ES8609265A1 - Procedimiento para preparar nuevos acidos 3-(5-aminopentil)-amino-1-benzazepin-2-ona-1-alcanoico - Google Patents
Procedimiento para preparar nuevos acidos 3-(5-aminopentil)-amino-1-benzazepin-2-ona-1-alcanoicoInfo
- Publication number
- ES8609265A1 ES8609265A1 ES544260A ES544260A ES8609265A1 ES 8609265 A1 ES8609265 A1 ES 8609265A1 ES 544260 A ES544260 A ES 544260A ES 544260 A ES544260 A ES 544260A ES 8609265 A1 ES8609265 A1 ES 8609265A1
- Authority
- ES
- Spain
- Prior art keywords
- benzazepin
- opt
- preparation
- lower alkyl
- tetrahydro
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
- C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D223/16—Benzazepines; Hydrogenated benzazepines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
- C07K5/022—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -X-C(=O)-(C)n-N-C-C(=O)-Y-; X and Y being heteroatoms; n being 1 or 2
- C07K5/0222—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -X-C(=O)-(C)n-N-C-C(=O)-Y-; X and Y being heteroatoms; n being 1 or 2 with the first amino acid being heterocyclic, e.g. Pro, Trp
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06008—Dipeptides with the first amino acid being neutral
- C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
- C07K5/06026—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atom, i.e. Gly or Ala
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06086—Dipeptides with the first amino acid being basic
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biochemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Cardiology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Heart & Thoracic Surgery (AREA)
- Hospice & Palliative Care (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Peptides Or Proteins (AREA)
Abstract
PROCEDIMIENTO PARA PREPARAR NUEVOS ACIDOS 3-(5-AMINOPENTIL)-AMINO-1-BENZAZEPIN-2-ONA-1-ALCANOICOS DE FORMULA GENERAL (I), PREPARADOS FARMACEUTICOS QUE CONTIENEN ESTOS COMPUESTOS Y SU APLICACION TERAPEUTICA. LOS ACIDOS PUEDEN OBTENERSE POR CICLACION DEL COMPUESTO (IX), CUYA OBTENCION TAMBIEN SE DESCRIBE EN LA INVENCION. LOS COMPUESTOS DE FORMULA (I) MUESTRAN VALIOSAS PROPIEDADES FARMACOLOGICAS CARDIOVASCULARES, COMO HIPOTENSIVOS/ANTIHIPERTENSIVOS AL INHIBIR SELECTIVAMENTE LA ENZIMA QUE TRANSFORMA ANGIOTENSINA EN MAMIFEROS.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US06/465,695 US4473575A (en) | 1982-07-19 | 1983-02-10 | 3-Amino-(1)-benzazepin-2-one-1-alkanoic acids |
Publications (2)
Publication Number | Publication Date |
---|---|
ES544260A0 ES544260A0 (es) | 1986-09-01 |
ES8609265A1 true ES8609265A1 (es) | 1986-09-01 |
Family
ID=23848805
Family Applications (10)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES529595A Expired ES8707216A1 (es) | 1983-02-10 | 1984-02-09 | Procedimiento para preparar nuevos acidos 3-(5-aminopentil)-amino-1-benzazepin-2-ona-1-alcanoicos |
ES529594A Expired ES8609261A1 (es) | 1983-02-10 | 1984-02-09 | Procedimiento para preparar nuevos acidos 3-amino-1-benzazepin-2-ona-1-alcanoicos |
ES544127A Expired ES8702363A1 (es) | 1983-02-10 | 1985-06-13 | Procedimiento para preparar nuevos acidos 3-amino-1-benzaze-pin-2-ona-1-alcanoicos |
ES544256A Expired ES8705409A1 (es) | 1983-02-10 | 1985-06-17 | Procedimiento para preparar nuevos acidos 3-(5-aminopentil)-amino-1-benzazepin-2-ona-1-alcanoico |
ES544257A Expired ES8609263A1 (es) | 1983-02-10 | 1985-06-17 | Procedimiento para preparar nuevos acidos 3-(5-aminopentil)-amino-1-benzazepin-2-ona-1-alcanoico |
ES544259A Expired ES8700239A1 (es) | 1983-02-10 | 1985-06-17 | Procedimiento para preparar nuevos acidos 3-(5-aminopentil)-amino-1-benzazepin-2-ona-1-alcanoico |
ES544255A Expired ES8609262A1 (es) | 1983-02-10 | 1985-06-17 | Procedimiento para preparar nuevos acidos 3-(5-aminopentil)-amino-1-benzazepin-2-ona-1-alcanoico |
ES544254A Expired ES8703859A1 (es) | 1983-02-10 | 1985-06-17 | Procedimiento para preparar nuevos acidos 3-(5-aminopentil)-amino-1-benzazepin-2-ona-1-alcanoico |
ES544260A Expired ES8609265A1 (es) | 1983-02-10 | 1985-06-17 | Procedimiento para preparar nuevos acidos 3-(5-aminopentil)-amino-1-benzazepin-2-ona-1-alcanoico |
ES544258A Expired ES8609264A1 (es) | 1983-02-10 | 1985-06-17 | Procedimiento para preparar nuevos acidos 3-(5-aminopentil)-amino-1-benzazepin-2-ona-1-alcanoico |
Family Applications Before (8)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES529595A Expired ES8707216A1 (es) | 1983-02-10 | 1984-02-09 | Procedimiento para preparar nuevos acidos 3-(5-aminopentil)-amino-1-benzazepin-2-ona-1-alcanoicos |
ES529594A Expired ES8609261A1 (es) | 1983-02-10 | 1984-02-09 | Procedimiento para preparar nuevos acidos 3-amino-1-benzazepin-2-ona-1-alcanoicos |
ES544127A Expired ES8702363A1 (es) | 1983-02-10 | 1985-06-13 | Procedimiento para preparar nuevos acidos 3-amino-1-benzaze-pin-2-ona-1-alcanoicos |
ES544256A Expired ES8705409A1 (es) | 1983-02-10 | 1985-06-17 | Procedimiento para preparar nuevos acidos 3-(5-aminopentil)-amino-1-benzazepin-2-ona-1-alcanoico |
ES544257A Expired ES8609263A1 (es) | 1983-02-10 | 1985-06-17 | Procedimiento para preparar nuevos acidos 3-(5-aminopentil)-amino-1-benzazepin-2-ona-1-alcanoico |
ES544259A Expired ES8700239A1 (es) | 1983-02-10 | 1985-06-17 | Procedimiento para preparar nuevos acidos 3-(5-aminopentil)-amino-1-benzazepin-2-ona-1-alcanoico |
ES544255A Expired ES8609262A1 (es) | 1983-02-10 | 1985-06-17 | Procedimiento para preparar nuevos acidos 3-(5-aminopentil)-amino-1-benzazepin-2-ona-1-alcanoico |
ES544254A Expired ES8703859A1 (es) | 1983-02-10 | 1985-06-17 | Procedimiento para preparar nuevos acidos 3-(5-aminopentil)-amino-1-benzazepin-2-ona-1-alcanoico |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES544258A Expired ES8609264A1 (es) | 1983-02-10 | 1985-06-17 | Procedimiento para preparar nuevos acidos 3-(5-aminopentil)-amino-1-benzazepin-2-ona-1-alcanoico |
Country Status (24)
Country | Link |
---|---|
US (1) | US4473575A (es) |
EP (2) | EP0119955B1 (es) |
JP (2) | JPS59172473A (es) |
KR (1) | KR900009023B1 (es) |
AR (8) | AR242564A1 (es) |
AT (2) | ATE50989T1 (es) |
AU (1) | AU574061B2 (es) |
CA (2) | CA1225397A (es) |
CY (1) | CY1674A (es) |
DD (1) | DD218359A5 (es) |
DE (2) | DE3480705D1 (es) |
DK (2) | DK58184A (es) |
ES (10) | ES8707216A1 (es) |
FI (1) | FI77857C (es) |
GR (1) | GR79809B (es) |
HK (1) | HK97592A (es) |
HU (1) | HU192394B (es) |
IE (1) | IE56858B1 (es) |
IL (1) | IL70881A (es) |
NO (1) | NO166232C (es) |
NZ (1) | NZ207091A (es) |
PT (1) | PT78075B (es) |
SG (1) | SG94992G (es) |
ZA (1) | ZA84958B (es) |
Families Citing this family (66)
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US4473575A (en) * | 1982-07-19 | 1984-09-25 | Ciba-Geigy Corporation | 3-Amino-(1)-benzazepin-2-one-1-alkanoic acids |
US4537885A (en) * | 1983-02-10 | 1985-08-27 | Ciba Geigy Corporation | Certain benzazocinone and benzazoninone derivatives |
US4575503A (en) * | 1983-02-10 | 1986-03-11 | Ciba-Geigy Corporation | 3-Amino-[1]-benzazepin-2-one-1-alkanoic acids |
US4600534A (en) * | 1984-02-06 | 1986-07-15 | Ciba-Geigy Corporation | Process and intermediates for manufacture of 3-(5-amino-1-carboxypentylamino)-tetrahydro-1-benzazepin-2-one-1-acetic acid |
DE3586445T2 (de) * | 1984-06-26 | 1993-01-14 | Merck & Co Inc | Kondensierte benzo-laktam-verbindungen und deren pharmazeutische zusammensetzungen. |
EP0166357A3 (en) * | 1984-06-26 | 1988-10-26 | Merck & Co. Inc. | Benzofused lactams and pharmaceutical compositions containing them |
US4692522A (en) * | 1985-04-01 | 1987-09-08 | Merck & Co., Inc. | Benzofused lactams useful as cholecystokinin antagonists |
US4785089A (en) * | 1985-06-13 | 1988-11-15 | Ciba-Geigy Corporation | Novel sulfonic acid esters and their preparation |
DE3767514D1 (de) * | 1986-03-11 | 1991-02-28 | Thompson Barry Antony | Fuettern von vieh mit polymeren. |
FI88723C (fi) * | 1986-05-28 | 1993-06-28 | Ciba Geigy Ag | /2,5-dihydro-2-oxo-5-fenyl-3-furanyl/aminer samt deras anvaendning vid framstaellning av ACE-inhibitorer |
AT399717B (de) * | 1986-05-28 | 1995-07-25 | Ciba Geigy Ag | Verfahren zur herstellung von (2,5-dihydro-2-oxo- 5-phenyl-3-furanyl)aminen |
US5028704A (en) * | 1986-05-28 | 1991-07-02 | Ciba-Geigy Corporation | (2,5-dihydro 5-phenyl-2-oxo-3-furanyl)amines, methods of manufacture, and use thereof in the production of angiotensin converting enzyme inhibitors |
US4918187A (en) * | 1986-05-28 | 1990-04-17 | Ciba-Geigy Corporation | [2,5-Dihydro 5-phenyl-2-oxo-3-furanyl]amines |
US4962105A (en) | 1987-10-19 | 1990-10-09 | Ciba-Geigy Corporation | Potentiation of antihypertensive effect of ace inhibitors |
JPH07116224B2 (ja) * | 1987-12-29 | 1995-12-13 | 吉富製薬株式会社 | ベンゾラクタム化合物 |
GB9100028D0 (en) * | 1991-01-02 | 1991-02-20 | Ici Plc | Compounds |
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US5801168A (en) * | 1994-06-09 | 1998-09-01 | Zeneca Limited | Substituted nitrogen heterocycles |
KR970705395A (ko) * | 1994-08-18 | 1997-10-09 | 폴락 도나 엘. | 2,3-디하이드로-1-(2,2,2-트리플루오로에틸)-2-옥소-5-페닐-1H-1,4-벤조디아제핀(2,3-Dihydro-1-(2,2,2-trifluoroethyl)-2-oxo-5-phenyl-1H-1,4-benzodiazepines) |
US5587375A (en) * | 1995-02-17 | 1996-12-24 | Bristol-Myers Squibb Company | Azepinone compounds useful in the inhibition of ACE and NEP |
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US5635504A (en) * | 1995-06-07 | 1997-06-03 | Bristol-Myers Squibb Co. | Diazepine containing dual action inhibitors |
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GB1305278A (es) * | 1970-03-12 | 1973-01-31 | ||
JPS5129522B2 (es) * | 1972-07-13 | 1976-08-26 | ||
JPS5520970B2 (es) * | 1972-07-15 | 1980-06-06 | ||
FR2358151A1 (fr) * | 1976-03-31 | 1978-02-10 | Roussel Uclaf | Nouvelles benzazepines et leurs sels, procede de preparation et application a titre de medicaments |
IL58849A (en) * | 1978-12-11 | 1983-03-31 | Merck & Co Inc | Carboxyalkyl dipeptides and derivatives thereof,their preparation and pharmaceutical compositions containing them |
US4377515A (en) * | 1979-10-01 | 1983-03-22 | Merck & Co., Inc. | Long lasting agonists and antagonists of LH-RH |
GR74635B (es) * | 1980-08-18 | 1984-06-29 | Merck & Co Inc | |
US4409146A (en) * | 1980-10-06 | 1983-10-11 | Merck & Co., Inc. | Substituted caprolactam derivatives as antihypertensives |
IN156096B (es) * | 1981-03-19 | 1985-05-11 | Usv Pharma Corp | |
US4415496A (en) * | 1981-03-23 | 1983-11-15 | Merck & Co., Inc. | Bicyclic lactams |
DE3269625D1 (en) * | 1981-08-11 | 1986-04-10 | Ciba Geigy Ag | Benzazepin-2-ones, process for their preparation, pharmaceutical preparations containing these compounds and the compounds for therapeutical use |
ZA825779B (en) * | 1981-08-11 | 1984-04-25 | Ciba Geigy Ag | Benzazepins-2-ones |
US4410520A (en) * | 1981-11-09 | 1983-10-18 | Ciba-Geigy Corporation | 3-Amino-[1]-benzazepin-2-one-1-alkanoic acids |
US4473575A (en) * | 1982-07-19 | 1984-09-25 | Ciba-Geigy Corporation | 3-Amino-(1)-benzazepin-2-one-1-alkanoic acids |
DE3373469D1 (en) * | 1982-09-30 | 1987-10-15 | Merck & Co Inc | 1-n-alkylcarboxy-benzofused lactams useful as antihypertensive agents |
-
1983
- 1983-02-10 US US06/465,695 patent/US4473575A/en not_active Expired - Lifetime
-
1984
- 1984-02-06 AT AT84810071T patent/ATE50989T1/de active
- 1984-02-06 DE DE8484810072T patent/DE3480705D1/de not_active Expired - Lifetime
- 1984-02-06 EP EP84810072A patent/EP0119955B1/de not_active Expired
- 1984-02-06 AT AT84810072T patent/ATE48598T1/de active
- 1984-02-06 DE DE8484810071T patent/DE3481612D1/de not_active Expired - Lifetime
- 1984-02-06 EP EP84810071A patent/EP0119954B1/de not_active Expired - Lifetime
- 1984-02-07 IL IL70881A patent/IL70881A/xx not_active IP Right Cessation
- 1984-02-08 CA CA000446971A patent/CA1225397A/en not_active Expired
- 1984-02-08 GR GR73754A patent/GR79809B/el unknown
- 1984-02-08 FI FI840513A patent/FI77857C/fi not_active IP Right Cessation
- 1984-02-08 PT PT78075A patent/PT78075B/pt not_active IP Right Cessation
- 1984-02-08 CA CA000446970A patent/CA1218993A/en not_active Expired
- 1984-02-09 JP JP59020905A patent/JPS59172473A/ja active Granted
- 1984-02-09 ES ES529595A patent/ES8707216A1/es not_active Expired
- 1984-02-09 ZA ZA84958A patent/ZA84958B/xx unknown
- 1984-02-09 HU HU84523A patent/HU192394B/hu not_active IP Right Cessation
- 1984-02-09 IE IE302/84A patent/IE56858B1/en not_active IP Right Cessation
- 1984-02-09 DK DK58184A patent/DK58184A/da not_active Application Discontinuation
- 1984-02-09 DK DK058284A patent/DK171257B1/da not_active IP Right Cessation
- 1984-02-09 NZ NZ207091A patent/NZ207091A/en unknown
- 1984-02-09 ES ES529594A patent/ES8609261A1/es not_active Expired
- 1984-02-09 NO NO840487A patent/NO166232C/no unknown
- 1984-02-09 DD DD84259979A patent/DD218359A5/de not_active IP Right Cessation
- 1984-02-09 AU AU24430/84A patent/AU574061B2/en not_active Ceased
- 1984-02-10 AR AR84295689A patent/AR242564A1/es active
- 1984-02-10 JP JP59022031A patent/JPS59172475A/ja active Granted
- 1984-02-10 KR KR1019840000630A patent/KR900009023B1/ko not_active IP Right Cessation
-
1985
- 1985-06-13 ES ES544127A patent/ES8702363A1/es not_active Expired
- 1985-06-17 ES ES544256A patent/ES8705409A1/es not_active Expired
- 1985-06-17 ES ES544257A patent/ES8609263A1/es not_active Expired
- 1985-06-17 ES ES544259A patent/ES8700239A1/es not_active Expired
- 1985-06-17 ES ES544255A patent/ES8609262A1/es not_active Expired
- 1985-06-17 ES ES544254A patent/ES8703859A1/es not_active Expired
- 1985-06-17 ES ES544260A patent/ES8609265A1/es not_active Expired
- 1985-06-17 ES ES544258A patent/ES8609264A1/es not_active Expired
-
1986
- 1986-08-15 AR AR86304921A patent/AR242191A1/es active
- 1986-08-15 AR AR86304926A patent/AR243161A1/es active
- 1986-08-15 AR AR86304922A patent/AR243165A1/es active
- 1986-08-15 AR AR86304925A patent/AR243162A1/es active
- 1986-08-15 AR AR86304924A patent/AR243163A1/es active
- 1986-08-15 AR AR86304920A patent/AR242190A1/es active
- 1986-08-15 AR AR86304923A patent/AR243164A1/es active
-
1992
- 1992-09-21 SG SG949/92A patent/SG94992G/en unknown
- 1992-12-03 HK HK975/92A patent/HK97592A/xx not_active IP Right Cessation
-
1993
- 1993-10-10 CY CY1674A patent/CY1674A/xx unknown
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Legal Events
Date | Code | Title | Description |
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PC1A | Transfer granted | ||
FD1A | Patent lapsed |
Effective date: 20000201 |