CZ302615B6 - Zpusob cištení kapsulárních polysacharidu od bunecných komponent gramnegativních a grampozitivních bakterií a modifikovaný kapsulární polysacharid - Google Patents
Zpusob cištení kapsulárních polysacharidu od bunecných komponent gramnegativních a grampozitivních bakterií a modifikovaný kapsulární polysacharid Download PDFInfo
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- CZ302615B6 CZ302615B6 CZ20002373A CZ20002373A CZ302615B6 CZ 302615 B6 CZ302615 B6 CZ 302615B6 CZ 20002373 A CZ20002373 A CZ 20002373A CZ 20002373 A CZ20002373 A CZ 20002373A CZ 302615 B6 CZ302615 B6 CZ 302615B6
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- capsular polysaccharide
- polysaccharide
- capsular
- cps
- gram
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- 239000008103 glucose Substances 0.000 description 1
- OGEROIBRQCWGOI-UHFFFAOYSA-N hexanedioic acid;hydrazine Chemical compound NN.NN.OC(=O)CCCCC(O)=O OGEROIBRQCWGOI-UHFFFAOYSA-N 0.000 description 1
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- 238000007918 intramuscular administration Methods 0.000 description 1
- 238000007912 intraperitoneal administration Methods 0.000 description 1
- 238000001990 intravenous administration Methods 0.000 description 1
- 150000002500 ions Chemical class 0.000 description 1
- 238000002955 isolation Methods 0.000 description 1
- 238000011005 laboratory method Methods 0.000 description 1
- 239000008101 lactose Substances 0.000 description 1
- 238000011031 large-scale manufacturing process Methods 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 238000004811 liquid chromatography Methods 0.000 description 1
- 238000004020 luminiscence type Methods 0.000 description 1
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- 235000013372 meat Nutrition 0.000 description 1
- 239000011859 microparticle Substances 0.000 description 1
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- 229940031348 multivalent vaccine Drugs 0.000 description 1
- 231100000219 mutagenic Toxicity 0.000 description 1
- 230000003505 mutagenic effect Effects 0.000 description 1
- 229940060155 neuac Drugs 0.000 description 1
- CERZMXAJYMMUDR-UHFFFAOYSA-N neuraminic acid Natural products NC1C(O)CC(O)(C(O)=O)OC1C(O)C(O)CO CERZMXAJYMMUDR-UHFFFAOYSA-N 0.000 description 1
- 230000000926 neurological effect Effects 0.000 description 1
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- 229920001155 polypropylene Polymers 0.000 description 1
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- FGIUAXJPYTZDNR-UHFFFAOYSA-N potassium nitrate Inorganic materials [K+].[O-][N+]([O-])=O FGIUAXJPYTZDNR-UHFFFAOYSA-N 0.000 description 1
- 238000001556 precipitation Methods 0.000 description 1
- 208000012113 pregnancy disease Diseases 0.000 description 1
- 238000004237 preparative chromatography Methods 0.000 description 1
- 239000003755 preservative agent Substances 0.000 description 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 description 1
- 230000000069 prophylactic effect Effects 0.000 description 1
- 125000006239 protecting group Chemical group 0.000 description 1
- 235000004252 protein component Nutrition 0.000 description 1
- 229940023143 protein vaccine Drugs 0.000 description 1
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- 201000003068 rheumatic fever Diseases 0.000 description 1
- 210000003296 saliva Anatomy 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- 229910052708 sodium Inorganic materials 0.000 description 1
- QDRKDTQENPPHOJ-UHFFFAOYSA-N sodium ethoxide Chemical compound [Na+].CC[O-] QDRKDTQENPPHOJ-UHFFFAOYSA-N 0.000 description 1
- 229910000104 sodium hydride Inorganic materials 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 239000000600 sorbitol Substances 0.000 description 1
- 238000005507 spraying Methods 0.000 description 1
- 239000003381 stabilizer Substances 0.000 description 1
- 239000007858 starting material Substances 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
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- 230000001225 therapeutic effect Effects 0.000 description 1
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- 239000013638 trimer Substances 0.000 description 1
- 125000000026 trimethylsilyl group Chemical group [H]C([H])([H])[Si]([*])(C([H])([H])[H])C([H])([H])[H] 0.000 description 1
- 229910021642 ultra pure water Inorganic materials 0.000 description 1
- 239000012498 ultrapure water Substances 0.000 description 1
- 238000002255 vaccination Methods 0.000 description 1
- 229940118696 vibrio cholerae Drugs 0.000 description 1
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
- C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P19/00—Preparation of compounds containing saccharide radicals
- C12P19/04—Polysaccharides, i.e. compounds containing more than five saccharide radicals attached to each other by glycosidic bonds
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P19/00—Preparation of compounds containing saccharide radicals
- C12P19/26—Preparation of nitrogen-containing carbohydrates
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Microbiology (AREA)
- General Chemical & Material Sciences (AREA)
- General Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Materials Engineering (AREA)
- Medicinal Chemistry (AREA)
- Polymers & Plastics (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US6860897P | 1997-12-23 | 1997-12-23 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CZ20002373A3 CZ20002373A3 (cs) | 2000-12-13 |
| CZ302615B6 true CZ302615B6 (cs) | 2011-08-03 |
Family
ID=22083630
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CZ20002373A CZ302615B6 (cs) | 1997-12-23 | 1998-12-23 | Zpusob cištení kapsulárních polysacharidu od bunecných komponent gramnegativních a grampozitivních bakterií a modifikovaný kapsulární polysacharid |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US6248570B1 (https=) |
| EP (3) | EP2226336B1 (https=) |
| JP (2) | JP4435413B2 (https=) |
| KR (2) | KR100757630B1 (https=) |
| AT (1) | ATE468403T2 (https=) |
| AU (1) | AU754256C (https=) |
| CA (1) | CA2316975C (https=) |
| CZ (1) | CZ302615B6 (https=) |
| DE (1) | DE69841676D1 (https=) |
| DK (1) | DK1051506T4 (https=) |
| ES (2) | ES2346022T3 (https=) |
| HU (1) | HUP0100623A3 (https=) |
| NO (1) | NO331100B1 (https=) |
| WO (1) | WO1999032653A1 (https=) |
Families Citing this family (46)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SI21352A (sl) | 2001-01-23 | 2004-06-30 | Aventis Pasteur | Multivalentno meningokokno cepivo iz konjugata polisaharida-proteina |
| US7816514B2 (en) | 2001-02-16 | 2010-10-19 | Cargill, Incorporated | Glucosamine and method of making glucosamine from microbial biomass |
| US20020115639A1 (en) * | 2001-02-16 | 2002-08-22 | Weiyu Fan | Glucosamine and method of making glucosamine from microbial blomass |
| US7923437B2 (en) * | 2001-02-16 | 2011-04-12 | Cargill, Incorporated | Water soluble β-glucan, glucosamine, and N-acetylglucosamine compositions and methods for making the same |
| US6693188B2 (en) | 2001-08-08 | 2004-02-17 | Cargill Incorporated | N-acetyl-D-glucosamine and process for producing N-acetyl-D-glucosamine |
| US8222232B2 (en) * | 2001-02-16 | 2012-07-17 | Cargill, Incorporated | Glucosamine and N-acetylglucosamine compositions and methods of making the same fungal biomass |
| GB0115176D0 (en) | 2001-06-20 | 2001-08-15 | Chiron Spa | Capular polysaccharide solubilisation and combination vaccines |
| ES2616180T3 (es) * | 2002-03-26 | 2017-06-09 | Glaxosmithkline Biologicals Sa | Sacáridos modificados con estabilidad mejorada en agua para su uso como medicamento |
| WO2004011027A1 (en) * | 2002-07-30 | 2004-02-05 | Baxter International Inc. | Chimeric multivalent polysaccharide conjugate vaccines |
| US20060058263A1 (en) * | 2002-11-01 | 2006-03-16 | Rogers Brent D | Heat pasturized liquids containing glucosamine |
| US20060003965A1 (en) * | 2002-11-01 | 2006-01-05 | Fosdick Lawrence D | N-acetyl-d-glucosamine (nag) supplemented food products and beverages |
| EP2172213B1 (en) | 2003-01-30 | 2013-04-03 | Novartis AG | Injectable vaccines against multiple meningococcal serogroups |
| CA2530364C (en) * | 2003-06-23 | 2014-03-18 | Baxter International Inc. | Vaccines against group y neisseria meningitidis and meningococcal combinations thereof |
| GB0406013D0 (en) * | 2004-03-17 | 2004-04-21 | Chiron Srl | Analysis of saccharide vaccines without interference |
| US8652334B2 (en) | 2004-08-12 | 2014-02-18 | Lipoxen Technologies Limited | Fractionation of charged polysaccharide |
| GB0502095D0 (en) * | 2005-02-01 | 2005-03-09 | Chiron Srl | Conjugation of streptococcal capsular saccharides |
| GB0502096D0 (en) * | 2005-02-01 | 2005-03-09 | Chiron Srl | Purification of streptococcal capsular polysaccharide |
| EP3311836A1 (en) | 2005-04-08 | 2018-04-25 | Wyeth LLC | Multivalent pneumococcal polysaccharide-protein conjugate composition |
| AU2011253684B8 (en) * | 2005-04-08 | 2013-07-11 | Wyeth Llc | Multivalent pneumococcal polysaccharide-protein conjugate composition |
| CA2620416A1 (en) * | 2005-08-24 | 2007-03-01 | Novartis Vaccines And Diagnostics S.R.L. | Zwitterionization of capsular saccharides |
| GB0522303D0 (en) | 2005-11-01 | 2005-12-07 | Chiron Srl | Culture method |
| EP1976857A4 (en) * | 2006-01-13 | 2011-08-03 | Baxter Int | PROCESS FOR CLEANING POLYSACCHARIDES |
| PL2004225T3 (pl) | 2006-03-22 | 2012-09-28 | Novartis Ag | Schematy immunizacji koniugatami meningokokowymi |
| US10828361B2 (en) | 2006-03-22 | 2020-11-10 | Glaxosmithkline Biologicals Sa | Regimens for immunisation with meningococcal conjugates |
| GB0605757D0 (en) * | 2006-03-22 | 2006-05-03 | Chiron Srl | Separation of conjugated and unconjugated components |
| US8808707B1 (en) | 2006-05-08 | 2014-08-19 | Wyeth Llc | Pneumococcal dosing regimen |
| EP1872791A1 (en) | 2006-06-30 | 2008-01-02 | Institut Pasteur | Use of bacterial polysaccharides for biofilm inhibition |
| EP2409995A3 (en) | 2007-02-28 | 2012-08-15 | Lipoxen Technologies Limited | Reduction of endotoxin in polysialic acids |
| SI2114421T1 (en) | 2007-03-05 | 2018-04-30 | Om Pharma | A bacterial extract for respiratory disorders and a process for its preparation |
| CN101663327B (zh) * | 2007-03-23 | 2014-05-07 | 惠氏公司 | 产生肺炎链球菌(streptococcus pneumoniae)荚膜多糖的缩短的纯化方法 |
| GB0818453D0 (en) | 2008-10-08 | 2008-11-12 | Novartis Ag | Fermentation processes for cultivating streptococci and purification processes for obtaining cps therefrom |
| JP5339243B2 (ja) * | 2008-04-24 | 2013-11-13 | 株式会社微生物化学研究所 | ストレプトコッカス・スイス感染症予防用ワクチン |
| WO2011005587A1 (en) * | 2009-06-24 | 2011-01-13 | University Of Dubuque | Vaccine compositions and methods of use to protect against infectious disease |
| BR112013024322B1 (pt) * | 2011-03-22 | 2020-04-22 | Serum Inst India Ltd | processo para preparação de polissacarídeos |
| US9400250B2 (en) | 2013-09-30 | 2016-07-26 | Han Sheng Biotech Co., Ltd. | Method for analyzing mushrooms |
| MY186874A (en) * | 2014-02-25 | 2021-08-26 | Msd Wellcome Trust Hilleman Laboratories Pvt Ltd | A novel downstream process for purifying polysaccharides |
| EP2942396A1 (en) | 2014-05-07 | 2015-11-11 | Novartis AG | Polysaccharides produced by CPSC mutants |
| EP3034516A1 (en) * | 2014-12-19 | 2016-06-22 | Novartis AG | Purification of streptococcal capsular polysaccharide |
| MY182282A (en) * | 2015-05-04 | 2021-01-18 | Pfizer | Group b streptococcus polysaccharide-protein conjugates, methods for producing conjugates, immunogenic compositions comprising conjugates, and uses thereof |
| BE1025162B9 (fr) * | 2016-12-06 | 2019-01-07 | Glaxosmithkline Biologicals Sa | Procede de purification pour les polysaccharides capsulaires |
| US11739356B2 (en) * | 2017-05-05 | 2023-08-29 | Serum Institute Of India Private Limited | Method for removal of impurities from bacterial capsular polysaccharide based preparations |
| JP7111799B2 (ja) * | 2017-07-05 | 2022-08-02 | インベントプライズ リミテッド ライアビリティ カンパニー | 溶菌酵素、接線流濾過、及びマルチモードクロマトグラフィを用いたワクチン生産のための多糖精製 |
| CN111093650B (zh) | 2017-09-07 | 2024-03-01 | 默沙东有限责任公司 | 肺炎球菌多糖及其在免疫原性多糖-载体蛋白缀合物中的用途 |
| FR3078977B1 (fr) | 2018-03-16 | 2023-03-17 | Biomerieux Sa | Procede d'extraction d'acides nucleiques |
| WO2022084852A1 (en) * | 2020-10-22 | 2022-04-28 | Pfizer Inc. | Methods for purifying bacterial polysaccharides |
| CN117512031B (zh) * | 2023-10-16 | 2024-06-25 | 江苏金迪克生物技术股份有限公司 | 一种肺炎球菌荚膜多糖的纯化方法 |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4413057A (en) * | 1980-04-14 | 1983-11-01 | Merck & Co., Inc. | Group B streptococcal capsular polysaccharides |
| EP0238739A1 (en) * | 1986-03-27 | 1987-09-30 | Swiss Serum and Vaccine Institute Berne | Klebsiella capsular polysaccharide vaccine |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3523801A (en) † | 1966-01-13 | 1970-08-11 | Kyowa Hakko Kogyo Kk | Process for the preparation of seasonings |
| US3577527A (en) * | 1969-01-27 | 1971-05-04 | Us Navy | Neisseria meningitidis antigen |
| US4258029A (en) | 1979-04-23 | 1981-03-24 | Connaught Laboratories Limited | Synthetic adjuvants for stimulation of antigenic responses |
| US4356170A (en) * | 1981-05-27 | 1982-10-26 | Canadian Patents & Development Ltd. | Immunogenic polysaccharide-protein conjugates |
| US4644059A (en) † | 1982-07-06 | 1987-02-17 | Connaught Laboratories, Inc. | Haemophilus influenzae B polysaccharide-diptheria toxoid conjugate vaccine |
| AU586857B2 (en) * | 1986-03-27 | 1989-07-27 | Swiss Serum And Vaccine Institute Berne | Klebsiella capsular polysaccharide vaccine |
| US5530101A (en) | 1988-12-28 | 1996-06-25 | Protein Design Labs, Inc. | Humanized immunoglobulins |
| US5190746A (en) * | 1989-05-10 | 1993-03-02 | The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Plaque inhibiting oligosaccharide |
| HU9201966D0 (en) | 1989-12-14 | 1992-10-28 | Ca Nat Research Council | An improved vaccine of meningococcus-polysaccharide conjunction |
| NZ239643A (en) | 1990-09-17 | 1996-05-28 | North American Vaccine Inc | Vaccine containing bacterial polysaccharide protein conjugate and adjuvant (c-nd-che-a-co-b-r) with a long chain alkyl group. |
| ZA937034B (en) * | 1992-09-24 | 1995-06-23 | Brigham & Womens Hospital | Group B streptococcus type II and type V polysaccharide-protein conjugate vaccines |
| US5811102A (en) * | 1995-06-07 | 1998-09-22 | National Research Council Of Canada | Modified meningococcal polysaccharide conjugate vaccines |
-
1998
- 1998-12-23 KR KR1020067013976A patent/KR100757630B1/ko not_active Expired - Fee Related
- 1998-12-23 WO PCT/US1998/027375 patent/WO1999032653A1/en not_active Ceased
- 1998-12-23 EP EP10005184.6A patent/EP2226336B1/en not_active Expired - Lifetime
- 1998-12-23 CA CA002316975A patent/CA2316975C/en not_active Expired - Lifetime
- 1998-12-23 EP EP16182410.7A patent/EP3118225A1/en not_active Withdrawn
- 1998-12-23 AT AT98966468T patent/ATE468403T2/de active
- 1998-12-23 JP JP2000525570A patent/JP4435413B2/ja not_active Expired - Lifetime
- 1998-12-23 AU AU23071/99A patent/AU754256C/en not_active Expired
- 1998-12-23 ES ES98966468T patent/ES2346022T3/es not_active Expired - Lifetime
- 1998-12-23 EP EP98966468.5A patent/EP1051506B2/en not_active Expired - Lifetime
- 1998-12-23 CZ CZ20002373A patent/CZ302615B6/cs not_active IP Right Cessation
- 1998-12-23 KR KR1020007006995A patent/KR100641490B1/ko not_active Expired - Lifetime
- 1998-12-23 HU HU0100623A patent/HUP0100623A3/hu unknown
- 1998-12-23 DE DE69841676T patent/DE69841676D1/de not_active Expired - Lifetime
- 1998-12-23 DK DK98966468.5T patent/DK1051506T4/da active
- 1998-12-23 ES ES10005184.6T patent/ES2611464T3/es not_active Expired - Lifetime
- 1998-12-23 US US09/221,630 patent/US6248570B1/en not_active Expired - Lifetime
-
2000
- 2000-06-21 NO NO20003226A patent/NO331100B1/no not_active IP Right Cessation
-
2009
- 2009-09-07 JP JP2009206304A patent/JP5144613B2/ja not_active Expired - Lifetime
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4413057A (en) * | 1980-04-14 | 1983-11-01 | Merck & Co., Inc. | Group B streptococcal capsular polysaccharides |
| EP0238739A1 (en) * | 1986-03-27 | 1987-09-30 | Swiss Serum and Vaccine Institute Berne | Klebsiella capsular polysaccharide vaccine |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PD00 | Pending as of 2000-06-30 in czech republic | ||
| MK4A | Patent expired |
Effective date: 20181223 |