CS226731B2 - Method of preparing benzopyrane compounds - Google Patents

Method of preparing benzopyrane compounds Download PDF

Info

Publication number
CS226731B2
CS226731B2 CS814509A CS450981A CS226731B2 CS 226731 B2 CS226731 B2 CS 226731B2 CS 814509 A CS814509 A CS 814509A CS 450981 A CS450981 A CS 450981A CS 226731 B2 CS226731 B2 CS 226731B2
Authority
CS
Czechoslovakia
Prior art keywords
group
formula
compound
dihydro
benzopyran
Prior art date
Application number
CS814509A
Other languages
Czech (cs)
English (en)
Inventor
Masami Shiratsuchi
Noboru Shimizu
Hiromichi Shigyo
Yoshinori Kyotani
Hisashi Kunieda
Kiyoshi Kawamura
Seiichi Sato
Toshihiro Akashi
Original Assignee
Kowa Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from JP8084180A external-priority patent/JPS6054317B2/ja
Priority claimed from JP55182854A external-priority patent/JPS57106619A/ja
Application filed by Kowa Co filed Critical Kowa Co
Publication of CS226731B2 publication Critical patent/CS226731B2/cs

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/22—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/02—Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
    • C07D311/64—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4 with oxygen atoms directly attached in position 8
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
    • C07D311/66—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4 with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cardiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Hospice & Palliative Care (AREA)
  • Pain & Pain Management (AREA)
  • Neurology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
CS814509A 1980-06-17 1981-06-16 Method of preparing benzopyrane compounds CS226731B2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP8084180A JPS6054317B2 (ja) 1980-06-17 1980-06-17 新規ベンゾピラン誘導体
JP55182854A JPS57106619A (en) 1980-12-25 1980-12-25 Remedy for circulatory disease

Publications (1)

Publication Number Publication Date
CS226731B2 true CS226731B2 (en) 1984-04-16

Family

ID=26421809

Family Applications (1)

Application Number Title Priority Date Filing Date
CS814509A CS226731B2 (en) 1980-06-17 1981-06-16 Method of preparing benzopyrane compounds

Country Status (16)

Country Link
US (1) US4394382A (da)
EP (1) EP0042299B1 (da)
KR (1) KR850000193B1 (da)
AU (1) AU543347B2 (da)
CA (1) CA1178598A (da)
CS (1) CS226731B2 (da)
DD (1) DD160453A5 (da)
DE (1) DE3166300D1 (da)
DK (1) DK154557C (da)
ES (1) ES503091A0 (da)
FI (1) FI79307C (da)
IE (1) IE52067B1 (da)
NO (1) NO154495C (da)
PL (1) PL130537B1 (da)
SU (1) SU1212325A3 (da)
ZA (1) ZA814042B (da)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5965076A (ja) * 1982-10-05 1984-04-13 Kowa Co 新規なキノリン誘導体
JPS60181083A (ja) * 1984-02-29 1985-09-14 Kowa Co 新規ラセミ体及びその変換方法
JPS60208973A (ja) * 1984-03-31 1985-10-21 Kowa Co 循環系疾患治療剤
GB8730051D0 (en) * 1987-12-23 1988-02-03 Beecham Group Plc Novel compounds
WO1997043272A2 (en) * 1996-05-14 1997-11-20 Glaxo Group Limited Benzofurans and benzopyrans as chronobiological agents
TWI290470B (en) 1999-12-01 2007-12-01 Sankyo Co The composition for treating glaucoma
AP2005003232A0 (en) 2002-08-19 2005-03-31 Pfizer Prod Inc Combination therapy for hyperproliferative diseases.
WO2004037246A1 (ja) * 2002-10-24 2004-05-06 Kowa Co., Ltd. 神経線維再生促進剤
US20050037063A1 (en) * 2003-07-21 2005-02-17 Bolton Anthony E. Combined therapies
GT200600381A (es) 2005-08-25 2007-03-28 Compuestos organicos
US7741317B2 (en) 2005-10-21 2010-06-22 Bristol-Myers Squibb Company LXR modulators
US7888376B2 (en) 2005-11-23 2011-02-15 Bristol-Myers Squibb Company Heterocyclic CETP inhibitors
ES2382009T3 (es) 2006-12-01 2012-06-04 Bristol-Myers Squibb Company Derivados de N-((3-bencil)-2,2-(bis-fenil-)-propan-1-amina como inhibidores de CETP para el tratamiento de aterosclerosis y enfermedades cardiovasculares
TWI646091B (zh) * 2012-12-28 2019-01-01 日商衛斯克慧特股份有限公司 鹽類及晶形
CN105143203A (zh) 2013-04-17 2015-12-09 辉瑞大药厂 用于治疗心血管疾病的n-哌啶-3-基苯甲酰胺衍生物
WO2016055901A1 (en) 2014-10-08 2016-04-14 Pfizer Inc. Substituted amide compounds
WO2020150473A2 (en) 2019-01-18 2020-07-23 Dogma Therapeutics, Inc. Pcsk9 inhibitors and methods of use thereof

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1493998A (en) * 1975-06-03 1977-12-07 Beecham Group Ltd Propanolamine derivatives
JPS54106476A (en) * 1978-01-04 1979-08-21 Merck & Co Inc Multiisubstituted 22*33lower alkylaminoo22 r100propoxy*pyridine
DE2804625A1 (de) * 1978-02-03 1979-08-09 Thomae Gmbh Dr K Neue 4-acylamino-phenyl-aethanolamine
DE2805404A1 (de) * 1978-02-09 1979-08-16 Merck Patent Gmbh 1-aryloxy-3-nitratoalkylamino-2-propanole und verfahren zu ihrer herstellung

Also Published As

Publication number Publication date
EP0042299B1 (en) 1984-09-26
DK264181A (da) 1981-12-18
FI79307C (fi) 1989-12-11
ES8300104A1 (es) 1982-10-01
IE52067B1 (en) 1987-06-10
KR830006268A (ko) 1983-09-20
ZA814042B (en) 1982-06-30
US4394382A (en) 1983-07-19
DK154557B (da) 1988-11-28
KR850000193B1 (ko) 1985-03-05
NO154495B (no) 1986-06-23
PL231734A1 (da) 1982-08-16
EP0042299A1 (en) 1981-12-23
DE3166300D1 (en) 1984-10-31
NO812042L (no) 1981-12-18
FI79307B (fi) 1989-08-31
AU7165281A (en) 1981-12-24
ES503091A0 (es) 1982-10-01
IE811312L (en) 1981-12-17
FI811856L (fi) 1981-12-18
CA1178598A (en) 1984-11-27
DK154557C (da) 1989-04-17
AU543347B2 (en) 1985-04-18
PL130537B1 (en) 1984-08-31
NO154495C (no) 1986-10-01
DD160453A5 (de) 1983-08-03
SU1212325A3 (ru) 1986-02-15

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