DD153376A5 - Siehe eb - Google Patents

Siehe eb Download PDF

Info

Publication number
DD153376A5
DD153376A5 DD80224266A DD22426680A DD153376A5 DD 153376 A5 DD153376 A5 DD 153376A5 DD 80224266 A DD80224266 A DD 80224266A DD 22426680 A DD22426680 A DD 22426680A DD 153376 A5 DD153376 A5 DD 153376A5
Authority
DD
German Democratic Republic
Prior art keywords
ceph
solution
pyridiniummethyl
carboxyprop
carboxylate
Prior art date
Application number
DD80224266A
Other languages
German (de)
English (en)
Inventor
Alastair C Brodie
Lewis A Wetherill
Original Assignee
Glaxo Group Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glaxo Group Ltd filed Critical Glaxo Group Ltd
Publication of DD153376A5 publication Critical patent/DD153376A5/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
    • C07D501/24—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3
    • C07D501/38—Methylene radicals, substituted by nitrogen atoms; Lactams thereof with the 2-carboxyl group; Methylene radicals substituted by nitrogen-containing hetero rings attached by the ring nitrogen atom; Quaternary compounds thereof
    • C07D501/46—Methylene radicals, substituted by nitrogen atoms; Lactams thereof with the 2-carboxyl group; Methylene radicals substituted by nitrogen-containing hetero rings attached by the ring nitrogen atom; Quaternary compounds thereof with the 7-amino radical acylated by carboxylic acids containing hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Cephalosporin Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
DD80224266A 1979-10-02 1980-10-01 Siehe eb DD153376A5 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB7934204 1979-10-02

Publications (1)

Publication Number Publication Date
DD153376A5 true DD153376A5 (de) 1982-01-06

Family

ID=10508246

Family Applications (1)

Application Number Title Priority Date Filing Date
DD80224266A DD153376A5 (de) 1979-10-02 1980-10-01 Siehe eb

Country Status (36)

Country Link
US (1) US4329453A (uk)
JP (1) JPS5657791A (uk)
KR (1) KR840001776B1 (uk)
AT (1) AT368161B (uk)
AU (1) AU539519B2 (uk)
BE (1) BE885489A (uk)
BG (1) BG33586A3 (uk)
CA (1) CA1142919A (uk)
CH (1) CH645118A5 (uk)
CS (1) CS214721B2 (uk)
CY (1) CY1338A (uk)
DD (1) DD153376A5 (uk)
DE (1) DE3037102C2 (uk)
DK (1) DK155525C (uk)
EC (1) ECSP941099A (uk)
ES (1) ES8106908A1 (uk)
FI (1) FI71157C (uk)
FR (1) FR2466467A1 (uk)
GB (1) GB2063871B (uk)
GR (1) GR69123B (uk)
HK (1) HK78686A (uk)
HU (1) HU184835B (uk)
IT (1) IT1144006B (uk)
KE (1) KE3641A (uk)
MX (1) MX6545E (uk)
MY (1) MY8500315A (uk)
NL (1) NL190329C (uk)
NO (1) NO156246C (uk)
PL (1) PL126606B1 (uk)
PT (1) PT71860B (uk)
RO (1) RO82721B (uk)
SE (1) SE449614B (uk)
SU (1) SU942599A3 (uk)
UA (1) UA7208A1 (uk)
YU (1) YU42357B (uk)
ZA (1) ZA806081B (uk)

Families Citing this family (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4443444A (en) * 1980-08-11 1984-04-17 Fujisawa Pharmaceutical Co., Ltd. Cephem compounds
US4427677A (en) 1980-12-31 1984-01-24 Fujisawa Pharmaceutical Co., Ltd. Cephem compounds
US4394503A (en) 1981-12-07 1983-07-19 Bristol-Myers Company Cephalosporin derivatives
US4474954A (en) * 1981-12-07 1984-10-02 Bristol-Myers Company Intermediates for cephalosporin derivatives
JPS58198489A (ja) * 1982-05-14 1983-11-18 Meiji Seika Kaisha Ltd ７β−（２Ｄ−２−アミノ−２−カルボキシエチルチオアセトアミド）−７α−メトキシ−３−（１−メチル−１Ｈ−テトラゾ−ル−５−イル）−チオメチル−３−セフエム−４−カルボン酸ナトリウム塩の七水和物及びその製造方法
ES8502863A1 (es) * 1982-09-10 1985-02-01 Glaxo Group Ltd Un procedimiento para la produccion de un recipiente hermeticamente cerrado que contiene al menos un antibiotico de beta-lactama.
DE3313816A1 (de) * 1983-04-16 1984-10-18 Hoechst Ag, 6230 Frankfurt Neue kristallmodifikation von ceftazidim
DE3313818A1 (de) * 1983-04-16 1984-10-18 Hoechst Ag, 6230 Frankfurt Neue kristallmodifikation von ceftazidim
GB8406218D0 (en) * 1984-03-09 1984-04-11 Glaxo Group Ltd Process
US4537959A (en) * 1984-03-26 1985-08-27 Eli Lilly And Company Crystalline cephalosporin antibiotic salt
JPS60231683A (ja) * 1984-05-02 1985-11-18 Teijin Ltd セフアロスポリン誘導体その製造法及びそれを有効成分とする抗菌剤
US4616080A (en) * 1984-07-02 1986-10-07 Eli Lilly And Company Simplified process of forming crystalline ceftazidime pentahydrate
DE3577656D1 (de) * 1984-07-23 1990-06-21 Lilly Co Eli Pharmazeutische zusammensetzungen von ceftazidim.
US4626534A (en) * 1984-07-23 1986-12-02 Eli Lilly And Company Pharmaceutical formulation
US4659813A (en) * 1984-11-08 1987-04-21 Eli Lilly And Company Crystallization process for ceftazidime derivative
EP0187450B1 (en) * 1984-11-08 1991-01-30 Eli Lilly And Company Process for the preparation of crystalline ceftazidime pentahydrate
US4994451A (en) * 1988-01-19 1991-02-19 Bristol-Myers Company Cephalosporin salts and injectable compositions
US4910301A (en) * 1985-08-05 1990-03-20 Bristol-Myers Company Cefepime cephalosporin salts
US5244891A (en) * 1985-08-05 1993-09-14 Bristol-Myers Squibb Company Injectable compositions of cefepime dihydrochloride hydrate
AT387390B (de) * 1986-10-07 1989-01-10 Biochemie Gmbh Verfahren zur herstellung des antibiotikums (6r,7r)-7-(2-(2-amino-4-thiazolyl)-2-(2-carboxy
US4954624A (en) * 1986-10-07 1990-09-04 Sandoz Ltd. Process for the production of cephalosporin derivatives
US5021564A (en) * 1987-02-02 1991-06-04 Eli Lilly And Company Process for preparing ceftazidime pentahydrate
DE3871542T2 (de) * 1987-02-02 1992-12-24 Lilly Co Eli Verfahren zur herstellung von ceftazidime-pentahydrat.
WO1988010262A1 (fr) * 1987-06-25 1988-12-29 Banyu Pharmaceutical Co., Ltd. Compose cristallin de cephalosporine
KR950010084B1 (ko) * 1987-06-25 1995-09-06 반유세이야꾸 가부시끼가이샤 결정성 세팔로스포린 화합물, 그의 제조법 및 그의 제조 중간체
GB8802622D0 (en) * 1988-02-05 1988-03-02 Glaxo Group Ltd Chemical compound
KR940000112B1 (ko) * 1990-07-05 1994-01-05 주식회사 대웅제약 신규의 3-치환 세펨화합물 및 그의 제조방법
US5831085A (en) * 1997-01-16 1998-11-03 Lupin Laboratories Limited Process for manufacture of cephalosporin such as ceftazidime and intermediate thereof
CN1328281C (zh) * 2004-11-16 2007-07-25 广州白云山制药股份有限公司 头孢他啶的纯化方法
CN102924483B (zh) * 2012-10-31 2015-06-17 海南合瑞制药股份有限公司 一种头孢他啶晶体化合物、其制备方法及其无菌混合粉形式的药物组合物
CN102875576A (zh) * 2012-10-31 2013-01-16 苏州致君万庆药业有限公司 一种抗菌素头孢他啶的合成、注射用头孢他啶及其制备方法
CN104876949A (zh) * 2015-05-28 2015-09-02 浙江长典医药有限公司 一种小儿用头孢他啶化合物实体及其制剂
CN106420658A (zh) * 2016-09-23 2017-02-22 临沂草之美医药科技有限公司 一种治疗外科手术感染的药物头孢他啶胶囊
CN109111467A (zh) * 2017-06-22 2019-01-01 宁应 一种51/4水头孢他啶化合物及其药物组合物制剂

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR228726A1 (es) * 1978-05-26 1983-04-15 Glaxo Group Ltd Procedimiento para la preparacion del antibiotico(6r,7r)-7-((z)-2-(2-aminotiazol-4-il)-2-(2-carboxiprop-2-oxiimino)acetamido)-3-(1-piridiniometil)cef-3-em-4-carboxilato

Also Published As

Publication number Publication date
ZA806081B (en) 1982-05-26
CS214721B2 (en) 1982-05-28
AU6288280A (en) 1981-04-09
SE8006861L (sv) 1981-04-03
JPH0128036B2 (uk) 1989-05-31
FR2466467A1 (fr) 1981-04-10
FR2466467B1 (uk) 1984-02-10
BG33586A3 (en) 1983-03-15
ECSP941099A (es) 1995-01-16
MX6545E (es) 1985-07-10
IT8049783A0 (it) 1980-10-01
BE885489A (fr) 1981-04-01
ATA490080A (de) 1982-01-15
PT71860A (en) 1980-11-01
JPS5657791A (en) 1981-05-20
NO156246B (no) 1987-05-11
AT368161B (de) 1982-09-27
PT71860B (en) 1982-04-02
IT1144006B (it) 1986-10-29
FI71157C (fi) 1986-11-24
YU249780A (en) 1983-02-28
CA1142919A (en) 1983-03-15
GR69123B (uk) 1982-05-03
CY1338A (en) 1987-01-16
FI803126L (fi) 1981-04-03
AU539519B2 (en) 1984-10-04
CH645118A5 (de) 1984-09-14
HK78686A (en) 1986-10-24
NL190329B (nl) 1993-08-16
DE3037102A1 (de) 1981-04-23
DK155525B (da) 1989-04-17
US4329453A (en) 1982-05-11
DK414780A (da) 1981-04-03
NO156246C (no) 1987-08-19
UA7208A1 (uk) 1995-06-30
YU42357B (en) 1988-08-31
SU942599A3 (ru) 1982-07-07
FI71157B (fi) 1986-08-14
RO82721A (ro) 1984-09-29
MY8500315A (en) 1985-12-31
NL8005443A (nl) 1981-04-06
NO802913L (no) 1981-04-03
DK155525C (da) 1989-09-04
PL126606B1 (en) 1983-08-31
KR830004317A (ko) 1983-07-09
ES495534A0 (es) 1981-09-01
KE3641A (en) 1986-07-11
GB2063871B (en) 1983-06-02
HU184835B (en) 1984-10-29
KR840001776B1 (ko) 1984-10-19
DE3037102C2 (de) 1986-04-10
GB2063871A (en) 1981-06-10
ES8106908A1 (es) 1981-09-01
RO82721B (ro) 1984-10-30
SE449614B (sv) 1987-05-11
PL227019A1 (uk) 1981-06-05
NL190329C (nl) 1994-01-17

Similar Documents

Publication Publication Date Title
DD153376A5 (de) Siehe eb
DE2332878C2 (de) Salze von Cephalosporinen mit Arginin und Lysin, ihre Herstellung und injizierbare pharmazeutische Zubereitungen
DE3143219C2 (uk)
DE2738712C2 (uk)
EP2194057A1 (de) Stabiles kristallines Salz der 5-Methyl-(6S)-tetrahydrofolsäure
DE3037104C2 (de) Kristallines Bishydrochlorid von (6R,7R)-7-[(Z)-2-(2-Aminothiazol-4-yl)-2-(2-carboxyprop-2-oximino)acetamido]-3-(1-pyridiniummethyl)ceph-3-em-4-carboxylat
DE2439880A1 (de) Antibiotika und verfahren zu ihrer herstellung
DD284807A5 (de) Verf. z. herstellung eine pyhsikalischen gemisches aus mindestens einem salz des ((1-methyl-1-pyrrolidinio)- methyl)-3-cephem-4-carboxylats u. einer pharmazeutisch vertraeglichen, nicht toxischen, organischen oder anorganischen base
DE2816873A1 (de) Cephalosporinderivate, verfahren zu ihrer herstellung und sie enthaltende pharmazeutische zubereitungen
DE2500386A1 (de) 7-eckige klammer auf d-alpha-amino- alpha-(p-hydroxyphenyl)-acetamido eckige klammer zu-3-(1,2,3-triazol-5-yl-thiomethyl)-3-cephem.4.carbonsaeure-1,2-propylen-glykolat, verfahren zur herstellung und arzneimittel
DE2738711C2 (de) Salze des Cefotiams
DE2718730A1 (de) Cephalosporin-antibiotika
DE1770620A1 (de) Neue Penicilline
DE2225694C3 (de) Cephalosporinverbindungen und Verfahren zu deren Herstellung
CH675581A5 (uk)
DE3443065C2 (uk)
CH644868A5 (de) In 3- und 7-stellung substituierte cephemcarbonsaeure(ester).
DD261163A5 (de) Verfahren zur reinigung von cephalosporin-antibiotika
DE3139554C2 (uk)
DE2234280B2 (de) Cephalosporinverbindungen und Verfahren zu deren Herstellung
DE2949485C2 (uk)
DE2522998A1 (de) Neues cephalosporinderivat, verfahren zu seiner herstellung und arzneimittel
DE2645144C2 (de) Cephalosporine, Verfahren zu deren Herstellung und diese enthaltende pharmazeutische Mittel
DE2655717A1 (de) Thiadiazolylderivate von 7-acylamido-3-cephem-4-carbonsaeure, verfahren zu deren herstellung und dieselben enthaltende pharmazeutische und veterinaermedizinische mittel
DE2165200A1 (de) Verfahren zur Herstellung der wasserfreien Form von 6- eckige Klammer auf D(-)-alpha-Aminopheny lacetamido eckige Klammer zu -penicilliansäure

Legal Events

Date Code Title Description
ENJ Ceased due to non-payment of renewal fee