DD143729A5 - Verfahren zur herstellung eines immunbiotherapeutischen arzneimittels gegen infektionen der atemwege - Google Patents
Verfahren zur herstellung eines immunbiotherapeutischen arzneimittels gegen infektionen der atemwege Download PDFInfo
- Publication number
- DD143729A5 DD143729A5 DD79213101A DD21310179A DD143729A5 DD 143729 A5 DD143729 A5 DD 143729A5 DD 79213101 A DD79213101 A DD 79213101A DD 21310179 A DD21310179 A DD 21310179A DD 143729 A5 DD143729 A5 DD 143729A5
- Authority
- DD
- German Democratic Republic
- Prior art keywords
- nctc
- lysate
- strains
- sodium
- culture medium
- Prior art date
Links
- 239000003814 drug Substances 0.000 title claims description 10
- 208000015181 infectious disease Diseases 0.000 title description 5
- 238000004519 manufacturing process Methods 0.000 title description 2
- 230000001580 bacterial effect Effects 0.000 claims abstract description 10
- 239000001963 growth medium Substances 0.000 claims abstract description 4
- 239000006166 lysate Substances 0.000 claims description 14
- 229940079593 drug Drugs 0.000 claims description 6
- 238000002360 preparation method Methods 0.000 claims description 6
- 238000000034 method Methods 0.000 claims description 5
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 claims description 4
- PVNIIMVLHYAWGP-UHFFFAOYSA-N Niacin Chemical compound OC(=O)C1=CC=CN=C1 PVNIIMVLHYAWGP-UHFFFAOYSA-N 0.000 claims description 4
- 206010057190 Respiratory tract infections Diseases 0.000 claims description 4
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 claims description 4
- 239000008103 glucose Substances 0.000 claims description 4
- 241000606768 Haemophilus influenzae Species 0.000 claims description 3
- 229940041514 candida albicans extract Drugs 0.000 claims description 3
- 239000000284 extract Substances 0.000 claims description 3
- 239000012138 yeast extract Substances 0.000 claims description 3
- 239000004251 Ammonium lactate Substances 0.000 claims description 2
- VMHLLURERBWHNL-UHFFFAOYSA-M Sodium acetate Chemical compound [Na+].CC([O-])=O VMHLLURERBWHNL-UHFFFAOYSA-M 0.000 claims description 2
- 241000191967 Staphylococcus aureus Species 0.000 claims description 2
- 241000193998 Streptococcus pneumoniae Species 0.000 claims description 2
- 241000193996 Streptococcus pyogenes Species 0.000 claims description 2
- 241001312524 Streptococcus viridans Species 0.000 claims description 2
- 229940059265 ammonium lactate Drugs 0.000 claims description 2
- 235000019286 ammonium lactate Nutrition 0.000 claims description 2
- RZOBLYBZQXQGFY-HSHFZTNMSA-N azanium;(2r)-2-hydroxypropanoate Chemical compound [NH4+].C[C@@H](O)C([O-])=O RZOBLYBZQXQGFY-HSHFZTNMSA-N 0.000 claims description 2
- 235000013372 meat Nutrition 0.000 claims description 2
- 235000001968 nicotinic acid Nutrition 0.000 claims description 2
- 229960003512 nicotinic acid Drugs 0.000 claims description 2
- 239000011664 nicotinic acid Substances 0.000 claims description 2
- 239000001632 sodium acetate Substances 0.000 claims description 2
- 235000017281 sodium acetate Nutrition 0.000 claims description 2
- 239000011780 sodium chloride Substances 0.000 claims description 2
- JZRWCGZRTZMZEH-UHFFFAOYSA-N thiamine Chemical compound CC1=C(CCO)SC=[N+]1CC1=CN=C(C)N=C1N JZRWCGZRTZMZEH-UHFFFAOYSA-N 0.000 claims description 2
- 235000019157 thiamine Nutrition 0.000 claims description 2
- 239000011721 thiamine Substances 0.000 claims description 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 2
- 241000588653 Neisseria Species 0.000 claims 2
- 241000588744 Klebsiella pneumoniae subsp. ozaenae Species 0.000 claims 1
- 239000008156 Ringer's lactate solution Substances 0.000 claims 1
- UIIMBOGNXHQVGW-DEQYMQKBSA-M Sodium bicarbonate-14C Chemical compound [Na+].O[14C]([O-])=O UIIMBOGNXHQVGW-DEQYMQKBSA-M 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 239000000203 mixture Substances 0.000 claims 1
- 239000000243 solution Substances 0.000 claims 1
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 9
- 239000000825 pharmaceutical preparation Substances 0.000 description 8
- 108060003951 Immunoglobulin Proteins 0.000 description 7
- 102000018358 immunoglobulin Human genes 0.000 description 7
- 244000052616 bacterial pathogen Species 0.000 description 6
- 229940072221 immunoglobulins Drugs 0.000 description 6
- 206010006451 bronchitis Diseases 0.000 description 5
- 210000004027 cell Anatomy 0.000 description 5
- 239000002609 medium Substances 0.000 description 5
- 241000699670 Mus sp. Species 0.000 description 4
- 239000002775 capsule Substances 0.000 description 4
- 206010006458 Bronchitis chronic Diseases 0.000 description 3
- 208000005141 Otitis Diseases 0.000 description 3
- KWYUFKZDYYNOTN-UHFFFAOYSA-M Potassium hydroxide Chemical compound [OH-].[K+] KWYUFKZDYYNOTN-UHFFFAOYSA-M 0.000 description 3
- 239000004480 active ingredient Substances 0.000 description 3
- 239000007640 basal medium Substances 0.000 description 3
- 208000007451 chronic bronchitis Diseases 0.000 description 3
- 230000009089 cytolysis Effects 0.000 description 3
- 208000019258 ear infection Diseases 0.000 description 3
- 238000011534 incubation Methods 0.000 description 3
- 210000002345 respiratory system Anatomy 0.000 description 3
- 201000009890 sinusitis Diseases 0.000 description 3
- 239000007787 solid Substances 0.000 description 3
- 206010002383 Angina Pectoris Diseases 0.000 description 2
- 241000588748 Klebsiella Species 0.000 description 2
- 241000588747 Klebsiella pneumoniae Species 0.000 description 2
- 201000008197 Laryngitis Diseases 0.000 description 2
- 201000007100 Pharyngitis Diseases 0.000 description 2
- 208000036142 Viral infection Diseases 0.000 description 2
- 230000001154 acute effect Effects 0.000 description 2
- 238000005273 aeration Methods 0.000 description 2
- 239000000443 aerosol Substances 0.000 description 2
- 238000013019 agitation Methods 0.000 description 2
- 230000003115 biocidal effect Effects 0.000 description 2
- 239000012141 concentrate Substances 0.000 description 2
- 235000008504 concentrate Nutrition 0.000 description 2
- 238000002474 experimental method Methods 0.000 description 2
- 238000001914 filtration Methods 0.000 description 2
- 230000008569 process Effects 0.000 description 2
- 230000000069 prophylactic effect Effects 0.000 description 2
- 230000028327 secretion Effects 0.000 description 2
- 210000002966 serum Anatomy 0.000 description 2
- 239000000725 suspension Substances 0.000 description 2
- 238000002560 therapeutic procedure Methods 0.000 description 2
- 206010044008 tonsillitis Diseases 0.000 description 2
- 230000009385 viral infection Effects 0.000 description 2
- 229920001817 Agar Polymers 0.000 description 1
- 241000736839 Chara Species 0.000 description 1
- 108010010803 Gelatin Proteins 0.000 description 1
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 1
- 241001465754 Metazoa Species 0.000 description 1
- 241000699666 Mus <mouse, genus> Species 0.000 description 1
- 102000004160 Phosphoric Monoester Hydrolases Human genes 0.000 description 1
- 108090000608 Phosphoric Monoester Hydrolases Proteins 0.000 description 1
- 240000004808 Saccharomyces cerevisiae Species 0.000 description 1
- 235000014680 Saccharomyces cerevisiae Nutrition 0.000 description 1
- 241000295644 Staphylococcaceae Species 0.000 description 1
- 239000008272 agar Substances 0.000 description 1
- BGAOCLJKLCQHTR-UHFFFAOYSA-H azane;cobalt(3+);tricarbonate Chemical compound N.N.N.N.N.N.[Co+3].[Co+3].[O-]C([O-])=O.[O-]C([O-])=O.[O-]C([O-])=O BGAOCLJKLCQHTR-UHFFFAOYSA-H 0.000 description 1
- 102000005936 beta-Galactosidase Human genes 0.000 description 1
- 108010005774 beta-Galactosidase Proteins 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 230000008260 defense mechanism Effects 0.000 description 1
- 230000035622 drinking Effects 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 239000012530 fluid Substances 0.000 description 1
- 229940083124 ganglion-blocking antiadrenergic secondary and tertiary amines Drugs 0.000 description 1
- 239000008273 gelatin Substances 0.000 description 1
- 229920000159 gelatin Polymers 0.000 description 1
- 235000019322 gelatine Nutrition 0.000 description 1
- 235000011852 gelatine desserts Nutrition 0.000 description 1
- 239000008187 granular material Substances 0.000 description 1
- 238000003306 harvesting Methods 0.000 description 1
- 230000035876 healing Effects 0.000 description 1
- 230000028993 immune response Effects 0.000 description 1
- 230000001024 immunotherapeutic effect Effects 0.000 description 1
- 206010022000 influenza Diseases 0.000 description 1
- 238000011081 inoculation Methods 0.000 description 1
- 238000007912 intraperitoneal administration Methods 0.000 description 1
- 230000002262 irrigation Effects 0.000 description 1
- 238000003973 irrigation Methods 0.000 description 1
- 238000009630 liquid culture Methods 0.000 description 1
- 230000002934 lysing effect Effects 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 230000007246 mechanism Effects 0.000 description 1
- 244000005700 microbiome Species 0.000 description 1
- 238000002156 mixing Methods 0.000 description 1
- 210000003024 peritoneal macrophage Anatomy 0.000 description 1
- 230000000144 pharmacologic effect Effects 0.000 description 1
- 238000001556 precipitation Methods 0.000 description 1
- 150000003141 primary amines Chemical class 0.000 description 1
- 230000001681 protective effect Effects 0.000 description 1
- 208000020029 respiratory tract infectious disease Diseases 0.000 description 1
- 206010039083 rhinitis Diseases 0.000 description 1
- 210000003296 saliva Anatomy 0.000 description 1
- 229910052708 sodium Inorganic materials 0.000 description 1
- 239000011734 sodium Substances 0.000 description 1
- 230000000638 stimulation Effects 0.000 description 1
- 239000006188 syrup Substances 0.000 description 1
- 235000020357 syrup Nutrition 0.000 description 1
- 239000003826 tablet Substances 0.000 description 1
- 241000712461 unidentified influenza virus Species 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/66—Microorganisms or materials therefrom
- A61K35/74—Bacteria
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/66—Microorganisms or materials therefrom
- A61K35/74—Bacteria
- A61K35/741—Probiotics
- A61K35/744—Lactic acid bacteria, e.g. enterococci, pediococci, lactococci, streptococci or leuconostocs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
- C12N1/20—Bacteria; Culture media therefor
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Microbiology (AREA)
- Veterinary Medicine (AREA)
- Organic Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Mycology (AREA)
- Biotechnology (AREA)
- Genetics & Genomics (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Molecular Biology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Virology (AREA)
- Biomedical Technology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- Pulmonology (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CH580578A CH633188A5 (fr) | 1978-05-26 | 1978-05-26 | Medicament contre des maladies infectieuses des voies respiratoires. |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DD143729A5 true DD143729A5 (de) | 1980-09-10 |
Family
ID=4299594
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DD79213101A DD143729A5 (de) | 1978-05-26 | 1979-05-23 | Verfahren zur herstellung eines immunbiotherapeutischen arzneimittels gegen infektionen der atemwege |
Country Status (15)
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2550707B1 (fr) * | 1983-08-17 | 1986-02-28 | Lipha | Medicament immunomodulateur d'origine biologique et son procede de preparation |
| CH680045A5 (enrdf_load_stackoverflow) * | 1990-02-16 | 1992-06-15 | Om Lab Sa | |
| CH685498A5 (fr) * | 1992-02-14 | 1995-07-31 | Om Lab Sa | Extrait de macromolécules bactériennes, procédé pour sa préparation et composition pharmaceutique contenant cet extrait. |
| WO1997045530A1 (fr) * | 1996-05-27 | 1997-12-04 | UZILOVA, Irina Semenovna, Heiress of UZILOV | Utilisation de souches de streptococcus faecium et composition a base de ces souches |
| SE511648C2 (sv) * | 1998-04-17 | 1999-11-01 | Bacterum Ab | Streptokockpreparat för behandling av öroninflammation |
| WO2008109669A2 (en) * | 2007-03-05 | 2008-09-12 | Om Pharma | Bacterial extract for respiratory disorders and proces for its preparation |
| CN104922330A (zh) * | 2015-07-15 | 2015-09-23 | 龚灿锋 | 一种治疗扁桃体炎的中药 |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BE543985A (enrdf_load_stackoverflow) * | ||||
| FR2892M (fr) * | 1963-07-25 | 1964-11-02 | Inst Rech Scient | Substances a action immunisante et désensibilisante. |
| FR6513M (enrdf_load_stackoverflow) * | 1967-07-12 | 1968-12-02 | ||
| FR7010M (enrdf_load_stackoverflow) * | 1967-11-10 | 1969-06-02 | ||
| FR7461M (enrdf_load_stackoverflow) * | 1968-06-19 | 1970-01-05 | ||
| NL174267B (nl) * | 1969-05-20 | Roussel Uclaf | Verbetering van de werkwijze voor de bereiding van een somatisch antigeen volgens het nederlandse octrooischrift 169754 en werkwijze ter bereiding van een farmaceutisch preparaat. | |
| US3929994A (en) * | 1969-05-20 | 1975-12-30 | Roussel Uclaf | Anti-inflammatory glycoprotein compositions and method of use |
| BE795417A (fr) * | 1972-02-15 | 1973-08-14 | Roussel Uclaf | Nouveaux composes d'origine-bacterienne et procede d'obtention |
| FR2253499B1 (enrdf_load_stackoverflow) * | 1973-12-10 | 1977-11-04 | Fabre Sa Pierre | |
| GB1518277A (en) * | 1974-09-06 | 1978-07-19 | Inst Rech Chem Et Biolog Appli | Antigenic composition |
| FR2307542A1 (fr) * | 1975-04-14 | 1976-11-12 | Synthelabo | Nouvelle preparation immunostimulante |
| FR2315944A1 (fr) * | 1975-07-04 | 1977-01-28 | Tournade Francois | Preparation pharmaceutique presentant une action de stimulation immunitaire non specifique de l'organisme |
-
1978
- 1978-05-26 CH CH580578A patent/CH633188A5/fr not_active IP Right Cessation
-
1979
- 1979-05-02 DE DE2917730A patent/DE2917730C2/de not_active Expired
- 1979-05-10 ES ES480448A patent/ES480448A1/es not_active Expired
- 1979-05-10 BE BE0/195087A patent/BE876164A/xx not_active IP Right Cessation
- 1979-05-17 CS CS793429A patent/CS222673B2/cs unknown
- 1979-05-22 RO RO7997611A patent/RO78451A/ro unknown
- 1979-05-23 DD DD79213101A patent/DD143729A5/de not_active IP Right Cessation
- 1979-05-23 FR FR7913157A patent/FR2426470A1/fr active Granted
- 1979-05-24 PL PL1979215824A patent/PL126416B1/pl unknown
- 1979-05-24 IT IT49157/79A patent/IT1116213B/it active
- 1979-05-25 JP JP6411579A patent/JPS54154509A/ja active Granted
- 1979-05-25 HU HU79LA957A patent/HU180005B/hu unknown
- 1979-05-25 GB GB7918310A patent/GB2021415B/en not_active Expired
- 1979-05-25 PT PT69674A patent/PT69674A/pt unknown
- 1979-05-25 YU YU1236/79A patent/YU41864B/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| DE2917730C2 (de) | 1986-04-03 |
| CH633188A5 (fr) | 1982-11-30 |
| RO78451A (ro) | 1982-02-26 |
| YU123679A (en) | 1983-04-30 |
| GB2021415B (en) | 1983-03-30 |
| YU41864B (en) | 1988-02-29 |
| HU180005B (en) | 1983-01-28 |
| PL126416B1 (en) | 1983-08-31 |
| FR2426470A1 (fr) | 1979-12-21 |
| IT1116213B (it) | 1986-02-10 |
| PT69674A (pt) | 1979-06-01 |
| GB2021415A (en) | 1979-12-05 |
| BE876164A (fr) | 1979-09-03 |
| JPS6337770B2 (enrdf_load_stackoverflow) | 1988-07-27 |
| ES480448A1 (es) | 1979-12-16 |
| JPS54154509A (en) | 1979-12-05 |
| CS222673B2 (en) | 1983-07-29 |
| DE2917730A1 (de) | 1979-11-29 |
| PL215824A1 (enrdf_load_stackoverflow) | 1980-02-11 |
| FR2426470B1 (enrdf_load_stackoverflow) | 1983-08-05 |
| IT7949157A0 (it) | 1979-05-24 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| ENJ | Ceased due to non-payment of renewal fee |