1982-07-19 1984-09-25 Ciba-Geigy Corporation 3-Amino-(1)-benzazepin-2-one-1-alkanoic acids
US4537885A (en) * 1983-02-10 1985-08-27 Ciba Geigy Corporation Certain benzazocinone and benzazoninone derivatives
US4575503A (en) * 1983-02-10 1986-03-11 Ciba-Geigy Corporation 3-Amino-[1]-benzazepin-2-one-1-alkanoic acids
US4600534A (en) * 1984-02-06 1986-07-15 Ciba-Geigy Corporation Process and intermediates for manufacture of 3-(5-amino-1-carboxypentylamino)-tetrahydro-1-benzazepin-2-one-1-acetic acid
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US4692522A (en) * 1985-04-01 1987-09-08 Merck & Co., Inc. Benzofused lactams useful as cholecystokinin antagonists
US4785089A (en) * 1985-06-13 1988-11-15 Ciba-Geigy Corporation Novel sulfonic acid esters and their preparation
DE3767514D1 (de) * 1986-03-11 1991-02-28 Thompson Barry Antony Fuettern von vieh mit polymeren.
FI88723C (fi) * 1986-05-28 1993-06-28 Ciba Geigy Ag /2,5-dihydro-2-oxo-5-fenyl-3-furanyl/aminer samt deras anvaendning vid framstaellning av ACE-inhibitorer
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Also Published As

Publication number Publication date
IL70881A (en) 1987-10-30
ES8609264A1 (es) 1986-09-01
ES8703859A1 (es) 1987-03-01
JPS59172473A (ja) 1984-09-29
ES8609263A1 (es) 1986-09-01
PT78075B (en) 1986-06-11
EP0119954A2 (de) 1984-09-26
ES8609262A1 (es) 1986-09-01
ES529594A0 (es) 1986-07-16
ES544254A0 (es) 1987-03-01
ES8705409A1 (es) 1987-05-01
PT78075A (en) 1984-03-01
FI840513A0 (fi) 1984-02-08
EP0119954B1 (de) 1990-03-14
AR243161A1 (es) 1993-07-30
NO840487L (no) 1984-08-13
JPS59172475A (ja) 1984-09-29
CY1674A (en) 1993-10-10
CA1218993A (en) 1987-03-10
KR840007722A (ko) 1984-12-10
ES8700239A1 (es) 1986-10-16
EP0119955A2 (de) 1984-09-26
ES544257A0 (es) 1986-09-01
DK58184D0 (da) 1984-02-09
EP0119954A3 (en) 1986-06-11
ES8707216A1 (es) 1987-07-16
AR243163A1 (es) 1993-07-30
FI840513A (fi) 1984-08-11
AU2443084A (en) 1984-08-16
JPH0421665B2 (xx) 1992-04-13
NO166232C (no) 1991-06-19
DK58284D0 (da) 1984-02-09
CA1225397A (en) 1987-08-11
HK97592A (en) 1992-12-11
FI77857C (fi) 1989-05-10
US4473575A (en) 1984-09-25
GR79809B (xx) 1984-10-31
AR243162A1 (es) 1993-07-30
AR242564A1 (es) 1993-04-30
DE3481612D1 (de) 1990-04-19
AR243164A1 (es) 1993-07-30
DK58284A (da) 1984-08-11
AR242190A1 (es) 1993-03-31
EP0119955A3 (en) 1986-06-11
IL70881A0 (en) 1984-05-31
DK58184A (da) 1984-08-11
ES8702363A1 (es) 1987-01-01
IE56858B1 (en) 1992-01-01
DE3480705D1 (de) 1990-01-18
ES529595A0 (es) 1987-07-16
NZ207091A (en) 1985-11-08
EP0119955B1 (de) 1989-12-13
ES544127A0 (es) 1987-01-01
ES8609261A1 (es) 1986-07-16
ES544255A0 (es) 1986-09-01
SG94992G (en) 1992-12-04
ZA84958B (en) 1984-09-26
ATE50989T1 (de) 1990-03-15
ES544260A0 (es) 1986-09-01
HU192394B (en) 1987-06-29
AU574061B2 (en) 1988-06-30
ES544258A0 (es) 1986-09-01
KR900009023B1 (ko) 1990-12-17
ES8609265A1 (es) 1986-09-01
ATE48598T1 (de) 1989-12-15
AR243165A1 (es) 1993-07-30
AR242191A1 (es) 1993-03-31
DK171257B1 (da) 1996-08-12
ES544259A0 (es) 1986-10-16
FI77857B (fi) 1989-01-31
IE840302L (en) 1984-08-10
JPH0460108B2 (xx) 1992-09-25
ES544256A0 (es) 1987-05-01
NO166232B (no) 1991-03-11

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