DD160453A5 - Verfahren zur herstellung von benzopyranverbindungen - Google Patents
Verfahren zur herstellung von benzopyranverbindungen Download PDFInfo
- Publication number
- DD160453A5 DD160453A5 DD81230894A DD23089481A DD160453A5 DD 160453 A5 DD160453 A5 DD 160453A5 DD 81230894 A DD81230894 A DD 81230894A DD 23089481 A DD23089481 A DD 23089481A DD 160453 A5 DD160453 A5 DD 160453A5
- Authority
- DD
- German Democratic Republic
- Prior art keywords
- group
- compound
- dihydro
- benzopyran
- formula
- Prior art date
Links
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- 150000001562 benzopyrans Chemical class 0.000 title description 4
- 150000001875 compounds Chemical class 0.000 claims abstract description 149
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- 125000000217 alkyl group Chemical group 0.000 claims abstract description 17
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- 125000002947 alkylene group Chemical group 0.000 claims abstract description 10
- 125000005843 halogen group Chemical group 0.000 claims abstract description 9
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims abstract description 9
- 125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 claims abstract description 6
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- 125000005529 alkyleneoxy group Chemical group 0.000 claims description 4
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- 150000002170 ethers Chemical class 0.000 description 1
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- LNOFDINSFMGNGX-UHFFFAOYSA-N ethyl [3-(hydroxymethyl)-3,4-dihydro-2h-chromen-8-yl] carbonate Chemical compound C1C(CO)COC2=C1C=CC=C2OC(=O)OCC LNOFDINSFMGNGX-UHFFFAOYSA-N 0.000 description 1
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
- C07D311/22—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/02—Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
- C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
- C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
- C07D311/64—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4 with oxygen atoms directly attached in position 8
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
- C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
- C07D311/66—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4 with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Cardiology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Heart & Thoracic Surgery (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Hospice & Palliative Care (AREA)
- Pain & Pain Management (AREA)
- Neurology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP8084180A JPS6054317B2 (ja) | 1980-06-17 | 1980-06-17 | 新規ベンゾピラン誘導体 |
| JP55182854A JPS57106619A (en) | 1980-12-25 | 1980-12-25 | Remedy for circulatory disease |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DD160453A5 true DD160453A5 (de) | 1983-08-03 |
Family
ID=26421809
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DD81230894A DD160453A5 (de) | 1980-06-17 | 1981-06-17 | Verfahren zur herstellung von benzopyranverbindungen |
Country Status (16)
| Country | Link |
|---|---|
| US (1) | US4394382A (cs) |
| EP (1) | EP0042299B1 (cs) |
| KR (1) | KR850000193B1 (cs) |
| AU (1) | AU543347B2 (cs) |
| CA (1) | CA1178598A (cs) |
| CS (1) | CS226731B2 (cs) |
| DD (1) | DD160453A5 (cs) |
| DE (1) | DE3166300D1 (cs) |
| DK (1) | DK154557C (cs) |
| ES (1) | ES503091A0 (cs) |
| FI (1) | FI79307C (cs) |
| IE (1) | IE52067B1 (cs) |
| NO (1) | NO154495C (cs) |
| PL (1) | PL130537B1 (cs) |
| SU (1) | SU1212325A3 (cs) |
| ZA (1) | ZA814042B (cs) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5965076A (ja) * | 1982-10-05 | 1984-04-13 | Kowa Co | 新規なキノリン誘導体 |
| JPS60181083A (ja) * | 1984-02-29 | 1985-09-14 | Kowa Co | 新規ラセミ体及びその変換方法 |
| JPS60208973A (ja) * | 1984-03-31 | 1985-10-21 | Kowa Co | 循環系疾患治療剤 |
| GB8730051D0 (en) * | 1987-12-23 | 1988-02-03 | Beecham Group Plc | Novel compounds |
| JP2000511518A (ja) * | 1996-05-14 | 2000-09-05 | グラクソ、グループ、リミテッド | 時間生物学的薬剤としてのベンゾフランおよびベンゾピラン |
| TWI290470B (en) | 1999-12-01 | 2007-12-01 | Sankyo Co | The composition for treating glaucoma |
| EP1545519B1 (en) | 2002-08-19 | 2011-03-23 | Pfizer Inc. | Combination therapy for hyperproliferative diseases |
| KR20050059274A (ko) * | 2002-10-24 | 2005-06-17 | 코와 가부시키가이샤 | 신경섬유 재생 촉진제 |
| US20050037063A1 (en) * | 2003-07-21 | 2005-02-17 | Bolton Anthony E. | Combined therapies |
| GT200600381A (es) | 2005-08-25 | 2007-03-28 | Compuestos organicos | |
| US7741317B2 (en) | 2005-10-21 | 2010-06-22 | Bristol-Myers Squibb Company | LXR modulators |
| US7888376B2 (en) | 2005-11-23 | 2011-02-15 | Bristol-Myers Squibb Company | Heterocyclic CETP inhibitors |
| EP2094643B1 (en) | 2006-12-01 | 2012-02-29 | Bristol-Myers Squibb Company | N-((3-benzyl)-2,2-(bis-phenyl)-propan-1-amine derivatives as cetp inhibitors for the treatment of atherosclerosis and cardiovascular diseases |
| TWI646091B (zh) * | 2012-12-28 | 2019-01-01 | 日商衛斯克慧特股份有限公司 | 鹽類及晶形 |
| CN105143203A (zh) | 2013-04-17 | 2015-12-09 | 辉瑞大药厂 | 用于治疗心血管疾病的n-哌啶-3-基苯甲酰胺衍生物 |
| WO2016055901A1 (en) | 2014-10-08 | 2016-04-14 | Pfizer Inc. | Substituted amide compounds |
| ES3007652T3 (en) | 2019-01-18 | 2025-03-20 | Astrazeneca Ab | 6'-[[(1s,3s)-3-[[5-(difluoromethoxy)-2-pyrimidinyl]amino]cyclopentyl]amino][1(2h),3'-bipyridin]-2-one as pcsk9 inhibitor and methods of use thereof |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1493998A (en) * | 1975-06-03 | 1977-12-07 | Beecham Group Ltd | Propanolamine derivatives |
| JPS54106476A (en) * | 1978-01-04 | 1979-08-21 | Merck & Co Inc | Multiisubstituted 22*33lower alkylaminoo22 r100propoxy*pyridine |
| DE2804625A1 (de) * | 1978-02-03 | 1979-08-09 | Thomae Gmbh Dr K | Neue 4-acylamino-phenyl-aethanolamine |
| DE2805404A1 (de) * | 1978-02-09 | 1979-08-16 | Merck Patent Gmbh | 1-aryloxy-3-nitratoalkylamino-2-propanole und verfahren zu ihrer herstellung |
-
1981
- 1981-06-09 US US06/271,927 patent/US4394382A/en not_active Expired - Lifetime
- 1981-06-11 AU AU71652/81A patent/AU543347B2/en not_active Expired
- 1981-06-12 IE IE1312/81A patent/IE52067B1/en not_active IP Right Cessation
- 1981-06-12 CA CA000379656A patent/CA1178598A/en not_active Expired
- 1981-06-15 FI FI811856A patent/FI79307C/fi not_active IP Right Cessation
- 1981-06-16 ZA ZA814042A patent/ZA814042B/xx unknown
- 1981-06-16 NO NO812042A patent/NO154495C/no not_active IP Right Cessation
- 1981-06-16 CS CS814509A patent/CS226731B2/cs unknown
- 1981-06-16 DK DK264181A patent/DK154557C/da not_active IP Right Cessation
- 1981-06-16 DE DE8181302700T patent/DE3166300D1/de not_active Expired
- 1981-06-16 ES ES503091A patent/ES503091A0/es active Granted
- 1981-06-16 KR KR1019810002196A patent/KR850000193B1/ko not_active Expired
- 1981-06-16 SU SU813300799A patent/SU1212325A3/ru active
- 1981-06-16 EP EP81302700A patent/EP0042299B1/en not_active Expired
- 1981-06-17 PL PL1981231734A patent/PL130537B1/pl unknown
- 1981-06-17 DD DD81230894A patent/DD160453A5/de not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| DK264181A (da) | 1981-12-18 |
| PL130537B1 (en) | 1984-08-31 |
| EP0042299B1 (en) | 1984-09-26 |
| FI79307B (fi) | 1989-08-31 |
| AU7165281A (en) | 1981-12-24 |
| DE3166300D1 (en) | 1984-10-31 |
| KR830006268A (ko) | 1983-09-20 |
| ZA814042B (en) | 1982-06-30 |
| NO154495C (no) | 1986-10-01 |
| FI811856L (fi) | 1981-12-18 |
| DK154557B (da) | 1988-11-28 |
| ES8300104A1 (es) | 1982-10-01 |
| FI79307C (fi) | 1989-12-11 |
| NO154495B (no) | 1986-06-23 |
| KR850000193B1 (ko) | 1985-03-05 |
| IE811312L (en) | 1981-12-17 |
| EP0042299A1 (en) | 1981-12-23 |
| CA1178598A (en) | 1984-11-27 |
| US4394382A (en) | 1983-07-19 |
| NO812042L (no) | 1981-12-18 |
| ES503091A0 (es) | 1982-10-01 |
| PL231734A1 (cs) | 1982-08-16 |
| SU1212325A3 (ru) | 1986-02-15 |
| IE52067B1 (en) | 1987-06-10 |
| AU543347B2 (en) | 1985-04-18 |
| CS226731B2 (en) | 1984-04-16 |
| DK154557C (da) | 1989-04-17 |
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| Date | Code | Title | Description |
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| ENJ | Ceased due to non-payment of renewal fee |