DD146296A5 - Verfahren zur herstellung von kortikoid-21-sulfopropionaten - Google Patents

Verfahren zur herstellung von kortikoid-21-sulfopropionaten Download PDF

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Publication number
DD146296A5
DD146296A5 DD79215930A DD21593079A DD146296A5 DD 146296 A5 DD146296 A5 DD 146296A5 DD 79215930 A DD79215930 A DD 79215930A DD 21593079 A DD21593079 A DD 21593079A DD 146296 A5 DD146296 A5 DD 146296A5
Authority
DD
German Democratic Republic
Prior art keywords
corticoid
hydrogen atom
salts
general formula
dione
Prior art date
Application number
DD79215930A
Other languages
German (de)
English (en)
Inventor
Henry Laurent
Peter Esperling
Joachim-Friedrich Kapp
Rudolf Wiechert
Original Assignee
Schering Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE19782843690 external-priority patent/DE2843690A1/de
Priority claimed from DE19792932166 external-priority patent/DE2932166A1/de
Application filed by Schering Ag filed Critical Schering Ag
Publication of DD146296A5 publication Critical patent/DD146296A5/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P33/00—Preparation of steroids
    • C12P33/06—Hydroxylating
    • C12P33/08—Hydroxylating at 11 position
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J31/00—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring
    • C07J31/006—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring not covered by C07J31/003
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J51/00—Normal steroids with unmodified cyclopenta(a)hydrophenanthrene skeleton not provided for in groups C07J1/00 - C07J43/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J53/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton has been modified by condensation with a carbocyclic rings or by formation of an additional ring by means of a direct link between two ring carbon atoms, including carboxyclic rings fused to the cyclopenta(a)hydrophenanthrene skeleton are included in this class
    • C07J53/002—Carbocyclic rings fused
    • C07J53/004—3 membered carbocyclic rings
    • C07J53/005—3 membered carbocyclic rings in position 12
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J63/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton has been modified by expansion of only one ring by one or two atoms
    • C07J63/008—Expansion of ring D by one atom, e.g. D homo steroids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
    • C07J71/0005—Oxygen-containing hetero ring
    • C07J71/0026—Oxygen-containing hetero ring cyclic ketals
    • C07J71/0031—Oxygen-containing hetero ring cyclic ketals at positions 16, 17

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Microbiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
DD79215930A 1978-10-04 1979-10-01 Verfahren zur herstellung von kortikoid-21-sulfopropionaten DD146296A5 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19782843690 DE2843690A1 (de) 1978-10-04 1978-10-04 Kortikoid-2l-sulfopropionate und deren salze, verfahren zu ihrer herstellung und pharmazeutische praeparate, die diese verbindungen enthalten
DE19792932166 DE2932166A1 (de) 1979-08-06 1979-08-06 Kortikoid-21-sulfopropionate und deren salze, verfahren zu ihrer herstellung und pharmazeutische praeparate, die diese verbindungen enthalten

Publications (1)

Publication Number Publication Date
DD146296A5 true DD146296A5 (de) 1981-02-04

Family

ID=25775997

Family Applications (1)

Application Number Title Priority Date Filing Date
DD79215930A DD146296A5 (de) 1978-10-04 1979-10-01 Verfahren zur herstellung von kortikoid-21-sulfopropionaten

Country Status (13)

Country Link
US (1) US4296109A (es)
EP (1) EP0010056B1 (es)
CA (1) CA1127630A (es)
CS (1) CS215030B2 (es)
DD (1) DD146296A5 (es)
DE (1) DE2966092D1 (es)
DK (1) DK404879A (es)
ES (1) ES484706A1 (es)
GB (1) GB2034715A (es)
GR (1) GR74136B (es)
HU (1) HU183000B (es)
IE (1) IE48954B1 (es)
SU (1) SU818489A3 (es)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4472392A (en) * 1983-01-21 1984-09-18 The Upjohn Company Sulfonate containing ester prodrugs of corticosteroids
US4469689A (en) * 1983-03-30 1984-09-04 The Upjohn Company Sulfonate containing ester prodrugs of corticosteroids
CA1310009C (en) * 1984-03-28 1992-11-10 John Mark Braughler Ester prodrugs of steroids
US4948533A (en) * 1984-03-28 1990-08-14 The Upjohn Company 11a-hydroxy steroid diester
US4588718A (en) * 1984-03-28 1986-05-13 The Upjohn Company Carboxy containing ester prodrugs of corticosteroids
AU597723B2 (en) * 1986-08-21 1990-06-07 J.W. Broadbent Nominees Pty. Ltd. Sodium scymnol sulphate isolated form shark tissues
CA1296322C (en) * 1986-08-21 1992-02-25 Takuo Kosuge Active principle isolated from shark tissue
ATE84300T1 (de) * 1987-07-16 1993-01-15 Upjohn Co Aminosalze von alkan-1,n-dicarbonsaeure-mono-(2sulfato-|thyl)amiden.
US5250711A (en) * 1987-07-16 1993-10-05 The Upjohn Company Amine salts of alkane-1,n-dicarboxylic acid mono-(2-sulfato-ethyl) amides
DE4334823C2 (de) * 1993-10-09 1998-09-17 Schering Ag Verfahren zur Herstellung von Schwefelsäurehalbestern von Estrogenen
AU2002311995A1 (en) * 2001-05-23 2002-12-03 Amersham Biosciences Ab Peptide analysis using a solid support
US7074570B2 (en) * 2001-05-23 2006-07-11 Ge Healthcare Bio-Sciences Ab Peptide fragmentation
US20040171070A1 (en) * 2002-05-20 2004-09-02 Ramagauri Bhikhabhai Peptide analysis using a solid support

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3089881A (en) * 1957-10-29 1963-05-14 Schering Corp Sulfocarboxylic acid esters of hydroxylated steroids
DE1090207B (de) * 1958-04-21 1960-10-06 Chimiotherapie Lab Franc Verfahren zur Herstellung wasserloeslicher Corticosteroidderivate
FR1392048A (fr) * 1964-02-21 1965-03-12 Ile D Etudes Et De Brevets Nov Procédé de fabrication de composés stéroïdes de la série de l'androstane et de l'oestrane
DE2703543C2 (de) * 1977-01-26 1985-06-05 Schering AG, 1000 Berlin und 4709 Bergkamen 2l-(3-Benzoylpropionyloxy)-11β,17α-dihydroxy-1,4-pregnadien-3,20-dion, Verfahren zu seiner Herstellung und diese Verbindung enthaltende pharmazeutische Präparate

Also Published As

Publication number Publication date
GB2034715A (en) 1980-06-11
HU183000B (en) 1984-03-28
CA1127630A (en) 1982-07-13
EP0010056B1 (de) 1983-08-24
ES484706A1 (es) 1980-06-16
SU818489A3 (ru) 1981-03-30
IE791879L (en) 1980-04-04
DE2966092D1 (en) 1983-09-29
IE48954B1 (en) 1985-06-26
CS215030B2 (en) 1982-06-25
EP0010056A1 (de) 1980-04-16
GR74136B (es) 1984-06-06
DK404879A (da) 1980-04-05
US4296109A (en) 1981-10-20

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