AR243162A1 - Procedimiento para obtener novedosos acidos 3-(5-aminopentil)-amino-1-benzazepin-2-ona-1-alcanoicos. - Google Patents

Procedimiento para obtener novedosos acidos 3-(5-aminopentil)-amino-1-benzazepin-2-ona-1-alcanoicos.

Info

Publication number
AR243162A1
AR243162A1 AR86304925A AR30492586A AR243162A1 AR 243162 A1 AR243162 A1 AR 243162A1 AR 86304925 A AR86304925 A AR 86304925A AR 30492586 A AR30492586 A AR 30492586A AR 243162 A1 AR243162 A1 AR 243162A1
Authority
AR
Argentina
Prior art keywords
benzazepin
amino
alkanoic acids
alkanoic
acids
Prior art date
Application number
AR86304925A
Other languages
English (en)
Original Assignee
Ciba Geigy
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ciba Geigy filed Critical Ciba Geigy
Application granted granted Critical
Publication of AR243162A1 publication Critical patent/AR243162A1/es

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D223/00Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
    • C07D223/14Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D223/16Benzazepines; Hydrogenated benzazepines
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/04Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/12Antihypertensives
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K5/00Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/022Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -X-C(=O)-(C)n-N-C-C(=O)-Y-; X and Y being heteroatoms; n being 1 or 2
    • C07K5/0222Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -X-C(=O)-(C)n-N-C-C(=O)-Y-; X and Y being heteroatoms; n being 1 or 2 with the first amino acid being heterocyclic, e.g. Pro, Trp
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K5/00Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06Dipeptides
    • C07K5/06008Dipeptides with the first amino acid being neutral
    • C07K5/06017Dipeptides with the first amino acid being neutral and aliphatic
    • C07K5/06026Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atom, i.e. Gly or Ala
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K5/00Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06Dipeptides
    • C07K5/06086Dipeptides with the first amino acid being basic
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02PCLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00Technologies relating to chemical industry
    • Y02P20/50Improvements relating to the production of bulk chemicals
    • Y02P20/55Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
AR86304925A 1983-02-10 1986-08-15 Procedimiento para obtener novedosos acidos 3-(5-aminopentil)-amino-1-benzazepin-2-ona-1-alcanoicos. AR243162A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/465,695 US4473575A (en) 1982-07-19 1983-02-10 3-Amino-(1)-benzazepin-2-one-1-alkanoic acids

Publications (1)

Publication Number Publication Date
AR243162A1 true AR243162A1 (es) 1993-07-30

Family

ID=23848805

Family Applications (8)

Application Number Title Priority Date Filing Date
AR84295689A AR242564A1 (es) 1983-02-10 1984-02-10 Un procedimiento para obtener novedosos derivados de acidos 3-(5-aminopentil)-amino-1-benzazepin-2-ona-1-alcanoicos.
AR86304922A AR243165A1 (es) 1983-02-10 1986-08-15 Procedimiento para obtener novedosos acidos 3-(5-aminopentil)-amino-1-benzacepin-2-ona-1-alcanoicos.
AR86304920A AR242190A1 (es) 1983-02-10 1986-08-15 Procedimiento para obtener novedosos acidos 3-(5-aminopentil)-amino-1-benzacepin-2-ona-1-alcanoicos.
AR86304924A AR243163A1 (es) 1983-02-10 1986-08-15 Procedimiento para obtener novedosos acidos 3-(5-aminopentil)-amino-1-benzazepin-2-ona-1-alcanoicos.
AR86304921A AR242191A1 (es) 1983-02-10 1986-08-15 Procedimiento para obtener novedosos acidos 3-(5-aminopentil)-amino-1-benzacepin-2-ona-1-alcanoicos.
AR86304926A AR243161A1 (es) 1983-02-10 1986-08-15 Procedimiento para obtener novedosos acidos 3-(5-aminopentil)-amino-1-benzazepin-2-ona-1-alcanoicos.
AR86304923A AR243164A1 (es) 1983-02-10 1986-08-15 Procedimiento para obtener novedosos acidos 3-(5-aminopentil)-amino-1-benzazepin-2-ona-1-alcanoicos.
AR86304925A AR243162A1 (es) 1983-02-10 1986-08-15 Procedimiento para obtener novedosos acidos 3-(5-aminopentil)-amino-1-benzazepin-2-ona-1-alcanoicos.

Family Applications Before (7)

Application Number Title Priority Date Filing Date
AR84295689A AR242564A1 (es) 1983-02-10 1984-02-10 Un procedimiento para obtener novedosos derivados de acidos 3-(5-aminopentil)-amino-1-benzazepin-2-ona-1-alcanoicos.
AR86304922A AR243165A1 (es) 1983-02-10 1986-08-15 Procedimiento para obtener novedosos acidos 3-(5-aminopentil)-amino-1-benzacepin-2-ona-1-alcanoicos.
AR86304920A AR242190A1 (es) 1983-02-10 1986-08-15 Procedimiento para obtener novedosos acidos 3-(5-aminopentil)-amino-1-benzacepin-2-ona-1-alcanoicos.
AR86304924A AR243163A1 (es) 1983-02-10 1986-08-15 Procedimiento para obtener novedosos acidos 3-(5-aminopentil)-amino-1-benzazepin-2-ona-1-alcanoicos.
AR86304921A AR242191A1 (es) 1983-02-10 1986-08-15 Procedimiento para obtener novedosos acidos 3-(5-aminopentil)-amino-1-benzacepin-2-ona-1-alcanoicos.
AR86304926A AR243161A1 (es) 1983-02-10 1986-08-15 Procedimiento para obtener novedosos acidos 3-(5-aminopentil)-amino-1-benzazepin-2-ona-1-alcanoicos.
AR86304923A AR243164A1 (es) 1983-02-10 1986-08-15 Procedimiento para obtener novedosos acidos 3-(5-aminopentil)-amino-1-benzazepin-2-ona-1-alcanoicos.

Country Status (24)

Country Link
US (1) US4473575A (es)
EP (2) EP0119955B1 (es)
JP (2) JPS59172473A (es)
KR (1) KR900009023B1 (es)
AR (8) AR242564A1 (es)
AT (2) ATE48598T1 (es)
AU (1) AU574061B2 (es)
CA (2) CA1218993A (es)
CY (1) CY1674A (es)
DD (1) DD218359A5 (es)
DE (2) DE3480705D1 (es)
DK (2) DK171257B1 (es)
ES (10) ES8609261A1 (es)
FI (1) FI77857C (es)
GR (1) GR79809B (es)
HK (1) HK97592A (es)
HU (1) HU192394B (es)
IE (1) IE56858B1 (es)
IL (1) IL70881A (es)
NO (1) NO166232C (es)
NZ (1) NZ207091A (es)
PT (1) PT78075B (es)
SG (1) SG94992G (es)
ZA (1) ZA84958B (es)

Families Citing this family (66)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4473575A (en) * 1982-07-19 1984-09-25 Ciba-Geigy Corporation 3-Amino-(1)-benzazepin-2-one-1-alkanoic acids
US4537885A (en) * 1983-02-10 1985-08-27 Ciba Geigy Corporation Certain benzazocinone and benzazoninone derivatives
US4575503A (en) * 1983-02-10 1986-03-11 Ciba-Geigy Corporation 3-Amino-[1]-benzazepin-2-one-1-alkanoic acids
US4600534A (en) * 1984-02-06 1986-07-15 Ciba-Geigy Corporation Process and intermediates for manufacture of 3-(5-amino-1-carboxypentylamino)-tetrahydro-1-benzazepin-2-one-1-acetic acid
EP0166357A3 (en) * 1984-06-26 1988-10-26 Merck & Co. Inc. Benzofused lactams and pharmaceutical compositions containing them
DE3586445T2 (de) * 1984-06-26 1993-01-14 Merck & Co Inc Kondensierte benzo-laktam-verbindungen und deren pharmazeutische zusammensetzungen.
US4692522A (en) * 1985-04-01 1987-09-08 Merck & Co., Inc. Benzofused lactams useful as cholecystokinin antagonists
US4785089A (en) * 1985-06-13 1988-11-15 Ciba-Geigy Corporation Novel sulfonic acid esters and their preparation
EP0237267B1 (en) * 1986-03-11 1991-01-23 Barry Anthony Thompson Feeding livestock with polymers
US4918187A (en) * 1986-05-28 1990-04-17 Ciba-Geigy Corporation [2,5-Dihydro 5-phenyl-2-oxo-3-furanyl]amines
US5028704A (en) * 1986-05-28 1991-07-02 Ciba-Geigy Corporation (2,5-dihydro 5-phenyl-2-oxo-3-furanyl)amines, methods of manufacture, and use thereof in the production of angiotensin converting enzyme inhibitors
FI88723C (fi) * 1986-05-28 1993-06-28 Ciba Geigy Ag /2,5-dihydro-2-oxo-5-fenyl-3-furanyl/aminer samt deras anvaendning vid framstaellning av ACE-inhibitorer
AT399717B (de) * 1986-05-28 1995-07-25 Ciba Geigy Ag Verfahren zur herstellung von (2,5-dihydro-2-oxo- 5-phenyl-3-furanyl)aminen
US4962105A (en) 1987-10-19 1990-10-09 Ciba-Geigy Corporation Potentiation of antihypertensive effect of ace inhibitors
JPH07116224B2 (ja) * 1987-12-29 1995-12-13 吉富製薬株式会社 ベンゾラクタム化合物
GB9100028D0 (en) * 1991-01-02 1991-02-20 Ici Plc Compounds
US5428031A (en) * 1991-12-03 1995-06-27 Merck & Co., Inc. Methods of treating cardiac arrhythmia
US5552397A (en) * 1992-05-18 1996-09-03 E. R. Squibb & Sons, Inc. Substituted azepinone dual inhibitors of angiotensin converting enzyme and neutral exdopeptidase
RU2124503C1 (ru) 1992-05-18 1999-01-10 И.Р.Сквибб энд Санз, Инк. Гетероциклические азотсодержащие производные карбоновой кислоты, способ их получения и фармацевтическая композиция
GB9212308D0 (en) * 1992-06-10 1992-07-22 Ici Plc Therapeutic compositions
US5654294A (en) * 1993-05-13 1997-08-05 Bristol-Myers Squibb Spiro lactam dual action inhibitors
GB9311948D0 (en) * 1993-06-10 1993-07-28 Zeneca Ltd Substituted nitrogen heterocycles
JPH09505597A (ja) * 1993-11-22 1997-06-03 メルク エンド カンパニー インコーポレーテッド 3−アシルアミノベンゾアゼピン類
US5801168A (en) * 1994-06-09 1998-09-01 Zeneca Limited Substituted nitrogen heterocycles
BR9508608A (pt) * 1994-08-18 1997-12-30 Merck & Co Inc Composto formulação farmacêutica e processo para prevenir ou tratar arritmia
US5587375A (en) * 1995-02-17 1996-12-24 Bristol-Myers Squibb Company Azepinone compounds useful in the inhibition of ACE and NEP
US5877313A (en) * 1995-05-17 1999-03-02 Bristol-Myers Squibb Benzo-fused azepinone and piperidinone compounds useful in the inhibition of ACE and NEP
US5635504A (en) * 1995-06-07 1997-06-03 Bristol-Myers Squibb Co. Diazepine containing dual action inhibitors
US5631251A (en) * 1995-06-07 1997-05-20 Merck & Co., Inc. 5-cyclopropyl-1,4 benzodiazepine-2-ones
US5650408A (en) * 1995-06-07 1997-07-22 Karanewsky; Donald S. Thiazolo benzazepine containing dual action inhibitors
US5691331A (en) * 1995-06-07 1997-11-25 Merck & Co., Inc. N-(2,4-Dioxo-2,3,4,5-tetrahydro-1H-1,5-benzodiazepin-3yl) -3- amides
AU720378B2 (en) * 1995-06-07 2000-06-01 Merck & Co., Inc. Novel N-(4-oxo-2,3,4,5-tetrahydro-1H-1, 5-benzodiazepin-3yl)-3-amides
US5700797A (en) * 1995-06-07 1997-12-23 Merck & Co, Inc. N-(2,4-dioxo-2,3,4,5-tetrahydro-1H-1,5-benzodiazepin-3-yl)-3-amides
US5726171A (en) * 1995-06-07 1998-03-10 Merck & Co Inc N-(1-alkyl-5-phenyl-2,3,4,5-tetrahydro-1H-benzo B! 1,4!diazepin-3yl)-acetamides
US6191166B1 (en) * 1997-11-21 2001-02-20 Elan Pharmaceuticals, Inc. Methods and compounds for inhibiting β-amyloid peptide release and/or its synthesis
US6211235B1 (en) 1996-11-22 2001-04-03 Elan Pharmaceuticals, Inc. Compounds for inhibiting β-amyloid peptide release and/or its synthesis
US6635632B1 (en) 1996-12-23 2003-10-21 Athena Neurosciences, Inc. Cycloalkyl, lactam, lactone and related compounds, pharmaceutical compositions comprising same, and methods for inhibiting β-amyloid peptide release and/or its synthesis by use of such compounds
US6683075B1 (en) 1996-12-23 2004-01-27 Athena Neurosciences, Inc. Cycloalkyl, lactam, lactone and related compounds, pharmaceutical compositions comprising same, and methods for inhibiting β-amyloid peptide release and/or its synthesis by use
JP2002241368A (ja) * 1997-02-18 2002-08-28 Shionogi & Co Ltd 新規ベンゾラクタム誘導体およびそれを含有する医薬組成物
WO1998041510A1 (fr) * 1997-03-14 1998-09-24 Shionogi & Co., Ltd. Nouveaux derives du benzolactame et compositions medicamenteuses les contenant
US6509331B1 (en) 1998-06-22 2003-01-21 Elan Pharmaceuticals, Inc. Deoxyamino acid compounds, pharmaceutical compositions comprising same, and methods for inhibiting β-amyloid peptide release and/or its synthesis by use of such compounds
US6528505B1 (en) 1998-06-22 2003-03-04 Elan Pharmaceuticals, Inc. Cyclic amino acid compounds pharmaceutical compositions comprising same and methods for inhibiting β-amyloid peptide release and/or its synthesis by use of such compounds
US6569851B1 (en) * 1998-06-22 2003-05-27 Elan Pharmaceutials, Inc. Cycloalkyl, lactam, lactone and related compounds, pharmaceutical compositions comprising same, and methods for inhibiting β-amyloid peptide release and/or its synthesis by use of such compounds
US6552013B1 (en) 1998-06-22 2003-04-22 Elan Pharmaceuticals, Inc. Deoxyamino acid compounds, pharmaceutical compositions comprising same, and methods for inhibiting β-amyloid peptide release and/or its synthesis by use of such compounds
US6774125B2 (en) * 1998-06-22 2004-08-10 Elan Pharmaceuticals, Inc. Deoxyamino acid compounds, pharmaceutical compositions comprising same, and methods for inhibiting β-amyloid peptide release and/or its synthesis by use of such compounds
WO2001035964A1 (en) * 1999-11-18 2001-05-25 Antexpharma, Inc. Substituted 1-benzazepines and derivatives thereof
US7795468B2 (en) * 2001-01-19 2010-09-14 Chevron U.S.A. Inc. Functionalized higher diamondoids
US6984645B2 (en) * 2001-11-16 2006-01-10 Bristol-Myers Squibb Company Dual inhibitors of adipocyte fatty acid binding protein and keratinocyte fatty acid binding protein
US20050192265A1 (en) * 2003-03-20 2005-09-01 Thompson Richard C. Cycloalkyl, lactam, lactone and related compounds, pharmaceutical compositions comprising same, and methods for inhibiting beta-amyloid peptide release and/or its synthesis by use of such compounds
US20050203168A1 (en) * 2004-03-11 2005-09-15 The Regents Of The University Of Michigan Angiotensin converting enzyme inhibitor use for treatment and prevention of gastrointestinal disorders
US8080579B2 (en) * 2005-10-03 2011-12-20 The Regents Of The University Of Michigan Compositions and methods for treatment of inflammatory bowel disease
US7592461B2 (en) 2005-12-21 2009-09-22 Bristol-Myers Squibb Company Indane modulators of glucocorticoid receptor, AP-1, and/or NF-κB activity and use thereof
US20070238770A1 (en) * 2006-04-05 2007-10-11 Bristol-Myers Squibb Company Process for preparing novel crystalline forms of peliglitazar, novel stable forms produced therein and formulations
EP2089355A2 (en) 2006-11-01 2009-08-19 Brystol-Myers Squibb Company Modulators of glucocorticoid receptor, ap-1, and/or nf- kappa b activity and use thereof
JP2010508358A (ja) 2006-11-01 2010-03-18 ブリストル−マイヤーズ スクイブ カンパニー グルココルチコイド受容体、AP−1、および/またはNF−κB活性の調節剤、並びにその使用
CA2688161C (en) 2007-06-04 2020-10-20 Kunwar Shailubhai Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders
US8969514B2 (en) 2007-06-04 2015-03-03 Synergy Pharmaceuticals, Inc. Agonists of guanylate cyclase useful for the treatment of hypercholesterolemia, atherosclerosis, coronary heart disease, gallstone, obesity and other cardiovascular diseases
US7828840B2 (en) * 2007-11-15 2010-11-09 Med Institute, Inc. Medical devices and methods for local delivery of angiotensin II type 2 receptor antagonists
ES2522968T3 (es) 2008-06-04 2014-11-19 Synergy Pharmaceuticals Inc. Agonistas de guanilato ciclasa útiles para el tratamiento de trastornos gastrointestinales, inflamación, cáncer y otros trastornos
EP2334671A1 (en) 2008-06-24 2011-06-22 Bristol-Myers Squibb Company Cyclopentathiophene modulators of the glucocorticoid receptor, ap-1, and/or nf-kappa b activity and use thereof
ES2624828T3 (es) 2008-07-16 2017-07-17 Synergy Pharmaceuticals Inc. Agonistas de la guanilato ciclasa útiles para el tratamiento de trastornos gastrointestinales, inflamación, cáncer y otros
US9616097B2 (en) 2010-09-15 2017-04-11 Synergy Pharmaceuticals, Inc. Formulations of guanylate cyclase C agonists and methods of use
US9486494B2 (en) 2013-03-15 2016-11-08 Synergy Pharmaceuticals, Inc. Compositions useful for the treatment of gastrointestinal disorders
EP2970384A1 (en) 2013-03-15 2016-01-20 Synergy Pharmaceuticals Inc. Agonists of guanylate cyclase and their uses
JP6606491B2 (ja) 2013-06-05 2019-11-13 シナジー ファーマシューティカルズ インコーポレイテッド グアニル酸シクラーゼcの超高純度アゴニスト、その作成および使用方法
WO2015027021A1 (en) 2013-08-22 2015-02-26 Bristol-Myers Squibb Company Imide and acylurea derivatives as modulators of the glucocorticoid receptor

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3330823A (en) * 1964-12-16 1967-07-11 Squibb & Sons Inc N-amino-loweralkylene-benzo-lactams
US3395150A (en) * 1965-02-26 1968-07-30 Squibb & Sons Inc Benzothiazepine carboxamides and derivatives thereof
GB1305278A (es) * 1970-03-12 1973-01-31
JPS5129522B2 (es) * 1972-07-13 1976-08-26
JPS5520970B2 (es) * 1972-07-15 1980-06-06
FR2358151A1 (fr) * 1976-03-31 1978-02-10 Roussel Uclaf Nouvelles benzazepines et leurs sels, procede de preparation et application a titre de medicaments
IL58849A (en) * 1978-12-11 1983-03-31 Merck & Co Inc Carboxyalkyl dipeptides and derivatives thereof,their preparation and pharmaceutical compositions containing them
US4377515A (en) * 1979-10-01 1983-03-22 Merck & Co., Inc. Long lasting agonists and antagonists of LH-RH
GR74635B (es) * 1980-08-18 1984-06-29 Merck & Co Inc
US4409146A (en) * 1980-10-06 1983-10-11 Merck & Co., Inc. Substituted caprolactam derivatives as antihypertensives
IN156096B (es) * 1981-03-19 1985-05-11 Usv Pharma Corp
US4415496A (en) * 1981-03-23 1983-11-15 Merck & Co., Inc. Bicyclic lactams
GB2103614B (en) * 1981-08-11 1984-11-21 Ciba Geigy Ag Benzazepin-2-ones
ZA825779B (en) * 1981-08-11 1984-04-25 Ciba Geigy Ag Benzazepins-2-ones
US4410520A (en) * 1981-11-09 1983-10-18 Ciba-Geigy Corporation 3-Amino-[1]-benzazepin-2-one-1-alkanoic acids
US4473575A (en) * 1982-07-19 1984-09-25 Ciba-Geigy Corporation 3-Amino-(1)-benzazepin-2-one-1-alkanoic acids
EP0107095B1 (en) * 1982-09-30 1987-09-09 Merck & Co. Inc. 1-n-alkylcarboxy-benzofused lactams useful as antihypertensive agents

Also Published As

Publication number Publication date
AR243161A1 (es) 1993-07-30
EP0119954B1 (de) 1990-03-14
ES8609264A1 (es) 1986-09-01
JPS59172473A (ja) 1984-09-29
ES544257A0 (es) 1986-09-01
ES544127A0 (es) 1987-01-01
ES544255A0 (es) 1986-09-01
DD218359A5 (de) 1985-02-06
AR243165A1 (es) 1993-07-30
FI840513A (fi) 1984-08-11
CY1674A (en) 1993-10-10
NO166232C (no) 1991-06-19
ZA84958B (en) 1984-09-26
HK97592A (en) 1992-12-11
AR242190A1 (es) 1993-03-31
ES8609263A1 (es) 1986-09-01
ES8702363A1 (es) 1987-01-01
ES8609261A1 (es) 1986-07-16
ES8707216A1 (es) 1987-07-16
ES8609265A1 (es) 1986-09-01
EP0119955A2 (de) 1984-09-26
PT78075B (en) 1986-06-11
AU2443084A (en) 1984-08-16
JPH0460108B2 (es) 1992-09-25
ES544254A0 (es) 1987-03-01
NO840487L (no) 1984-08-13
HU192394B (en) 1987-06-29
ES8609262A1 (es) 1986-09-01
EP0119954A2 (de) 1984-09-26
DE3481612D1 (de) 1990-04-19
AU574061B2 (en) 1988-06-30
AR242191A1 (es) 1993-03-31
ES544260A0 (es) 1986-09-01
KR840007722A (ko) 1984-12-10
ES529595A0 (es) 1987-07-16
NO166232B (no) 1991-03-11
FI840513A0 (fi) 1984-02-08
AR243163A1 (es) 1993-07-30
DK58184D0 (da) 1984-02-09
AR242564A1 (es) 1993-04-30
ES8705409A1 (es) 1987-05-01
NZ207091A (en) 1985-11-08
ES8703859A1 (es) 1987-03-01
DK171257B1 (da) 1996-08-12
KR900009023B1 (ko) 1990-12-17
IE840302L (en) 1984-08-10
IE56858B1 (en) 1992-01-01
US4473575A (en) 1984-09-25
ES529594A0 (es) 1986-07-16
AR243164A1 (es) 1993-07-30
PT78075A (en) 1984-03-01
ATE48598T1 (de) 1989-12-15
CA1225397A (en) 1987-08-11
FI77857C (fi) 1989-05-10
ES544258A0 (es) 1986-09-01
EP0119955A3 (en) 1986-06-11
JPS59172475A (ja) 1984-09-29
FI77857B (fi) 1989-01-31
IL70881A (en) 1987-10-30
GR79809B (es) 1984-10-31
ATE50989T1 (de) 1990-03-15
DE3480705D1 (de) 1990-01-18
EP0119954A3 (en) 1986-06-11
ES544259A0 (es) 1986-10-16
DK58284A (da) 1984-08-11
IL70881A0 (en) 1984-05-31
ES544256A0 (es) 1987-05-01
DK58184A (da) 1984-08-11
CA1218993A (en) 1987-03-10
JPH0421665B2 (es) 1992-04-13
SG94992G (en) 1992-12-04
ES8700239A1 (es) 1986-10-16
DK58284D0 (da) 1984-02-09
EP0119955B1 (de) 1989-12-13

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