DD153834A5 - Verfahren zur herstellung eines neuen faktors von antibiotikum a-30912 - Google Patents
Verfahren zur herstellung eines neuen faktors von antibiotikum a-30912 Download PDFInfo
- Publication number
- DD153834A5 DD153834A5 DD80221643A DD22164380A DD153834A5 DD 153834 A5 DD153834 A5 DD 153834A5 DD 80221643 A DD80221643 A DD 80221643A DD 22164380 A DD22164380 A DD 22164380A DD 153834 A5 DD153834 A5 DD 153834A5
- Authority
- DD
- German Democratic Republic
- Prior art keywords
- factor
- formula
- antibiotic
- group
- linoleoyl
- Prior art date
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- 108010062096 echinocandin C Proteins 0.000 description 1
- NZZDHXBKVFENNY-YBPCKFEPSA-N echinocandin c Chemical compound C([C@@H](O)[C@H]1C(=O)N[C@H](C(=O)N2C[C@H](C)[C@H](O)[C@H]2C(=O)N[C@H](O)[C@H](O)C[C@@H](C(N[C@H](C(=O)N2C[C@H](O)C[C@H]2C(=O)N1)[C@@H](C)O)=O)NC(=O)CCCCCCC\C=C/C\C=C/CCCCC)[C@@H](C)O)C1=CC=C(O)C=C1 NZZDHXBKVFENNY-YBPCKFEPSA-N 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 238000000921 elemental analysis Methods 0.000 description 1
- 239000012156 elution solvent Substances 0.000 description 1
- 229930195729 fatty acid Natural products 0.000 description 1
- 239000000194 fatty acid Substances 0.000 description 1
- 150000004665 fatty acids Chemical class 0.000 description 1
- 239000012847 fine chemical Substances 0.000 description 1
- 238000005187 foaming Methods 0.000 description 1
- 238000005755 formation reaction Methods 0.000 description 1
- 239000012634 fragment Substances 0.000 description 1
- 235000011389 fruit/vegetable juice Nutrition 0.000 description 1
- 239000007789 gas Substances 0.000 description 1
- 238000000227 grinding Methods 0.000 description 1
- 229910052739 hydrogen Inorganic materials 0.000 description 1
- 239000001257 hydrogen Substances 0.000 description 1
- 239000012535 impurity Substances 0.000 description 1
- 208000015181 infectious disease Diseases 0.000 description 1
- 230000005764 inhibitory process Effects 0.000 description 1
- 150000002500 ions Chemical class 0.000 description 1
- 229910052742 iron Inorganic materials 0.000 description 1
- 125000001972 isopentyl group Chemical group [H]C([H])([H])C([H])(C([H])([H])[H])C([H])([H])C([H])([H])* 0.000 description 1
- 235000020778 linoleic acid Nutrition 0.000 description 1
- OYHQOLUKZRVURQ-IXWMQOLASA-N linoleic acid Natural products CCCCC\C=C/C\C=C\CCCCCCCC(O)=O OYHQOLUKZRVURQ-IXWMQOLASA-N 0.000 description 1
- 238000011068 loading method Methods 0.000 description 1
- 230000033001 locomotion Effects 0.000 description 1
- 239000011777 magnesium Substances 0.000 description 1
- 229910052749 magnesium Inorganic materials 0.000 description 1
- 238000010907 mechanical stirring Methods 0.000 description 1
- 244000005700 microbiome Species 0.000 description 1
- 238000013508 migration Methods 0.000 description 1
- 230000005012 migration Effects 0.000 description 1
- LPUQAYUQRXPFSQ-DFWYDOINSA-M monosodium L-glutamate Chemical compound [Na+].[O-]C(=O)[C@@H](N)CCC(O)=O LPUQAYUQRXPFSQ-DFWYDOINSA-M 0.000 description 1
- 235000013923 monosodium glutamate Nutrition 0.000 description 1
- 239000004223 monosodium glutamate Substances 0.000 description 1
- 125000000740 n-pentyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 description 1
- 150000002823 nitrates Chemical class 0.000 description 1
- 229910017604 nitric acid Inorganic materials 0.000 description 1
- 231100000252 nontoxic Toxicity 0.000 description 1
- 230000003000 nontoxic effect Effects 0.000 description 1
- 238000000655 nuclear magnetic resonance spectrum Methods 0.000 description 1
- 239000003960 organic solvent Substances 0.000 description 1
- 239000003208 petroleum Substances 0.000 description 1
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 1
- 239000010452 phosphate Substances 0.000 description 1
- 230000019612 pigmentation Effects 0.000 description 1
- 239000003495 polar organic solvent Substances 0.000 description 1
- 239000002798 polar solvent Substances 0.000 description 1
- 229920001451 polypropylene glycol Polymers 0.000 description 1
- 239000011148 porous material Substances 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 230000033458 reproduction Effects 0.000 description 1
- QEVHRUUCFGRFIF-MDEJGZGSSA-N reserpine Chemical compound O([C@H]1[C@@H]([C@H]([C@H]2C[C@@H]3C4=C(C5=CC=C(OC)C=C5N4)CCN3C[C@H]2C1)C(=O)OC)OC)C(=O)C1=CC(OC)=C(OC)C(OC)=C1 QEVHRUUCFGRFIF-MDEJGZGSSA-N 0.000 description 1
- 238000012807 shake-flask culturing Methods 0.000 description 1
- 239000002356 single layer Substances 0.000 description 1
- 229910052708 sodium Inorganic materials 0.000 description 1
- 238000010186 staining Methods 0.000 description 1
- 239000008107 starch Substances 0.000 description 1
- 235000019698 starch Nutrition 0.000 description 1
- 239000007858 starting material Substances 0.000 description 1
- QAOWNCQODCNURD-UHFFFAOYSA-N sulfuric acid Substances OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 description 1
- 239000006228 supernatant Substances 0.000 description 1
- 238000004448 titration Methods 0.000 description 1
- PYJJCSYBSYXGQQ-UHFFFAOYSA-N trichloro(octadecyl)silane Chemical compound CCCCCCCCCCCCCCCCCC[Si](Cl)(Cl)Cl PYJJCSYBSYXGQQ-UHFFFAOYSA-N 0.000 description 1
- 239000012808 vapor phase Substances 0.000 description 1
- 238000009423 ventilation Methods 0.000 description 1
- 239000011800 void material Substances 0.000 description 1
- 239000012138 yeast extract Substances 0.000 description 1
- 239000011701 zinc Substances 0.000 description 1
- 229910052725 zinc Inorganic materials 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/50—Cyclic peptides containing at least one abnormal peptide link
- C07K7/54—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring
- C07K7/56—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring the cyclisation not occurring through 2,4-diamino-butanoic acid
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
- C12N1/14—Fungi; Culture media therefor
- C12N1/145—Fungal isolates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
- C12R2001/00—Microorganisms ; Processes using microorganisms
- C12R2001/645—Fungi ; Processes using fungi
- C12R2001/66—Aspergillus
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Wood Science & Technology (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biochemistry (AREA)
- Zoology (AREA)
- General Engineering & Computer Science (AREA)
- Biophysics (AREA)
- Mycology (AREA)
- Biomedical Technology (AREA)
- Virology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Botany (AREA)
- Microbiology (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Peptides Or Proteins (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US4687579A | 1979-06-08 | 1979-06-08 | |
| US11773980A | 1980-02-01 | 1980-02-01 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DD153834A5 true DD153834A5 (de) | 1982-02-03 |
Family
ID=26724393
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DD80221643A DD153834A5 (de) | 1979-06-08 | 1980-06-06 | Verfahren zur herstellung eines neuen faktors von antibiotikum a-30912 |
Country Status (16)
| Country | Link |
|---|---|
| EP (1) | EP0021685A1 (cs) |
| AR (1) | AR226848A1 (cs) |
| AU (1) | AU5901680A (cs) |
| CA (1) | CA1156218A (cs) |
| DD (1) | DD153834A5 (cs) |
| DK (1) | DK244780A (cs) |
| ES (1) | ES8105270A1 (cs) |
| FI (1) | FI801773A7 (cs) |
| FR (1) | FR2458551A1 (cs) |
| GB (1) | GB2050385B (cs) |
| GR (1) | GR69258B (cs) |
| IL (1) | IL60216A0 (cs) |
| IT (1) | IT1209417B (cs) |
| PL (1) | PL224775A1 (cs) |
| PT (1) | PT71350A (cs) |
| YU (1) | YU146480A (cs) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1982000587A1 (en) * | 1980-08-15 | 1982-03-04 | Tscherter H | New metabolites,processes for their production and their use |
| US4931352A (en) * | 1987-10-07 | 1990-06-05 | Merck & Co., Inc. | Antifungal fermentation product |
| US5166135A (en) * | 1988-09-12 | 1992-11-24 | Merck & Company, Inc. | Method for the control of pneumocystis carinii |
| US5202309A (en) * | 1989-06-30 | 1993-04-13 | Merck & Co., Inc. | Antibiotic cyclopeptide fermentation product |
| US5021341A (en) * | 1990-03-12 | 1991-06-04 | Merck & Co., Inc. | Antibiotic agent produced by the cultivation of Zalerion microorganism in the presence of mannitol |
| US5049546A (en) * | 1990-03-19 | 1991-09-17 | Merck & Co., Inc. | Antibiotic agents |
| US5386009A (en) * | 1990-03-19 | 1995-01-31 | Merck & Co. Inc. | Lipopeptide derivatives |
| US5021403A (en) * | 1990-03-19 | 1991-06-04 | Merck & Co., Inc. | Antibiotic agents |
| IE910892A1 (en) * | 1990-03-19 | 1991-09-25 | Merck & Co Inc | Lipopeptide compounds |
| US5219985A (en) * | 1990-10-31 | 1993-06-15 | Merck & Co., Inc. | Antifungal agent |
| US5369093A (en) * | 1991-03-15 | 1994-11-29 | Merck & Co., Inc. | Lipopeptide derivatives |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2704030A1 (de) * | 1976-02-12 | 1977-08-18 | Sandoz Ag | Neue organische verbindungen, ihre herstellung und verwendung |
| DE2742435A1 (de) * | 1976-09-28 | 1978-04-06 | Sandoz Ag | Aminoalkylaether der peptide tetrahydro- sl 7810/f-ii, s 31794/f-1, aculeacin a und tetrahydroechinocandin b, ihre verwendung und herstellung |
-
1980
- 1980-06-02 FI FI801773A patent/FI801773A7/fi not_active Application Discontinuation
- 1980-06-02 YU YU01464/80A patent/YU146480A/xx unknown
- 1980-06-02 FR FR8012212A patent/FR2458551A1/fr not_active Withdrawn
- 1980-06-03 IL IL60216A patent/IL60216A0/xx unknown
- 1980-06-03 AU AU59016/80A patent/AU5901680A/en not_active Abandoned
- 1980-06-04 CA CA000353369A patent/CA1156218A/en not_active Expired
- 1980-06-04 PT PT71350A patent/PT71350A/pt unknown
- 1980-06-05 IT IT8022586A patent/IT1209417B/it active
- 1980-06-06 GB GB8018641A patent/GB2050385B/en not_active Expired
- 1980-06-06 AR AR281323A patent/AR226848A1/es active
- 1980-06-06 EP EP80301913A patent/EP0021685A1/en not_active Ceased
- 1980-06-06 GR GR62150A patent/GR69258B/el unknown
- 1980-06-06 PL PL22477580A patent/PL224775A1/xx unknown
- 1980-06-06 DK DK244780A patent/DK244780A/da unknown
- 1980-06-06 DD DD80221643A patent/DD153834A5/de unknown
- 1980-06-06 ES ES492232A patent/ES8105270A1/es not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| YU146480A (en) | 1983-02-28 |
| ES492232A0 (es) | 1981-05-16 |
| AU5901680A (en) | 1980-12-11 |
| PT71350A (en) | 1980-07-01 |
| GR69258B (cs) | 1982-05-12 |
| ES8105270A1 (es) | 1981-05-16 |
| CA1156218A (en) | 1983-11-01 |
| AR226848A1 (es) | 1982-08-31 |
| IT8022586A0 (it) | 1980-06-05 |
| GB2050385A (en) | 1981-01-07 |
| FI801773A7 (fi) | 1981-01-01 |
| PL224775A1 (cs) | 1981-03-27 |
| EP0021685A1 (en) | 1981-01-07 |
| IT1209417B (it) | 1989-07-16 |
| IL60216A0 (en) | 1980-09-16 |
| DK244780A (da) | 1980-12-09 |
| FR2458551A1 (fr) | 1981-01-02 |
| GB2050385B (en) | 1983-02-16 |
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