DD135824A5 - Verfahren zur herstellung eines guanidinderivats - Google Patents

Verfahren zur herstellung eines guanidinderivats

Info

Publication number
DD135824A5
DD135824A5 DD78204901A DD20490178A DD135824A5 DD 135824 A5 DD135824 A5 DD 135824A5 DD 78204901 A DD78204901 A DD 78204901A DD 20490178 A DD20490178 A DD 20490178A DD 135824 A5 DD135824 A5 DD 135824A5
Authority
DD
German Democratic Republic
Prior art keywords
preparing
guanidine derivative
guanidine
derivative
Prior art date
Application number
DD78204901A
Other languages
German (de)
English (en)
Inventor
Tobias O Yellin
David J Gilman
Derrick F Jones
James M Wardleworth
Original Assignee
Ici Ltd
Ici America Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ici Ltd, Ici America Inc filed Critical Ici Ltd
Publication of DD135824A5 publication Critical patent/DD135824A5/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/44—Iso-indoles; Hydrogenated iso-indoles
    • C07D209/48—Iso-indoles; Hydrogenated iso-indoles with oxygen atoms in positions 1 and 3, e.g. phthalimide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/88—Nitrogen atoms, e.g. allantoin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/38—Nitrogen atoms
    • C07D277/44—Acylated amino or imino radicals
    • C07D277/48—Acylated amino or imino radicals by radicals derived from carbonic acid, or sulfur or nitrogen analogues thereof, e.g. carbonylguanidines

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
DD78204901A 1977-04-20 1978-04-19 Verfahren zur herstellung eines guanidinderivats DD135824A5 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB1638977 1977-04-20

Publications (1)

Publication Number Publication Date
DD135824A5 true DD135824A5 (de) 1979-05-30

Family

ID=10076448

Family Applications (1)

Application Number Title Priority Date Filing Date
DD78204901A DD135824A5 (de) 1977-04-20 1978-04-19 Verfahren zur herstellung eines guanidinderivats

Country Status (28)

Country Link
US (4) US4165377A (xx)
JP (3) JPS53147069A (xx)
AR (1) AR223315A1 (xx)
AT (1) AT363099B (xx)
AU (1) AU516297B2 (xx)
BE (1) BE866156A (xx)
CA (1) CA1097658A (xx)
CS (2) CS200546B2 (xx)
DD (1) DD135824A5 (xx)
DK (1) DK172778A (xx)
ES (3) ES468985A1 (xx)
FI (1) FI781230A (xx)
FR (2) FR2387970A1 (xx)
GB (1) GB2060607B (xx)
GR (1) GR62452B (xx)
HU (1) HU176807B (xx)
IE (1) IE47044B1 (xx)
IL (1) IL54549A0 (xx)
IN (1) IN148903B (xx)
IT (1) IT1094469B (xx)
NL (1) NL190486C (xx)
NO (1) NO781300L (xx)
NZ (1) NZ186965A (xx)
PL (2) PL113054B1 (xx)
PT (1) PT67921B (xx)
SE (1) SE7804461L (xx)
SU (1) SU730299A3 (xx)
ZA (1) ZA782129B (xx)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2951675A1 (de) * 1979-08-02 1981-02-05 Yamanouchi Pharma Co Ltd Neue guanidinothiazolverbindungen, verfahren zu deren herstellung und arzneimittelzubereitungen

Families Citing this family (42)

* Cited by examiner, † Cited by third party
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IL49528A (en) * 1975-05-21 1980-11-30 Smith Kline French Lab Imidazolyl(or thiazolyl)methylthio(or butyl)guanidine or thiourea derivatives,their preparation and pharmaceutical compositions comprising them
DE2961923D1 (en) * 1978-01-18 1982-03-11 Ici Plc Antisecretory guanidine derivatives, processes for their manufacture and pharmaceutical compositions containing them
ATE1353T1 (de) * 1978-05-24 1982-08-15 Imperial Chemical Industries Plc Anti-sekretion thiadiazol-derivate, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische zusammensetzungen.
US4200578A (en) 1978-12-18 1980-04-29 Bristol-Myers Company Thiazole derivatives
EP0014057B1 (en) * 1979-01-18 1985-01-02 Imperial Chemical Industries Plc Guanidine derivatives, processes for their manufacture and pharmaceutical compositions containing them
US4521418A (en) * 1979-02-21 1985-06-04 Smith Kline & French Laboratories Limited Guanidinothiazolyl derivatives
PH16099A (en) * 1979-03-06 1983-06-24 Yamanouchi Pharma Co Ltd Guanidinothiazole compounds,process for preparing them and medical composition containing them
CH644369A5 (de) * 1979-05-03 1984-07-31 Sandoz Ag 2-amino-4-chlorthiazolverbindungen.
US4242351A (en) * 1979-05-07 1980-12-30 Imperial Chemical Industries Limited Antisecretory oxadiazoles and pharmaceutical compositions containing them
NL189197C (nl) * 1979-09-04 1993-02-01 Bristol Myers Squibb Co 3,4-digesubstitueerde-1,2,5-thiadiazool-1-oxiden en 1,1-dioxiden, bereiding daarvan alsmede farmaceutische preparaten.
US4359466A (en) * 1979-10-24 1982-11-16 Smith Kline & French Laboratories Limited Guanidine compounds
IL61234A (en) * 1979-10-24 1984-03-30 Smith Kline French Lab Guanidino thiazolyl alkylamino(alkylthioalkylamino)nitrotetrahydropyridines,process for preparing them and pharmaceutical compositions containing them
GR71929B (xx) * 1979-11-13 1983-08-19 Ici Ltd
NZ196923A (en) * 1980-04-29 1983-12-16 Shionogi & Co 2-guanidino-4-(-acylaminoalkyl(thio)methyl)thiazoles and analogs
DE3168031D1 (en) * 1980-07-30 1985-02-14 Ici Plc Guanidine derivatives
JPS57501379A (xx) * 1980-08-11 1982-08-05
US4904792A (en) * 1980-10-02 1990-02-27 Eli Lilly And Company N-thiazolymethylthioalkyl-N'-alkylamidines and related compounds
US4760075A (en) * 1980-10-02 1988-07-26 Eli Lilly And Company N-thiazolylmethylthioalkyl-N-alkyl-amidines and related compounds
US4374843A (en) * 1980-10-14 1983-02-22 Pfizer Inc. 2-Guanidino-4-heteroarylthiazoles
DE3270716D1 (en) * 1981-02-27 1986-05-28 Ici Plc Guanidino-substituted heterocyclic derivatives having histamine h-2 antagonist activity
CA1209998A (en) * 1981-03-09 1986-08-19 David J. Gilman Amide derivatives as histamine h-2 receptor antagonists
CA1233818A (en) * 1981-03-09 1988-03-08 David J. Gilman Guanidine derivatives as histamine h-2 receptor antagonists
US4460584A (en) * 1981-03-13 1984-07-17 Imperial Chemical Industries Plc Nitrogen heterocycles
IN158869B (xx) * 1981-03-18 1987-02-07 Ici Plc
EP0065823A1 (en) * 1981-05-13 1982-12-01 Imperial Chemical Industries Plc Heterocyclic guanidines as histamine H-2 antagonists
DE3267110D1 (de) * 1981-05-18 1985-12-05 Ici Plc Amidine derivatives
US4452987A (en) * 1981-08-20 1984-06-05 Pfizer Inc. Haloacetyl imidazoles
US4510313A (en) * 1981-08-20 1985-04-09 Pfizer Inc. 2-Guanidino-4-heteroarylthiazoles
US4590299A (en) * 1981-08-20 1986-05-20 Pfizer Inc. 2-guanidino-4-heteroarylthiazoles
JPS5872571A (ja) * 1981-10-27 1983-04-30 Shionogi & Co Ltd ２−グアニジノ−４−〔２−（ホルムアミド）エチルチオメチル〕チアゾ−ルの製法
US4647557A (en) * 1982-12-28 1987-03-03 Gerard Moinet Novel heterocyclic derivatives bearing an amino radical, processes for their production and the pharmaceutical compositions containing them
JPS59227870A (ja) * 1983-06-07 1984-12-21 Yamanouchi Pharmaceut Co Ltd 新規２−グアニジノチアゾリン誘導体ならびにその製造法
JPS60255756A (ja) * 1984-06-01 1985-12-17 Ikeda Mohandou:Kk アミノアルキルフエノキシ誘導体
JPS6160673A (ja) * 1984-08-30 1986-03-28 Yamanouchi Pharmaceut Co Ltd グアニジノチアゾ−ル誘導体の製造法
US4814341A (en) * 1986-08-26 1989-03-21 Reiter Lawrence A 2-guanidino-4-(2-furyl) thiazoles as antiulcer agents
WO1988003141A1 (en) * 1986-10-29 1988-05-05 Pfizer Inc. Processes for 2-(1-pentyl-3-guanidino)-4-(2-methyl-4-imidazolyl)thiazole and analogs
AU1117497A (en) * 1995-11-13 1997-06-05 Albany Medical College Analgesic compounds and uses thereof
US5731442A (en) * 1997-03-11 1998-03-24 Albemarle Corporation Synthesis of thiazole derivatives
US5856500A (en) * 1997-03-11 1999-01-05 Albemarle Corporation Synthesis of thiazole derivatives
WO1998040367A1 (en) * 1997-03-11 1998-09-17 Albemarle Corporation Novel thiazole derivatives and their preparation
JP6378179B2 (ja) * 2013-07-03 2018-08-22 株式会社新日本科学 新規化合物，有機カチオントランスポーター３の検出剤及び活性阻害剤
EP4196793A1 (en) 2020-08-11 2023-06-21 Université de Strasbourg H2 blockers targeting liver macrophages for the prevention and treatment of liver disease and cancer

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BE758146A (fr) 1969-10-29 1971-04-28 Smith Kline French Lab Derives de l'amidine
GB1305547A (xx) 1969-10-29 1973-02-07
BE758145A (fr) 1969-10-29 1971-04-28 Smith Kline French Lab Iso-thio-urees et derives
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GB1341376A (en) 1969-11-19 1973-12-19 Smith Kline French Lab Pharmaceutical compositions comprising 4-methyl-5-2-aminoethyl imidazole
CA946968A (en) 1970-05-18 1974-05-07 Xerox Corporation System for generating laser light of the three primary colors
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GB1336061A (en) 1971-02-03 1973-11-07 Ilford Ltd Photographic emulsions
US4049672A (en) * 1971-03-09 1977-09-20 Smith Kline & French Laboratories Limited 4-Methyl-5-imidazolylmethylthioethylamine and -S-methylisothiourea
US3905984A (en) * 1971-03-09 1975-09-16 Smith Kline French Lab Pyridyl substituted thioalkyl-and oxyalkyl-thioureas and ureas
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GB1531221A (en) 1974-09-02 1978-11-08 Smith Kline French Lab Process for preparing guanidine derivatives
GB1533378A (en) 1974-09-02 1978-11-22 Smith Kline French Lab Process for the preparation of heterocyclic substituted thioureas
GB1531231A (en) 1974-09-02 1978-11-08 Smith Kline French Lab Process for the production of cyanoguanidine derivatives
GB1542840A (en) 1975-02-03 1979-03-28 Smith Kline French Lab Heterocyclic dithiocarbamates and isothioureas
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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2951675A1 (de) * 1979-08-02 1981-02-05 Yamanouchi Pharma Co Ltd Neue guanidinothiazolverbindungen, verfahren zu deren herstellung und arzneimittelzubereitungen

Also Published As

Publication number Publication date
AT363099B (de) 1981-07-10
JPS59130277A (ja) 1984-07-26
PT67921B (en) 1979-11-14
BE866156A (fr) 1978-10-19
IT1094469B (it) 1985-08-02
IE780728L (en) 1978-10-20
FR2387970B1 (xx) 1983-03-25
PT67921A (en) 1978-05-01
JPS53147069A (en) 1978-12-21
NL7804159A (nl) 1978-10-24
PL206191A1 (pl) 1979-06-04
PL113054B1 (en) 1980-11-29
IN148903B (xx) 1981-07-18
NL190486B (nl) 1993-10-18
AU3510678A (en) 1979-10-18
GR62452B (en) 1979-04-12
ATA276978A (de) 1980-12-15
DK172778A (da) 1978-10-21
ZA782129B (en) 1979-03-28
JPS625907B2 (xx) 1987-02-07
ES477387A1 (es) 1979-10-16
AU516297B2 (en) 1981-05-28
FI781230A (fi) 1978-10-21
NZ186965A (en) 1980-02-21
IE47044B1 (en) 1983-12-14
NO781300L (no) 1978-10-23
IT7822558A0 (it) 1978-04-20
GB2060607A (en) 1981-05-07
JPS6156231B2 (xx) 1986-12-01
ES474929A1 (es) 1979-04-16
FR2519341B1 (xx) 1984-05-18
GB2060607B (en) 1982-03-31
US4347370A (en) 1982-08-31
FR2387970A1 (fr) 1978-11-17
HU176807B (en) 1981-05-28
JPS59130276A (ja) 1984-07-26
IL54549A0 (en) 1978-07-31
PL113082B1 (en) 1980-11-29
US4262126A (en) 1981-04-14
CS200545B2 (en) 1980-09-15
AR223315A1 (es) 1981-08-14
US4234735A (en) 1980-11-18
US4165377A (en) 1979-08-21
CS200546B2 (en) 1980-09-15
ES468985A1 (es) 1979-09-16
CA1097658A (en) 1981-03-17
JPS6335629B2 (xx) 1988-07-15
SE7804461L (sv) 1978-10-21
NL190486C (nl) 1994-03-16
SU730299A3 (ru) 1980-04-25
FR2519341A1 (fr) 1983-07-08

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