CZ294217B6 - Nová oxabispidinová sloučenina vhodná pro léčení srdeční arytmie - Google Patents

Nová oxabispidinová sloučenina vhodná pro léčení srdeční arytmie Download PDF

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Publication number
CZ294217B6
CZ294217B6 CZ2003923A CZ2003923A CZ294217B6 CZ 294217 B6 CZ294217 B6 CZ 294217B6 CZ 2003923 A CZ2003923 A CZ 2003923A CZ 2003923 A CZ2003923 A CZ 2003923A CZ 294217 B6 CZ294217 B6 CZ 294217B6
Authority
CZ
Czechia
Prior art keywords
solution
added
mixture
compound
oxa
Prior art date
Application number
CZ2003923A
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Czech (cs)
English (en)
Other versions
CZ2003923A3 (cs
Inventor
Björsneámagnus
Cladingboeládavid
Ponténáfritiof
Strandlundágert
Original Assignee
Astrazenecaáab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from PCT/SE2000/001994 external-priority patent/WO2001028992A2/en
Application filed by Astrazenecaáab filed Critical Astrazenecaáab
Publication of CZ2003923A3 publication Critical patent/CZ2003923A3/cs
Publication of CZ294217B6 publication Critical patent/CZ294217B6/cs

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/08—Bridged systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics

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  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cardiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
CZ2003923A 2000-10-02 2001-10-01 Nová oxabispidinová sloučenina vhodná pro léčení srdeční arytmie CZ294217B6 (cs)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
PH12000002701 2000-10-02
PCT/SE2000/001994 WO2001028992A2 (en) 1999-10-18 2000-10-13 New oxabispidine compounds useful in the treatment of cardiac arrhythmias

Publications (2)

Publication Number Publication Date
CZ2003923A3 CZ2003923A3 (cs) 2003-08-13
CZ294217B6 true CZ294217B6 (cs) 2004-10-13

Family

ID=52573779

Family Applications (1)

Application Number Title Priority Date Filing Date
CZ2003923A CZ294217B6 (cs) 2000-10-02 2001-10-01 Nová oxabispidinová sloučenina vhodná pro léčení srdeční arytmie

Country Status (22)

Country Link
US (5) US6936712B1 (cg-RX-API-DMAC7.html)
EP (3) EP1900741A1 (cg-RX-API-DMAC7.html)
JP (2) JP2004510775A (cg-RX-API-DMAC7.html)
KR (2) KR20030032060A (cg-RX-API-DMAC7.html)
CN (3) CN1243754C (cg-RX-API-DMAC7.html)
AR (1) AR030756A1 (cg-RX-API-DMAC7.html)
AU (3) AU9250401A (cg-RX-API-DMAC7.html)
BR (2) BR0114366A (cg-RX-API-DMAC7.html)
CA (2) CA2421776A1 (cg-RX-API-DMAC7.html)
CZ (1) CZ294217B6 (cg-RX-API-DMAC7.html)
EE (1) EE200300131A (cg-RX-API-DMAC7.html)
HU (1) HUP0302288A3 (cg-RX-API-DMAC7.html)
IL (3) IL154803A0 (cg-RX-API-DMAC7.html)
IS (1) IS6744A (cg-RX-API-DMAC7.html)
MX (2) MXPA03002759A (cg-RX-API-DMAC7.html)
NO (2) NO20031413L (cg-RX-API-DMAC7.html)
NZ (2) NZ524573A (cg-RX-API-DMAC7.html)
PL (1) PL364047A1 (cg-RX-API-DMAC7.html)
RU (1) RU2003107668A (cg-RX-API-DMAC7.html)
SK (1) SK3862003A3 (cg-RX-API-DMAC7.html)
WO (2) WO2002028864A1 (cg-RX-API-DMAC7.html)
ZA (2) ZA200301757B (cg-RX-API-DMAC7.html)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE9903759D0 (sv) * 1999-10-18 1999-10-18 Astra Ab Pharmaceutically active compounds
GB0223712D0 (en) * 2002-10-14 2002-11-20 Astrazeneca Ab Chemical intermediate
SE0401539D0 (sv) * 2004-06-15 2004-06-15 Astrazeneca Ab New compounds
SE0401540D0 (sv) * 2004-06-15 2004-06-15 Astrazeneca Ab New compounds
CN101243093A (zh) 2005-06-13 2008-08-13 阿斯利康(瑞典)有限公司 用于治疗心律不齐的新型氧杂双哌啶化合物
WO2006137772A1 (en) * 2005-06-20 2006-12-28 Astrazeneca Ab New physical form of n,n´- disubstituted oxabispidines
WO2006137770A1 (en) * 2005-06-20 2006-12-28 Astrazeneca Ab Process for the preparation of n,n´- disubstituted oxabispidines
AR054391A1 (es) * 2005-06-20 2007-06-20 Astrazeneca Ab Procedimiento para la preparacion de 3,7- dihidroxi-1,5-diazaciclooctanos
BRPI0611841A2 (pt) * 2005-06-20 2016-08-30 Astrazeneca Ab processos para isolar um sal, para preparar um sal, e para a preparação de um composto
CN103319423B (zh) * 2013-06-28 2015-10-28 江苏师范大学 一种3,7-双芳基-1,5-二氧-3,7-二氮杂环辛烷的合成方法
KR20150082070A (ko) 2014-01-06 2015-07-15 (주)신비넷 위치 인식 시스템 및 그 시스템에서의 위치 인식을 위한 장치 및 방법
EP3059229A1 (en) 2015-02-17 2016-08-24 Evonik Degussa GmbH Method for the epoxidation of an olefin with hydrogen peroxide
CN115054728B (zh) * 2022-07-18 2023-11-07 中国科学院大学宁波华美医院 一种仿生骨组织工程支架材料及其制备方法

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3503939A (en) * 1967-03-29 1970-03-31 Du Pont Polyamides from heterocyclic diamines
DE2428792A1 (de) * 1974-06-14 1976-01-02 Knoll Ag Neue antiarrhythmika
DE3112055A1 (de) * 1981-03-27 1982-10-07 Basf Ag, 6700 Ludwigshafen Bispidinderivate, ihre herstellung und diese enthaltende arzneimittel
DE3234697A1 (de) * 1982-09-18 1984-03-22 Kali-Chemie Pharma Gmbh, 3000 Hannover Neue diazabicyclo-(3,3,1)-nonane
DE3732094A1 (de) * 1987-09-24 1989-04-06 Basf Ag Bispidinderivate als klasse iii-antiarrhythmika
DE3902357A1 (de) 1989-01-27 1990-08-02 Hoechst Ag Verwendung von rheniumorganischen verbindungen zur oxidation von c-c-mehrfachbindungen, darauf basierende oxidationsverfahren und neue rheniumorganische verbindungen
US5140033A (en) * 1989-04-03 1992-08-18 Bayer Aktiengesellschaft Antibacterial 5-alkylquinolonecarboxylic acids
US5110933A (en) * 1989-11-13 1992-05-05 Board Of Regents Of Oklahoma State University Salts of 3-azabicyclo[3.3.1]nonanes as antiarrhythmic agents, and precursors thereof
US5468858A (en) * 1993-10-28 1995-11-21 The Board Of Regents Of Oklahoma State University Physical Sciences N-alkyl and n-acyl derivatives of 3,7-diazabicyclo-[3.3.1]nonanes and selected salts thereof as multi-class antiarrhythmic agents
US5831099A (en) 1995-03-10 1998-11-03 The United States Of America As Represented By The Secretary Of The Army Compounds of 1,5-disubstituted-3,7 diaza bicyclo 3.3.0! octanes and products containing the same
US5939568A (en) 1997-01-31 1999-08-17 The Scripps Research Institute Accelerated catalysis of olefinic epoxidations
SE9704709D0 (sv) 1997-12-17 1997-12-17 Astra Ab Pharmaceutically active compounds
HK1042091A1 (zh) * 1999-04-09 2002-08-02 阿斯特拉曾尼卡有限公司 金剛烷衍生物
AUPQ274199A0 (en) 1999-09-09 1999-09-30 Ericsson Australia Pty Ltd Information transmission rate control across a core network
SE9903759D0 (sv) 1999-10-18 1999-10-18 Astra Ab Pharmaceutically active compounds
GB0223712D0 (en) * 2002-10-14 2002-11-20 Astrazeneca Ab Chemical intermediate

Also Published As

Publication number Publication date
NO20031413L (no) 2003-05-22
US20050171100A1 (en) 2005-08-04
EP1330462A1 (en) 2003-07-30
AU9250401A (en) 2002-04-15
KR20030032060A (ko) 2003-04-23
BR0114366A (pt) 2003-08-12
SK3862003A3 (en) 2003-10-07
BR0114367A (pt) 2003-12-09
US20040039199A1 (en) 2004-02-26
AU2001292504B2 (en) 2006-09-07
AR030756A1 (es) 2003-09-03
MXPA03002759A (es) 2003-07-28
CN1243754C (zh) 2006-03-01
JP2004510776A (ja) 2004-04-08
NZ524574A (en) 2004-11-26
CA2421776A1 (en) 2002-04-11
PL364047A1 (en) 2004-12-13
RU2003107668A (ru) 2004-11-27
JP2004510775A (ja) 2004-04-08
NO20031414L (no) 2003-05-26
HUP0302288A3 (en) 2004-11-29
CN1468244A (zh) 2004-01-14
CN1468245A (zh) 2004-01-14
NZ524573A (en) 2004-11-26
US7439355B2 (en) 2008-10-21
AU2001292503A1 (en) 2002-04-15
US20090240051A1 (en) 2009-09-24
EE200300131A (et) 2003-06-16
NO20031414D0 (no) 2003-03-27
KR100812920B1 (ko) 2008-03-11
CZ2003923A3 (cs) 2003-08-13
CA2422810A1 (en) 2002-04-11
IL154802A0 (en) 2003-10-31
NO20031413D0 (no) 2003-03-27
IL154803A0 (en) 2003-10-31
WO2002028864A1 (en) 2002-04-11
KR20030032061A (ko) 2003-04-23
CN1793146A (zh) 2006-06-28
US20090036675A1 (en) 2009-02-05
WO2002028863A8 (en) 2003-06-05
WO2002028863A1 (en) 2002-04-11
EP1900741A8 (en) 2010-08-04
IL154803A (en) 2008-03-20
EP1330461A1 (en) 2003-07-30
JP4248873B2 (ja) 2009-04-02
ZA200301757B (en) 2004-02-05
HUP0302288A2 (hu) 2003-10-28
MXPA03002679A (es) 2003-06-24
ZA200302202B (en) 2004-06-28
US6936712B1 (en) 2005-08-30
EP1900741A1 (en) 2008-03-19
IS6744A (is) 2003-03-13

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Legal Events

Date Code Title Description
MM4A Patent lapsed due to non-payment of fee

Effective date: 20051001