CA2316975C - Procedures for the extraction and isolation of bacterial capsular polysaccharides for use as vaccines or linked to proteins as conjugate vaccines - Google Patents

Procedures for the extraction and isolation of bacterial capsular polysaccharides for use as vaccines or linked to proteins as conjugate vaccines Download PDF

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Publication number
CA2316975C
CA2316975C CA002316975A CA2316975A CA2316975C CA 2316975 C CA2316975 C CA 2316975C CA 002316975 A CA002316975 A CA 002316975A CA 2316975 A CA2316975 A CA 2316975A CA 2316975 C CA2316975 C CA 2316975C
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CA
Canada
Prior art keywords
cps
group
polysaccharide
capsular
capsular polysaccharides
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
CA002316975A
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English (en)
French (fr)
Other versions
CA2316975A1 (en
Inventor
Francis Michon
Milan Blake
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pfizer Ireland Pharmaceuticals
Original Assignee
Baxter Healthcare SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=22083630&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CA2316975(C) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Baxter Healthcare SA filed Critical Baxter Healthcare SA
Publication of CA2316975A1 publication Critical patent/CA2316975A1/en
Application granted granted Critical
Publication of CA2316975C publication Critical patent/CA2316975C/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/04—Polysaccharides, i.e. compounds containing more than five saccharide radicals attached to each other by glycosidic bonds
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/26—Preparation of nitrogen-containing carbohydrates

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Materials Engineering (AREA)
  • Medicinal Chemistry (AREA)
  • Polymers & Plastics (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Peptides Or Proteins (AREA)
CA002316975A 1997-12-23 1998-12-23 Procedures for the extraction and isolation of bacterial capsular polysaccharides for use as vaccines or linked to proteins as conjugate vaccines Expired - Lifetime CA2316975C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US6860897P 1997-12-23 1997-12-23
US60/068,608 1997-12-23
PCT/US1998/027375 WO1999032653A1 (en) 1997-12-23 1998-12-23 Procedures for the extraction and isolation of bacterial capsular polysaccharides for use as vaccines or linked to proteins as conjugates vaccines

Publications (2)

Publication Number Publication Date
CA2316975A1 CA2316975A1 (en) 1999-07-01
CA2316975C true CA2316975C (en) 2009-03-24

Family

ID=22083630

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002316975A Expired - Lifetime CA2316975C (en) 1997-12-23 1998-12-23 Procedures for the extraction and isolation of bacterial capsular polysaccharides for use as vaccines or linked to proteins as conjugate vaccines

Country Status (14)

Country Link
US (1) US6248570B1 (https=)
EP (3) EP2226336B1 (https=)
JP (2) JP4435413B2 (https=)
KR (2) KR100757630B1 (https=)
AT (1) ATE468403T2 (https=)
AU (1) AU754256C (https=)
CA (1) CA2316975C (https=)
CZ (1) CZ302615B6 (https=)
DE (1) DE69841676D1 (https=)
DK (1) DK1051506T4 (https=)
ES (2) ES2346022T3 (https=)
HU (1) HUP0100623A3 (https=)
NO (1) NO331100B1 (https=)
WO (1) WO1999032653A1 (https=)

Families Citing this family (46)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SI21352A (sl) 2001-01-23 2004-06-30 Aventis Pasteur Multivalentno meningokokno cepivo iz konjugata polisaharida-proteina
US7816514B2 (en) 2001-02-16 2010-10-19 Cargill, Incorporated Glucosamine and method of making glucosamine from microbial biomass
US20020115639A1 (en) * 2001-02-16 2002-08-22 Weiyu Fan Glucosamine and method of making glucosamine from microbial blomass
US7923437B2 (en) * 2001-02-16 2011-04-12 Cargill, Incorporated Water soluble β-glucan, glucosamine, and N-acetylglucosamine compositions and methods for making the same
US6693188B2 (en) 2001-08-08 2004-02-17 Cargill Incorporated N-acetyl-D-glucosamine and process for producing N-acetyl-D-glucosamine
US8222232B2 (en) * 2001-02-16 2012-07-17 Cargill, Incorporated Glucosamine and N-acetylglucosamine compositions and methods of making the same fungal biomass
GB0115176D0 (en) 2001-06-20 2001-08-15 Chiron Spa Capular polysaccharide solubilisation and combination vaccines
ES2616180T3 (es) * 2002-03-26 2017-06-09 Glaxosmithkline Biologicals Sa Sacáridos modificados con estabilidad mejorada en agua para su uso como medicamento
WO2004011027A1 (en) * 2002-07-30 2004-02-05 Baxter International Inc. Chimeric multivalent polysaccharide conjugate vaccines
US20060058263A1 (en) * 2002-11-01 2006-03-16 Rogers Brent D Heat pasturized liquids containing glucosamine
US20060003965A1 (en) * 2002-11-01 2006-01-05 Fosdick Lawrence D N-acetyl-d-glucosamine (nag) supplemented food products and beverages
EP2172213B1 (en) 2003-01-30 2013-04-03 Novartis AG Injectable vaccines against multiple meningococcal serogroups
CA2530364C (en) * 2003-06-23 2014-03-18 Baxter International Inc. Vaccines against group y neisseria meningitidis and meningococcal combinations thereof
GB0406013D0 (en) * 2004-03-17 2004-04-21 Chiron Srl Analysis of saccharide vaccines without interference
US8652334B2 (en) 2004-08-12 2014-02-18 Lipoxen Technologies Limited Fractionation of charged polysaccharide
GB0502095D0 (en) * 2005-02-01 2005-03-09 Chiron Srl Conjugation of streptococcal capsular saccharides
GB0502096D0 (en) * 2005-02-01 2005-03-09 Chiron Srl Purification of streptococcal capsular polysaccharide
EP3311836A1 (en) 2005-04-08 2018-04-25 Wyeth LLC Multivalent pneumococcal polysaccharide-protein conjugate composition
AU2011253684B8 (en) * 2005-04-08 2013-07-11 Wyeth Llc Multivalent pneumococcal polysaccharide-protein conjugate composition
CA2620416A1 (en) * 2005-08-24 2007-03-01 Novartis Vaccines And Diagnostics S.R.L. Zwitterionization of capsular saccharides
GB0522303D0 (en) 2005-11-01 2005-12-07 Chiron Srl Culture method
EP1976857A4 (en) * 2006-01-13 2011-08-03 Baxter Int PROCESS FOR CLEANING POLYSACCHARIDES
PL2004225T3 (pl) 2006-03-22 2012-09-28 Novartis Ag Schematy immunizacji koniugatami meningokokowymi
US10828361B2 (en) 2006-03-22 2020-11-10 Glaxosmithkline Biologicals Sa Regimens for immunisation with meningococcal conjugates
GB0605757D0 (en) * 2006-03-22 2006-05-03 Chiron Srl Separation of conjugated and unconjugated components
US8808707B1 (en) 2006-05-08 2014-08-19 Wyeth Llc Pneumococcal dosing regimen
EP1872791A1 (en) 2006-06-30 2008-01-02 Institut Pasteur Use of bacterial polysaccharides for biofilm inhibition
EP2409995A3 (en) 2007-02-28 2012-08-15 Lipoxen Technologies Limited Reduction of endotoxin in polysialic acids
SI2114421T1 (en) 2007-03-05 2018-04-30 Om Pharma A bacterial extract for respiratory disorders and a process for its preparation
CN101663327B (zh) * 2007-03-23 2014-05-07 惠氏公司 产生肺炎链球菌(streptococcus pneumoniae)荚膜多糖的缩短的纯化方法
GB0818453D0 (en) 2008-10-08 2008-11-12 Novartis Ag Fermentation processes for cultivating streptococci and purification processes for obtaining cps therefrom
JP5339243B2 (ja) * 2008-04-24 2013-11-13 株式会社微生物化学研究所 ストレプトコッカス・スイス感染症予防用ワクチン
WO2011005587A1 (en) * 2009-06-24 2011-01-13 University Of Dubuque Vaccine compositions and methods of use to protect against infectious disease
BR112013024322B1 (pt) * 2011-03-22 2020-04-22 Serum Inst India Ltd processo para preparação de polissacarídeos
US9400250B2 (en) 2013-09-30 2016-07-26 Han Sheng Biotech Co., Ltd. Method for analyzing mushrooms
MY186874A (en) * 2014-02-25 2021-08-26 Msd Wellcome Trust Hilleman Laboratories Pvt Ltd A novel downstream process for purifying polysaccharides
EP2942396A1 (en) 2014-05-07 2015-11-11 Novartis AG Polysaccharides produced by CPSC mutants
EP3034516A1 (en) * 2014-12-19 2016-06-22 Novartis AG Purification of streptococcal capsular polysaccharide
MY182282A (en) * 2015-05-04 2021-01-18 Pfizer Group b streptococcus polysaccharide-protein conjugates, methods for producing conjugates, immunogenic compositions comprising conjugates, and uses thereof
BE1025162B9 (fr) * 2016-12-06 2019-01-07 Glaxosmithkline Biologicals Sa Procede de purification pour les polysaccharides capsulaires
US11739356B2 (en) * 2017-05-05 2023-08-29 Serum Institute Of India Private Limited Method for removal of impurities from bacterial capsular polysaccharide based preparations
JP7111799B2 (ja) * 2017-07-05 2022-08-02 インベントプライズ リミテッド ライアビリティ カンパニー 溶菌酵素、接線流濾過、及びマルチモードクロマトグラフィを用いたワクチン生産のための多糖精製
CN111093650B (zh) 2017-09-07 2024-03-01 默沙东有限责任公司 肺炎球菌多糖及其在免疫原性多糖-载体蛋白缀合物中的用途
FR3078977B1 (fr) 2018-03-16 2023-03-17 Biomerieux Sa Procede d'extraction d'acides nucleiques
WO2022084852A1 (en) * 2020-10-22 2022-04-28 Pfizer Inc. Methods for purifying bacterial polysaccharides
CN117512031B (zh) * 2023-10-16 2024-06-25 江苏金迪克生物技术股份有限公司 一种肺炎球菌荚膜多糖的纯化方法

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3523801A (en) † 1966-01-13 1970-08-11 Kyowa Hakko Kogyo Kk Process for the preparation of seasonings
US3577527A (en) * 1969-01-27 1971-05-04 Us Navy Neisseria meningitidis antigen
US4258029A (en) 1979-04-23 1981-03-24 Connaught Laboratories Limited Synthetic adjuvants for stimulation of antigenic responses
US4413057A (en) † 1980-04-14 1983-11-01 Merck & Co., Inc. Group B streptococcal capsular polysaccharides
US4356170A (en) * 1981-05-27 1982-10-26 Canadian Patents & Development Ltd. Immunogenic polysaccharide-protein conjugates
US4644059A (en) † 1982-07-06 1987-02-17 Connaught Laboratories, Inc. Haemophilus influenzae B polysaccharide-diptheria toxoid conjugate vaccine
AU586857B2 (en) * 1986-03-27 1989-07-27 Swiss Serum And Vaccine Institute Berne Klebsiella capsular polysaccharide vaccine
ATE72401T1 (de) 1986-03-27 1992-02-15 Schweiz Serum & Impfinst Impfstoff des klebsiella kapsulpolysaccharids.
US5530101A (en) 1988-12-28 1996-06-25 Protein Design Labs, Inc. Humanized immunoglobulins
US5190746A (en) * 1989-05-10 1993-03-02 The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Plaque inhibiting oligosaccharide
HU9201966D0 (en) 1989-12-14 1992-10-28 Ca Nat Research Council An improved vaccine of meningococcus-polysaccharide conjunction
NZ239643A (en) 1990-09-17 1996-05-28 North American Vaccine Inc Vaccine containing bacterial polysaccharide protein conjugate and adjuvant (c-nd-che-a-co-b-r) with a long chain alkyl group.
ZA937034B (en) * 1992-09-24 1995-06-23 Brigham & Womens Hospital Group B streptococcus type II and type V polysaccharide-protein conjugate vaccines
US5811102A (en) * 1995-06-07 1998-09-22 National Research Council Of Canada Modified meningococcal polysaccharide conjugate vaccines

Also Published As

Publication number Publication date
DK1051506T3 (da) 2010-09-13
AU754256B2 (en) 2002-11-07
KR100641490B1 (ko) 2006-10-31
EP1051506B2 (en) 2019-08-21
AU754256C (en) 2004-05-20
KR100757630B1 (ko) 2007-09-10
CA2316975A1 (en) 1999-07-01
US6248570B1 (en) 2001-06-19
HK1147506A1 (en) 2011-08-12
JP2010011862A (ja) 2010-01-21
ES2346022T3 (es) 2010-10-07
JP4435413B2 (ja) 2010-03-17
WO1999032653A9 (en) 1999-10-28
KR20060086978A (ko) 2006-08-01
EP1051506B8 (en) 2010-09-01
KR20010033494A (ko) 2001-04-25
EP1051506A1 (en) 2000-11-15
HUP0100623A3 (en) 2003-11-28
CZ302615B6 (cs) 2011-08-03
NO331100B1 (no) 2011-10-03
EP2226336A1 (en) 2010-09-08
DE69841676D1 (de) 2010-07-01
ES2611464T3 (es) 2017-05-09
JP2001526902A (ja) 2001-12-25
EP2226336B1 (en) 2016-10-19
EP3118225A1 (en) 2017-01-18
DK1051506T4 (da) 2019-10-21
WO1999032653A1 (en) 1999-07-01
JP5144613B2 (ja) 2013-02-13
NO20003226D0 (no) 2000-06-21
HUP0100623A2 (hu) 2001-06-28
CZ20002373A3 (cs) 2000-12-13
AU2307199A (en) 1999-07-12
EP1051506B1 (en) 2010-05-19
ATE468403T2 (de) 2010-06-15

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Effective date: 20181224