CZ300778B6 - Zpusob výroby šumivých prípravku, obsahujících léciva a šumivé prípravky - Google Patents
Zpusob výroby šumivých prípravku, obsahujících léciva a šumivé prípravky Download PDFInfo
- Publication number
- CZ300778B6 CZ300778B6 CZ20004171A CZ20004171A CZ300778B6 CZ 300778 B6 CZ300778 B6 CZ 300778B6 CZ 20004171 A CZ20004171 A CZ 20004171A CZ 20004171 A CZ20004171 A CZ 20004171A CZ 300778 B6 CZ300778 B6 CZ 300778B6
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- CZ
- Czechia
- Prior art keywords
- sugar
- effervescent
- optionally
- component
- components
- Prior art date
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- 239000000203 mixture Substances 0.000 title claims abstract description 45
- 239000003814 drug Substances 0.000 title claims abstract description 11
- 238000004519 manufacturing process Methods 0.000 title claims abstract description 7
- 235000000346 sugar Nutrition 0.000 claims abstract description 33
- 238000000034 method Methods 0.000 claims abstract description 25
- 239000003765 sweetening agent Substances 0.000 claims abstract description 20
- 235000021092 sugar substitutes Nutrition 0.000 claims abstract description 19
- 239000000126 substance Substances 0.000 claims abstract description 10
- 229960001138 acetylsalicylic acid Drugs 0.000 claims abstract description 4
- 150000005846 sugar alcohols Chemical class 0.000 claims abstract description 4
- 238000009472 formulation Methods 0.000 claims description 18
- 239000013543 active substance Substances 0.000 claims description 12
- 239000000546 pharmaceutical excipient Substances 0.000 claims description 12
- 239000000155 melt Substances 0.000 claims description 11
- 238000002360 preparation method Methods 0.000 claims description 10
- 239000002253 acid Substances 0.000 claims description 8
- 229910052799 carbon Inorganic materials 0.000 claims description 8
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims description 6
- 230000001476 alcoholic effect Effects 0.000 claims description 6
- -1 antidiabetics Substances 0.000 claims description 6
- 230000002378 acidificating effect Effects 0.000 claims description 5
- 239000004480 active ingredient Substances 0.000 claims description 5
- 239000003795 chemical substances by application Substances 0.000 claims description 5
- 238000002844 melting Methods 0.000 claims description 5
- 230000008018 melting Effects 0.000 claims description 5
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 4
- 238000001816 cooling Methods 0.000 claims description 4
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- 239000003434 antitussive agent Substances 0.000 claims description 2
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- OMOVVBIIQSXZSZ-UHFFFAOYSA-N [6-(4-acetyloxy-5,9a-dimethyl-2,7-dioxo-4,5a,6,9-tetrahydro-3h-pyrano[3,4-b]oxepin-5-yl)-5-formyloxy-3-(furan-3-yl)-3a-methyl-7-methylidene-1a,2,3,4,5,6-hexahydroindeno[1,7a-b]oxiren-4-yl] 2-hydroxy-3-methylpentanoate Chemical compound CC12C(OC(=O)C(O)C(C)CC)C(OC=O)C(C3(C)C(CC(=O)OC4(C)COC(=O)CC43)OC(C)=O)C(=C)C32OC3CC1C=1C=COC=1 OMOVVBIIQSXZSZ-UHFFFAOYSA-N 0.000 claims 1
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- PWKSKIMOESPYIA-BYPYZUCNSA-N L-N-acetyl-Cysteine Chemical compound CC(=O)N[C@@H](CS)C(O)=O PWKSKIMOESPYIA-BYPYZUCNSA-N 0.000 description 4
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- 239000011668 ascorbic acid Substances 0.000 description 4
- 239000000605 aspartame Substances 0.000 description 4
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- IAOZJIPTCAWIRG-QWRGUYRKSA-N aspartame Chemical compound OC(=O)C[C@H](N)C(=O)N[C@H](C(=O)OC)CC1=CC=CC=C1 IAOZJIPTCAWIRG-QWRGUYRKSA-N 0.000 description 4
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- HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 description 4
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- 239000001509 sodium citrate Substances 0.000 description 4
- NLJMYIDDQXHKNR-UHFFFAOYSA-K sodium citrate Chemical compound O.O.[Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O NLJMYIDDQXHKNR-UHFFFAOYSA-K 0.000 description 4
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- 235000019204 saccharin Nutrition 0.000 description 3
- CVHZOJJKTDOEJC-UHFFFAOYSA-N saccharin Chemical compound C1=CC=C2C(=O)NS(=O)(=O)C2=C1 CVHZOJJKTDOEJC-UHFFFAOYSA-N 0.000 description 3
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- SERLAGPUMNYUCK-YJOKQAJESA-N 6-O-alpha-D-glucopyranosyl-D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO[C@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O SERLAGPUMNYUCK-YJOKQAJESA-N 0.000 description 2
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- A—HUMAN NECESSITIES
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- Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
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- Pulmonology (AREA)
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- Neurology (AREA)
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- Anesthesiology (AREA)
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- Pain & Pain Management (AREA)
- Emergency Medicine (AREA)
- Oncology (AREA)
- Nutrition Science (AREA)
- Endocrinology (AREA)
- Communicable Diseases (AREA)
- Hospice & Palliative Care (AREA)
- Otolaryngology (AREA)
- Immunology (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19822036A DE19822036A1 (de) | 1998-05-15 | 1998-05-15 | Brausezubereitungen |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CZ20004171A3 CZ20004171A3 (cs) | 2001-03-14 |
| CZ300778B6 true CZ300778B6 (cs) | 2009-08-12 |
Family
ID=7868010
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CZ20004171A CZ300778B6 (cs) | 1998-05-15 | 1999-05-03 | Zpusob výroby šumivých prípravku, obsahujících léciva a šumivé prípravky |
Country Status (30)
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|---|---|
| EP (1) | EP1077684B1 (enExample) |
| JP (1) | JP4452403B2 (enExample) |
| KR (1) | KR100629817B1 (enExample) |
| AR (1) | AR016473A1 (enExample) |
| AT (1) | ATE246494T1 (enExample) |
| AU (1) | AU3929799A (enExample) |
| BR (1) | BR9910454A (enExample) |
| CA (1) | CA2331671C (enExample) |
| CO (1) | CO4830457A1 (enExample) |
| CZ (1) | CZ300778B6 (enExample) |
| DE (2) | DE19822036A1 (enExample) |
| DK (1) | DK1077684T3 (enExample) |
| EE (1) | EE04701B1 (enExample) |
| ES (1) | ES2203134T3 (enExample) |
| GT (1) | GT199900062A (enExample) |
| HN (1) | HN1999000067A (enExample) |
| HR (1) | HRP20000781B1 (enExample) |
| HU (1) | HU224034B1 (enExample) |
| ID (1) | ID27441A (enExample) |
| IL (1) | IL139240A (enExample) |
| NO (1) | NO20005722L (enExample) |
| PA (1) | PA8472001A1 (enExample) |
| PE (1) | PE20000465A1 (enExample) |
| PL (1) | PL194347B1 (enExample) |
| PT (1) | PT1077684E (enExample) |
| SI (1) | SI1077684T1 (enExample) |
| SK (1) | SK284621B6 (enExample) |
| TR (1) | TR200003357T2 (enExample) |
| UY (1) | UY25510A1 (enExample) |
| WO (1) | WO1999059553A1 (enExample) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6649186B1 (en) * | 1996-09-20 | 2003-11-18 | Ethypharm | Effervescent granules and methods for their preparation |
| ATE258046T1 (de) * | 1999-02-11 | 2004-02-15 | Hexal Ag | Pharmazeutische, metamizol enthaltende brauseformulierung |
| FR2823668B1 (fr) * | 2001-04-20 | 2004-02-27 | Ethypharm Lab Prod Ethiques | Comprimes effervescents orodispersibles |
| DE602006001295D1 (de) * | 2005-02-03 | 2008-07-03 | Nycomed Pharma As | Schmelzgranulation einer zusammensetzung mit einer calziumhaltigen verbindung |
| GR1007299B (el) * | 2010-03-24 | 2011-06-06 | Uni - Pharma Κλεων Τσετης Φαρμακευτικα Εργαστηρια Αβεε Με Δ.Τ. Uni-Pharma Αβεε, | Πρωτοτυπη αναβραζουσα φαρμακευτικη συνθεση υδροχλωρικης μετφορμινης με τη μορφη δισκιου |
| WO2013022410A2 (en) | 2011-08-08 | 2013-02-14 | Mahmut Bilgic | Production method for effervescent formulations comprising dexketoprofen |
| WO2016042372A1 (en) | 2014-09-17 | 2016-03-24 | Steer Engineering Private Limited | Effervescent composition and method of making it |
| WO2017011326A1 (en) * | 2015-07-10 | 2017-01-19 | Sanjay Gupta | Nasal foam via cribriform plate for medication delivery to the brain and/or body and for nasal moisturization and hygiene |
| US11219594B2 (en) * | 2015-12-12 | 2022-01-11 | Steerlife India Private Limited | Effervescent compositions of metformin and processes for preparation thereof |
| JP2018183067A (ja) * | 2017-04-24 | 2018-11-22 | 株式会社松原製餡所 | 発泡性添加物、及び、餡食品 |
| EP4045008A4 (en) * | 2019-10-17 | 2023-11-15 | ISP Investments LLC | A stable effervescent co-processed excipient composition and a process for preparing the same |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CZ282781B6 (cs) * | 1993-03-10 | 1997-10-15 | Běres Részvénytársaság | Šumivé tablety nebo granule a způsob jejich přípravy |
| CZ283351B6 (cs) * | 1992-01-13 | 1998-03-18 | Gergely Gerhard | Farmaceutický přípravek ve formě šumící a/ nebo rozpadající se tablety nebo instantního granulátu a způsob její výroby |
| CZ285475B6 (cs) * | 1993-09-09 | 1999-08-11 | Gerhard Gergely | Šumící granulát a způsob jeho výroby |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4004036A (en) * | 1966-05-31 | 1977-01-18 | Alberto Culver Company | Effervescent molded triturate tablets |
| US3653914A (en) * | 1970-03-20 | 1972-04-04 | Alberto Culver Co | Production of tablets |
| ATE108649T1 (de) * | 1990-02-14 | 1994-08-15 | Takeda Chemical Industries Ltd | Brausemischung, deren herstellung sowie verwendung. |
| RU2096955C1 (ru) * | 1991-03-01 | 1997-11-27 | Е.И.Дюпон Де Немур Энд Компани | Вододиспергируемая гранулированная пестицидная композиция, получаемая методом экструзии, и способ ее получения |
| GB2307857B (en) * | 1995-12-04 | 1999-01-27 | Euro Celtique Sa | An effervescent formulation |
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1998
- 1998-05-15 DE DE19822036A patent/DE19822036A1/de not_active Withdrawn
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1999
- 1999-04-29 GT GT199900062A patent/GT199900062A/es unknown
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- 1999-05-03 EP EP99922151A patent/EP1077684B1/de not_active Expired - Lifetime
- 1999-05-03 BR BR9910454-7A patent/BR9910454A/pt not_active IP Right Cessation
- 1999-05-03 CZ CZ20004171A patent/CZ300778B6/cs not_active IP Right Cessation
- 1999-05-03 KR KR1020007012745A patent/KR100629817B1/ko not_active Expired - Fee Related
- 1999-05-03 ES ES99922151T patent/ES2203134T3/es not_active Expired - Lifetime
- 1999-05-03 TR TR2000/03357T patent/TR200003357T2/xx unknown
- 1999-05-03 PT PT99922151T patent/PT1077684E/pt unknown
- 1999-05-03 HU HU0101822A patent/HU224034B1/hu active IP Right Grant
- 1999-05-03 DK DK99922151T patent/DK1077684T3/da active
- 1999-05-03 EE EEP200000650A patent/EE04701B1/xx not_active IP Right Cessation
- 1999-05-03 ID IDW20002354A patent/ID27441A/id unknown
- 1999-05-03 AT AT99922151T patent/ATE246494T1/de active
- 1999-05-03 SK SK1706-2000A patent/SK284621B6/sk not_active IP Right Cessation
- 1999-05-03 JP JP2000549218A patent/JP4452403B2/ja not_active Expired - Lifetime
- 1999-05-03 DE DE59906519T patent/DE59906519D1/de not_active Expired - Lifetime
- 1999-05-03 PL PL99344140A patent/PL194347B1/pl unknown
- 1999-05-03 SI SI9930356T patent/SI1077684T1/xx unknown
- 1999-05-03 HR HR20000781A patent/HRP20000781B1/xx not_active IP Right Cessation
- 1999-05-03 AU AU39297/99A patent/AU3929799A/en not_active Abandoned
- 1999-05-03 IL IL13924099A patent/IL139240A/xx not_active IP Right Cessation
- 1999-05-03 WO PCT/EP1999/002969 patent/WO1999059553A1/de not_active Ceased
- 1999-05-06 PA PA19998472001A patent/PA8472001A1/es unknown
- 1999-05-10 HN HN1999000067A patent/HN1999000067A/es unknown
- 1999-05-10 AR ARP990102193A patent/AR016473A1/es not_active Application Discontinuation
- 1999-05-13 CO CO99029806A patent/CO4830457A1/es unknown
- 1999-05-13 PE PE1999000400A patent/PE20000465A1/es not_active Application Discontinuation
- 1999-05-14 UY UY25510A patent/UY25510A1/es not_active IP Right Cessation
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2000
- 2000-11-13 NO NO20005722A patent/NO20005722L/no not_active Application Discontinuation
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CZ283351B6 (cs) * | 1992-01-13 | 1998-03-18 | Gergely Gerhard | Farmaceutický přípravek ve formě šumící a/ nebo rozpadající se tablety nebo instantního granulátu a způsob její výroby |
| CZ282781B6 (cs) * | 1993-03-10 | 1997-10-15 | Běres Részvénytársaság | Šumivé tablety nebo granule a způsob jejich přípravy |
| CZ285475B6 (cs) * | 1993-09-09 | 1999-08-11 | Gerhard Gergely | Šumící granulát a způsob jeho výroby |
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| Date | Code | Title | Description |
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| MK4A | Patent expired |
Effective date: 20190503 |