DD130477A5 - Verfahren zur herstellung von mercaptoacylaminosaeuren und deren salzen - Google Patents

Verfahren zur herstellung von mercaptoacylaminosaeuren und deren salzen

Info

Publication number
DD130477A5
DD130477A5 DD7700198728A DD19872877A DD130477A5 DD 130477 A5 DD130477 A5 DD 130477A5 DD 7700198728 A DD7700198728 A DD 7700198728A DD 19872877 A DD19872877 A DD 19872877A DD 130477 A5 DD130477 A5 DD 130477A5
Authority
DD
German Democratic Republic
Prior art keywords
mercaptoacylaminosaures
salts
production
Prior art date
Application number
DD7700198728A
Other languages
English (en)
Inventor
David W Cushman
Miguel A Ondetti
Original Assignee
Squibb & Sons Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Squibb & Sons Inc filed Critical Squibb & Sons Inc
Publication of DD130477A5 publication Critical patent/DD130477A5/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C319/00—Preparation of thiols, sulfides, hydropolysulfides or polysulfides
    • C07C319/14—Preparation of thiols, sulfides, hydropolysulfides or polysulfides of sulfides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D209/20—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals substituted additionally by nitrogen atoms, e.g. tryptophane
DD7700198728A 1976-05-10 1977-05-03 Verfahren zur herstellung von mercaptoacylaminosaeuren und deren salzen DD130477A5 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US05/684,606 US4053651A (en) 1976-05-10 1976-05-10 Compounds and method for alleviating angiotensin related hypertension

Publications (1)

Publication Number Publication Date
DD130477A5 true DD130477A5 (de) 1978-04-05

Family

ID=24748765

Family Applications (1)

Application Number Title Priority Date Filing Date
DD7700198728A DD130477A5 (de) 1976-05-10 1977-05-03 Verfahren zur herstellung von mercaptoacylaminosaeuren und deren salzen

Country Status (21)

Country Link
US (2) US4053651A (de)
JP (1) JPS52136117A (de)
AU (1) AU513622B2 (de)
BE (1) BE854458A (de)
CA (1) CA1119177A (de)
CH (2) CH620202A5 (de)
CS (1) CS204001B2 (de)
DD (1) DD130477A5 (de)
DE (1) DE2717548A1 (de)
DK (1) DK203177A (de)
FR (2) FR2372624A1 (de)
GB (1) GB1577415A (de)
HU (1) HU177750B (de)
IE (1) IE44821B1 (de)
NL (1) NL7704712A (de)
NO (1) NO771623L (de)
PL (2) PL107991B1 (de)
SE (1) SE7705382L (de)
SU (3) SU818479A3 (de)
YU (1) YU116877A (de)
ZA (1) ZA772256B (de)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0009898A1 (de) * 1978-09-11 1980-04-16 University Of Miami Anti-hypertensive Mercaptoacylaminosäurederivate, ihre Herstellung und Verwendung

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US4091024A (en) * 1976-12-03 1978-05-23 E. R. Squibb & Sons, Inc. Pyrrolidine and piperidine-2-carboxylic acid derivatives
US4176235A (en) * 1976-12-03 1979-11-27 E. R. Squibb & Sons, Inc. Substituted acyl derivatives of amino acids
US4116962A (en) * 1976-12-03 1978-09-26 E. R. Squibb & Sons, Inc. Pyrrolidine and piperidine-2-carboxylic acid derivatives
US4178291A (en) * 1976-12-03 1979-12-11 E. R. Squibb & Sons, Inc. Substituted acyl derivatives of amino acids
US4206121A (en) * 1976-12-03 1980-06-03 E. R. Squibb & Sons, Inc. Substituted acyl derivatives of amino acids
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US4113715A (en) * 1977-01-17 1978-09-12 E. R. Squibb & Sons, Inc. Amino acid derivatives
US4611002A (en) * 1977-07-14 1986-09-09 E. R. Squibb And Sons, Inc. Carboxymethyl esters of mercaptopropanoic acids as enkephalinase inhibitors
US4206137A (en) * 1978-03-27 1980-06-03 E. R. Squibb & Sons, Inc. Thioalkanoylalkanoic acid compounds
US4927853A (en) * 1978-04-24 1990-05-22 Massachusetts Institute Of Technology Composition for increasing blood pressure
US4690940A (en) * 1979-08-14 1987-09-01 University Of Miami Anti-hypertensive agents
US4690938A (en) * 1979-08-14 1987-09-01 University Of Miami Anti-hypertensive agents
US4698356A (en) * 1979-08-14 1987-10-06 University Of Miami Anti-hypertensive agents
US4695577A (en) * 1979-08-14 1987-09-22 University Of Miami Anti-hypertensive agents
US4690937A (en) * 1979-08-14 1987-09-01 University Of Miami Anti-hypertensive agents
US4698355A (en) * 1979-08-14 1987-10-06 University Of Miami Anti-hypertensive agents
US4690939A (en) * 1979-08-14 1987-09-01 University Of Miami Anti-hypertensive agents
ZA794723B (en) * 1978-09-11 1980-08-27 Univ Miami Anti-hypertensive agents
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JPS6058908B2 (ja) * 1978-10-11 1985-12-23 参天製薬株式会社 システイン誘導体
US4211786A (en) * 1979-03-08 1980-07-08 E. R. Squibb & Sons, Inc. Mercaptoacyldihydropyrazole carboxylic acid derivatives
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US4565825A (en) * 1979-07-13 1986-01-21 Usv Pharmaceutical Corp. Antihypertensive N-benzimidazolyl- and N-imidazolyl-amino acid derivatives
US4256761A (en) * 1979-07-13 1981-03-17 Usv Pharmaceutical Corporation Antihypertensive amides
US4549992A (en) * 1979-07-13 1985-10-29 Usv Pharmaceutical Corp. Antihypertensive amides
DE2951353A1 (de) * 1979-12-20 1981-07-02 Basf Ag, 6700 Ludwigshafen Kationische farbstoffe
PT70158A1 (en) * 1980-03-03 1982-03-01 Univ Miami Process for preparing anti-hypertensive agents
US4690936A (en) * 1980-03-05 1987-09-01 University Of Miami Anti-hypertensive agents
US4692458A (en) * 1980-03-05 1987-09-08 University Of Miami Anti-hypertensive agents
US4734420A (en) * 1980-03-05 1988-03-29 University Of Miami Anti-hypertensive agents
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US4432971A (en) * 1981-08-03 1984-02-21 E. R. Squibb & Sons, Inc. Phosphonamidate compounds
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US4474795A (en) * 1981-10-09 1984-10-02 E. R. Squibb & Sons, Inc. Enkephalinase inhibitors
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US4396772A (en) * 1981-11-23 1983-08-02 F. R. Squibb & Sons, Inc. Phosphinylalkanoyl amino acids
IT1140394B (it) * 1981-12-23 1986-09-24 Maggioni Farma Dipeptidi contenenti un residuo di metionina ad attivita' epatoprotettrice
US4555506A (en) * 1981-12-24 1985-11-26 E. R. Squibb & Sons, Inc. Phosphorus containing compounds and use as hypotensives
JPS58140065A (ja) * 1982-02-10 1983-08-19 Meito Sangyo Kk メルカプトベンジル脂肪酸誘導体類及びその製法
US4560680A (en) * 1982-03-15 1985-12-24 E. R. Squibb & Sons, Inc. Aminoalkyl and related substituted phosphinic acid angiotensin converting enzyme inhibitors
US4452791A (en) * 1982-03-15 1984-06-05 E. R. Squibb & Sons, Inc. Aminoalkyl and related substituted phosphinic acid angiotensin converting enzyme inhibitors
US4452790A (en) * 1982-06-23 1984-06-05 E. R. Squibb & Sons, Inc. Phosphonyl hydroxyacyl amino acid derivatives as antihypertensives
US4703043A (en) * 1982-06-23 1987-10-27 E. R. Squibb & Sons, Inc. Phosphonyl hydroxyacyl amino acid derivatives as antihypertensive
US4616005A (en) * 1982-06-23 1986-10-07 E. R. Squibb & Sons, Inc. Phosphonyl hydroxyacyl amino acid derivatives as antihypertensives
US4470973A (en) * 1982-07-19 1984-09-11 E. R. Squibb & Sons, Inc. Substituted peptide compounds
US4736066A (en) * 1982-07-19 1988-04-05 E. R. Squibb & Sons, Inc. Intermediate for substituted peptide compounds
US4661515A (en) * 1982-07-21 1987-04-28 Usv Pharmaceutical Corporation Compounds having angiotensin converting enzyme inhibitory activity and diuretic activity
IL69228A0 (en) * 1982-07-21 1983-11-30 Usv Pharma Corp Compounds having diuretic activity and angiotensin converting inhibitory activity,methods of the preparation thereof and pharmaceutical compositions containing the same
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US4742067A (en) * 1982-07-22 1988-05-03 E. R. Squibb & Sons, Inc. Acylalkylaminocarbonyl substituted amino and imino acid compounds
US4621092A (en) * 1982-07-22 1986-11-04 E. R. Squibb & Sons, Inc. Substituted proline compounds, composition and method of use
US4524212A (en) * 1982-09-27 1985-06-18 E. R. Squibb & Sons, Inc. Acyloxyketone substituted imino and amino acids
FR2540495B1 (fr) * 1983-02-07 1986-02-14 Roussel Uclaf Nouveaux derives de o-mercaptopropanamide et de ses homologues, leur procede de preparation, leur application comme medicaments, les compositions les renfermant et les nouveaux intermediaires obtenus
US4798904A (en) * 1983-10-03 1989-01-17 E. R. Squibb & Sons, Inc. Certain [(lower alkanoyl-thio)methyl-1-oxo-3-phenyl propyl amino]benzene lower alkanoic acid or ester derivatives which inhibit enkephalinase
US4722810A (en) * 1984-08-16 1988-02-02 E. R. Squibb & Sons, Inc. Enkephalinase inhibitors
US4774256A (en) * 1983-10-03 1988-09-27 E. R. Squibb & Sons, Inc. Use of enkephalinase inhibitors as analgesic agents
US4595700A (en) * 1984-12-21 1986-06-17 G. D. Searle & Co. Thiol based collagenase inhibitors
US4929641B1 (en) * 1988-05-11 1994-08-30 Schering Corp Mercapto-acylamino acid antihypertensives
EP0254032A3 (de) * 1986-06-20 1990-09-05 Schering Corporation Hemmer der neutralen Metallendopeptidase zur Behandlung von Hypertension
US4801609B1 (en) * 1987-03-27 1993-11-09 Mercapto-acylamino acid antihypertensives
US5262436A (en) * 1987-03-27 1993-11-16 Schering Corporation Acylamino acid antihypertensives in the treatment of congestive heart failure
CA1337400C (en) * 1987-06-08 1995-10-24 Norma G. Delaney Inhibitors of neutral endopeptidase
US5210266A (en) * 1987-12-03 1993-05-11 Dainippon Pharmaceutical Co., Ltd. N-substituted mercaptopropanamide derivatives
EP0318859A3 (de) * 1987-12-03 1990-08-16 Dainippon Pharmaceutical Co., Ltd. N-Substituierte Mercaptopropionamid-Derivate
US5179125A (en) * 1987-12-03 1993-01-12 Dainippon Pharmaceutical Co., Ltd. N-substituted mercaptopropanamide derivatives
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US5002964A (en) * 1988-06-15 1991-03-26 Brigham & Women's Hospital S-nitrosocaptopril compounds and the use thereof
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US5187183A (en) * 1988-06-15 1993-02-16 Brigham & Women's Hospital S-nitroso derivatives of ACE inhibitors and the use thereof
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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0009898A1 (de) * 1978-09-11 1980-04-16 University Of Miami Anti-hypertensive Mercaptoacylaminosäurederivate, ihre Herstellung und Verwendung

Also Published As

Publication number Publication date
JPS6120544B2 (de) 1986-05-22
SU818479A3 (ru) 1981-03-30
DK203177A (da) 1977-11-11
SU697049A3 (ru) 1979-11-05
IE44821L (en) 1977-11-10
PL107991B1 (pl) 1980-03-31
PL106032B1 (pl) 1979-11-30
JPS52136117A (en) 1977-11-14
GB1577415A (en) 1980-10-22
YU116877A (en) 1982-08-31
FR2372624A1 (fr) 1978-06-30
US4053651A (en) 1977-10-11
FR2367741B1 (de) 1982-10-29
HU177750B (en) 1981-12-28
CH621763A5 (de) 1981-02-27
ZA772256B (en) 1978-03-29
NO771623L (no) 1977-11-11
SU955857A3 (ru) 1982-08-30
CH620202A5 (de) 1980-11-14
FR2367741A1 (fr) 1978-05-12
DE2717548A1 (de) 1977-12-01
IE44821B1 (en) 1982-04-07
DE2717548C2 (de) 1990-05-03
FR2372624B1 (de) 1980-05-09
US4112119A (en) 1978-09-05
CA1119177A (en) 1982-03-02
AU2410677A (en) 1978-10-12
CS204001B2 (en) 1981-03-31
SE7705382L (sv) 1977-11-11
AU513622B2 (en) 1980-12-11
BE854458A (fr) 1977-11-10
PL197963A1 (pl) 1978-03-28
NL7704712A (nl) 1977-11-14

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