ES484706A1 - Procedimiento para la preparacion de corticoido-21-sulfopro-pianatos - Google Patents

Procedimiento para la preparacion de corticoido-21-sulfopro-pianatos

Info

Publication number
ES484706A1
ES484706A1 ES484706A ES484706A ES484706A1 ES 484706 A1 ES484706 A1 ES 484706A1 ES 484706 A ES484706 A ES 484706A ES 484706 A ES484706 A ES 484706A ES 484706 A1 ES484706 A1 ES 484706A1
Authority
ES
Spain
Prior art keywords
corticoid
salts
compounds
preparation
acid esters
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES484706A
Other languages
English (en)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bayer Pharma AG
Original Assignee
Schering AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE19782843690 external-priority patent/DE2843690A1/de
Priority claimed from DE19792932166 external-priority patent/DE2932166A1/de
Application filed by Schering AG filed Critical Schering AG
Publication of ES484706A1 publication Critical patent/ES484706A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P33/00—Preparation of steroids
    • C12P33/06—Hydroxylating
    • C12P33/08—Hydroxylating at 11 position
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J31/00—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring
    • C07J31/006—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring not covered by C07J31/003
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J51/00—Normal steroids with unmodified cyclopenta(a)hydrophenanthrene skeleton not provided for in groups C07J1/00 - C07J43/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J53/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton has been modified by condensation with a carbocyclic rings or by formation of an additional ring by means of a direct link between two ring carbon atoms, including carboxyclic rings fused to the cyclopenta(a)hydrophenanthrene skeleton are included in this class
    • C07J53/002—Carbocyclic rings fused
    • C07J53/004—3 membered carbocyclic rings
    • C07J53/005—3 membered carbocyclic rings in position 12
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J63/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton has been modified by expansion of only one ring by one or two atoms
    • C07J63/008—Expansion of ring D by one atom, e.g. D homo steroids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
    • C07J71/0005—Oxygen-containing hetero ring
    • C07J71/0026—Oxygen-containing hetero ring cyclic ketals
    • C07J71/0031—Oxygen-containing hetero ring cyclic ketals at positions 16, 17

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Microbiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)

Abstract

Procedimiento para la preparación de corticoido-21- sulfopropianatos y sus sales de la fórmula general I **(Fórmula01)** en donde St significa el núcleo estoroide de un corticoide activo como antiinflamatorio y sus sales con bases fisiológicamente inocuas, caracterizado porque se hace reaccionar un corticoide de la fórmula general III **(Fórmula02)** en donde St posee los significados arriba indicados, con anhídrido de ácido 3-sulfopropiónico de la fórmula IV **(Fórmula03)** y los corticoido-21sulfopropionatos obtenidos de transforman eventualmente en sus sales con bases fisiológicamente inocuas.
ES484706A 1978-10-04 1979-10-03 Procedimiento para la preparacion de corticoido-21-sulfopro-pianatos Expired ES484706A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19782843690 DE2843690A1 (de) 1978-10-04 1978-10-04 Kortikoid-2l-sulfopropionate und deren salze, verfahren zu ihrer herstellung und pharmazeutische praeparate, die diese verbindungen enthalten
DE19792932166 DE2932166A1 (de) 1979-08-06 1979-08-06 Kortikoid-21-sulfopropionate und deren salze, verfahren zu ihrer herstellung und pharmazeutische praeparate, die diese verbindungen enthalten

Publications (1)

Publication Number Publication Date
ES484706A1 true ES484706A1 (es) 1980-06-16

Family

ID=25775997

Family Applications (1)

Application Number Title Priority Date Filing Date
ES484706A Expired ES484706A1 (es) 1978-10-04 1979-10-03 Procedimiento para la preparacion de corticoido-21-sulfopro-pianatos

Country Status (13)

Country Link
US (1) US4296109A (es)
EP (1) EP0010056B1 (es)
CA (1) CA1127630A (es)
CS (1) CS215030B2 (es)
DD (1) DD146296A5 (es)
DE (1) DE2966092D1 (es)
DK (1) DK404879A (es)
ES (1) ES484706A1 (es)
GB (1) GB2034715A (es)
GR (1) GR74136B (es)
HU (1) HU183000B (es)
IE (1) IE48954B1 (es)
SU (1) SU818489A3 (es)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4472392A (en) * 1983-01-21 1984-09-18 The Upjohn Company Sulfonate containing ester prodrugs of corticosteroids
US4469689A (en) * 1983-03-30 1984-09-04 The Upjohn Company Sulfonate containing ester prodrugs of corticosteroids
US4948533A (en) * 1984-03-28 1990-08-14 The Upjohn Company 11a-hydroxy steroid diester
US4588718A (en) * 1984-03-28 1986-05-13 The Upjohn Company Carboxy containing ester prodrugs of corticosteroids
CA1310009C (en) * 1984-03-28 1992-11-10 John Mark Braughler Ester prodrugs of steroids
AU597723B2 (en) * 1986-08-21 1990-06-07 J.W. Broadbent Nominees Pty. Ltd. Sodium scymnol sulphate isolated form shark tissues
ZA876171B (en) * 1986-08-21 1988-10-26 Broadbent James Meredyth Active principle isolated from shark tissue
US5250711A (en) * 1987-07-16 1993-10-05 The Upjohn Company Amine salts of alkane-1,n-dicarboxylic acid mono-(2-sulfato-ethyl) amides
DE3877361T2 (de) * 1987-07-16 1993-05-13 Upjohn Co Aminosalze von alkan-1,n-dicarbonsaeure-mono-(2-sulfato-aethyl)amiden.
DE4334823C2 (de) * 1993-10-09 1998-09-17 Schering Ag Verfahren zur Herstellung von Schwefelsäurehalbestern von Estrogenen
US7074570B2 (en) * 2001-05-23 2006-07-11 Ge Healthcare Bio-Sciences Ab Peptide fragmentation
CA2448534A1 (en) * 2001-05-23 2002-11-28 Harold L. Vaughn Peptide analysis using a solid support
US20040171070A1 (en) * 2002-05-20 2004-09-02 Ramagauri Bhikhabhai Peptide analysis using a solid support

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3089881A (en) * 1957-10-29 1963-05-14 Schering Corp Sulfocarboxylic acid esters of hydroxylated steroids
DE1090207B (de) * 1958-04-21 1960-10-06 Chimiotherapie Lab Franc Verfahren zur Herstellung wasserloeslicher Corticosteroidderivate
FR1392048A (fr) * 1964-02-21 1965-03-12 Ile D Etudes Et De Brevets Nov Procédé de fabrication de composés stéroïdes de la série de l'androstane et de l'oestrane
DE2703543C2 (de) * 1977-01-26 1985-06-05 Schering AG, 1000 Berlin und 4709 Bergkamen 2l-(3-Benzoylpropionyloxy)-11β,17α-dihydroxy-1,4-pregnadien-3,20-dion, Verfahren zu seiner Herstellung und diese Verbindung enthaltende pharmazeutische Präparate

Also Published As

Publication number Publication date
DD146296A5 (de) 1981-02-04
DE2966092D1 (en) 1983-09-29
US4296109A (en) 1981-10-20
GR74136B (es) 1984-06-06
CA1127630A (en) 1982-07-13
IE48954B1 (en) 1985-06-26
HU183000B (en) 1984-03-28
EP0010056A1 (de) 1980-04-16
IE791879L (en) 1980-04-04
CS215030B2 (en) 1982-06-25
EP0010056B1 (de) 1983-08-24
DK404879A (da) 1980-04-05
GB2034715A (en) 1980-06-11
SU818489A3 (ru) 1981-03-30

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 20000201