SE7705382L - Forfarande for framstellning av foreningar som lindrar angiotensinforbunden hypertension - Google Patents

Forfarande for framstellning av foreningar som lindrar angiotensinforbunden hypertension

Info

Publication number
SE7705382L
SE7705382L SE7705382A SE7705382A SE7705382L SE 7705382 L SE7705382 L SE 7705382L SE 7705382 A SE7705382 A SE 7705382A SE 7705382 A SE7705382 A SE 7705382A SE 7705382 L SE7705382 L SE 7705382L
Authority
SE
Sweden
Prior art keywords
hypertension
angiotensian
associations
relieve
association
Prior art date
Application number
SE7705382A
Other languages
English (en)
Inventor
M A Ondetti
D W Cushman
Original Assignee
Squibb & Sons Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Squibb & Sons Inc filed Critical Squibb & Sons Inc
Publication of SE7705382L publication Critical patent/SE7705382L/sv

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C319/00—Preparation of thiols, sulfides, hydropolysulfides or polysulfides
    • C07C319/14—Preparation of thiols, sulfides, hydropolysulfides or polysulfides of sulfides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D209/20—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals substituted additionally by nitrogen atoms, e.g. tryptophane

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Indole Compounds (AREA)
SE7705382A 1976-05-10 1977-05-09 Forfarande for framstellning av foreningar som lindrar angiotensinforbunden hypertension SE7705382L (sv)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US05/684,606 US4053651A (en) 1976-05-10 1976-05-10 Compounds and method for alleviating angiotensin related hypertension

Publications (1)

Publication Number Publication Date
SE7705382L true SE7705382L (sv) 1977-11-11

Family

ID=24748765

Family Applications (1)

Application Number Title Priority Date Filing Date
SE7705382A SE7705382L (sv) 1976-05-10 1977-05-09 Forfarande for framstellning av foreningar som lindrar angiotensinforbunden hypertension

Country Status (21)

Country Link
US (2) US4053651A (sv)
JP (1) JPS52136117A (sv)
AU (1) AU513622B2 (sv)
BE (1) BE854458A (sv)
CA (1) CA1119177A (sv)
CH (2) CH620202A5 (sv)
CS (1) CS204001B2 (sv)
DD (1) DD130477A5 (sv)
DE (1) DE2717548A1 (sv)
DK (1) DK203177A (sv)
FR (2) FR2372624A1 (sv)
GB (1) GB1577415A (sv)
HU (1) HU177750B (sv)
IE (1) IE44821B1 (sv)
NL (1) NL7704712A (sv)
NO (1) NO771623L (sv)
PL (2) PL107991B1 (sv)
SE (1) SE7705382L (sv)
SU (3) SU818479A3 (sv)
YU (1) YU116877A (sv)
ZA (1) ZA772256B (sv)

Families Citing this family (112)

* Cited by examiner, † Cited by third party
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US4339600A (en) * 1976-05-10 1982-07-13 E. R. Squibb & Sons, Inc. Compounds for alleviating angiotensin related hypertension
US4175199A (en) * 1976-12-03 1979-11-20 E. R. Squibb & Sons, Inc. Substituted acyl derivatives of amino acids
US4091024A (en) * 1976-12-03 1978-05-23 E. R. Squibb & Sons, Inc. Pyrrolidine and piperidine-2-carboxylic acid derivatives
US4116962A (en) * 1976-12-03 1978-09-26 E. R. Squibb & Sons, Inc. Pyrrolidine and piperidine-2-carboxylic acid derivatives
US4206121A (en) * 1976-12-03 1980-06-03 E. R. Squibb & Sons, Inc. Substituted acyl derivatives of amino acids
US4178291A (en) * 1976-12-03 1979-12-11 E. R. Squibb & Sons, Inc. Substituted acyl derivatives of amino acids
US4176235A (en) * 1976-12-03 1979-11-27 E. R. Squibb & Sons, Inc. Substituted acyl derivatives of amino acids
US4113715A (en) * 1977-01-17 1978-09-12 E. R. Squibb & Sons, Inc. Amino acid derivatives
US4611002A (en) * 1977-07-14 1986-09-09 E. R. Squibb And Sons, Inc. Carboxymethyl esters of mercaptopropanoic acids as enkephalinase inhibitors
US4206137A (en) * 1978-03-27 1980-06-03 E. R. Squibb & Sons, Inc. Thioalkanoylalkanoic acid compounds
US4927853A (en) * 1978-04-24 1990-05-22 Massachusetts Institute Of Technology Composition for increasing blood pressure
GR73585B (sv) * 1978-09-11 1984-03-26 Univ Miami
US4690939A (en) * 1979-08-14 1987-09-01 University Of Miami Anti-hypertensive agents
US4698355A (en) * 1979-08-14 1987-10-06 University Of Miami Anti-hypertensive agents
US4695577A (en) * 1979-08-14 1987-09-22 University Of Miami Anti-hypertensive agents
US4698356A (en) * 1979-08-14 1987-10-06 University Of Miami Anti-hypertensive agents
US4690937A (en) * 1979-08-14 1987-09-01 University Of Miami Anti-hypertensive agents
US4690938A (en) * 1979-08-14 1987-09-01 University Of Miami Anti-hypertensive agents
US4690940A (en) * 1979-08-14 1987-09-01 University Of Miami Anti-hypertensive agents
ZA794723B (en) * 1978-09-11 1980-08-27 Univ Miami Anti-hypertensive agents
JPS6058908B2 (ja) * 1978-10-11 1985-12-23 参天製薬株式会社 システイン誘導体
JPS6011888B2 (ja) * 1978-10-11 1985-03-28 参天製薬株式会社 リウマチ疾患治療薬
US4211786A (en) * 1979-03-08 1980-07-08 E. R. Squibb & Sons, Inc. Mercaptoacyldihydropyrazole carboxylic acid derivatives
US4235885A (en) * 1979-06-25 1980-11-25 E. R. Squibb & Sons, Inc. Inhibitors of mammalian collagenase
US4549992A (en) * 1979-07-13 1985-10-29 Usv Pharmaceutical Corp. Antihypertensive amides
US4565825A (en) * 1979-07-13 1986-01-21 Usv Pharmaceutical Corp. Antihypertensive N-benzimidazolyl- and N-imidazolyl-amino acid derivatives
US4256761A (en) * 1979-07-13 1981-03-17 Usv Pharmaceutical Corporation Antihypertensive amides
DE2951353A1 (de) * 1979-12-20 1981-07-02 Basf Ag, 6700 Ludwigshafen Kationische farbstoffe
PT70158A1 (en) * 1980-03-03 1982-03-01 Univ Miami Process for preparing anti-hypertensive agents
US4690936A (en) * 1980-03-05 1987-09-01 University Of Miami Anti-hypertensive agents
US4692458A (en) * 1980-03-05 1987-09-08 University Of Miami Anti-hypertensive agents
US4734420A (en) * 1980-03-05 1988-03-29 University Of Miami Anti-hypertensive agents
US4482725A (en) * 1980-04-03 1984-11-13 E. R. Squibb & Sons, Inc. S-Acylation products of mercaptoacyl amino acids and carboxyl group containing diuretics
FR2480747A1 (fr) * 1980-04-17 1981-10-23 Roques Bernard Derives d'acides amines et leur application therapeutique
ZA811340B (en) * 1980-06-09 1982-03-31 Morton Norwich Products Inc N-(cycloalkyl)amino acid compounds
AU543804B2 (en) * 1980-10-31 1985-05-02 Takeda Chemical Industries Ltd. Amides having bicyclic substituents on nitrogen
US4521607A (en) * 1981-02-27 1985-06-04 Takeda Chemical Industries, Ltd. Chromanyl glycines
JPS57142962A (en) * 1981-02-28 1982-09-03 Santen Pharmaceut Co Ltd Cyclodextrin clathrate compound of sulfur-containing compound
US4329495A (en) * 1981-05-18 1982-05-11 Pfizer Inc. Enkephalinase enzyme inhibiting compounds
US4432972A (en) * 1981-08-03 1984-02-21 E. R. Squibb & Sons, Inc. Phosphonamidate compounds
US4432971A (en) * 1981-08-03 1984-02-21 E. R. Squibb & Sons, Inc. Phosphonamidate compounds
US4401677A (en) * 1981-10-09 1983-08-30 E. R. Squibb & Sons, Inc. Enkephalinase inhibitors
US4474799A (en) * 1981-10-09 1984-10-02 E. R. Squibb & Sons, Inc. Enkephalinase inhibitors
US4474795A (en) * 1981-10-09 1984-10-02 E. R. Squibb & Sons, Inc. Enkephalinase inhibitors
US4396772A (en) * 1981-11-23 1983-08-02 F. R. Squibb & Sons, Inc. Phosphinylalkanoyl amino acids
IT1140394B (it) * 1981-12-23 1986-09-24 Maggioni Farma Dipeptidi contenenti un residuo di metionina ad attivita' epatoprotettrice
US4555506A (en) * 1981-12-24 1985-11-26 E. R. Squibb & Sons, Inc. Phosphorus containing compounds and use as hypotensives
JPS58140065A (ja) * 1982-02-10 1983-08-19 Meito Sangyo Kk メルカプトベンジル脂肪酸誘導体類及びその製法
US4452791A (en) * 1982-03-15 1984-06-05 E. R. Squibb & Sons, Inc. Aminoalkyl and related substituted phosphinic acid angiotensin converting enzyme inhibitors
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US4616005A (en) * 1982-06-23 1986-10-07 E. R. Squibb & Sons, Inc. Phosphonyl hydroxyacyl amino acid derivatives as antihypertensives
US4452790A (en) * 1982-06-23 1984-06-05 E. R. Squibb & Sons, Inc. Phosphonyl hydroxyacyl amino acid derivatives as antihypertensives
US4703043A (en) * 1982-06-23 1987-10-27 E. R. Squibb & Sons, Inc. Phosphonyl hydroxyacyl amino acid derivatives as antihypertensive
US4470973A (en) * 1982-07-19 1984-09-11 E. R. Squibb & Sons, Inc. Substituted peptide compounds
US4736066A (en) * 1982-07-19 1988-04-05 E. R. Squibb & Sons, Inc. Intermediate for substituted peptide compounds
US4661515A (en) * 1982-07-21 1987-04-28 Usv Pharmaceutical Corporation Compounds having angiotensin converting enzyme inhibitory activity and diuretic activity
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US4623729A (en) 1982-07-22 1986-11-18 E. R. Squibb & Sons, Inc. Acylalkylaminocarbonyl substituted amino and imino acid compounds
US4621092A (en) * 1982-07-22 1986-11-04 E. R. Squibb & Sons, Inc. Substituted proline compounds, composition and method of use
US4742067A (en) * 1982-07-22 1988-05-03 E. R. Squibb & Sons, Inc. Acylalkylaminocarbonyl substituted amino and imino acid compounds
US4524212A (en) * 1982-09-27 1985-06-18 E. R. Squibb & Sons, Inc. Acyloxyketone substituted imino and amino acids
FR2540495B1 (fr) * 1983-02-07 1986-02-14 Roussel Uclaf Nouveaux derives de o-mercaptopropanamide et de ses homologues, leur procede de preparation, leur application comme medicaments, les compositions les renfermant et les nouveaux intermediaires obtenus
US4774256A (en) * 1983-10-03 1988-09-27 E. R. Squibb & Sons, Inc. Use of enkephalinase inhibitors as analgesic agents
US4722810A (en) * 1984-08-16 1988-02-02 E. R. Squibb & Sons, Inc. Enkephalinase inhibitors
US4798904A (en) * 1983-10-03 1989-01-17 E. R. Squibb & Sons, Inc. Certain [(lower alkanoyl-thio)methyl-1-oxo-3-phenyl propyl amino]benzene lower alkanoic acid or ester derivatives which inhibit enkephalinase
US4595700A (en) * 1984-12-21 1986-06-17 G. D. Searle & Co. Thiol based collagenase inhibitors
US4929641B1 (en) * 1988-05-11 1994-08-30 Schering Corp Mercapto-acylamino acid antihypertensives
US4801609B1 (en) * 1987-03-27 1993-11-09 Mercapto-acylamino acid antihypertensives
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US5262436A (en) * 1987-03-27 1993-11-16 Schering Corporation Acylamino acid antihypertensives in the treatment of congestive heart failure
CA1337400C (en) * 1987-06-08 1995-10-24 Norma G. Delaney Inhibitors of neutral endopeptidase
US5179125A (en) * 1987-12-03 1993-01-12 Dainippon Pharmaceutical Co., Ltd. N-substituted mercaptopropanamide derivatives
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US5210266A (en) * 1987-12-03 1993-05-11 Dainippon Pharmaceutical Co., Ltd. N-substituted mercaptopropanamide derivatives
US5292926A (en) * 1988-01-25 1994-03-08 Santen Pharmaceutical Co., Ltd. Cysteine derivatives
US5002964A (en) * 1988-06-15 1991-03-26 Brigham & Women's Hospital S-nitrosocaptopril compounds and the use thereof
US5187183A (en) * 1988-06-15 1993-02-16 Brigham & Women's Hospital S-nitroso derivatives of ACE inhibitors and the use thereof
US5356890A (en) * 1988-06-15 1994-10-18 Brigham And Women's Hospital S-nitroso derivatives of ace inhibitors and the use thereof
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FR2679564A1 (fr) * 1991-07-23 1993-01-29 Inst Nat Sante Rech Med Nouveaux acylmercaptoalcanoldipeptides, leur preparation et les compositions qui les contiennent.
US5504080A (en) * 1992-10-28 1996-04-02 Bristol-Myers Squibb Co. Benzo-fused lactams
US5424447A (en) * 1993-07-07 1995-06-13 The Medical College Of Wisconsin Research Foundation, Inc. Heme binding compounds and use thereof
FR2712286B1 (fr) * 1993-11-12 1995-12-22 Oreal Nouveaux N-mercaptoalkyl alcanediamines et leur utilisation.
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US5670545A (en) * 1996-02-09 1997-09-23 Board Of Regents Of The University Of Colorado Method for the treatment of ischemic disease and reperfusion injury and the prevention of the adverse effects of reactive oxygen species
FR2745571B1 (fr) * 1996-03-04 1998-06-19 Inst Nat Sante Rech Med Nouveaux derives soufres comportant une liaison amide, leur procede de preparation, leur application a titre de medicaments, et les compositions pharmaceutiques les renfermant
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CA1009252A (en) 1972-10-03 1977-04-26 Santen Pharmaceutical Co. N-(mercaptoacyl) aminoacids
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AU509899B2 (en) 1976-02-13 1980-05-29 E.R. Squibb & Sons, Inc. Proline derivatives and related compounds

Also Published As

Publication number Publication date
FR2367741B1 (sv) 1982-10-29
IE44821L (en) 1977-11-10
FR2372624A1 (fr) 1978-06-30
SU955857A3 (ru) 1982-08-30
US4053651A (en) 1977-10-11
DK203177A (da) 1977-11-11
GB1577415A (en) 1980-10-22
JPS52136117A (en) 1977-11-14
DE2717548C2 (sv) 1990-05-03
CA1119177A (en) 1982-03-02
IE44821B1 (en) 1982-04-07
BE854458A (fr) 1977-11-10
FR2367741A1 (fr) 1978-05-12
DE2717548A1 (de) 1977-12-01
NL7704712A (nl) 1977-11-14
CH621763A5 (sv) 1981-02-27
SU818479A3 (ru) 1981-03-30
DD130477A5 (de) 1978-04-05
AU2410677A (en) 1978-10-12
HU177750B (en) 1981-12-28
PL106032B1 (pl) 1979-11-30
CS204001B2 (en) 1981-03-31
FR2372624B1 (sv) 1980-05-09
NO771623L (no) 1977-11-11
PL197963A1 (pl) 1978-03-28
SU697049A3 (ru) 1979-11-05
PL107991B1 (pl) 1980-03-31
ZA772256B (en) 1978-03-29
AU513622B2 (en) 1980-12-11
CH620202A5 (sv) 1980-11-14
US4112119A (en) 1978-09-05
JPS6120544B2 (sv) 1986-05-22
YU116877A (en) 1982-08-31

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