DK264181A - Benzopyranforbindelser og syreadditionssalte deraf deres fremstilling og anvendelse - Google Patents

Benzopyranforbindelser og syreadditionssalte deraf deres fremstilling og anvendelse

Info

Publication number
DK264181A
DK264181A DK264181A DK264181A DK264181A DK 264181 A DK264181 A DK 264181A DK 264181 A DK264181 A DK 264181A DK 264181 A DK264181 A DK 264181A DK 264181 A DK264181 A DK 264181A
Authority
DK
Denmark
Prior art keywords
preparation
acid addition
addition salts
benzopyrane
compounds
Prior art date
Application number
DK264181A
Other languages
English (en)
Other versions
DK154557C (da
DK154557B (da
Inventor
M Shitaysuchi
N Shimizu
H Shigyo
Y Kyotani
H Kunieda
K Kawamura
S Sato
T Akashi
M Nagakura
N Sawada
Y Uchida
Original Assignee
Kowa Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from JP8084180A external-priority patent/JPS6054317B2/ja
Priority claimed from JP55182854A external-priority patent/JPS57106619A/ja
Application filed by Kowa Co filed Critical Kowa Co
Publication of DK264181A publication Critical patent/DK264181A/da
Publication of DK154557B publication Critical patent/DK154557B/da
Application granted granted Critical
Publication of DK154557C publication Critical patent/DK154557C/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/22—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/02—Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
    • C07D311/64—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4 with oxygen atoms directly attached in position 8
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
    • C07D311/66—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4 with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cardiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Hospice & Palliative Care (AREA)
  • Pain & Pain Management (AREA)
  • Neurology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
DK264181A 1980-06-17 1981-06-16 Analogifremgangsmaade til fremstilling af 3,4-dihydro-8-((2-hydroxy-3-alkylamino)-propoxy)-2h-1-benzopyranderivater eller et farmaceutisk acceptabelt syreadditionssalt deraf DK154557C (da)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
JP8084180 1980-06-17
JP8084180A JPS6054317B2 (ja) 1980-06-17 1980-06-17 新規ベンゾピラン誘導体
JP55182854A JPS57106619A (en) 1980-12-25 1980-12-25 Remedy for circulatory disease
JP18285480 1980-12-25

Publications (3)

Publication Number Publication Date
DK264181A true DK264181A (da) 1981-12-18
DK154557B DK154557B (da) 1988-11-28
DK154557C DK154557C (da) 1989-04-17

Family

ID=26421809

Family Applications (1)

Application Number Title Priority Date Filing Date
DK264181A DK154557C (da) 1980-06-17 1981-06-16 Analogifremgangsmaade til fremstilling af 3,4-dihydro-8-((2-hydroxy-3-alkylamino)-propoxy)-2h-1-benzopyranderivater eller et farmaceutisk acceptabelt syreadditionssalt deraf

Country Status (16)

Country Link
US (1) US4394382A (da)
EP (1) EP0042299B1 (da)
KR (1) KR850000193B1 (da)
AU (1) AU543347B2 (da)
CA (1) CA1178598A (da)
CS (1) CS226731B2 (da)
DD (1) DD160453A5 (da)
DE (1) DE3166300D1 (da)
DK (1) DK154557C (da)
ES (1) ES503091A0 (da)
FI (1) FI79307C (da)
IE (1) IE52067B1 (da)
NO (1) NO154495C (da)
PL (1) PL130537B1 (da)
SU (1) SU1212325A3 (da)
ZA (1) ZA814042B (da)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5965076A (ja) * 1982-10-05 1984-04-13 Kowa Co 新規なキノリン誘導体
JPS60181083A (ja) * 1984-02-29 1985-09-14 Kowa Co 新規ラセミ体及びその変換方法
JPS60208973A (ja) * 1984-03-31 1985-10-21 Kowa Co 循環系疾患治療剤
GB8730051D0 (en) * 1987-12-23 1988-02-03 Beecham Group Plc Novel compounds
BR9708949A (pt) * 1996-05-14 1999-08-03 Glaxo Group Ltd Composto formulação farmacêutica e processos de preparação dos mesmos e de tratamento de um mamífero incluindo o homem
JP4000505B2 (ja) 1999-12-01 2007-10-31 第一三共株式会社 緑内障を治療するための併用剤
MXPA05001958A (es) 2002-08-19 2005-04-28 Pfizer Prod Inc Terapia de combinacion para enfermedades hiperproliferativas.
JP4675232B2 (ja) * 2002-10-24 2011-04-20 興和株式会社 神経線維再生促進剤
US20050037063A1 (en) * 2003-07-21 2005-02-17 Bolton Anthony E. Combined therapies
GT200600381A (es) 2005-08-25 2007-03-28 Compuestos organicos
US7741317B2 (en) 2005-10-21 2010-06-22 Bristol-Myers Squibb Company LXR modulators
US7888376B2 (en) 2005-11-23 2011-02-15 Bristol-Myers Squibb Company Heterocyclic CETP inhibitors
CN101663262B (zh) 2006-12-01 2014-03-26 百时美施贵宝公司 用于治疗动脉粥样硬化和心血管疾病的作为cetp抑制剂的n-(3-苄基)-2,2-(二苯基)-丙-1胺衍生物
TWI646091B (zh) * 2012-12-28 2019-01-01 日商衛斯克慧特股份有限公司 鹽類及晶形
CN105143203A (zh) 2013-04-17 2015-12-09 辉瑞大药厂 用于治疗心血管疾病的n-哌啶-3-基苯甲酰胺衍生物
WO2016055901A1 (en) 2014-10-08 2016-04-14 Pfizer Inc. Substituted amide compounds
CN113574055B (zh) 2019-01-18 2024-07-23 阿斯利康(瑞典)有限公司 Pcsk9抑制剂及其使用方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1493998A (en) * 1975-06-03 1977-12-07 Beecham Group Ltd Propanolamine derivatives
JPS54106476A (en) * 1978-01-04 1979-08-21 Merck & Co Inc Multiisubstituted 22*33lower alkylaminoo22 r100propoxy*pyridine
DE2804625A1 (de) * 1978-02-03 1979-08-09 Thomae Gmbh Dr K Neue 4-acylamino-phenyl-aethanolamine
DE2805404A1 (de) * 1978-02-09 1979-08-16 Merck Patent Gmbh 1-aryloxy-3-nitratoalkylamino-2-propanole und verfahren zu ihrer herstellung

Also Published As

Publication number Publication date
AU543347B2 (en) 1985-04-18
CA1178598A (en) 1984-11-27
ES8300104A1 (es) 1982-10-01
DD160453A5 (de) 1983-08-03
IE811312L (en) 1981-12-17
US4394382A (en) 1983-07-19
FI79307C (fi) 1989-12-11
DE3166300D1 (en) 1984-10-31
PL231734A1 (da) 1982-08-16
ES503091A0 (es) 1982-10-01
NO812042L (no) 1981-12-18
KR830006268A (ko) 1983-09-20
DK154557C (da) 1989-04-17
ZA814042B (en) 1982-06-30
SU1212325A3 (ru) 1986-02-15
PL130537B1 (en) 1984-08-31
NO154495C (no) 1986-10-01
CS226731B2 (en) 1984-04-16
FI79307B (fi) 1989-08-31
KR850000193B1 (ko) 1985-03-05
FI811856L (fi) 1981-12-18
EP0042299B1 (en) 1984-09-26
AU7165281A (en) 1981-12-24
DK154557B (da) 1988-11-28
NO154495B (no) 1986-06-23
IE52067B1 (en) 1987-06-10
EP0042299A1 (en) 1981-12-23

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