NL190486B - Guanidinederivaten en werkwijze voor de bereiding van een deel van deze guanidinederivaten. - Google Patents

Guanidinederivaten en werkwijze voor de bereiding van een deel van deze guanidinederivaten.

Info

Publication number
NL190486B
NL190486B NLAANVRAGE7804159,A NL7804159A NL190486B NL 190486 B NL190486 B NL 190486B NL 7804159 A NL7804159 A NL 7804159A NL 190486 B NL190486 B NL 190486B
Authority
NL
Netherlands
Prior art keywords
guanidine derivatives
preparing part
guanidine
derivatives
preparing
Prior art date
Application number
NLAANVRAGE7804159,A
Other languages
English (en)
Other versions
NL7804159A (nl
NL190486C (nl
Original Assignee
Ici Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ici Ltd filed Critical Ici Ltd
Publication of NL7804159A publication Critical patent/NL7804159A/nl
Publication of NL190486B publication Critical patent/NL190486B/nl
Application granted granted Critical
Publication of NL190486C publication Critical patent/NL190486C/nl

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D209/00Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/44Iso-indoles; Hydrogenated iso-indoles
    • C07D209/48Iso-indoles; Hydrogenated iso-indoles with oxygen atoms in positions 1 and 3, e.g. phthalimide
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D233/00Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/88Nitrogen atoms, e.g. allantoin
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D277/00Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/38Nitrogen atoms
    • C07D277/44Acylated amino or imino radicals
    • C07D277/48Acylated amino or imino radicals by radicals derived from carbonic acid, or sulfur or nitrogen analogues thereof, e.g. carbonylguanidines

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
NLAANVRAGE7804159,A 1977-04-20 1978-04-19 Guanidinederivaten en werkwijze voor de bereiding van een deel van deze guanidinederivaten. NL190486C (nl)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB1638977 1977-04-20

Publications (3)

Publication Number Publication Date
NL7804159A NL7804159A (nl) 1978-10-24
NL190486B true NL190486B (nl) 1993-10-18
NL190486C NL190486C (nl) 1994-03-16

Family

ID=10076448

Family Applications (1)

Application Number Title Priority Date Filing Date
NLAANVRAGE7804159,A NL190486C (nl) 1977-04-20 1978-04-19 Guanidinederivaten en werkwijze voor de bereiding van een deel van deze guanidinederivaten.

Country Status (28)

Country Link
US (4) US4165377A (nl)
JP (3) JPS53147069A (nl)
AR (1) AR223315A1 (nl)
AT (1) AT363099B (nl)
AU (1) AU516297B2 (nl)
BE (1) BE866156A (nl)
CA (1) CA1097658A (nl)
CS (2) CS200546B2 (nl)
DD (1) DD135824A5 (nl)
DK (1) DK172778A (nl)
ES (3) ES468985A1 (nl)
FI (1) FI781230A (nl)
FR (2) FR2387970A1 (nl)
GB (1) GB2060607B (nl)
GR (1) GR62452B (nl)
HU (1) HU176807B (nl)
IE (1) IE47044B1 (nl)
IL (1) IL54549A0 (nl)
IN (1) IN148903B (nl)
IT (1) IT1094469B (nl)
NL (1) NL190486C (nl)
NO (1) NO781300L (nl)
NZ (1) NZ186965A (nl)
PL (2) PL113054B1 (nl)
PT (1) PT67921B (nl)
SE (1) SE7804461L (nl)
SU (1) SU730299A3 (nl)
ZA (1) ZA782129B (nl)

Families Citing this family (43)

* Cited by examiner, † Cited by third party
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IL49528A (en) * 1975-05-21 1980-11-30 Smith Kline French Lab Imidazolyl(or thiazolyl)methylthio(or butyl)guanidine or thiourea derivatives,their preparation and pharmaceutical compositions comprising them
EP0003640B1 (en) * 1978-01-18 1982-01-27 Imperial Chemical Industries Plc Antisecretory guanidine derivatives, processes for their manufacture and pharmaceutical compositions containing them
ATE1353T1 (de) * 1978-05-24 1982-08-15 Imperial Chemical Industries Plc Anti-sekretion thiadiazol-derivate, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische zusammensetzungen.
US4200578A (en) 1978-12-18 1980-04-29 Bristol-Myers Company Thiazole derivatives
EP0014057B1 (en) * 1979-01-18 1985-01-02 Imperial Chemical Industries Plc Guanidine derivatives, processes for their manufacture and pharmaceutical compositions containing them
US4521418A (en) * 1979-02-21 1985-06-04 Smith Kline & French Laboratories Limited Guanidinothiazolyl derivatives
JPS6056143B2 (ja) * 1979-08-02 1985-12-09 山之内製薬株式会社 アミジン誘導体ならびにその製造法
PH16099A (en) * 1979-03-06 1983-06-24 Yamanouchi Pharma Co Ltd Guanidinothiazole compounds,process for preparing them and medical composition containing them
CH644369A5 (de) * 1979-05-03 1984-07-31 Sandoz Ag 2-amino-4-chlorthiazolverbindungen.
US4242351A (en) * 1979-05-07 1980-12-30 Imperial Chemical Industries Limited Antisecretory oxadiazoles and pharmaceutical compositions containing them
NL189197C (nl) * 1979-09-04 1993-02-01 Bristol Myers Squibb Co 3,4-digesubstitueerde-1,2,5-thiadiazool-1-oxiden en 1,1-dioxiden, bereiding daarvan alsmede farmaceutische preparaten.
US4359466A (en) * 1979-10-24 1982-11-16 Smith Kline & French Laboratories Limited Guanidine compounds
IL61234A (en) * 1979-10-24 1984-03-30 Smith Kline French Lab Guanidino thiazolyl alkylamino(alkylthioalkylamino)nitrotetrahydropyridines,process for preparing them and pharmaceutical compositions containing them
GR71929B (nl) * 1979-11-13 1983-08-19 Ici Ltd
NZ196923A (en) * 1980-04-29 1983-12-16 Shionogi & Co 2-guanidino-4-(-acylaminoalkyl(thio)methyl)thiazoles and analogs
EP0045155B1 (en) * 1980-07-30 1985-01-02 Imperial Chemical Industries Plc Guanidine derivatives
JPS57501379A (nl) * 1980-08-11 1982-08-05
US4760075A (en) * 1980-10-02 1988-07-26 Eli Lilly And Company N-thiazolylmethylthioalkyl-N-alkyl-amidines and related compounds
US4904792A (en) * 1980-10-02 1990-02-27 Eli Lilly And Company N-thiazolymethylthioalkyl-N'-alkylamidines and related compounds
US4374843A (en) * 1980-10-14 1983-02-22 Pfizer Inc. 2-Guanidino-4-heteroarylthiazoles
EP0059597B1 (en) * 1981-02-27 1986-04-23 Imperial Chemical Industries Plc Guanidino-substituted heterocyclic derivatives having histamine h-2 antagonist activity
CA1209998A (en) * 1981-03-09 1986-08-19 David J. Gilman Amide derivatives as histamine h-2 receptor antagonists
CA1233818A (en) * 1981-03-09 1988-03-08 David J. Gilman Guanidine derivatives as histamine h-2 receptor antagonists
US4460584A (en) * 1981-03-13 1984-07-17 Imperial Chemical Industries Plc Nitrogen heterocycles
IN158869B (nl) * 1981-03-18 1987-02-07 Ici Plc
EP0065823A1 (en) * 1981-05-13 1982-12-01 Imperial Chemical Industries Plc Heterocyclic guanidines as histamine H-2 antagonists
DE3267110D1 (de) * 1981-05-18 1985-12-05 Ici Plc Amidine derivatives
US4590299A (en) * 1981-08-20 1986-05-20 Pfizer Inc. 2-guanidino-4-heteroarylthiazoles
US4510313A (en) * 1981-08-20 1985-04-09 Pfizer Inc. 2-Guanidino-4-heteroarylthiazoles
US4452987A (en) * 1981-08-20 1984-06-05 Pfizer Inc. Haloacetyl imidazoles
JPS5872571A (ja) * 1981-10-27 1983-04-30 Shionogi & Co Ltd 2−グアニジノ−4−〔2−(ホルムアミド)エチルチオメチル〕チアゾ−ルの製法
US4647557A (en) * 1982-12-28 1987-03-03 Gerard Moinet Novel heterocyclic derivatives bearing an amino radical, processes for their production and the pharmaceutical compositions containing them
JPS59227870A (ja) * 1983-06-07 1984-12-21 Yamanouchi Pharmaceut Co Ltd 新規2−グアニジノチアゾリン誘導体ならびにその製造法
JPS60255756A (ja) * 1984-06-01 1985-12-17 Ikeda Mohandou:Kk アミノアルキルフエノキシ誘導体
JPS6160673A (ja) * 1984-08-30 1986-03-28 Yamanouchi Pharmaceut Co Ltd グアニジノチアゾ−ル誘導体の製造法
US4814341A (en) * 1986-08-26 1989-03-21 Reiter Lawrence A 2-guanidino-4-(2-furyl) thiazoles as antiulcer agents
WO1988003141A1 (en) * 1986-10-29 1988-05-05 Pfizer Inc. Processes for 2-(1-pentyl-3-guanidino)-4-(2-methyl-4-imidazolyl)thiazole and analogs
JP2001526625A (ja) * 1995-11-13 2001-12-18 オールバニ メジカル カレッジ 鎮痛性化合物およびその使用
US5731442A (en) * 1997-03-11 1998-03-24 Albemarle Corporation Synthesis of thiazole derivatives
US5856500A (en) * 1997-03-11 1999-01-05 Albemarle Corporation Synthesis of thiazole derivatives
WO1998040367A1 (en) * 1997-03-11 1998-09-17 Albemarle Corporation Novel thiazole derivatives and their preparation
US9745274B2 (en) 2013-07-03 2017-08-29 Shin Nippon Biomedical Laboratories, Ltd. Compound, organic cation transporter 3 detection agent, and organic cation transporter 3 activity inhibitor
EP4196793A1 (en) 2020-08-11 2023-06-21 Université de Strasbourg H2 blockers targeting liver macrophages for the prevention and treatment of liver disease and cancer

Family Cites Families (52)

* Cited by examiner, † Cited by third party
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GB1305548A (nl) 1969-10-29 1973-02-07
GB1305549A (nl) 1969-10-29 1973-02-07
BE758146A (fr) 1969-10-29 1971-04-28 Smith Kline French Lab Derives de l'amidine
BE758145A (fr) 1969-10-29 1971-04-28 Smith Kline French Lab Iso-thio-urees et derives
GB1305547A (nl) 1969-10-29 1973-02-07
GB1305550A (nl) 1969-10-29 1973-02-07
GB1341375A (en) 1969-11-19 1973-12-19 Smith Kline French Lab Aminoalkylimidazoles and process for their production
GB1341376A (en) 1969-11-19 1973-12-19 Smith Kline French Lab Pharmaceutical compositions comprising 4-methyl-5-2-aminoethyl imidazole
CA946968A (en) 1970-05-18 1974-05-07 Xerox Corporation System for generating laser light of the three primary colors
GB1307539A (en) 1970-06-25 1973-02-21 Smith Kline French Lab Thiourea derivatives
GB1336061A (en) 1971-02-03 1973-11-07 Ilford Ltd Photographic emulsions
US4049672A (en) * 1971-03-09 1977-09-20 Smith Kline & French Laboratories Limited 4-Methyl-5-imidazolylmethylthioethylamine and -S-methylisothiourea
GB1338169A (en) * 1971-03-09 1973-11-21 Smith Kline French Lab Ureas thioureas and guanidines
US4053473A (en) * 1971-07-22 1977-10-11 Smith Kline & French Laboratories Limited Pharmacologically active thiourea and urea compounds
US4018931A (en) * 1971-03-09 1977-04-19 Smith Kline & French Laboratories Limited Pharmacologically active thiourea and urea compounds
US3950353A (en) * 1971-03-09 1976-04-13 Smith Kline & French Laboratories Limited Pharmacologically active thiourea and urea compounds
US3905984A (en) * 1971-03-09 1975-09-16 Smith Kline French Lab Pyridyl substituted thioalkyl-and oxyalkyl-thioureas and ureas
GB1395929A (en) 1972-08-08 1975-05-29 Smith Kline French Lab Thioureas
US3932427A (en) * 1971-03-09 1976-01-13 Smith Kline & French Laboratories, Inc. Pyridyl substituted aminoalkyl-thioureas and ureas
US4018928A (en) * 1971-03-09 1977-04-19 Smith Kline & French Laboratories Limited Pyridyl substituted aminoalkyl-thioureas and ureas
GB1399283A (en) 1972-04-20 1975-07-02 Smith Kline French Lab Pharmaceutical compositions
GB1400319A (en) 1972-04-20 1975-07-16 Smith Kline French Lab Pharmaceutical compositions
US3975530A (en) * 1972-09-05 1976-08-17 Smith Kline & French Laboratories Limited N-cyano-N'-heterocyclic-alkyl quanidine inhibitors of H2 histamine receptors
US3920822A (en) * 1972-09-05 1975-11-18 Smith Kline French Lab Inhibition of histamine activity with cyanoguanidines
GB1397436A (en) 1972-09-05 1975-06-11 Smith Kline French Lab Heterocyclic n-cyanoguinidines
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GB1493931A (en) 1974-02-07 1977-11-30 Smith Kline French Lab Guanidines isothioureas and thioureas
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GB1531221A (en) 1974-09-02 1978-11-08 Smith Kline French Lab Process for preparing guanidine derivatives
GB1533378A (en) 1974-09-02 1978-11-22 Smith Kline French Lab Process for the preparation of heterocyclic substituted thioureas
GB1530895A (en) 1974-09-02 1978-11-01 Smith Kline French Lab Electrochemical reduction of 4-imidazole carboxylic acids
GB1533380A (en) 1974-09-02 1978-11-22 Smith Kline French Lab Process for the preparation of heterocyclic substituted thioureas and h-cyanoguanidines
GB1531231A (en) 1974-09-02 1978-11-08 Smith Kline French Lab Process for the production of cyanoguanidine derivatives
GB1533379A (en) 1974-09-02 1978-11-22 Smith Kline French Lab Process for the preparation of heterocyclic substituted ureas
GB1542840A (en) 1975-02-03 1979-03-28 Smith Kline French Lab Heterocyclic dithiocarbamates and isothioureas
GB1554153A (en) 1975-05-15 1979-10-17 Smith Kline French Lab Process for making 2-amino-2-alkylthionitroethylenes
GB1563090A (en) 1975-07-31 1980-03-19 Smith Kline French Lab Cyclobutene-diones
FR2317591B1 (fr) 1975-07-08 1979-06-15 Clarel Appareil d'eclairage pour lampes fluorescentes
GB1564502A (en) 1975-07-31 1980-04-10 Smith Kline French Lab Guanidines thioureas and 1,1-diamino-2-nitroethylene derivatives
GB1565647A (en) 1975-07-31 1980-04-23 Smith Kline French Lab Pharmacologically active compounds 4-substituted-imidazole-5-methanols
IN146736B (nl) 1975-10-02 1979-08-25 Smith Kline French Lab
US4099672A (en) * 1977-02-28 1978-07-11 Ray Albert Sheahan Shower-head fixture
US4309435A (en) * 1978-10-16 1982-01-05 Imperial Chemical Industries Ltd. Antisecretory guanidine derivatives and pharmaceutical compositions containing them
JPS6056143B2 (ja) * 1979-08-02 1985-12-09 山之内製薬株式会社 アミジン誘導体ならびにその製造法

Also Published As

Publication number Publication date
JPS6335629B2 (nl) 1988-07-15
BE866156A (fr) 1978-10-19
FR2387970A1 (fr) 1978-11-17
IN148903B (nl) 1981-07-18
FI781230A (fi) 1978-10-21
JPS59130276A (ja) 1984-07-26
JPS59130277A (ja) 1984-07-26
PT67921B (en) 1979-11-14
FR2519341B1 (nl) 1984-05-18
IT7822558A0 (it) 1978-04-20
AT363099B (de) 1981-07-10
US4234735A (en) 1980-11-18
SE7804461L (sv) 1978-10-21
DD135824A5 (de) 1979-05-30
JPS625907B2 (nl) 1987-02-07
NL7804159A (nl) 1978-10-24
FR2519341A1 (fr) 1983-07-08
PT67921A (en) 1978-05-01
PL113082B1 (en) 1980-11-29
FR2387970B1 (nl) 1983-03-25
ZA782129B (en) 1979-03-28
ES477387A1 (es) 1979-10-16
ES474929A1 (es) 1979-04-16
ATA276978A (de) 1980-12-15
AR223315A1 (es) 1981-08-14
AU3510678A (en) 1979-10-18
JPS53147069A (en) 1978-12-21
CS200545B2 (en) 1980-09-15
JPS6156231B2 (nl) 1986-12-01
CA1097658A (en) 1981-03-17
NL190486C (nl) 1994-03-16
GB2060607B (en) 1982-03-31
CS200546B2 (en) 1980-09-15
NO781300L (no) 1978-10-23
US4165377A (en) 1979-08-21
IL54549A0 (en) 1978-07-31
IE780728L (en) 1978-10-20
GB2060607A (en) 1981-05-07
IT1094469B (it) 1985-08-02
GR62452B (en) 1979-04-12
SU730299A3 (ru) 1980-04-25
IE47044B1 (en) 1983-12-14
ES468985A1 (es) 1979-09-16
AU516297B2 (en) 1981-05-28
NZ186965A (en) 1980-02-21
US4262126A (en) 1981-04-14
PL206191A1 (pl) 1979-06-04
US4347370A (en) 1982-08-31
DK172778A (da) 1978-10-21
PL113054B1 (en) 1980-11-29
HU176807B (en) 1981-05-28

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Legal Events

Date Code Title Description
A85 Still pending on 85-01-01
BA A request for search or an international-type search has been filed
BB A search report has been drawn up
BC A request for examination has been filed
TNT Modifications of names of proprietors of patents or applicants of examined patent applications

Owner name: IMPERIAL CHEMICAL INDUSTRIES PLC

TNT Modifications of names of proprietors of patents or applicants of examined patent applications

Owner name: IMPERIAL CHEMICAL INDUSTRIES PLC

V4 Discontinued because of reaching the maximum lifetime of a patent

Free format text: 980419