ES529594A0 - Procedimiento para preparar nuevos acidos 3-amino-1-benzazepin-2-ona-1-alcanoicos - Google Patents

Procedimiento para preparar nuevos acidos 3-amino-1-benzazepin-2-ona-1-alcanoicos

Info

Publication number
ES529594A0
ES529594A0 ES529594A ES529594A ES529594A0 ES 529594 A0 ES529594 A0 ES 529594A0 ES 529594 A ES529594 A ES 529594A ES 529594 A ES529594 A ES 529594A ES 529594 A0 ES529594 A0 ES 529594A0
Authority
ES
Spain
Prior art keywords
benzazepin
ona
amino
procedure
prepare new
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
ES529594A
Other languages
English (en)
Other versions
ES8609261A1 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Novartis AG
Original Assignee
Ciba Geigy AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ciba Geigy AG filed Critical Ciba Geigy AG
Publication of ES8609261A1 publication Critical patent/ES8609261A1/es
Publication of ES529594A0 publication Critical patent/ES529594A0/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
    • C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D223/16—Benzazepines; Hydrogenated benzazepines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/022—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -X-C(=O)-(C)n-N-C-C(=O)-Y-; X and Y being heteroatoms; n being 1 or 2
    • C07K5/0222—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -X-C(=O)-(C)n-N-C-C(=O)-Y-; X and Y being heteroatoms; n being 1 or 2 with the first amino acid being heterocyclic, e.g. Pro, Trp
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
    • C07K5/06026—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atom, i.e. Gly or Ala
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06086—Dipeptides with the first amino acid being basic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
ES529594A 1983-02-10 1984-02-09 Procedimiento para preparar nuevos acidos 3-amino-1-benzazepin-2-ona-1-alcanoicos Expired ES8609261A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/465,695 US4473575A (en) 1982-07-19 1983-02-10 3-Amino-(1)-benzazepin-2-one-1-alkanoic acids

Publications (2)

Publication Number Publication Date
ES8609261A1 ES8609261A1 (es) 1986-07-16
ES529594A0 true ES529594A0 (es) 1986-07-16

Family

ID=23848805

Family Applications (10)

Application Number Title Priority Date Filing Date
ES529594A Expired ES8609261A1 (es) 1983-02-10 1984-02-09 Procedimiento para preparar nuevos acidos 3-amino-1-benzazepin-2-ona-1-alcanoicos
ES529595A Expired ES8707216A1 (es) 1983-02-10 1984-02-09 Procedimiento para preparar nuevos acidos 3-(5-aminopentil)-amino-1-benzazepin-2-ona-1-alcanoicos
ES544127A Expired ES8702363A1 (es) 1983-02-10 1985-06-13 Procedimiento para preparar nuevos acidos 3-amino-1-benzaze-pin-2-ona-1-alcanoicos
ES544258A Expired ES8609264A1 (es) 1983-02-10 1985-06-17 Procedimiento para preparar nuevos acidos 3-(5-aminopentil)-amino-1-benzazepin-2-ona-1-alcanoico
ES544260A Expired ES8609265A1 (es) 1983-02-10 1985-06-17 Procedimiento para preparar nuevos acidos 3-(5-aminopentil)-amino-1-benzazepin-2-ona-1-alcanoico
ES544255A Expired ES8609262A1 (es) 1983-02-10 1985-06-17 Procedimiento para preparar nuevos acidos 3-(5-aminopentil)-amino-1-benzazepin-2-ona-1-alcanoico
ES544256A Expired ES8705409A1 (es) 1983-02-10 1985-06-17 Procedimiento para preparar nuevos acidos 3-(5-aminopentil)-amino-1-benzazepin-2-ona-1-alcanoico
ES544257A Expired ES8609263A1 (es) 1983-02-10 1985-06-17 Procedimiento para preparar nuevos acidos 3-(5-aminopentil)-amino-1-benzazepin-2-ona-1-alcanoico
ES544259A Expired ES8700239A1 (es) 1983-02-10 1985-06-17 Procedimiento para preparar nuevos acidos 3-(5-aminopentil)-amino-1-benzazepin-2-ona-1-alcanoico
ES544254A Expired ES8703859A1 (es) 1983-02-10 1985-06-17 Procedimiento para preparar nuevos acidos 3-(5-aminopentil)-amino-1-benzazepin-2-ona-1-alcanoico

Family Applications After (9)

Application Number Title Priority Date Filing Date
ES529595A Expired ES8707216A1 (es) 1983-02-10 1984-02-09 Procedimiento para preparar nuevos acidos 3-(5-aminopentil)-amino-1-benzazepin-2-ona-1-alcanoicos
ES544127A Expired ES8702363A1 (es) 1983-02-10 1985-06-13 Procedimiento para preparar nuevos acidos 3-amino-1-benzaze-pin-2-ona-1-alcanoicos
ES544258A Expired ES8609264A1 (es) 1983-02-10 1985-06-17 Procedimiento para preparar nuevos acidos 3-(5-aminopentil)-amino-1-benzazepin-2-ona-1-alcanoico
ES544260A Expired ES8609265A1 (es) 1983-02-10 1985-06-17 Procedimiento para preparar nuevos acidos 3-(5-aminopentil)-amino-1-benzazepin-2-ona-1-alcanoico
ES544255A Expired ES8609262A1 (es) 1983-02-10 1985-06-17 Procedimiento para preparar nuevos acidos 3-(5-aminopentil)-amino-1-benzazepin-2-ona-1-alcanoico
ES544256A Expired ES8705409A1 (es) 1983-02-10 1985-06-17 Procedimiento para preparar nuevos acidos 3-(5-aminopentil)-amino-1-benzazepin-2-ona-1-alcanoico
ES544257A Expired ES8609263A1 (es) 1983-02-10 1985-06-17 Procedimiento para preparar nuevos acidos 3-(5-aminopentil)-amino-1-benzazepin-2-ona-1-alcanoico
ES544259A Expired ES8700239A1 (es) 1983-02-10 1985-06-17 Procedimiento para preparar nuevos acidos 3-(5-aminopentil)-amino-1-benzazepin-2-ona-1-alcanoico
ES544254A Expired ES8703859A1 (es) 1983-02-10 1985-06-17 Procedimiento para preparar nuevos acidos 3-(5-aminopentil)-amino-1-benzazepin-2-ona-1-alcanoico

Country Status (24)

Country Link
US (1) US4473575A (es)
EP (2) EP0119955B1 (es)
JP (2) JPS59172473A (es)
KR (1) KR900009023B1 (es)
AR (8) AR242564A1 (es)
AT (2) ATE48598T1 (es)
AU (1) AU574061B2 (es)
CA (2) CA1218993A (es)
CY (1) CY1674A (es)
DD (1) DD218359A5 (es)
DE (2) DE3480705D1 (es)
DK (2) DK171257B1 (es)
ES (10) ES8609261A1 (es)
FI (1) FI77857C (es)
GR (1) GR79809B (es)
HK (1) HK97592A (es)
HU (1) HU192394B (es)
IE (1) IE56858B1 (es)
IL (1) IL70881A (es)
NO (1) NO166232C (es)
NZ (1) NZ207091A (es)
PT (1) PT78075B (es)
SG (1) SG94992G (es)
ZA (1) ZA84958B (es)

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US4473575A (en) * 1982-07-19 1984-09-25 Ciba-Geigy Corporation 3-Amino-(1)-benzazepin-2-one-1-alkanoic acids
US4537885A (en) * 1983-02-10 1985-08-27 Ciba Geigy Corporation Certain benzazocinone and benzazoninone derivatives
US4575503A (en) * 1983-02-10 1986-03-11 Ciba-Geigy Corporation 3-Amino-[1]-benzazepin-2-one-1-alkanoic acids
US4600534A (en) * 1984-02-06 1986-07-15 Ciba-Geigy Corporation Process and intermediates for manufacture of 3-(5-amino-1-carboxypentylamino)-tetrahydro-1-benzazepin-2-one-1-acetic acid
EP0166357A3 (en) * 1984-06-26 1988-10-26 Merck & Co. Inc. Benzofused lactams and pharmaceutical compositions containing them
DE3586445T2 (de) * 1984-06-26 1993-01-14 Merck & Co Inc Kondensierte benzo-laktam-verbindungen und deren pharmazeutische zusammensetzungen.
US4692522A (en) * 1985-04-01 1987-09-08 Merck & Co., Inc. Benzofused lactams useful as cholecystokinin antagonists
US4785089A (en) * 1985-06-13 1988-11-15 Ciba-Geigy Corporation Novel sulfonic acid esters and their preparation
EP0237267B1 (en) * 1986-03-11 1991-01-23 Barry Anthony Thompson Feeding livestock with polymers
US4918187A (en) * 1986-05-28 1990-04-17 Ciba-Geigy Corporation [2,5-Dihydro 5-phenyl-2-oxo-3-furanyl]amines
US5028704A (en) * 1986-05-28 1991-07-02 Ciba-Geigy Corporation (2,5-dihydro 5-phenyl-2-oxo-3-furanyl)amines, methods of manufacture, and use thereof in the production of angiotensin converting enzyme inhibitors
FI88723C (fi) * 1986-05-28 1993-06-28 Ciba Geigy Ag /2,5-dihydro-2-oxo-5-fenyl-3-furanyl/aminer samt deras anvaendning vid framstaellning av ACE-inhibitorer
AT399717B (de) * 1986-05-28 1995-07-25 Ciba Geigy Ag Verfahren zur herstellung von (2,5-dihydro-2-oxo- 5-phenyl-3-furanyl)aminen
US4962105A (en) 1987-10-19 1990-10-09 Ciba-Geigy Corporation Potentiation of antihypertensive effect of ace inhibitors
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US5552397A (en) * 1992-05-18 1996-09-03 E. R. Squibb & Sons, Inc. Substituted azepinone dual inhibitors of angiotensin converting enzyme and neutral exdopeptidase
RU2124503C1 (ru) 1992-05-18 1999-01-10 И.Р.Сквибб энд Санз, Инк. Гетероциклические азотсодержащие производные карбоновой кислоты, способ их получения и фармацевтическая композиция
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Also Published As

Publication number Publication date
AR243161A1 (es) 1993-07-30
EP0119954B1 (de) 1990-03-14
ES8609264A1 (es) 1986-09-01
JPS59172473A (ja) 1984-09-29
ES544257A0 (es) 1986-09-01
ES544127A0 (es) 1987-01-01
ES544255A0 (es) 1986-09-01
DD218359A5 (de) 1985-02-06
AR243165A1 (es) 1993-07-30
FI840513A (fi) 1984-08-11
CY1674A (en) 1993-10-10
NO166232C (no) 1991-06-19
ZA84958B (en) 1984-09-26
HK97592A (en) 1992-12-11
AR242190A1 (es) 1993-03-31
ES8609263A1 (es) 1986-09-01
ES8702363A1 (es) 1987-01-01
ES8609261A1 (es) 1986-07-16
ES8707216A1 (es) 1987-07-16
ES8609265A1 (es) 1986-09-01
EP0119955A2 (de) 1984-09-26
PT78075B (en) 1986-06-11
AU2443084A (en) 1984-08-16
JPH0460108B2 (es) 1992-09-25
ES544254A0 (es) 1987-03-01
NO840487L (no) 1984-08-13
HU192394B (en) 1987-06-29
ES8609262A1 (es) 1986-09-01
EP0119954A2 (de) 1984-09-26
DE3481612D1 (de) 1990-04-19
AU574061B2 (en) 1988-06-30
AR243162A1 (es) 1993-07-30
AR242191A1 (es) 1993-03-31
ES544260A0 (es) 1986-09-01
KR840007722A (ko) 1984-12-10
ES529595A0 (es) 1987-07-16
NO166232B (no) 1991-03-11
FI840513A0 (fi) 1984-02-08
AR243163A1 (es) 1993-07-30
DK58184D0 (da) 1984-02-09
AR242564A1 (es) 1993-04-30
ES8705409A1 (es) 1987-05-01
NZ207091A (en) 1985-11-08
ES8703859A1 (es) 1987-03-01
DK171257B1 (da) 1996-08-12
KR900009023B1 (ko) 1990-12-17
IE840302L (en) 1984-08-10
IE56858B1 (en) 1992-01-01
US4473575A (en) 1984-09-25
AR243164A1 (es) 1993-07-30
PT78075A (en) 1984-03-01
ATE48598T1 (de) 1989-12-15
CA1225397A (en) 1987-08-11
FI77857C (fi) 1989-05-10
ES544258A0 (es) 1986-09-01
EP0119955A3 (en) 1986-06-11
JPS59172475A (ja) 1984-09-29
FI77857B (fi) 1989-01-31
IL70881A (en) 1987-10-30
GR79809B (es) 1984-10-31
ATE50989T1 (de) 1990-03-15
DE3480705D1 (de) 1990-01-18
EP0119954A3 (en) 1986-06-11
ES544259A0 (es) 1986-10-16
DK58284A (da) 1984-08-11
IL70881A0 (en) 1984-05-31
ES544256A0 (es) 1987-05-01
DK58184A (da) 1984-08-11
CA1218993A (en) 1987-03-10
JPH0421665B2 (es) 1992-04-13
SG94992G (en) 1992-12-04
ES8700239A1 (es) 1986-10-16
DK58284D0 (da) 1984-02-09
EP0119955B1 (de) 1989-12-13

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